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| 1 | Knockout mouse models of insulin signaling: Relevance past and future显示文摘Insulin resistance is a hallmark of type 2 diabetes. In an effort to understand and treat this condition, re searchers have used genetic manipulation of mice to uncover insulin signaling pathways and determine the effects of their perturbation. After decades of research much has been learned, but the pathophysiology o insulin resistance in human diabetes remains contro versial, and treating insulin resistance remains a chal lenge. This review will discuss limitations of mouse models lacking select insulin signaling molecule genes In the most influential mouse models, glucose metabo lism differs from that of humans at the cellular, organ and whole-organism levels, and these differences limi the relevance and benefit of the mouse models both in terms of mechanistic investigations and therapeutic development. These differences are due partly to im mutable differences in mouse and human biology, and partly to the failure of genetic modifications to produce an accurate model of human diabetes. Several fac tors often limit the mechanistic insights gained from experimental mice to the particular species and strain including: developmental effects, unexpected meta bolic adjustments, genetic background effects, and technical issues. We conclude that the limitations and weaknesses of genetically modified mouse models of insulin resistance underscore the need for redirection of research efforts toward methods that are more directly relevant to human physiology. | Anne E Bunner P Charukeshi Chandrasekera Neal D Barnard | 2014 | World Journal of Diabetes2014，5，2： | 9 |
| 2 | 持续气道正压通气在预防阻塞性睡眠呼吸暂停患者心血管事件中的作用显示文摘阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)导致阵发性低氧血症,夜间交感神经系统激活,血压、氧化应激和炎症指标的升高以及高凝血症。较大的胸内负压波动也会给心脏和大血管施加机械应力。基于人群和睡眠诊所的队列研究显示,OSA与心脑血管事件,特别是脑卒中相关。 | McEvoy RD Antic NA Heeley E Luo Y Ou Q Zhang X Mediano O Chen R Drager LF Liu Z Chen G Du B McArdle N Mukherjee S Tripathi M Billot L Li Q Lorenzi-Filho G Barbe F Redline S Wang J Arima H Neal B White DP Grunstein RR Zhong N Anderson CS 练桂丽 叶鹏 | 2016 | 中华高血压杂志2016，24，11： | 4 |
| 3 | Effects of fibrates on cardiovascular outcomes: a systematic review and meta-analysis显示文摘 | Min Jun Celine Foote Jicheng Lv Bruce Neal Anushka Patel Stephen J Nicholls Diederick E Grobbee Alan Cass John Chalmers Vlado Perkovic | 2010 | The Lancet . 2010 (9729)2010，，9729： | 2 |
| 4 | Changes in efficiency and resource utilization after increasing experience with double balloon enteroscopy显示文摘AIM:To investigate changes in efficiency and resource utilization as a single endoscopist's experience increased with each subsequent 100 double balloon enteroscopy(DBE) procedures.METHODS:We reviewed consecutive DBE procedures performed by a single endoscopist at our center over 4 years.DBE was employed when the clinician deemed the procedure was needed for disease management.The approach(oral,anal or both) was chosen based on suspected location of the target lesion.All DBE was performed in a standard endoscopy room with a portable fluoroscopy unit.Fluoroscopy was used to aid in shortening the small intestine and reducing bowel loops.For oral DBE,measurements were taken from the incisors.For anal DBE,measurements were taken from the anal verge.Enteroscopy continued until the target lesion was reached,until the entire small intestine was examined,or until no further progress was deemed possible.The length of small intestine examined(cm),procedure duration(min),and fluoroscopy time(s) were analyzed for sequential groups of 100 DBE.Sub-groups of diagnostic and therapeutic procedures were analyzed using multivariable linear regression.RESULTS:802 consecutive DBE procedures were analyzed.For oral DBE,median [interquartile range(IQR)] length of small bowel examined was 230.8 cm(range:210-248 cm) and for anal DBE was 143.5 cm(range:100-180 cm).No significant increase in length examined was noted for either the oral or anal approach with advancing position in series.In terms of duration of procedure,the median(IQR) for oral DBE was 86 min(range:71-105 min) and for anal DBE was 81.3 min(range:67-105 min).When comparing by the position in series,there was a significant(P value < 0.001) decrease in procedure duration for both upper and lower procedures with increasing experience.Median(IQR) time of exposure to fluoroscopy for oral DBE was 190 s(114-275) compared to anal DBE which was 196.4 s(312-128).This represented a significant(P value < 0.001) decrease in the amount of fluoroscopy used with increasing position in series.For both oral and anal DBE,fluoroscopy time was reduced by greater than 50% over the course of 802 total procedures performed.Sub-group analysis was conducted on therapeutic and diagnostic groups.Out of 802 procedures,a total of 434 were considered therapeutic.Argon plasma coagulation was by far the most common therapeutic intervention performed.There was no evidence of a difference in length examined or fluoroscopy exposure among oral DBE for diagnostic and therapeutic procedures,P = 0.91 and P = 0.32 respectively.The median(IQR) for length was 235 cm(range:178-280 cm) for diagnostic vs 230 cm(range:180-275 cm) for therapeutic procedures;additionally,fluoroscopy time median(IQR) was 180 s(range:110-295 s) and 162 s(range:102-263 s) for no intervention and intervention.However,there was a significant difference in procedure duration among oral DBE(P < 0.001).The median(IQR) was 80 min(range:60-97 min) and 94 min(range:77-110 min) for diagnostic and therapeutic interventions respectively.CONCLUSION:For a single endoscopist,increased DBE experience with number of performed procedures is associated with increased efficiency and decreased resource utilization. | Neal C Patel William C Palmer Kanwar R Gill David Cangemi Nancy Diehl Mark E Stark | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，3： | 2 |
| 5 | CD133,a novel marker for human prostatic epithelial stem cells显示文摘 | Richardson G D Robson C N Lang S H Neal D E Maitland N J Collins A T | 2004 | J Cell Sci2004，117，16： | 1 |
| 6 | Rapid Ped-2E9 Cell- Based Cytotoxicity Analysis and Genotyping of Bacillus Species 显示文摘 | GRAY K M BANADA P P O'NEAL E | 2005 | Journal of clinical Microbiology2005，43，12： | 1 |
| 7 | Virtu-alness and Knowledge in Teams:Managing the Love Triangle of Organizations,Individuals,And Information Technology 显示文摘 | GRIFFITH T L SAWYER J E NEALE M A | 2003 | MIS Quarterly2003，，2： | 1 |
| 8 | Transcriptional and post-transcriptional regulation of proangiogenic factors by the unfolded protein response显示文摘 | PEREIRA E R LIAO N NEALE G A | | 0，，09： | 1 |
| 9 | Di- verse groups and information sharing: The effect of congruent ties显示文摘 | Williams K W Mannix E A Neale M A | 2004 | Journal of Experimental Social Psy- chology2004，40，4： | 1 |
| 10 | Comparative analysis of flow eytometry and polymerase chain reaction for the detection of minimal residual disease in childhood acute lymphoblastic leukemia显示文摘 | Neale GA Coustan-Smith E Stow P Pan Q Chen X Pui CH Campana D | 2004 | Leukemia2004，18，5： | 1 |
| 11 | Detection of minimal residual disease in acute lymphoblastic leukemia:The St Jude experience 显示文摘 | Campana D Neale GA Coustan - Smith E | 2001 | Leukemia2001，15，2： | 1 |
| 12 | Flight Data Analysis of the HyShot 2 Scramjet Flight Experiment显示文摘 | Michael K Smart Neal E Hass | 2006 | AIAA Jour- nal2006，44，10： | 1 |
| 13 | Chemical Kinetics of the Oxidation of Methyl Tert-butyl Ether (MTBE)显示文摘 | Brocard J C Baronnet F O'Neal H E | 1983 | Combustion and Flame1983，52，： | 1 |
| 14 | Development of an Effective Palladium Removal Process for VEGF Oncology Candidate AG13736 and a Simple,Efficient Screening Technique for Scavenger Reagent Identification显示文摘 | ERIK J F BRIGITTE L E NEAL W S | 2008 | Organic Process Research & Development2008，，12： | 1 |
| 15 | Cellular response to cancer chemopreventive agents : contribution of the antioxidant responsive element to the adaptive response to oxidative and chemical stress显示文摘 | HAYES J D ELLIS E M NEAL G E | 1999 | Biochem Soc Syrup1999，64，： | 1 |
| 16 | The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial显示文摘 | NEAL E G CHAFFE H SCHWARTZ R H | 2008 | Lancet Neurol2008，7，： | 1 |
| 17 | What differences make a dif-ference: The promise and reality of diverse teams inorganizations 显示文摘 | Mannix E Neale M A | 2005 | Psychological Science in the PublicInterest2005，，6： | 1 |
| 18 | Anaerobic methane oxidation on the Amazon shelf显示文摘 | Neal E B Aller R C | 1995 | Geochimica et Cosmochimica Acta1995，59，18： | 1 |
| 19 | The wake-sleep algorithm for self-organizing neural networks显示文摘 | G E Hinton P Dayan B Frey R Neal | 1995 | Science1995，268，： | 1 |
| 20 | Caspase-3 in postnatal retinal development and degeneration显示文摘 | Zeiss C J Neal J Johnson E A | 2004 | Invest Ophthalmol Vis Sci2004，45，3： | 1 |
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