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| 1 | Helicobacter species ribosomal DNA in the pancreas, stomach and duodenum of pancreatic cancer patients显示文摘瞄准:决定胃、伤寒的 Helicobacter 种类是否与胰腺的癌症被联系。方法:有外分泌的病人胰腺的癌症(n = 40 ) ,神经内分泌癌症(n = 14 ) ,多重内分泌的瘤形成类型 1 (n = 8 ) ,并且慢性胰炎(n = 5 ) 被学习。另外的良性的胰腺的疾病(n = 10 ) 并且正常的胰的标本(n = 7 ) 作为控制被包括。胰腺的织物标本被 Helicobacter 特定的 PCR 试金分析,产品被使中毒描绘坡度电气泳动和定序 DNA。从胰腺的癌症病人的一个子集,象胆囊和管一样的胃或十二指肠的织物我们胆总管织物被分析。胆囊和胆总管样品作为控制被包括。胃和十二指肠样品被调查分析胃的 helicobacter 是否可能在胰腺的癌症病人传播到胰。胰腺的标本被 Bacteroides 特定的 PCR 为检测土生土长的内脏微生物的易位到 diseased 胰分析。结果:Helicobacter DNA 在胰(肿瘤或包围组织) 被检测有外分泌癌症的 75% 病人,有神经内分泌癌症的 57% 病人,有多重内分泌的瘤形成的 38% 病人,和有慢性胰炎的 60% 病人。从另外的良性的胰腺的疾病和正常的胰的所有样品是否定的。百分之 33 个病人在胃与十二指肠的标本是 helicobacter 积极的。令人惊讶地, H。胆汁在 60% 积极胃与十二指肠的样品被识别。所有胆囊和管我们胆总管标本为 helicobacter 是否定的。Bacteroides PCR 试金为所有胰腺的样品是否定的。结论:通常在胰腺的癌症检测的 Helicobacter DNA 在慢性胰炎和胰腺的癌症的发展建议新兴的病原体的一个可能的角色。 | Hans-Olof Nilsson Unne Stenram Ingemar Ihse Torkel Wadstr(o|¨)m | 2006 | World Journal of Gastroenterology2006，12，19： | 19 |
| 2 | Gastroenteropancreatic neuroendocrine tumours显示文摘 | Irvin M Modlin Kjell Oberg Daniel C Chung Robert T Jensen Wouter W de Herder Rajesh V Thakker Martyn Caplin Gianfranco Delle Fave Greg A Kaltsas Eric P Krenning Steven F Moss Ola Nilsson Guido Rindi Ramon Salazar Philippe Ruszniewski Anders Sundin | 2008 | Lancet Oncology2008，，1： | 8 |
| 3 | Mapping aboveground biomass and its prediction uncertainty using LiDAR and field data, accounting for tree-level allometric and LiDAR model errors显示文摘Background: The increasing availability of remotely sensed data has recently challenged the traditional way of performing forest inventories, and induced an interest in model-based inference. Like traditional design-based inference, model-based inference allows for regional estimates of totals and means, but in addition for wall-to-wall mapping of forest characteristics. Recently Light Detection and Ranging(LiDAR)-based maps of forest attributes have been developed in many countries and been well received by users due to their accurate spatial representation of forest resources. However, the correspondence between such mapping and model-based inference is seldom appreciated. In this study we applied hierarchical model-based inference to produce aboveground biomass maps as well as maps of the corresponding prediction uncertainties with the same spatial resolution. Further, an estimator of mean biomass at regional level, and its uncertainty, was developed to demonstrate how mapping and regional level assessment can be combined within the framework of model-based inference.Results: Through a new version of hierarchical model-based estimation, allowing models to be nonlinear, we accounted for uncertainties in both the individual tree-level biomass models and the models linking plot level biomass predictions with LiDAR metrics. In a 5005 km2 large study area in south-central Sweden the predicted aboveground biomass at the level of 18 m×18 m map units was found to range between 9 and 447 Mg·ha^-1. The corresponding root mean square errors ranged between 10 and 162 Mg·ha^-1. For the entire study region, the mean aboveground biomass was 55 Mg·ha^-1 and the corresponding relative root mean square error 8%. At this level 75%of the mean square error was due to the uncertainty associated with tree-level models.Conclusions: Through the proposed method it is possible to link mapping and estimation within the framework of model-based inference. Uncertainties in both tree-level biomass models and models linking plot level biomass with LiDAR data are accounted for, both for the uncertainty maps and the overall estimates. The development of hierarchical model-based inference to handle nonlinear models was an important prerequisite for the study. | Svetlana Saarela AndréWästlund Emma Holmström Alex Appiah Mensah Sören Holm Mats Nilsson Jonas Fridman Göran Ståhl | 2020 | Forest Ecosystems2020，7，3： | 3 |
| 4 | preliminary study of D-dimer as a possible marker of acute bowel ischaemia 显示文摘 | Acosta S Nilsson TK Bjorck M | 2001 | Br J Surg2001，88，3： | 2 |
| 5 | Increased risk of cirrhosis and hepatocellular cancer during long-term follow-up of patients with biopsy-proven NAFLD显示文摘 | Kristina ? nnerhag Peter M Nilsson Stefan Lindgren | 2014 | Scandinavian Journal of Gastroenterology2014，，9： | 2 |
| 6 | Improved cryopreservation of human hepatocytes using a new xeno free cryoprotectant solution显示文摘AIM:To optimize a xeno-free cryopreservation protocol for primary human hepatocytes.METHODS:The demand for cryopreserved hepatocytes is increasing for both clinical and research purposes.Despite several hepatocyte cryopreservation protocols being available,improvements are urgently needed.We first compared controlled rate freezing to polystyrene box freezing and did not find any significant change between the groups.Using the polystyrene box freezing,we compared two xeno-free freezing solutions for freezing of primary human hepatocytes:a new medium(STEM-CELLBANKER,CB),which contains dimethylsulphoxide(DMSO) and anhydrous dextrose,both permeating and non-permeating cryoprotectants,and the frequently used DMSO-University of Wisconsin(DMSOUW) medium.The viability of the hepatocytes was assessed by the trypan blue exclusion method as well as a calcein-esterase based live-dead assay before and after cryopreservation.The function of the hepatocytes was evaluated before and after cryopreservation by assessing enzymatic activity of 6 major cytochrome P450 isoforms(CYPs):CYP1A2,CYP2C9,CYP2C19,CYP2D6,CYP3A4 and CYP3A7.RESULTS:The new cryoprotectant combination preserved hepatocyte viability significantly better than the standard DMSO-UW protocol(P < 0.01).There was no significant difference in viability estimation between both the trypan blue(TB) and the Live-Dead Assay methods.There was a correlation between viability of fresh hepatocytes and the difference in cell viability between CB and DMSO protocols(r 2 = 0.69) using the TB method.However,due to high within-group variability in the activities of the major CYPs,any statistical between-group differences were precluded.Cryopreservation of human hepatocytes using the cryoprotectant combination was a simple and xeno-free procedure yielding better hepatocyte viability.Thus,it may be a better alternative to the standard DMSO-UW protocol.Estimating CYP activities did not seem to be a relevant way to compare hepatocyte function between different groups due to high normal variability between different liver samples.CONCLUSION:The cryoprotectant combination may be a better alternative to the standard DMSO-UW protocol in primary human hepatocyte cryopreservation. | Mohammed Saliem Frida Holm Rosita Bergstrm Tengzelius Carl Jorns Lisa-Mari Nilsson Bo-Gran Ericzon Ewa Ellis Outi Hovatta | 2012 | World Journal of Hepatology2012，4，5： | 2 |
| 7 | Interferon-γ inhibits ghrelin expression and secretion via a somatostatin-mediated mechanism显示文摘AIM:To investigate if and how the proinflammatory cytokine interferon γ(IFNγ) affects ghrelin expression in mice.METHODS:The plasma concentration of ghrelin,andgastric ghrelin and somatostatin expression,were examined in wild-type mice and mice infected with Helicobacter pylori(H.pylori).Furthermore,ghrelin expression was examined in two achlorhydric mouse models with varying degrees of gastritis due to bacterial overgrowth.To study the effect of IFNγ alone,mice were given a subcutaneous infusion of IFNγ for 7 d.Finally,the influence of IFNγ and somatostatin on the ghrelin promoter was characterized.RESULTS:H.pylori infection was associated with a 50% reduction in ghrelin expression and plasma concentration.Suppression of ghrelin expression was inversely correlated with gastric inflammation in achlorhdyric mouse models.Subcutaneous infusion of IFNγ suppressed fundic ghrelin mRNA expression and plasma ghrelin concentrations.Finally,we showed that the ghrelin promoter operates under the control of somatostatin but not under that of IFNγ.CONCLUSION:Gastric infection and inflammation is associated with increased IFNγ expression and reduced ghrelin expression.IFNγ does not directly control ghrelin expression but inhibits it indirectly via somatostatin. | Jesper AB Strickertsson Kristina BV DΦssing Anna JM Aabakke Hans-Olof Nilsson Thomas VO Hansen Ulrich Knigge Andreas Kjr Torkel Wadstrm Lennart Friis-Hansen | 2011 | World Journal of Gastroenterology2011，17，26： | 2 |
| 8 | Optimising islet engraftment is critical for successful clinical islet transplantation显示文摘 | O Korsgren T Lundgren M Felldin A Foss B Isaksson J Permert N H Persson E Rafael M Rydén K Salmela A Tibell G Tufveson B Nilsson | 2008 | Diabetologia2008，，2： | 2 |
| 9 | Appendectomy versus Antibiotic Treatment in Acute Appendicitis. A Prospective Multicenter Randomized Controlled Trial显示文摘 | Johan Styrud MD PhD Staffan Eriksson MD PhD Ingemar Nilsson MD PhD Gunnar Ahlberg MD PhD Staffan Haapaniemi MD PhD Gunnar Neovius MD Lars Rex MD Ibrahim Badume MD Lars Granstr?m MD PhD | 2006 | World Journal of Surgery2006，，6： | 2 |
| 10 | Differential activation of vascular genes by hypoxia in primary endothelial cells显示文摘 | Nilsson I Shibuya M Wennstrom S | 2004 | Exp Cell Res2004，299，2： | 1 |
| 11 | Approximate geodesic distances reveal biologically relevant structures in microarray data 显示文摘 | Nilsson J Fioretos T Hoglund M | 2004 | Bioinformaties2004，20，6： | 1 |
| 12 | Nuclear Jak2 and Transcription Factor NF1-C2: a Novel Mechanism of Prolactin Signaling in Mammary Epithelial Cells显示文摘 | Nilsson J Bjursell G Kannius-Janson M | 2006 | Molecular And Cellular Biology2006，15，26： | 1 |
| 13 | Enriched environment increases neurogenceis in the adult rat dentate gyrus and improves spatial memory显示文摘 | Nilsson M Perfilieva E Johansson U | 1999 | J Neurobiol1999，39，4： | 1 |
| 14 | ^13C NMR spectroscopy studies of forest soil microbial activity: glucose uptake and fatty acid biosynthesis显示文摘 | Lundberg P Ekblad A Nilsson M | 2001 | Soil Biology & Biochemistry2001，33，： | 1 |
| 15 | Protective and regenerative effects of the GH/IGFI axis on the brain显示文摘 | Isgaard J Aberg D Nilsson M | 2007 | Minerva Endocri- nol2007，32，2： | 1 |
| 16 | Does seed dormancy benefit the mother plant by reducing sib competition?显示文摘 | Nilsson P Fagerstrm T Tuomi J | 1994 | Evolutionary Ecology1994，8，： | 1 |
| 17 | Rabbit articular cartilage defects treated with autologous cultured chondrocy test显示文摘 | Brittberg M Nilsson A Lindahl A | 1996 | Clin Orthop1996，326，： | 1 |
| 18 | Leukemia inhibitory factor (LIF) promotes the primordial to primary follicle transtion in rat ovaries显示文摘 | Nilsson E E Kezele P Skinner M K | 2002 | Mol Cell Endocrinol2002，188，： | 1 |
| 19 | Increased uveoscleral outflow as a possible mechanism of ocular hypotension caused by prostaglandin F2α1-isopropylester in the cynomolgus monkey 显示文摘 | Nilsson SF Samuelsson M Bill A | 1989 | Exp Eye Res1989，48，： | 1 |
| 20 | Proteomic studies of potential cerebrospinal fluid protein markers for Alzheimer's disease显示文摘 | Puehades M Hansson SF Nilsson CL | 2003 | Brain Res Mol2003，118，12： | 1 |
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