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| 1 | Hypoxia,angiogenesis and liver fibrogenesis in the progression of chronic liver diseases显示文摘Angiogenesis is a dynamic,hypoxia-stimulated and growth factor-dependent process,and is currently referred to as the formation of new vessels from preexisting blood vessels.Experimental and clinical studies have unequivocally reported that hepatic angiogenesis,irrespective of aetiology,occurs in conditions of chronic liver diseases(CLDs) characterized by perpetuation of cell injury and death,inflammatory response and progressive fibrogenesis.Angiogenesis and related changes in liver vascular architecture,that in turn concur to increase vascular resistance and portal hypertension and to decrease parenchymal perfusion,have been proposed to favour fibrogenic progression of the disease towards the end-point of cirrhosis.Moreover,hepatic angiogenesis has also been proposed to modulate the genesis of portal-systemic shunts and increase splanchnic blood flow,thus potentially affecting complications of cirrhosis.Hepatic angiogenesis is also crucial for the growth and progression of hepatocellular carcinoma.Recent literature has identified a number of cellular and molecular mechanisms governing the cross-talk between angiogenesis and fibrogenesis,with a specifi c emphasis on the crucial role of hypoxic conditions and hepatic stellate cells,particularly when activated to the myofibroblast-like pro-fibrogenic.Experimental anti-angiogenic therapy has been proven to be effective in limiting the progression of CLDs in animal models.From a clinical point of view,anti-angiogenic therapy is currently emerging as a new pharmacologic intervention in patients with advanced fibrosis and cirrhosis. | Claudia Paternostro Ezio David Erica Novo Maurizio Parola | 2010 | World Journal of Gastroenterology2010，16，3： | 23 |
| 2 | Atherosclerosis,inflammation and Chlamydia pneumoniae显示文摘Coronary heart disease is the single most common cause of illness and death in the developed world.Coronary atherosclerosis is by far the most frequent cause of ischemic heart disease,and plaque disruption with superimposed thrombosis is the main cause of the acute coronary syndromes of unstable angina,myocardial infarction,and sudden death.Atherosclerosis is the result of a complex interaction between blood elements,disturbed flow,and vessel wall abnormality,involving several pathological processes:inflammation,with increased endothelial permeability,endothelial activation,and monocyte recruitment;growth,with smooth muscle cell proliferation,migration,and matrix synthesis;degeneration,with lipid accumulation;necrosis,possibly related to the cytotoxic effect of oxidized lipid;calcification/ossification,which may represent an active rather than a dystrophic process;and thrombosis,with platelet recruitment and fibrin formation.In this review we discuss these processes and the possible pathological effects of Chlamydia infection and the ensuing phlogosis. | Giovanni Fazio Maria Giovino Alessandro Gullotti Daniela Bacarella Giuseppina Novo Salvatore Novo | 2009 | World Journal of Cardiology2009，1，1： | 10 |
| 3 | Thiazolidinedione treatment inhibits bile duct proliferation and fibrosis in a rat model of chronic cholestasis显示文摘AIM: To investigate the effects of troglitazone (TGZ), an anti-diabetic drug which activates peroxisome proliferatoractivated receptor-γ (PPAR-γ), for liver tissue repair, and the development of ductular reaction, following common bile duct ligation (BDL) in rats.METHODS: Rats were supplemented with TGZ (0.2% w/w in the pelleted food) for 1 wk before BDL or sham operation.Animals were killed at 1, 2, or 4 wk after surgery.RESULTS: The development of liver fibrosis was reduced in rats receiving TGZ, as indicated by significant decreases of procollagen type Ⅰ gene expression and liver hydroxyproline levels. Accumulation of α-smooth-muscle actin (SMA)-expressing cells surrounding newly formed bile ducts following BDL, as well as total hepatic levels of SMA were partially inhibited by TGZ treatment, indicating the presence of a reduced number and/or activation of hepatic stellate cells (HSC) and myofibroblasts. Development of the ductular reaction was inhibited by TGZ, as indicated by histochemical evaluation and hepatic activity of γ-glutamyltransferase (GGT).CONCLUSION: Treatment with thiazolidinedione reduces ductular proliferation and fibrosis in a model of chronic cholestasis, and suggests that limiting cholangiocyte proliferation may contribute to the lower development of scarring in this system. | Fabio Marra Raffaella DeFranco Gaia Robino Erica Novo Eva Efsen Sabrina Pastacaldi Elena Zamara Alessandro Vercelli Benedetta Lottini Carlo Spirli Mario Strazzabosco Massimo Pinzani Maurizio Parola | 2005 | World Journal of Gastroenterology2005，11，32： | 9 |
| 4 | Proangiogenic Cytokines as Hypoxia-Dependent Factors Stimulating Migration of Human Hepatic Stellate Cells显示文摘 | Erica Novo Stefania Cannito Elena Zamara Lorenzo Valfrè di Bonzo Alessandra Caligiuri Carlo Cravanzola Alessandra Compagnone Sebastiano Colombatto Fabio Marra Massimo Pinzani Maurizio Parola | 2007 | The American Journal of Pathology2007，，6： | 6 |
| 5 | 肠道衍生的血清脂多糖与心房颤动患者主要不良心血管事件的风险增加相关:地中海膳食的影响显示文摘肠道微生物群正在成为动脉粥样硬化血栓形成的新型危险因素,但肠道衍生的脂多糖的预测作用尚不清楚。来自意大利罗马Sapienza大学的Pastori等进行了一项前瞻性单中心研究,分析了脂多糖与心房颤动中主要不良心血管事件(major adverse cardiovascular events,MACE)之间的关系,以及坚持地中海膳食(Mediterranean diet,Med-diet)对上述关系的影响。 | 刘莉 叶鹏 Pastori D Carnevale R Nocella C Novo M Santulli M Cammisotto V Menichelli D Pignatelli P Violi F | 2017 | 中华高血压杂志2017，25，9： | 5 |
| 6 | Downregulation of the Basic Peroxidase Isoenzyme from Zinnia elegans by Gibberellic Acid显示文摘Hypocotyl formation during the epigeal germination of seedlings is under strict hormonal regulation. In a 3 d old Zinnia elegans seedling system, gibberellic acid (GA3) exerts an opposite effect to that exerted by light on hypocotyl photomorphogenesis because GA3 promotes an etiolated-like growth with an inhibition of radial (secondary) growth. For this reason, the effect of GA3 on the basic peroxidase isoenzyme from Z. elegans (ZePrx), an enzyme involved in hypocotyl lignin biosynthesis, was studied. The results showed that GA3 reduces ZePrx activity, similarly to the way in which it reduces seedling secondary growth. This hormonal response is supported by the analysis of the ZePrx promoter, which contains four types of GA3-responsive cis-elements: the W Box/O2S; the Pyr Box; the GARE; and the Amy Box. Taken together, these results suggest that ZePrx is directly regulated by GA3, with this effect matching the inhibitory effect of GA on the hypocotyl secondary growth. | María Josefa López Núez-Flores Jorge Gutirrez Laura V.Gómez-Ros Esther Novo Uzal Mariana Sottomayor Alfonso Ros Barceló | 2010 | Journal of Integrative Plant Biology2010，52，2： | 3 |
| 7 | Aortic stenosis: insights on pathogenesis and clinical implications显示文摘大动脉的狭窄(作为) 是在西方的人口的普通的瓣膜的心疾病,与在在 75 年的成年人的 3% 的估计的全面流行。为了理解它的 patho 生物的过程,代表优先级。在老病人,作为通常包含 trileaflet 阀门并且被叫作退化石灰质的过程。科学证据建议活跃 “ 的参与; atherosclerosis-like”在开始阶段的致病退化作为。到矛盾,前进能被不同力量驾驶(例如在发炎和石灰化之间的机械应力,基因因素和相互作用) 。改进理解为阻止并且禁止疾病的发展和前进介绍潜在地新的治疗学的目标。而且,在临床的实践管理作为病人暗示概括动脉粥样硬化患者表明的评估(即,在里面冠并且颈动脉动脉) 甚至为预示的原因。在 counselling 老病人,风险层化应该超过通用风险分数探讨单个脆弱。在这些,问候,合作病态,和特别地那些连接了到全球动脉粥样硬化患者负担,应该小心地被调查以便为侵略治疗策略定义风险 / 利益比率。我们在场在致病的卓见的详细概述就象可能的实际含意。 | Patrizia Carita Giuseppe Coppola Giuseppina Novo Giuseppa Caccamo Marco Guglielmo FabioBalasus Salvatore Novo Sebastiano Castrovinci Marco Moscarelli Khalil Fattouch Egle Corrado | 2016 | Journal of Geriatric Cardiology2016，13，6： | 3 |
| 8 | Cellular and molecular mechanisms in liver fibrogenesis显示文摘 | Erica Novo Stefania Cannito Claudia Paternostro Claudia Bocca Antonella Miglietta Maurizio Parola | 2013 | Archives of Biochemistry and Biophysics2013，，： | 2 |
| 9 | Leptin gene transfer into muscle increases lipolysis and oxygen consumption in white fat tissue in ob/ob mice显示文摘 | Marti A Novo F J Martinez-Anso E | 1998 | Biochem Biophys Res Commun1998，246，： | 2 |
| 10 | Spectral classification of water masses under the influence of the Amazon River plume显示文摘The large amount of dissolved and particulate material discharged by the Amazon River into the Equatorial Atlantic Ocean cause distinct spectral response of its waters as compared to the nearby ocean waters. This paper shows the application of K-means clustering algorithm for classifying water masses in the region under the Amazon River plume influence according to their spectral behavior. Salinity and temperature data from 67 oceanographic stations were related to Sea-viewing Wide Field-of-view Sensor (SeaWiFS) remote sensing reflectances values and the following bio-optical products: (i) chlorophyll-a concentration, (ii) water attenuation coefficient and (iii) absorption coefficient for dissolved and detrital material. Four different water masses were identified such as: (1) oceanic water, (2) intermediate oceanic water, (3) intermediate river plume water and (4) Amazon River plume water. The spectral behavior of these water masses allowed concluding that the main active optical component of the waters in the region is the colored dissolved organic matter originated mostly from the Amazon River. | Gustavo Souto Fontes Molleri Milton Kampel Evlyn Mrcia Leo de Moraes Novo | 2010 | Acta Oceanologica Sinica2010，29，3： | 2 |
| 11 | Postprocessing the Galerkin method : a novel approach, to approximate inertial manifolds 显示文摘 | Garcia - Archilla B Novo J Titi E S | 1998 | SIAM Journal on Numerical Analysis1998，35，： | 1 |
| 12 | Circulating Transforming Growth Factor- 1 Levels in Asymptomatic Carotid Plaques显示文摘 | Ferroni P Novo S Davi V | 2005 | Stroke2005，36，3： | 1 |
| 13 | Congenital anomalies of the tracheobronchial tree,lung,and mediastinum:embryology,radiology,and pathology显示文摘 | Berrocal T Madrid C Novo S | | 0，，： | 1 |
| 14 | High sensitivity of C-reactive protein in primary prevention显示文摘 | Corrado E Novo S | | 0，，： | 1 |
| 15 | Congenital anomalies of the tracheobronchial tree,lung, and ediastinum : embryology, radiology, and pathology 显示文摘 | Berrocal T Madrid C Novo S | 2003 | Radiographics2003，24，： | 1 |
| 16 | An approximate inertial manifolds approach to postprocessing the Galerkin method for the navier - stokes equations显示文摘 | Garcia - Archilla B Novo J Titi E S | 1999 | Mathematics of Computation1999，68，： | 1 |
| 17 | Proper efficiency in vector optimization on real linear spaces 显示文摘 | Adan M Novo V | 2004 | Journal of Optimization Theory and Applications2004，121，3： | 1 |
| 18 | Plasmon Coupling ofGold Nanorods at Short Distances and in Different Geometries显示文摘 | Funston A M Novo C Davis T J | 2009 | Nano Lett2009，9，4： | 1 |
| 19 | The degree of articular depression as a predictor of raft-tissue injuries in tibial plateau fracture显示文摘 | Spiro AS Regier M Novo de Oliveira A | 2013 | Knee Surg Sports Tratmmtol Arthrosc2013，21，3： | 1 |
| 20 | Resolution of GPR bowtie antennas: An experimental approach显示文摘 | Fernando I. Rial Manuel Pereira Henrique Lorenzo Pedro Arias Alexandre Novo | 2008 | Journal of Applied Geophysics2008，，4： | 1 |
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