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| 1 | Serum manganese superoxide dismutase and thioredoxin are potential prognostic markers for hepatitis C virus-related hepatocellular carcinoma显示文摘AIM:To evaluate the clinical significance of oxidative stress markers in patients with hepatitis C virus(HCV)related hepatocellular carcinoma(HCC).METHODS:Sixty-four consecutive patients who were admitted to Kagoshima University Medical and Dental Hospital were enrolled in this retrospective study.All patients had chronic liver disease(CLD) due to infection with HCV.Thirty patients with HCV-related HCC,34 with HCV-related CLD without HCC(non-HCC),and 20 healthy volunteers(HVs) were enrolled.Possible associations between serum manganese superoxide dismutase(MnSOD) and thioredoxin(TRX) levels and clinical parameters or patient prognosis were analyzed over a mean follow-up period of 31.7 mo.RESULTS:The serum MnSOD levels were significantly higher in patients with HCV-related HCC than in patients without HCC(P = 0.03) or HVs(P < 0.001).Similarly,serum TRX levels were also significantly higher in patients with HCV-related HCC than in patients without HCC(P = 0.04) or HVs(P < 0.01).However,serum levels of MnSOD and TRX were not correlated in patients with HCC.Among patients with HCC,the overall survival rate(OSR) was lower in patients with MnSOD levels ≥ 110 ng/mL than in patients with levels < 110 ng/mL(P = 0.01),and the OSR tended to be lower in patients with TRX levels < 80 ng/mL(P = 0.05).In addition,patient prognosis with HCC was poorest with serum MnSOD levels ≥ 110 ng/mL and serum TRX levels < 80 ng/mL.Furthermore,a multivariate analysis using a Cox proportional hazard model and serum levels of five factors(MnSOD,prothrombin time,serum albumin,serum α-fetoprotein(AFP),and serum des-γ-carboxy prothrombin) revealed that MnSOD levels ≥ 110 ng/mL(risk ratio:4.12,95% confidential interval:1.22-13.88,P = 0.02) and AFP levels ≥ 40 ng/mL(risk ratio:6.75;95% confidential interval:1.70-26.85,P < 0.01) were independent risk factors associated with a poor patient prognosis.CONCLUSION:Serum MnSOD and TRX levels are potential clinical biomarkers that predict patient prognosis in HCV-related HCC. | Tsutomu Tamai Hirofumi Uto Yoichiro Takami Kouhei Oda Akiko Saishoji Masashi Hashiguchi Kotaro Kumagai Takeshi Kure Seiichi Mawatari Akihiro Moriuchi Makoto Oketani Akio Ido Hirohito Tsubouchi | 2011 | World Journal of Gastroenterology2011，17，44： | 7 |
| 2 | Catheter ablation of atrial fibrillation guided by complex fractionated atrial electrogram mapping of atrial fibrillation substrate 显示文摘 | NADEMANEE K LOCKWOOD E OKETANI N | 2010 | J Cardiol2010，55，1： | 1 |
| 3 | Efficacy and safety of eltrombopag in Japanese patients with chronic liver disease and thrombocytopenia: a randomized, open-label, phase II study显示文摘 | Takumi Kawaguchi Atsumasa Komori Masataka Seike Shigetoshi Fujiyama Hiroshi Watanabe Masatoshi Tanaka Shotaro Sakisaka Makoto Nakamuta Yutaka Sasaki Makoto Oketani Toshihiro Hattori Koichi Katsura Michio Sata | 2012 | Journal of Gastroenterology2012，，12： | 1 |
| 4 | Inhibition by arsenic trioxide of human hepatoma cell growth显示文摘 | Oketani M Kohara K Tuvdendorj D | 2002 | Cancer Lett2002，183，2： | 1 |
| 5 | Inhibition by Arsenic trioxide of human hepatoma cell growth显示文摘 | Oketani M Kohara K Tuvdendorj D | 2002 | Cancer Lett2002，183，： | 1 |
| 6 | Risk factors for local recurrence of small hepatocellular carcinoma tumors after a single session, single application of percutaneous radiofrequency ablation 显示文摘 | Komorizono Y Oketani M Sako K | 2003 | Cancer2003，97，5： | 1 |
| 7 | Inhibition by arsenic trioxide of human hepatoma cell growth显示文摘 | Oketani M Kohara K Tuvdendorj D | 2002 | Cancer Lett2002，183，2： | 1 |
| 8 | Regulation of K(ATP) channels by P(2Y) purinoceptors coupled to PIP(2) metabolism in guinea pig ventricular cells显示文摘 | Oketani N Kakei M Ichinari K | 2002 | Am J Physiol Heart Circ Physiol2002，282，2： | 1 |
| 9 | Prevention of hepatitis B virus reactivation in patients receiving immunosuppressive therapy or chemotherapy显示文摘 | Oketani M Ido A Uto H | 2012 | Hepatology research2012，42，7： | 1 |
| 10 | Etiology and prog- nosis of fulminant hepatitis and late -onset hepatic failure in Ja- pan: summary of the annual nationwide survey between 2004 and 2009显示文摘 | OKETANI M IDO A NAKAYAMA N | 2013 | Hepatol Res2013，43，2： | 1 |
| 11 | Inhibition by arsenic trioxide of human hepatoma cells growth 显示文摘 | Kohara K Tuvdendorj D | 2002 | Cancer Lett2002，183，2： | 1 |
| 12 | Effect of right ventricular apex pacing on the Tei index and brain natriuretic peptide in patients with a dual-chamber pacemaker显示文摘 | Ichiki H Oketani N Hamasaki S | 2006 | Pacing Clin Electrophysiol2006，29，9： | 1 |
| 13 | Characteristics of hydrogen sulfide removal in a carrier packed biological deodorization system显示文摘 | SHINABE K OKETANI S OCHI T | 2000 | Biochemical Engineering Journal2000，5，3： | 1 |
| 14 | Guidelines for the management of hepatitis B virus infection显示文摘 | Asahina Y Izumi N Oketani M | 2013 | Kanzo (Jpn J Hepatol)2013，54，3： | 1 |
| 15 | Risk factors for local recurrence of small hepatocellular carcinoma tumors after a single session, single application of percutaneous radiofrequency ablation显示文摘 | Komorizono Y Oketani M Sako K | 2003 | Cancer2003，97，： | 1 |
| 16 | Regulation of K(ATP) channels by P(2Y) purinoceptors coupled to PIP(2) metabolism in guinea pig ventricular cells显示文摘 | Oketani N Kakei M Ichinari K | 2002 | Am J Physiol Heart Circ Physiol2002，282，2： | 1 |
| 17 | Prevention and management of hep- atitis B virus reactivation during antieancer or immunosup- pressive therapy 显示文摘 | Oketani M Tsubouchi H | 2011 | Nihon Rinsho Japanese Journal of Clini- cal Medicine2011，69，4： | 1 |
| 18 | Changing etiologies and outcomes of acute liver failure: A perspective from Japan 显示文摘 | Oketani M Ido A Tsubouehi H | 2011 | J Gastroenterol Hepatol2011，261，： | 1 |
| 19 | Decentralized control of chaos in nonlinear networks 显示文摘 | USHIO T HIRAI K | 1995 | Phys Lett1995，198，： | 1 |
| 20 | Etiology and prognosis of fulminant hepatitis and late-onset hepatic failure in Japan: sum- mary of the annual nationwide survey between 2004 and 2009 显示文摘 | Oketani M Ido A Nakayama N | 2013 | Hepatol Res2013，43，2： | 1 |
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