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| 1 | Deep-learning classifier with ultrawide-field fundus ophthalmoscopy for detecting branch retinal vein occlusion显示文摘AIM: To investigate and compare the efficacy of two machine-learning technologies with deep-learning(DL) and support vector machine(SVM) for the detection of branch retinal vein occlusion(BRVO) using ultrawide-field fundus images. METHODS: This study included 237 images from 236 patients with BRVO with a mean±standard deviation of age 66.3±10.6 y and 229 images from 176 non-BRVO healthy subjects with a mean age of 64.9±9.4 y. Training was conducted using a deep convolutional neural network using ultrawide-field fundus images to construct the DL model. The sensitivity, specificity, positive predictive value(PPV), negative predictive value(NPV) and area under the curve(AUC) were calculated to compare the diagnostic abilities of the DL and SVM models. RESULTS: For the DL model, the sensitivity, specificity, PPV, NPV and AUC for diagnosing BRVO was 94.0%(95%CI: 93.8%-98.8%), 97.0%(95%CI: 89.7%-96.4%), 96.5%(95%CI: 94.3%-98.7%), 93.2%(95%CI: 90.5%-96.0%) and 0.976(95%CI: 0.960-0.993), respectively. In contrast, for the SVM model, these values were 80.5%(95%CI: 77.8%-87.9%), 84.3%(95%CI: 75.8%-86.1%), 83.5%(95%CI: 78.4%-88.6%), 75.2%(95%CI: 72.1%-78.3%) and 0.857(95%CI: 0.811-0.903), respectively. The DL model outperformed the SVM model in all the aforementioned parameters(P<0.001). CONCLUSION: These results indicate that the combination of the DL model and ultrawide-field fundus ophthalmoscopy may distinguish between healthy and BRVO eyes with a high level of accuracy. The proposed combination may be used for automatically diagnosing BRVO in patients residing in remote areas lacking access to an ophthalmic medical center. | Daisuke Nagasato Hitoshi Tabuchi Hideharu Ohsugi Hiroki Masumoto Hiroki Enno Naofumi Ishitobi Tomoaki Sonobe Masahiro Kameoka Masanori Niki Yoshinori Mitamura | 2019 | International Journal of Ophthalmology(English edition)2019，12，1： | 16 |
| 2 | Effects of Weak Light on Starch Accumulation and Starch Synthesis Enzyme Activities in Rice at the Grain Filling Stage显示文摘Dynamic changes of starch, amylose, sucrose contents and the activities of starch synthesis enzymes under shading treatments after flowering were studied using two rice varieties IR72 (indica) and Nipponbare (japonica) as materials. Under shading treatments, the starch, amylose and sucrose contents decreased, while ADP-glucose pyrophosphorylase (ADPGPPase) activity only changed a little, soluble starch synthase activity and granule bound starch synthase activity decreased, soluble starch branching enzyme (SSBE, Q-enzyme) activity and granule bound starch branching enzyme (GBSBE, Q-enzyme) activity increased, and starch debranching enzyme (DBE, R-enzyme) activity varied with varieties. Correlation analyses showed that the changes of starch content were positively and significantly correlated with the changes of sucrose content in the weak light. Both ADPGPPase activity and SSBE activity werep ositively and significantly correlated with starch accumulation rate. It was implied that the decline of starch synthase activities was related to the decrease of starch content and the increase of the activity of starch branching enzyme played an important role in the decrease of the ratio of amylose to the total starch under the weak light. | LI Tian Ryu OHSUGI Tohru YAMAGISHI Haruto SASAKI | 2006 | Rice science2006，13，1： | 7 |
| 3 | High Temperature During Rice Grain Filling Enhances Aspartate Metabolism in Grains and Results in Accumulation of AspartateFamily Amino Acids and Protein Components显示文摘Global warming causes the exacerbation of rice growing environment, which seriously affects rice growth and reproduction, and finally results in the decrease of rice yield and quality. We investigated the activities of aspartate metabolism enzymes in grains, and the contents of Aspartate-family amino acids and protein components to further understand the effects of high temperature(HT) on rice nutritional quality during rice grain filling. Under HT, the average activities of aspartate aminotransferase(AAT) and aspartokinase(AK) in grains significantly increased, the amino acid contents of aspartate(Asp), lysine(Lys), threonine(Thr), methionine(Met) and isoleucine(Ile) and the protein contents of albumin, globulin, prolamin and glutelin also significantly increased. The results indicated that HT enhanced Asp metabolism during rice grain filling and the enhancement of Asp metabolism might play an important role in the increase of Asp-family amino acids and protein components in grains. In case of the partial appraisal of the change of Asp-family amino acids and protein components under HT, we introduced eight indicators(amino acid or protein content, ratio of amino acid or protein, amino acid or protein content per grain and amino acid or protein content per panicle) to estimate the effects of HT. It is suggested that HT during rice grain filling was benefit for the accumulation of Asp-family amino acids and protein components. Combined with the improvement of Asp-family amino acid ratio in grains under HT, it is suggested that HT during grain filling may improve the rice nutritional quality. However, the yields of parts of Asp-family amino acids and protein components were decreased under HT during rice grain filling. | LIANG Cheng-gang ZHANG Qing XU Guang-li WANG Yan Ryu OHSUGI LI Tian | 2013 | Rice science2013，20，5： | 6 |
| 4 | Effect of High Temperature on Sucrose Content and Sucrose Cleaving Enzyme Activity in Rice Grain During the Filling Stage显示文摘Dynamic changes of sucrose, fructose, glucose contents and differences in activities of sucrose synthase, vacuolar invertase, and cell wall bound invertase in rice grain after flowering stage were studied under natural and high temperatures by using two japonica rice varieties Koshihikari and Sasanishiki. In rice grains, the sucrose synthase activity was higher than that of invertase, which was significantly correlated with starch accumulation rate, indicating that the sucrose synthase played an important role in sucrose degradation and starch synthesis. Under high temperature, the significant increase in grain sucrose content without any increase in fructose and glucose contents, suggested that the high temperature treatment enhanced sucrose accumulation, while diminished sucrose degradation in rice grains. Compared with the control plants, the decrease in activities of sucrose synthase, vacuolar invertase, and cell wall bound invertase with high temperature treated plants indicated that the deceleration of sucrose-degradation was related to the decrease in activities of sucrose synthase and invertase. | LI Tian LIU Qi-hua Ryu OHSUGI Tohru YAMAGISHI Haruto SASAKI | 2006 | Rice science2006，13，3： | 5 |
| 5 | Changes in choroidal thickness in healthy pediatric individuals: a longitudinal study显示文摘● AIM: To investigate the changes in the choroidal thickness in healthy pediatric children in a longitudinal study, and to determine the ocular and systemic parameters that were significantly correlated with the changes in the choroidal thickness.● METHODS: This study included 64 eyes of 34 healthy Japanese children with a mean age(±SD) of 4.4(±0.4)y(range, 3.6-5.8 y) at baseline. Swept-source optical coherence tomography(SS-OCT) was used to record images of the retina and choroid at the baseline and after a mean followup period of about 1.5 y. The 3 D raster scan protocol was used to construct the choroidal thickness map. Mean choroidal thickness was calculated for each of the nine sectors of the Early Treatment Diabetic Retinopathy Study grid. Best-corrected visual acuity, axial length, body height, and weight were also measured. Changes in measurements were defined as the baseline values subtracted from the values at the final visit. A generalized estimating equation was used to eliminate the effect of within-subject intereye correlations.● RESULTS: The mean central choroidal thickness was significantly reduced during the follow-up period(baseline, 301.8±8.6 μm; final visit, 286.6±8.0 μm, P<0.001). The decrease in the choroidal thickness was greatest in the central sector, followed by the sectors of the inner and outer rings. The inner and outer rings had diameters of 1 to 3 mm and 3 to 6 mm, respectively. The changes in the choroidal thickness in the central, inner ring, and outer ring sectors were significantly and negatively correlated with the age, baseline body height, baseline body weight, and elongation of the axial length.● CONCLUSION: These results indicate that the choroidal thickness among preschool-aged Japanese children decreased significantly during the follow-up period. The choroidal thinning is significantly associated with the elongation of axial length. These characteristics should be considered in the evaluation of choroidal thickness in younger children with retinochoroidal disorders. | Eiko Ohsugi Yoshinori Mitamura Kayo Shinomiya Masanori Niki Hiroki Sano Toshihiko Nagasawa Yukiko Shimizu Daisuke Nagasato Hitoshi Tabuchi | 2018 | International Journal of Ophthalmology(English edition)2018，11，7： | 2 |
| 6 | Tob,a novel protein that interacts with p185erbB2,is associated with anti-proliferative activity显示文摘 | Matsuda S Kawamura-Tsuzuku J Ohsugi M | 1996 | Oncogene1996，12，4： | 1 |
| 7 | Blockade of interleukin-6 receptor suppresses reactive astrogliosis and ameliorates functional recovery in experimental spinal cord injury显示文摘 | Okada S Nakamura M Mikami Y Shimazaki T Mihara M Ohsugi Y | 2004 | J Neurosci Res2004，76，2： | 1 |
| 8 | Effect of a novel substance from natto on tissue-type plasminogen activator(t-PA)release in perfused rat hindlegs显示文摘 | OHSUGI T SUMIDA E SUMI H | 2013 | Open Food Science Journal2013，7，： | 1 |
| 9 | Active-oxygen scaven ging activity of traditional nourishing-tonic herbal medi cines and active constituents of Rhodiola sacra 显示文摘 | Ohsugi M Fan W Hase K | 1999 | J Eth nopharmacol1999，67，： | 1 |
| 10 | E- cadherin null mutant embryos fail to form a trophec- toderm epithelium显示文摘 | LARUE L OHSUGI M HIRCHENHAIN J | 1994 | Proc Natl Acad Sci U S A1994，91，17： | 1 |
| 11 | Antitumor and immunosuppressive effects of mycophenolic acid derivatives 显示文摘 | Ohsugi Y Suzuki S Takagaki Y | 1976 | Cancer Res1976，36，8： | 1 |
| 12 | Interleukin-6 receptor-mediated activation of signal transducer and activator of transcription-3 ( STAT3 ) promotes choroidal neovascularization 显示文摘 | Izumi-Nagai K Nagai N Ozawa Y Mihara M Ohsugi Y Kurihara T | 2007 | Am J Pathol2007，170，6： | 1 |
| 13 | Beta-catenin is a major tyrosine-phosphurylated protein during mouse oocyte maturation and preimplantation development 显示文摘 | Ohsugi M Butz S Kemler R | 1999 | Dev Dyn1999，216，2： | 1 |
| 14 | Hepatoprotective effect of Hoven iadulcis Thunb on experimental liver injuries induces by carbon tetrachloride or D-galactosamine/lipopolysaccharide 显示文摘 | Hase K Ohsugi M XiongQB | 1997 | Biol and pharma bulletin1997，20，4： | 1 |
| 15 | Tob, a novel protein that interacts with p185erbB2 is associated with anti-proliferative activity显示文摘 | Matsuda S Kawamura-Tsuzuku J Ohsugi M | 1996 | Oncogene1996，12，： | 1 |
| 16 | Rapid tumor death model for evaluation of new therapeutic agents for adult T-cell leukemia显示文摘 | OHSUGI T YAMAGUCHI K KUMASAKA T el al | 2004 | Lab Invest2004，84，2： | 1 |
| 17 | Endoplasmie retieulum stress -induced apoptosis is partly mediated by reduced insulin signaling through phosphatidylinositol 3 - kinase/Akt and increased glycogen synthase kinase - 3beta in mouse insulinoma cells 显示文摘 | Srinivasan S Ohsugi M Liu Z | 2005 | Diabetes2005，54，4： | 1 |
| 18 | Enzymatic corrections for cells derived from Fabry disease patients by a recombinant adenovirus vector 显示文摘 | Ohsugi K Kobayashi K ltoh K Sakuraba H Sakuragawa N | 2000 | J Hum Genet2000，45，1： | 1 |
| 19 | Glucose and insulin treatment of insulinoma cells results in transcriptional regulation of a common set of genes显示文摘 | Ohsugi Mitsuru Cras-M 6 neur Corentin | 2004 | Diabetes2004，53，6： | 1 |
| 20 | Gene expression of oligodendrocyte markers in human amniotic epithelial cells using neural cell-type-specific expression system显示文摘 | Ishii T Ohsugi K Nakamura S | 1999 | Neurosci Lett1999，268，： | 1 |
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