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| 1 | Cyclooxygenase-2 expression after preoperative chemoradiotherapy correlates with more frequent esophageal cancer recurrence显示文摘AIM: To investigate the relationship between cycloo- xygenase-2 (COX-2), and vascular endothelial growth factor (VEGF), and to determine the clinical significance of this relationship in esophageal cancer patients undergoing chemoradiotherapy (CRT). METHODS: Immunohistochemical staining was used to evaluate COX-2 and VEGF expression in 40 patients with histologically-confirmed esophageal squamous carcinoma (ESCC) who were undergoing preoperative CRT. RESULTS: Fourteen out of 40 ESCC patients showed a pathological complete response (CR) after CRT. COX-2 and VEGF protein expressions were observed in the cytoplasm of 17 and 13 tumors, respectively, with null expression in 9 and 13 tumors, respectively. COX-2 expression was strongly correlated with VEGF expression (P < 0.05). There were also significant associations between COX-2 expression, tumor recurrence, and lymph-node involvement (P = 0.0277 and P = 0.0095, respectively). COX-2 expression and VEGF expression had significant prognostic value for disease-free survival (log-rank test; P = 0.0073 and P = 0.0341, respectively), but not for overall survival, as assessed by univariate analysis. CONCLUSION: Our results suggest that COX-2 expression correlates with VEGF expression and might be a useful prognostic factor for more frequent tumor recurrence in ESCC patients undergoing neoadjuvant CRT. These findings support the use of anti-angiogenic COX-2 inhibitors in the treatment of ESCC. | Reigetsu Yoshikawa Yoshinori Fujiwara Kenji Koishi Syoudou Kojima Tomohiro Matsumoto Hidenori Yanagi Takehira Yamamura Tomoko Hashimoto-Tamaoki Takashi Nishigami Tohru Tsujimura | 2007 | World Journal of Gastroenterology2007，13，16： | 9 |
| 2 | Diffuse gastroduodenitis and pouchitis associated with ulcerative colitis显示文摘We experienced a very rare case of ulcerative colitis (UC) accompanied with analogous lesions in the stomach, duodenum, and ileal J -pouch. Ileal J-pouch anal anastomosis was performed on a 29-year old woman in 1996. Six years later, she was admitted again to our hospital because of epigastralgia, nausea, watery diarrhea and low fever. Based on the results of endoscopic examination, we diagnosed it as pouchitis. Moreover, on hypotonic duodenography, expansion of the duodenal bulb and the descending portion were poor. Kerckring folds disappeared with typical lead-pipe appearance. The pathogenesis of the gastric and duodenal lesion in this patient was similar to that of the colonic lesions of UC. For the gastroduodenal lesions in this patient, symptomatic remission was obtained following administration of crushed mesalazine tablets (1500 mg/d) for 14 d with continuous administration of omeprazole. Firstly we used ciprofloxacin to treat pouchitis. On the fifth day, she got a fever because of catheter infection. In the catheter culture, methicillin-resistant Staphylococcus aureus (MRSA) was detected. Therefore we changed ciprofloxacin to vancomycin hydrochloride (Vancomycin?). Vancomycin was very effective, and the stool frequency dramatically improved in three days. Now she continues to take mesalazine, but her condition is stable and there has been no recurrence of pouchitis. | Hiroki Ikeuchi Kazutoshi Hori Takashi Nishigami Hiroki Nakano Motoi Uchino Mitsuhiro Nakamura Nobuaki Kaibe Masafumi Noda Hidenori Yanagi Takehira Yamamura | 2006 | World Journal of Gastroenterology2006，12，36： | 3 |
| 3 | Point-of-care echocardiography for aorticdissection, pulmonary embolism and acute coronary syn-drome inpatients with killer chest pain : EASY screeningfocused on the assessment of effusion, aorta, ventricularsize andshape and ventricular asynergy 显示文摘 | Nishigami K | 2015 | J Echocardio-gr2015，13，4： | 1 |
| 4 | Tight heart rate control reduces secondary adverse events in patients with type B acute aortic dissection显示文摘 | Kodama K Nishigami K Sakamoto T | 2008 | Circulation2008，118，： | 1 |
| 5 | Carcinoid tumor of the gall bladder显示文摘 | Nishigami T Yamada M Nakasho K | 1996 | Intern Med1996，35，12： | 1 |
| 6 | Tight heart rate control reduces secondary adverse events in patients with type B acute aortic dissection 显示文摘 | Kodama K Nishigami K Sakamoto T | 2008 | Circulation2008，118，14： | 1 |
| 7 | Quantification of mitral regurgitant stroke volume by the proximal isovelocity surface area method显示文摘 | Nishigami K Yoshikawa J Yoshida K | 1993 | J Cardiol1993，23，1： | 1 |
| 8 | Deep structure of the Mozumi Sukenobu fault,central Japan,estimated from the subsurface array observation of fault zone trapped waves显示文摘 | Mizuno T Nishigami K Ito H | 2004 | Geophysical Journal International2004，159，： | 1 |
| 9 | Prediction of progression or regression of type a aortic intramural hematoma by computed tomography显示文摘 | Kaji S Nishigami K Akasaka T | 1999 | Circulation1999，100，： | 1 |
| 10 | Carcinoid tumor of the gall bladder显示文摘 | Nishigami T Yamada M Nakasho K | 1996 | Intern Med1996，35，12： | 1 |
| 11 | Autopsy case of congenital pulmonary lymphangiectasis显示文摘 | Hirano H Nishigami T Okimura A | 2004 | Pathol Int2004，54，7： | 1 |
| 12 | Tight heart rate control reduces secondary adverse events in patients with type B acute aortic dissection 显示文摘 | Kodama K Nishigami K Sakamoto T | 2008 | Circulation2008，118，： | 1 |
| 13 | Unblinded pilot study of autologous transplantation of bone marrow mononuclear cells in patients with thromboangiitis obliterans显示文摘 | Miyamoto K Nishigami K Nagaya N | 2006 | Circulation2006，114，24： | 1 |
| 14 | Tight Heart Rate Control Reduces Secondary Adverse Events in Patients With Type B Acute Aortic Dissection显示文摘 | Kazuhisa Kodama Kazuhiro Nishigami Tomohiro Sakamoto Tadashi Sawamura Touitsu Hirayama Hiroyasu Misumi Koichi Nakao | 2008 | Circulation ( Suppl )2008，，14： | 1 |
| 15 | Development of heat hyperalgesia and changes of TRPVl and NGF expression in rat dorsal root ganglion following joint immobilization 显示文摘 | NISHIGAMI T OSAKO Y IKEUCHI M | 2013 | Physiol Res2013，62，2： | 1 |
| 16 | Association between serotonin transporter gene polymorphism and chronic fatigue syndrome显示文摘 | Narita M Nishigami N Nariha N | 2003 | Biochem Biophys Res Commun2003，311，： | 1 |
| 17 | Association between serotonin transportergene polymorphism and chronic fatigue syndrome显示文摘 | Narita M Nishigami N Narita N | 2003 | Biochem Biophys Res Commun2003，311，2： | 1 |
| 18 | Tight heart rate control reduces secondary adverse events in patients with type B acute aortic dissection显示文摘 | Kazuhisa Kodama Kazuhiro Nishigami | 2008 | Circulation2008，30，： | 1 |
| 19 | Tight heart rate control reduces secondary adverse events in patients with type B acute aortic dissection显示文摘 | Kodama K Nishigami K Sakamoto T | 2008 | Circulation2008，118，141： | 1 |
| 20 | Adrenomedullin enhances therapeu-tic potency of bone marrow transplantation for myocar-dial infarction in rats 显示文摘 | Fujii T Nagaya N Iwase T Murakami S Miyahara Y Nishigami K | 2005 | Am J Physiol Heart Circ Physiol2005，288，： | 1 |
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