|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | High body mass index predicts multiple prostate cancer lymph node metastases after radical prostatectomy and extended pelvic lymph node dissection显示文摘Our aim is to evaluate the association between body mass index(BMI)and preoperative total testosterone(TT)levels with the risk of single and multiple metastatic lymph node invasion(LNI)in prostate cancer patients undergoing radical prostatectomy and extended pelvic lymph node dissection.Preoperative BMI,basal levels of TT,and prostate-specific antigen(PSA)were evaluated in 361 consecutive patients undergoing radical prostatectomy with extended pelvic lymph node dissection between 2014 and 2017・Patients were grouped into either nonmetastatic,one,or more than one metastatic lymph node invasion groups.The association among clinical factors and LNI was evaluated.LNI was detected in 52(14.4%)patients:28(7.8%)cases had one metastatic node and 24(6.6%)had more than one metastatic node.In the overall study population,BMI correlated inversely with TT(r=-0.256;P<0.0001).In patients without metastases,BMI inversely correlated with TT(r=-0.282;P<0.0001).In patients with metastasis,this correlation was lost.In the overall study population,BMI(odds ratio[OR]=1.268;P=0.005)was the only in dependent clinical factor associated with the risk of multiple metastatic LNI compared to cases with one metastatic node.In the nonmetastatic group,TT was lower in patients with BMI>28 kg m^2(P<0.0001).In patients with any LNI,this association was lost(P=0.232).The median number of positive nodes was higher in patients with BMI>28 kg m^2(P-0.048).In our study,overweight and obese patients had a higher risk of harboring multiple prostate cancer lymph node metastases and lower TT levels when compared to patients with normal BMI. | Antonio B Porcaro Alessandro Tafuri Marco Sebben Tania Processali Marco Pirozzi Nelia Amigoni Riccardo Rizzetto Aliasger Shakir Maria Angela Cerruto Matteo Brunelli Salvatore Siracusano Walter Artibani | 2020 | Asian Journal of Andrology2020，22，3： | 3 |
| 2 | Hepatotoxicity Induced by Biological Agents: Clinical Features and Current Controversies显示文摘Novel biological agents including cytokines and recombinant fusion proteins are increasingly prescribed for cancer,rheumatologic,autoimmune,and inflammatory diseases,and are currently being evaluated in hepatocellular carcinoma(HCC).They are classified by their mechanism of action and include tumor necrosis factor-alpha(TNF-α)antagonists,T cell mediated antitumor inhibitors,interleukin receptor antagonists,and immune checkpoint inhibitors(ICIs).Some ICIs cause frequent hepatotoxicity with a variable clinical,biochemical,and serological presentation,especially in patients receiving another immunomodulatory agent.Half of the cases of liver damage induced by biological agents spontaneously regress after drug withdrawal,but the others require steroid therapy.Unfortunately,there are no widely accepted recommendation for the use of corticosteroids in these patients,even though international cancer societies have their own guidelines.Differentiating drug-induced autoimmune hepatitis(DIAIH)from classic AIH is challenging for pathologists,but liver biopsy is valuable,particularly in cases with unclear clinical presentation.Interesting,novel histological patterns have been described in liver damage induced by these agents(i.e.,endothelitis,ring granuloma and secundary sclerosing cholangitis associated with lymphocytic infiltration of cytotoxic CD8+T cells).Here,we describe the clinical and biochemical characteristics of patients with hepatotoxicity induced by TNF-αantagonists and ICIs.Controversial issues involved in the administration of corticosteroid therapy,and hepatitis B virus(HBV)reactivation induced by immunosuppressive therapy are also discussed. | Nelia Hernandez Fernando Bessone | 2022 | Journal of Clinical and Translational Hepatology2022，10，3： | 2 |
| 3 | Analysis of high-speed intershaft cylindrical roller hearing with flexible rings显示文摘 | Cavallaro G Nelias D | 2010 | Trihology Transactions2010，48，2： | 1 |
| 4 | Nonlinear Dynamic Analysis of Cylindrical Roller Bearing with Flexible Rings显示文摘 | Alexandre Leblanc Daniel Nelias Cyril Defaye | 2009 | Journal of Sound and Vibration2009，325，12： | 1 |
| 5 | Role of inclusions,surface roughness and operating conditions on rolling contact fatigue 显示文摘 | Nelias D Dumount M L Champiot F | 1999 | J Tribology Tran ASME1999，121，： | 1 |
| 6 | FE-model for titanium alloy(Ti-6Al-4V) cutting based on the identification of limiting shear stress at tool-chip interface显示文摘 | ZHANG Yancheng MABROUKI T NELIAS D | 2011 | International journal of material forming2011，4，1： | 1 |
| 7 | Ball motion and sliding friction in a fourcontact-point ball bearing 显示文摘 | Leblanc A Nelias D | 2007 | Tribology Tractions of ASME2007，129，4： | 1 |
| 8 | A three-dimensional semi-analytical elastic-plastic sliding contacts 显示文摘 | Nelias D Antaluca E Boucly V | 2007 | Transation of the ASME :Joural of Tribology2007，129，： | 1 |
| 9 | Health assessment for mercury exposure among schoolchildren residing near a gold processing and refining plant in Apokon, Tagum, Davao del Norte, Philippines显示文摘 | Akagi H Castillo E S Nelia C M | 2000 | Science of the Total Environment2000，259，1： | 1 |
| 10 | Contact analyses for bodies with frictional heating and plastic behavior显示文摘 | Boucly V Nelias D Liu S B | 2005 | Journal of Tribology2005，127，2： | 1 |
| 11 | Ball motion and sliding friction in a four-contact-point ball bearing显示文摘 | LEBIANC A NELIAS D | 2007 | Journal of Tribology2007，129，： | 1 |
| 12 | Development of a three- dimensional semi-analytical elastic-plastic contact code显示文摘 | Jacq C Nelias D Lormand G | 2002 | Journal of Tribology2002，124，4： | 1 |
| 13 | Nonlinear dynamic analysis of cylindrical roller bearing with flexible rings 显示文摘 | Leblanc A Nelias D Defaye C | 2009 | Journal of Sound and Vibration2009，325，： | 1 |
| 14 | Detrimental Effects of Debris Dents on Rolling Contact Fatigue 显示文摘 | Nelias D Ville F | 2000 | Journal of Tribology2000，122，1： | 1 |
| 15 | Thermo mechanical analysis of laser beam welding of thin plate with complex boundary conditions显示文摘 | ZAIN-UL-ABDEIN M NELIAS D JULLIEN J F etal | 2008 | International Journal of Material Forming2008，1，： | 1 |
| 16 | Chip formation in orthogo- nal cutting considering interface limiting shear stress and dam- age evolution based on fracture energy approach 显示文摘 | Zhang Y C Mabrouki T Nelias D | 2011 | Finite El- ement in Analysis and Design2011，47，7： | 1 |
| 17 | FE-model for titanium alloy (Ti-6A1-4V) cutting based on the identification of limiting shear stress at tool-chip in- terface显示文摘 | ZHANG Yancheng TAREK Mabrouki DANIEL Nelias | 2011 | Int J Mater Form2011，，4： | 1 |
| 18 | Effects ofheat treatments on the microstructure and mechanical properties ofa 6061 aluminium alloy 显示文摘 | MAISONNETTE D SUERY M NELIAS D | 2011 | Materials Science and Engineering2011，528，6： | 1 |
| 19 | Chip formation in orthogonal cutting considering interface limiting shear stress and damage evolution based on fracture energy approach显示文摘 | Y.C. Zhang T. Mabrouki D. Nelias Y.D. Gong | 2011 | Finite Elements in Analysis & Design2011，，7： | 1 |
| 20 | Analysis of Double - Row Tapered Roller Beatings, Part II : Results : Prediction of Fatigue Life and Heat Dissipation 显示文摘 | Nelias D Bercea I Mifu N | 2003 | Tribology Trans- actions2003，46，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员