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| 1 | 非胰岛素依赖型糖尿病冠状动脉疾病的危险因素:英国糖尿病前瞻性研究(UKPDS:23)显示文摘目的:评价2型糖尿病患者冠状动脉疾病的基线危险因素。设计:对2 693例资料完整的患者进行年龄和性别调整的逐步选择过程分析,以确定哪些冠状动脉疾病的危险因素应纳入 Cox 比例风险模型。对象:3 055例白人患者,平均年龄52岁,均新近诊断为2型糖尿病,且无动脉粥样硬化相关疾病的证据。平均随访期7.9年。335例患者于10年内出现冠状动脉疾病。结局评定:具有明确异常心电图的心绞痛、致死或非致死性心肌梗塞。结果:冠状动脉疾病与低密度脂蛋白胆固醇浓度升高、高密度脂蛋白胆固醇浓度降低、甘油三酯浓度升高、高血红蛋白 A_(1c)、高收缩压、高空腹血糖以及吸烟史密切相关。低密度脂蛋白胆固醇较高1/3对较低1/3区间的估计风险比为2.26(95%可信区间为1.70~3.00),高密度脂蛋白胆固醇为0.55(0.41~0.73),血红蛋白 A_(1c)为1.52(1.15~2.01),收缩压为1.82(1.34~2.47)。吸烟者的估计风险比为1.41(1.06~1.88)。结论:2型糖尿病患者中,存在冠状动脉疾病潜在的、可变的5种危险因素的交叉重叠影响。它们是低密度脂蛋白胆固醇浓度升高、高密度脂蛋白胆固醇浓度降低、高血压、高血糖和吸烟。 | R C Turner H Millns H A W Neil I M Stratton S E Manley D R Matthews R R Holman 赵维纲 | 1998 | 英国医学杂志中文版1998，0，3： | 11 |
| 2 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 3 | Trabecular Bone Score: A Noninvasive Analytical Method Based Upon the DXA Image显示文摘 | Barbara C Silva William D Leslie Heinrich Resch Olivier Lamy Olga Lesnyak Neil Binkley Eugene V McCloskey John A Kanis John P Bilezikian | 2014 | J Bone Miner Res2014，，3： | 2 |
| 4 | Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis显示文摘 | Anakk Sayeepriyadarshini Watanabe Mitsuhiro Ochsner Scott A McKenna Neil J Finegold Milton J Moore David D | 2011 | Journal of Clinical Investigation2011，，1： | 2 |
| 5 | Comparative study of variable size perturbation and observation maximum power point trackers for PV systems显示文摘 | Neil S D Luiz A C Liu Xuejun | 2010 | Eleclric Power Systems Research2010，，80： | 1 |
| 6 | Validation of real-time three-dimensional echocardiography for quantifying left ventricular volumes in the presence of a left ventricular aneurysm: in vitro and in vivo studies显示文摘 | Jian Xin Qin Michael Jones Takahiro Shiota Neil L Greenberg Hiroyuki Tsujino Michael S Firstenberg Pankaj C Gupta Arthur D Zetts Yong Xu Jing Ping Sun Lisa A Cardon Jill A Odabashian Scott D Flamm Richard D White Julio A Panza James D Thomas | 2000 | Journal of the American College of Cardiology2000，，3： | 1 |
| 7 | Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial显示文摘 | Helen M Colhoun D John Betteridge Paul N Durrington Graham A Hitman H Andrew W Neil Shona J Livingstone Margaret J Thomason Michael I Mackness Valentine Charlton-Menys John H Fuller | 2004 | The Lancet . 2004 (9435)2004，，9435： | 1 |
| 8 | Understanding the Char- acteristics of Quality for Software Engineering Processes : A Grounded Theory Investigation 显示文摘 | TRENT A K NEIL J D STEPHEN C C | 2014 | Information and Software Technology2014，56，2： | 1 |
| 9 | Expression and regulation of the human β-defensins hBD-1 and hBD-2 in intestinal epithelium显示文摘 | O'Neil D A Porter EM Elewaut D | 1999 | J Immunology1999，163，： | 1 |
| 10 | Modeling the impact of patient and lesion characteristics on the cost-effectiveness of drugeluting stents (abstr) 显示文摘 | Greenberg D Bakhai A Neil N | 2003 | J Am Coll Cardiol2003，41，： | 1 |
| 11 | Human pigmentation genes: identification, structure and consequences of polymorphic variation显示文摘 | Richard A Sturm Rohan D Teasdale Neil F Box | 2001 | Gene2001，，1： | 1 |
| 12 | The carotenoid and abscisic acid content of viviparous kernels and seedings of Zea mays 显示文摘 | Neil S J Horgan R Parry A D | 1989 | Planta1989，169，： | 1 |
| 13 | Measurement of the percentage volume particle size distribution of powdered microcrystalline cellulose using reflectance near-infrared speetroscopy显示文摘 | O'NEIL A J JEER D MOFFAT A C | 2003 | Analyst2003，128，： | 1 |
| 14 | Identification of an up- take hydrogenase required for hydrogen-dependent reduc- tion of Fe( Ⅲ ) and other electron acceptors by Geobacter sulfurreducens显示文摘 | Coppi M V O'Neil R A Lovley D R | 2004 | Journal of Bacteriology2004，186，10： | 1 |
| 15 | Cortisol is necessary for seawater tolerance in larvae of a marine teleost the summer flounder显示文摘 | PHILIP A V MARICRUZ M NEIL D M | 2007 | General and Comparative Endocrinology2007，151，1： | 1 |
| 16 | Hepatocellular carcinoma and dysplastic nodules in patients with cirrhosis: prospective diagnsis with MR imaging and explantation correlation显示文摘 | Glenn A Vivian S Neil D | 2001 | Radiology2001，219，2： | 1 |
| 17 | Determina- tion of beta-agonist residues in bovine urine using liquid chromatography-tandem mass spectrometry 显示文摘 | Fesser A C Dickson L C Mac Neil J D | 2005 | J AOAC Int2005，88，1： | 1 |
| 18 | Drug hepalotoxicity显示文摘 | Rabul A Nathwani MD Neil Kaplowitz M D | 2006 | Clin Liver Dis2006，10，3： | 1 |
| 19 | The comet assay:a comprehensive revies显示文摘 | Fairbaim D W Reyes W A O Neil K L | 1995 | Mutas Res1995，，339： | 1 |
| 20 | Comparative study of variable size perturbation and observation maximum power point trackers for PV systems 显示文摘 | Neil S D Luiz A C Liu Xuejun | 2010 | Electric Power Systems Research2010，80，3： | 1 |
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