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| 1 | 非胰岛素依赖型糖尿病冠状动脉疾病的危险因素:英国糖尿病前瞻性研究(UKPDS:23)显示文摘目的:评价2型糖尿病患者冠状动脉疾病的基线危险因素。设计:对2 693例资料完整的患者进行年龄和性别调整的逐步选择过程分析,以确定哪些冠状动脉疾病的危险因素应纳入 Cox 比例风险模型。对象:3 055例白人患者,平均年龄52岁,均新近诊断为2型糖尿病,且无动脉粥样硬化相关疾病的证据。平均随访期7.9年。335例患者于10年内出现冠状动脉疾病。结局评定:具有明确异常心电图的心绞痛、致死或非致死性心肌梗塞。结果:冠状动脉疾病与低密度脂蛋白胆固醇浓度升高、高密度脂蛋白胆固醇浓度降低、甘油三酯浓度升高、高血红蛋白 A_(1c)、高收缩压、高空腹血糖以及吸烟史密切相关。低密度脂蛋白胆固醇较高1/3对较低1/3区间的估计风险比为2.26(95%可信区间为1.70~3.00),高密度脂蛋白胆固醇为0.55(0.41~0.73),血红蛋白 A_(1c)为1.52(1.15~2.01),收缩压为1.82(1.34~2.47)。吸烟者的估计风险比为1.41(1.06~1.88)。结论:2型糖尿病患者中,存在冠状动脉疾病潜在的、可变的5种危险因素的交叉重叠影响。它们是低密度脂蛋白胆固醇浓度升高、高密度脂蛋白胆固醇浓度降低、高血压、高血糖和吸烟。 | R C Turner H Millns H A W Neil I M Stratton S E Manley D R Matthews R R Holman 赵维纲 | 1998 | 英国医学杂志中文版1998，0，3： | 11 |
| 2 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 3 | Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial显示文摘 | Helen M Colhoun D John Betteridge Paul N Durrington Graham A Hitman H Andrew W Neil Shona J Livingstone Margaret J Thomason Michael I Mackness Valentine Charlton-Menys John H Fuller | 2004 | The Lancet . 2004 (9435)2004，，9435： | 1 |
| 4 | Subband coding of images 显示文摘 | | 1986 | IEEE TRASACTIONS ON ACOUSTICS SPPECH AND SIGNAL PROCESSING1986，34，5： | 1 |
| 5 | Gouhy pore pressure estimation from mudrock porosities in Tertiary basins, southeast Asia 显示文摘 | Toby W D H Richard E S Neil R | 1999 | AAPG Bulletin1999，83，7： | 1 |
| 6 | Continuation of Long-Term Care for Cervical Dystonia at an Academic Movement Disorders Clinie显示文摘 | CHANDLER E Gill NEIL D Manus Michael W Pelster | 2013 | Toxins2013，5，4： | 1 |
| 7 | Calicivirus Emergence from Ocean Reservoirs: Zoonotic and Interspecies Movements显示文摘 | Smith Alvin W Skilling D E Neil Cherry | 1998 | The CDC''s Emerging Infectious Diseases1998，4，1： | 1 |
| 8 | Subband coding of images显示文摘 | J W Woods S D O′Neil | 1986 | IEEE Trans Acoust Speech Signal Process1986，34，5： | 1 |
| 9 | Neodymium-142 Evidence for Hadean Marie Crust显示文摘 | O'Neil J Carlson R W Francis D Stevenson R K | 2008 | Seience2008，321，： | 1 |
| 10 | The comet assay:a comprehensive revies显示文摘 | Fairbaim D W Reyes W A O Neil K L | 1995 | Mutas Res1995，，339： | 1 |
| 11 | Analysis of Transit Service Areas Using Geographic Infor- mation Systems显示文摘 | O' Neil W Ramsey D Chou J | 1992 | Transportation Research Record1992，1364，： | 1 |
| 12 | Search for complex order parameters in grain boundary junctions显示文摘 | NEILS W K VAN HARLINGEN D J | 2000 | Physica B: Condensed Matter2000，，1： | 1 |
| 13 | Medication beliefs predict medication adherence in ambulatory patients with decompensated cirrhosis显示文摘AIM To investigate the impact of medication beliefs, illness perceptions and quality of life on medication adherence in people with decompensated cirrhosis.METHODS One hundred adults with decompensated cirrhosis completed a structured questionnaire when they attended for routine outpatient hepatology review. Measures of self-reported medication adherence(Morisky Medication Adherence Scale), beliefs surrounding medications(Beliefs about Medicines Questionnaire), perceptions of illness and medicines(Brief Illness Perception Questionnaire), and quality of life(Chronic Liver Disease Questionnaire) were examined. Clinical data were obtained via patient history and review of medical records. Least absolute shrinkage and selection operator and stepwise backwards regression techniques were used to construct the multivariable logistic regression model. Statistical significance was set at alpha = 0.05.RESULTS Medication adherence was ' High ' in 42 % o f participants, 'Medium' in 37%, and 'Low' in 21%. Compared to patients with 'High' adherence, those with 'Medium' or 'Low' adherence were more likely to report difficulty affording their medications(P < 0.001), lower perception of treatment helpfulness(P = 0.003) and stronger medication concerns relative to medication necessity beliefs(P = 0.003). People with 'Low' adherence also experienced greater symptom burden and poorer quality of life, including more frequent abdominal pain(P = 0.023), shortness of breath(P = 0.030), and emotional disturbances(P = 0.050). Multivariable analysis identified having stronger medication concerns relative to necessity beliefs(Necessity-Concerns Differential ≤ 5, OR = 3.66, 95%CI: 1.18-11.40) and more frequent shortness of breath(shortness of breath score ≤ 3, OR = 3.87,95%CI: 1.22-12.25) as independent predictors of 'Low'adherence.CONCLUSION The association between 'Low' adherence and patients having strong concerns or doubting the necessity or helpfulness of their medications should be explored further given the clinical relevance. | Kelly L Hayward Patricia C Valery Jennifer H Martin Antara Karmakar Preya J Patel Leigh U Horsfall Caroline J Tallis Katherine A Stuart Penny L Wright David D Smith Katharine M Irvine Elizabeth E Powell W Neil Cottrell | 2017 | World Journal of Gastroenterology2017，23，40： | 1 |
| 14 | Subband coding of images 显示文摘 | John W Woods and Scan D O'neil | 1986 | IEEE TRASACTIONS ON ACOUSTICS SPPECH AND SIGNAL PROCESSING1986，34，12： | 1 |
| 15 | Dopamine and serotonin receptor binding and antipsychotic efficacy显示文摘 | Neil M R Jeffrey A W Aaron D L | 2007 | Neuropsy chopharmacology2007，32，： | 1 |
| 16 | Banana con- tains a diverse array of endogenous badnaviruses 显示文摘 | Andrew D W G Neil E O Glyn H | 2005 | Journal of General Virology2005，86，： | 1 |
| 17 | Continuous fractional crystallization显示文摘 | Freeman J W Mc Neil D J | 1968 | Application Chemistry1968，18，6： | 1 |
| 18 | Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor显示文摘 | Mark J Mulvihill Andrew Cooke Maryland Rosenfeld-Franklin Elizabeth Buck Ken Foreman Darla Landfair Matthew O&rsquor Connor Caroline Pirritt Yingchaun Sun Yan Yao Lee D Arnold Neil W Gibson Qun-Sheng Ji | 2009 | Future Med Chem2009，，6： | 1 |
| 19 | Partitioning the Contributions of Forage-based Production System Components to Weight Gain of Juvenile Crayfish(Procambarus clarkii ) 显示文摘 | McClain W R Neil W H Gatlin III D M | 1992 | Aquaculture1992，101，： | 1 |
| 20 | The relative risks of hyperglycaemia ,obesity and dyslipidaemia in the relatives of patients with type Ⅱ diabetes mellitus 显示文摘 | SHAW J T E PURDIE D M NEIL HA W | 1999 | Diabetologia1999，42，： | 1 |
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