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| 1 | Association of NFKB1 gene polymorphism (rs28362491) with levels of inflammatory biomarkers and susceptibility to diabetic nephropathy in Asian Indians显示文摘AIM To investigate the association of NFKB1 gene-94 ATTG insertion/deletion(rs28362491) polymorphism with inflammatory markers and risk of diabetic nephropathy in Asian Indians.METHODS A total of 300 subjects were recruited(100 each), normoglycemic,(NG); type 2 diabetes mellitus(T2DM) without any complications(DM) and T2 DM with diabetic nephropathy [DM-chronic renal disease(CRD)]. Analysis was carried out by polymerase chain reaction-restriction fragment length polymorphism and ELISA. Pearson's correlation, analysis of variance and logistic regression wereused for statistical analysis.RESULTS The allelic frequencies of-94 ATTG insertion/deletion were 0.655/0.345(NG), 0.62/0.38(DM) and 0.775/0.225(DM-CRD). The-94 ATTG ins allele was associated with significantly increased levels of urinary monocyte chemoattractant protein-1(u MCP-1); u MCP-1(P = 0.026) and plasma tumor necrosis factor-alpha(TNF-α); TNF-α(P = 0.030) and almost doubled the risk of diabetic nephropathy(OR = 1.91, 95%CI: 1.080-3.386, P = 0.025).CONCLUSION-94 ATTG ins/ins polymorphism might be associated with increased risk of developing nephropathy in Asian Indian subjects with diabetes mellitus. | Amar Gautam Stuti Gupta Mohit Mehndiratta Mohini Sharma Kalpana Singh Om P Kalra Sunil Agarwal Jasvinder K Gambhir | 2017 | World Journal of Diabetes2017，8，2： | 4 |
| 2 | 欧洲和中国的心脏与肾脏远程缺血预适应研究:一项随机对照试验显示文摘远程缺血预适应(remote ischemic preconditioning,RIPC)对经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术后造影剂肾病(contrast-induced nephropathy,CIN)的潜在保护作用尚待确定。该研究为双盲、随机、安慰剂对照的多中心研究,纳入年龄〈85岁,肾清除率为30~60mL/(min·1.73m^2)的有临床适应证的患者,除了直接PCI外均按1∶1给予RIPC或标准治疗。主要终点是CIN的发生率。次要终点是围手术期心肌梗死(peri-procedural myocardial infarction,PMI)的发生率。 | 刘青 叶鹏 Moretti C Cerrato E Cavallero E Lin S Rossi ML Picchi A Sanguineti F Ugo F Palazzuoli A Bertaina M Presbitero P Shao-Liang C Pozzi R Giammaria M Limbruno U Lefèvre T Gasparetto V Garbo R OmedèP Sheiban I Escaned J Biondi-Zoccai G Gaita F Perl L D'Ascenzo F | 2018 | 中华高血压杂志2018，26，4： | 3 |
| 3 | A rare case of langerhans cell histiocytosis of the gastrointestinal tract显示文摘Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the proliferation of specialized,bone marrow-derived langerhans cells and mature eosinophils.The clinical spectrum ranges from an acute,fulminant,disseminated disease called LettererSiwe disease to solitary or few,indolent and chronic lesions of the bone or other organs called eosinophilic granuloma.Involvement of the gastrointestinal tract is very rare in LCH.We present the case of a 53-yearold woman referred by her primary care physician for a screening colonoscopy.A single sessile polyp,measuring 4 mm in size,was found in the rectum.Histopathological examination revealed that the lesion was relatively well circumscribed and comprised mainly a mixture of polygonal cells with moderate-to-abundant pink slightly granular cytoplasm.The nuclei within these cells had frequent grooves and were occasionally folded.Immunohistochemical staining was positive for CD1a which confirmed the diagnosis of LCH.On further workup,there was no evidence of involvement of any other organ.On follow up colonoscopy one year later,there was no evidence of disease recurrence.Review of the published literature revealed that LCH presenting as solitary colonic polyp is rare.However,with the increas-ing rates of screening colonoscopy,more colonic polyps may be identified as LCH on histopathology.This underscores the importance of recognizing this rare condition and ensuring proper follow-up to rule out systemic disease. | Uday Shankar Monika Prasad Om P Chaurasia | 2012 | World Journal of Gastroenterology2012，18，12： | 2 |
| 4 | Perils of Rib Fractures显示文摘 | Sharma Om P Oswanski Michael F Jolly Shashank Lauer Sherry K Dressel Rhonda Stombaugh Heather A | 2008 | The American Surgeon2008，，4： | 2 |
| 5 | Effect of K2O addition on crystallization and microstructural behaviour of the strontium titanate-borosilicate glass-ceramic system显示文摘 | THAKUR O P KUMAR Devendra PARKASH Om etal | 1995 | Mater Lett1995，23，： | 2 |
| 6 | A prosp ective study toevaluate the anatomic and functionaloutcome of a transobturator mesh kit ( proliftant erior) for symptom atic cystocele repair 显示文摘 | H inou 1 P Om beletWU B urgerMP | 2008 | JM inim Invasive Gynecol2008，15，5： | 1 |
| 7 | Parkinson-like syndrome induced by continuous MPTP infusion:convergent roles of the ubiquitin-proteasome system and α-synuclein显示文摘 | Fornai F Schlüter OM Lenzi P | 2005 | Proc Natl Acad Sci USA2005，102，9： | 1 |
| 8 | Recurrence of hyperpro?lactinemia after withdrawal of dopamine agonists , systematic review and meta-analysis显示文摘 | Dekkers OM Lagro 1 Burman P | 2010 | 1 Clin Endocrinol Metab2010，95，1： | 1 |
| 9 | DPPH antioxidant assay revisited显示文摘 | OM P S EJ K B | 2009 | Food Chem2009，113，： | 1 |
| 10 | Brain single photon emission computed tomography (SPECT)in neuropediatrics 显示文摘 | Uvebrant P Bjure J Hedstr Om A | 1991 | Neuropediatrics1991，2，1： | 1 |
| 11 | Solution for a fractional diffusion-wave equation defined in a bounded domain显示文摘 | Om P Agrawal | 2002 | Nonlinear dynamics2002，29，： | 1 |
| 12 | Phase-only synthesis of minimum peak side lobe patterns for linear and planar arrays显示文摘 | Jonh F Deford Gandhi Om P | 1988 | IEEE Transaction on Antennas and Propagation1988，36，2： | 1 |
| 13 | Residual renal function and mortality risk in hemodialysis patients显示文摘 | Shemin D Bost om AG Laliberty P | 2001 | Am J Kidney Dis2001，38，01： | 1 |
| 14 | Immunotherapy of diffuse gliomas: biological background, current status and future developments显示文摘 | Grauer OM Wesseling P Adema GJ | 2009 | Brain Pathol2009，19，4： | 1 |
| 15 | Mechanical efficacy of vertebroplasty: influence of cement type, BMO, fracture severity, and disc degeneration 显示文摘 | Luo J Skrzypiec OM Pollintine P | 2007 | Bone2007，40，4： | 1 |
| 16 | The acute rise in plasma fibrinogen concentration with exercise is influenced by the G-453-A polymorphism of the β-fibrinogon gene显示文摘 | Clarkaon P Nwose OM | 1996 | Arteriosvler Thromb Vaac Biol1996，16，： | 1 |
| 17 | Recurrence of hyperpro- laetinemia after withdrawal of dopamine agonists : systematic review andmeta-analysis 显示文摘 | Dekkers OM Lagro J Burman P | 2010 | Clin Endocrinol Metab2010，95，1： | 1 |
| 18 | Chronic obstructive pulmonary disease is associated with osteoporosis and low levels of vitamin D显示文摘 | Franco CB Paz-Filho G G omes P E N ascimento V B Kulak CA Boguszewski CL Borba VZ | | 0，，： | 1 |
| 19 | DPPH antioxidant assay revisited显示文摘 | Om P Sharma Tej K Bhat | 2009 | Food Chemistry2009，113，4： | 1 |
| 20 | Laparoscopic radical cystectomy:a 5-year review of a single institute's operative data and complications and a systematic review of the literature显示文摘 | Aboumarzouk OM Drewa T Olejniczak P | 2012 | Int Braz J Urol2012，38，3： | 1 |
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