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| 1 | Octreotide induces caspase activation and apoptosis in human hepatoma HepG2 cells显示文摘AIM: To investigate the role of octreotide on cellular proliferation and apoptosis of human hepatoma (HepG2) cells. METHODS: We studied cellular proliferation, apoptosis and the possible internal caspase-mediated apoptosis pathway involved, after treatment of HepG2 carcinoma cells with octreotide in comparison with the apoptosis caused by tumor necrosis factor-α (TNF-α). Activities of caspase-3, caspase-9, caspase-8 and caspase-2 were studied, while apoptosis was investigated through detection of DNA fragmentation and through identification of apoptotic cells with the annexin-V/propidium iodide flow cytometric method. RESULTS: After an initial increase in HepG2 cellular proliferation, a significant inhibition was observed with 10-8 mol/L octreotide, while TNF-α dose-dependently decreased proliferation. Early and late apoptosis was significantly increased with both substances. Octreotide significantly increased caspase-3, caspase-8 and caspase-2 activity. TNF-α signifi cantly increased only caspase-2. Cellular proliferation was decreased after treatment with octreotide or TNF-α alone but, in contrast to TNF-α, octreotide decreased proliferation only at concentrations of 10-8 mol/L, while lower concentrations increased proliferation. CONCLUSION: Our findings are suggestive of caspasemediated signaling pathways of octreotide antitumor activity in HepG2 cells, and indicate that measurements of serum octreotide levels may be important, at least in clinical trials, to verify optimal therapeutic drug concentrations. | Nikos J Tsagarakis Ioannis Drygiannakis Antonis G Batistakis George Kolios Elias A Kouroumalis | 2011 | World Journal of Gastroenterology2011，17，3： | 5 |
| 2 | 室温及非传统条件下AlCl3-尿素低共熔溶剂中铝的电沉积(英文)显示文摘研究在接近室温下AlCl3-尿素低共熔溶剂(DESs)体系中铝在玻璃碳和铝基底上的电沉积,而不需要对用于制备电解质的化学试剂进行额外的净化处理,也没有严格控制工作场所中的水分和氧气。研究改变温度、工作电势、受控沉积电流密度和沉积时间对在不搅拌电解质情况下沉积铝的形貌的影响。采用恒电势和恒电流技术,25~50℃下,在低共熔溶剂(n(AlCl3):n(Urea)=1.6:1)中将铝电沉积到玻璃状碳和铝基底上。利用SEM、EDS和XRD技术对两种基底进行研究,证实在恒电势和恒电流两种情形下均存在铝沉积物。所沉积的A1晶粒的形状和尺寸取决于沉积时间,尺寸从纳米级到微米级,形状从规则晶体到针状和片状结构。 | Vesna SCVETKOVIĆ Nataša MVUKIĆEVIĆ Niko JOVIĆEVIĆ Jasmina SSTEVANOVIĆ Jovan NJOVIĆEVIĆ | 2020 | Transactions of Nonferrous Metals Society of China2020，30，3： | 3 |
| 3 | Genome sequence and analysis of the soil cellulolytic actinomyeete Thermobifidafusca YX 显示文摘 | Athanasios L Konstantinos M Natalia I lain A Miriam L Genevieve D Michele M Alia L Susan L Alex C Paul R David BW Nikos K | 2007 | J Bacteriol2007，189，6： | 1 |
| 4 | Pulse pressure in normotensive:A marker of cardiovascular disease显示文摘 | Lekakis CM Nikos A John P | 2001 | Am J Hypertens2001，14，： | 1 |
| 5 | Stabilization of enzymes in nanoporous materials for biosensor applications显示文摘 | Sofia Sotiropoulou Vicky Vamvakaki Nikos A Chaniotakis | 2005 | Biosensors and Bioelectronics2005，20，： | 1 |
| 6 | Identifying constituents in commercial gasoline using Fourier transform infrared spectroscopy and independent component analysis显示文摘 | Nikos Pasadakis Kardamakis Andreas A | 2006 | Analytica Chiraiea Acta2006，578，2： | 1 |
| 7 | Evaluation of design alternatives for the 2-D-discrete wavelet transform 显示文摘 | Nikos D Z Giorgos P A | 2001 | IEEE Transactions on Circuits and Systems for Video Technology2001，11，12： | 1 |
| 8 | The stabilization of Au NP-AChE nanocomposites by biosilica encapsulation for the development of a thiocholine biosensor 显示文摘 | Raluca B Nikos A C | 2012 | Bioelectrochemistry2012，86，： | 1 |
| 9 | Selective catalytic reduction of NO by Propene in Excess Oxygen on Pt-and Rh supported Alumina catalysts显示文摘 | Niko L A Stergioula E S Efihimiadis E A | 1999 | CatalToday1999，54，4： | 1 |
| 10 | Transmission expansion planning of systems with increasing wind power integration显示文摘 | Orfanos George A Georgilakis Pavlos S Hatziargyriou Nikos D | 2013 | IEEE Transactions on Power Systems2013，28，2： | 1 |
| 11 | Transformation and normalvector calculation of parametrically defined surfacesbased on dual vectors and screw theory : Application toPhong's shading model 显示文摘 | Stavros G P Nikos A A | 2006 | Computer Graphics Forum2006，25，2： | 1 |
| 12 | Maternal left ventricular diastolic and systolic long-axis function during normal pregnancy 显示文摘 | Jacqueline EAK Bamfo Nikos A | 2007 | Eur J Echocardiography2007，8，： | 1 |
| 13 | A stability algorithm for the dynamic analysis of inverter dominated unbalanced LV microgrids显示文摘 | NIKDS L S STAVROS A P NIKOS D H | 2007 | IEEE Trans on Power Systems2007，22，1： | 1 |
| 14 | Microgrids显示文摘 | Nikos H Hiroshi A Chris M I R | 2007 | IEEE Power and Energy Magazine2007，5，4： | 1 |
| 15 | Microgrids显示文摘 | Nikos H Hiroshi A Reza I | 2007 | IEEE Power & Ener- gy Magazine2007，6，3： | 1 |
| 16 | A stability algorithm for the dynamic analysis of inverter dominated unbalanced LV microgrids显示文摘 | Soultanis Nikos L Papathanasiou Stavros A Hatziargyriou Nikos D | 2007 | IEEE Transactions on Power System2007，22，1： | 1 |
| 17 | Calculation and Stability Investigation of Periodic Steady States of the Voltage Converter Buck DC-DC Converter显示文摘 | GEORGIOS A P NIKOS I M | 2004 | IEEE Transactions on Power Electronics2004，19，7： | 1 |
| 18 | Autoregressive modeling of near-IR spectra and MLR to predict RON values of gasolines显示文摘 | ANDREAS A K NIKOS P | 2010 | Fuel2010，89，1： | 1 |
| 19 | Calculation and stability investigation of periodic steady states of the voltage converter buck DC-DC converter显示文摘 | Georegios A P Nikos I M | 2004 | IEEE Transaction on Power Electronics2004，19，7： | 1 |
| 20 | MR imaging findings of an atypical pulmonary hamartoma in a 12-year-old显示文摘 | Efthymia A Nikos E Kostas N | 2008 | Pediatr Radiol2008，38，10： | 1 |
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