|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Amyloid and tau positive mild cognitive impairment:clinical and biomarker characteristics of dementia progression显示文摘Background:According to the amyloid,tau,neurodegeneration research framework classification,amyloid and tau positive(A+T+)mild cognitive impairment(MCI)individuals are defined as prodromal Alzheimer disease.This study was designed to compare the clinical and biomarker features between A+T+MCI individuals who progressed to progressive MCI(pMCI)and those who remained stable MCI(sMCI),and to identify relevant baseline clinical biomarker and features that could be used to predict progression to dementia within 2 years.Methods:We stratified 197 A+T+MCI individuals into pMCI(n=64)and sMCI(n=133)over 2 years.Demographics and cognitive assessment scores,cerebrospinal fluid(CSF),and neuroimaging biomarkers(18F-florbetapir positron emission tomography mean standardized uptake value ratios[SUVR]and structural magnetic resonance imaging[MRI])were compared between pMCI and sMCI at baseline,12-and 24-month follow-up.Logistic regression models then were used to evaluate clinical baseline and biomarker features that predicted dementia progression in A+T+MCI.Results:pMCI individuals had higher mean 18F-florbetapir SUVR,CSF total-tau(t-tau),and p-tau181P than those in sMCI individuals.pMCI individuals performed poorer in cognitive assessments,both global and domain specific(memory,executive,language,attention,and visuospatial skills)than sMCI.At baseline,there were significant differences in regions of interest of structural MRI between the two groups,including bilateral amygdala,hippocampus and entorhinal,bilateral inferior lateral ventricle,left superior and middle temporal,left posterior and caudal anterior cingulate(P<0.05).Baseline CSF t-tau levels and cognitive scores of Montreal cognitive assessment,functional assessment questionnaire,and everyday cognition by the patient’s study partner language domain could predict progression to dementia in A+T+MCI within 2 years.Conclusions:In future clinical trials,specific CSF and cognitive measures that predict dementia progression in A+T+MCI might be useful risk factors for assessing the risk of dementia progression. | Hong-Chun Wei Bing Li Kok Pin Ng Qing-Xi Fu Sheng-Jie Dong Mao-Wen Ba Min Kong | 2021 | Chinese Medical Journal2021，，14： | 3 |
| 2 | High-power potassium-titanyl-phosphate photoselective laser vaporization of prostute for treatment of benign prostatic hyperplasia in men with large prostate显示文摘 | Sadhu JS Ng C Vanderorink BA | 2004 | Urology2004，64，6： | 1 |
| 3 | Treatment of post- pneumonectomy empyema with debridement followed by continuous antibiotic irrigation显示文摘 | NG T Ryder BA Maziak DE | 2008 | J Am Coll Surg2008，206，3： | 1 |
| 4 | Pathogenic micro-organisms in slaughterhouse sludge-A survey显示文摘 | Fransen NG Elzen AM Urlings BA Bijker PG | 1996 | Canadian Metallurgical Quarterly1996，33，23： | 1 |
| 5 | High-power postassium-titanyl-phosphate photoselectivelaser vaporization of prostate for treatment of benignprostatic hyperplasia in men with large prostates 显示文摘 | Sandhu JS Casey NG Vanderbrink BA | 2004 | Urol2004，64，6： | 1 |
| 6 | High-power postassium-titanyl-phosphate photoselectivelaser vaporization of prostate for treatment of benignprostatic hyperplasia in men with large prostates显示文摘 | Sandhu JS Casey NG Vanderbrink BA | 2004 | Urol2004，64，6： | 1 |
| 7 | A comparison between patients suffering in-hospital and out-of-hospital cardiac arrest in terms of treatment and outcome显示文摘 | HERLITZ J BANG A EKSTRM L | | 0，，01： | 1 |
| 8 | An integrated decision support system deal- ing with qualitative and quantitative objectives for enterprise software selection 显示文摘 | Ceyda G u ng?r ?en Hayri Bara?l? Sel?uk ?en H u seyin Ba?l?gil | 2009 | Expert Systems with Applications2009，36，3： | 1 |
| 9 | An improved reagent for mycobacterial nitrate reductase tests显示文摘 | Warren NG Body BA Dalton HP | 1983 | J Clin Microbiol1983，18，3： | 1 |
| 10 | Bone Marrow Stress Decreases Osteogenic Progenitors 显示文摘 | Ng AH Baht GS Alman BA | 2015 | Calcif Tissue lnt2015，97，5： | 1 |
| 11 | Treatment of postpneumonectomy em- pyema with debridement followed by continuous antibiotic irrigation显示文摘 | Ng T Ryder BA Maziak DE | 2008 | J Am Coil Surg2008，206，3： | 1 |
| 12 | Effects of central administration of distinct fatty acids on hypothalamic neuropeptide expression and energy metabolism显示文摘 | Schwinkendorf DR Tsatsos NG Gosnell BA et a l | 2011 | Int] Obes CLond)2011，35，33： | 1 |
| 13 | Numerical study of the plasma flow field and particle in-fight behavior with the obstruction of a curved substrate显示文摘 | BA T KANG Chang-wei NG H W | 2009 | Journal of Thermal Spray Technology2009，18，56： | 1 |
| 14 | Leukocyte-depleted blood transfu- sion is associated with decreased survival in resectcd early-stage lung cancer 显示文摘 | Ng T Ryder BA Chern H | 2012 | J Thorac Cardiovasc Surg2012，143，4： | 1 |
| 15 | Treatment of postpneumonee-tomy empyema with debridement followed by continuous antibiot-ic irrigation 显示文摘 | Ng T Ryder BA Maziak DE | 2008 | J AM Coil Surg2008，206，3： | 1 |
| 16 | Leukocyte-depleted blood transfusion is associated with decreased survival in resected early-stage lung cancer显示文摘 | Ng T Ryder BA Chern H | 2012 | J Thorac Cardiovasc Surg2012，143，4： | 1 |
| 17 | Neuroprotective effects of caspase-3 inhibition on functional recovery and tissue sparing after acute spinal cord injury显示文摘 | Citron BA Arnold PM Haynes NG | 2008 | Spine(Phila Pa 1976)2008，33，21： | 1 |
| 18 | Abnormally thickened papillary muscle resulting in dynamic left ventricular outflow tract obstruction:an unusual presentation of hypertrophic cardiomyopathy 显示文摘 | Austin BA Kwon DH medira NG | 2009 | J Am Soc Echocardiogr2009，22，1： | 1 |
| 19 | High-power potassium-tita- nyl-phosphate photoselective laser vaporization of prostate for treat- ment of benign prostatic hyperplasia in men with large prostates显示文摘 | Sandhu JS Ng C Vanderbrink BA | 2004 | Urology2004，64，6： | 1 |
| 20 | Safety of magnetic res- onance imaging in patients with permanent pacemakers: a col- laborative clinical approach显示文摘 | Boilson BA Wokhlu A Acker NG | 2012 | J Intervent Card Electrophysiol2012，33，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员