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| 1 | 铅对肾上腺皮质细胞线粒体的氧化损伤显示文摘【目的】研究铅对肾上腺皮质细胞氧化应激和线粒体功能的影响 ,为了解其肾上腺皮质毒作用机制提供依据。【方法】原代分离培养豚鼠肾上腺皮质细胞 ,以 0、6 2 5、12 5、2 5、5 0、10 0 μmol/L醋酸铅 (PbAc)处理细胞 ,观察PbAc诱导肾上腺皮质细胞活性氧 (ROS)产生和线粒体损伤作用。ROS检测采用荧光分光光度法 ,线粒体膜电位 (MMP)和细胞存活状态采用Rh12 3和PI双标记、流式细胞术检测 ,细胞ATP水平采用化学发光法测定。【结果】PbAc染毒后肾上腺皮质细胞ROS形成水平随剂量增加而增加 ,具有剂量效应关系 [^y=4 16 +10 2 1× 1g(x+1) ,P <0 0 1,R2 =0 6 41];线粒体膜电位呈剂量依赖性降低 ,Rh12 3的平均荧光强度 (MFI)在 6 2 5~ 10 0 μmol/L各剂量组依次为 1 0 1,0 94,0 96 ,0 95和 0 91,与对照组(1 35 )比较具有显著性差异 (P <0 0 1) ;染毒后细胞死亡率轻度增加 ,与对照组 (1 0 2 % )比较 ,5 0 μmol/L和 10 0 μmol/L的PbAc组分别为 3 16 %和 3 40 % ,差异具有显著性 (P <0 0 5 ) ;ATP水平降低与PbAc剂量之间存在剂量效应关系 [^y =2 12 96 5 7- 5 15 92 5× 1g(x +1) ,P <0 0 1,R2 =0 5 6 8],剂量和时间对ATP水平的影响呈协同抑制作用 (P <0 0 1)。【结论】线粒体氧化应激介导肾? | 杨杏芬 庄志雄 魏青 凌莉 范瑞泉 Shen H M Ong C N | 2001 | 中山医科大学学报2001，22，1： | 8 |
| 2 | Hepatitis B infection among adults in the philippines:A national seroprevalence study显示文摘AIM:To determine the prevalence of hepatitis B surface antigen(HBsAg)seropositivity among adult Filipinos.METHODS:Testing for HBsAg was performed on serum samples from persons aged ≥ 20 years old who participated in the National Nutrition and Health Survey(NNHeS)conducted in 2003.Information on age,sex,marital status,educational attainment,employment status,and income were collected.For this study,marital status was classified as never married or otherwise(i.e.,married,divorced,separated,widowed);educational attainment was classified as high school graduate or below or at least some tertiary education;and employment status was classified as currently employed or currently unemployed.Annual income was divided into 4 quartiles in Philippine pesos(PhP):Q1,≤ PhP 53064;Q2,PhP 53065-92192;Q3,PhP 92193-173387;and Q4,≥ PhP 173388.Prevalence estimates were weighted so that they represented the general population.Social and demographic factors were correlated with HBsAg seropositivity.Multivariate analysis was used to determine independent predictors of HBsAg seropositivity.RESULTS:A total of 2150 randomly selected adults,20 years and over,out of the 4753 adult participants of NNHeS were tested for HBsAg.The HBsAg seroprevalence was 16.7%(95%CI:14.3%-19.1%),which corresponded to an estimated 7278968 persons infected with hepatitis B.There was no significant difference between males and females(17.5% vs 16.0%;P = 0.555).This corresponded to an estimated 3721775 men and 3557193 women infected with hepatitis B.The HBsAg seroprevalence peaked at age 20-39 years old,with declining prevalence in the older age groups.The only independent predictor of HBsAg seropositivity was the annual income,with persons in the highest income quartile being less likely to be HBsAg positive(age-adjusted OR = 0.51;95%CI:0.30-0.86)compared to subjects in the lowest income quartile.Sex,marital status,educational attainment,and employment status were not found to be independent predictors of HBsAg seropositivity.CONCLUSION:The high HBsAg seroprevalence among adults in the Philippines classifies the country as hyperendemic for HBV infection and appears unchanged over the last few decades. | Stephen N Wong Janus P Ong Madalinee Eternity D Labio Oscar T Cabahug Maria Lourdes O Daez Erlinda V Valdellon Jose D Sollano Jr Marilyn O Arguillas | 2013 | World Journal of Hepatology2013，5，4： | 3 |
| 3 | Long-Term Follow-Up of Biopsy-Proven Viral Myocarditis显示文摘 | Stefan Grün Julia Schumm Simon Greulich Anja Wagner Steffen Schneider Oliver Bruder Eva-Maria Kispert Stephan Hill Peter Ong Karin Klingel Reinhardt Kandolf Udo Sechtem Heiko Mahrholdt | 2012 | Journal of the American College of Cardiology2012，，18： | 2 |
| 4 | CMR Imaging Predicts Death and Other Adverse Events in Suspected Cardiac Sarcoidosis显示文摘 | Simon Greulich Claudia Christina Deluigi Steffen Gloekler Andreas Wahl Christine Zürn Ulrich Kramer Detlev Nothnagel Helmut Bültel Julia Schumm Stefan Grün Peter Ong Anja Wagner Steffen Schneider Kai Nassenstein Meinrad Gawaz Udo Sechtem Oliver Bruder Hei | 2013 | JACC: Cardiovascular Imaging2013，，： | 2 |
| 5 | Noor Grafting of sodium carboxymethylcellulose (CMC) with glycidyl methacrylate and development of UV curable coatings from CMC-g-GMA induced by cationic photoinitiators显示文摘 | Lin Ong Hui Kumar R N Rozman H D | 2005 | Carbohydrate Polymers2005，59，1： | 1 |
| 6 | Proteolytic pattern and organic acid profiles of probiotic Cheeddar cheese as influenced by probiotic strains of Lactobacillus acidophilus, LactobaciUus paracasei, Lactobacillus casei or Bifidobacterium sp 显示文摘 | ONG L HENRIKSSON A SHAH N P | 2007 | International Dairy Journal2007，17，1： | 1 |
| 7 | Role of intracellular thiol depletion, mitochondrial dysfunction and reactive oxygen species in Salvia Miltiorrhiza-induced apoptosis in human hepatoma HepG2 cells 显示文摘 | Liu J Shen H M Ong C N | 2001 | Life Sciences2001，69，16： | 1 |
| 8 | Synthesis, characterization and comparative study of nano- Ag--TiO2 against Gram- positive and Gram- negative bacteria under fluorescent light 显示文摘 | BARUDIN N H A SREEKANTAN S ONG M T | 2014 | Food Control2014，，46： | 1 |
| 9 | Drug-related pemphigus and angiotensin converting enzyme inhibitors显示文摘 | Ong CS Cook N Lee S | 2000 | Australas J Dermatol2000，41，4： | 1 |
| 10 | Semi-ductile grinding and polishing of Pyrex glass显示文摘 | ONG N S VENKATSH V C | 1998 | Materials Processing Technology1998，83，： | 1 |
| 11 | Glass forming ability of bulk glass forming alloys显示文摘 | Li Y Ng S N Ong C K | 1997 | Scripta Material1997，36，7： | 1 |
| 12 | 显示文摘 | Ong H R Khan M R Chowdhury M N K | 2014 | Fuel2014，120，： | 1 |
| 13 | Strategies employed in the de- sign and optimization of synthetic antimicrobial peptide amphiphiles with enhanced therapeutic potentials 显示文摘 | Ong ZY Wiradharma N Yang YY | 2014 | Advanced Drug Delivery Reviews2014，30，78： | 1 |
| 14 | Automated high-performance liquid chromatographic method with pre-column reduction for the determination of ubiquinol and ubiquinone plasma 显示文摘 | WANG Q LEE B L ONG C N | 1999 | J Chromatogr B1999，726，： | 1 |
| 15 | Investigation of thermal benefits of rooftop garden in the tropical environment显示文摘 | Wong N H Chen Y Ong G L | 2003 | Build Environ2003，38，： | 1 |
| 16 | Stimulation of Phos- phatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins 显示文摘 | ONG SH HADARI YR GOTOH N | 2001 | Proc Nail Aead Sci USA2001，98，11： | 1 |
| 17 | Defining the impact of weakly estrogenic chemicals on the action of steroidal estrogens显示文摘 | RAJAPAKSE N ONG D KORTENKAMP A | | 0，，： | 1 |
| 18 | Experimental investigation into micro injection molding of plastic parts显示文摘 | Ong N S Koh Y H | 2005 | Materials and ManufacturingProcesses2005，20，2： | 1 |
| 19 | Analysis of step-lifetest data:a new approach 显示文摘 | Sun YS Goh T N Ong H L | 1996 | IEEE Transactions on Reliability1996，45，1： | 1 |
| 20 | Polyphyllin D-a potential anticancer agent to kill hepatocarcinoma cells with multi-drug resistance显示文摘 | Lee R K Y Ong R C Y Cheung J Y N | 2009 | Current Opinion in Chemical Biology2009，，3： | 1 |
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