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| 1 | Male obesity and subfertility, is it really about increased adiposity?显示文摘在繁殖的人的过重和肥胖的流行全球正在增加,与 > 70% 人 >作为在一些西方的国家超重或肥胖分类的 18 年。男肥胖与男 subfertility 被联系,损害性荷尔蒙,减少精子计数,增加氧化精子 DNA 损坏并且改变精子的 epigenetic 地位。精子的这些变化由于肥胖工作,进一步在人与损害胚胎开发,减少的实时出生率和增加的流产率被联系。动物模型建议了这些不利繁殖效果能被传给后代;在概念建议那人的健康可以影响他们的孩子的健康。除了更高的脂肪过多,男肥胖与 comorbidities 被联系,包括新陈代谢的症候群,血胆脂醇过多, hyperleptinemia 和一个支持 inflammatory 州,独立地与男 subfertility 被连接了的所有。一起拿,这些调查结果建议生育力上的男肥胖的效果是可能的 multifactorial 与也影响精子的联系 comorbidities,怀孕和随后的孩子健康。 | Nicole O McPherson | 2015 | Asian Journal of Andrology2015，17，3： | 10 |
| 2 | Family integrated care:Supporting parents as primary caregivers in the neonatal intensive care unit显示文摘Family integrated care (FICare) is a collaborative model of neonatal care which aims to address the negative impacts of the neonatal intensive care unit (NICU) environment by involving parents as equal partners, minimizing separation, and supporting parent-infant closeness. FICare incorporates psychological, educational, communication, and environmental strategies to support parents to cope with the NICU environment and to prepare them to be able to emotionally, cognitively, and physically care for their infant. FICare has been associated with improved infant feeding, growth, and parent wellbeing and self-efficacy;important mediators for long-term improved infant neurodevelopmental and behavioural outcomes. FICare implementation requires multi-disciplinary commitment, staff motivation, and sufficient time for preparation and readiness for change as professionals relinquish power and control to instead develop collaborative partnerships with parents. Successful FICare implementation and culture change have been applied by neonatal teams internationally, using practical approaches suited to their local environments. Strategies such as parent and staff meetings and relational communication help to break down barriers to change by providing space for the co-creation of knowledge, the negotiation of caregiving roles and the development of trusting relationships. The COVID-19 pandemic highlighted the vulnerability within programs supporting parental presence in neonatal units and the profound impacts of parent-infant separation. New technologies and digital innovations can help to mitigate these challenges, and support renewed efforts to embed FICare philosophy and practice in neonatal care during the COVID-19 recovery and beyond. | Chandra Waddington Nicole Rvan Veenendaal Karel O’Brien Neil Patel for the International Steering Committee for Family Integrated Care | 2021 | Pediatric Investigation2021，5，2： | 9 |
| 3 | Helicobacter pylori eradication: Sequential therapy and Lactobacillus reuteri supplementation显示文摘AIM:To evaluate the role of sequential therapy and Lactobacillus reuteri (L. reuteri ) supplementation, in the eradication treatment of Helicobacter pylori (H. pylori ). METHODS:H. pylori infection was diagnosed in 90 adult dyspeptic patients. Patients were excluded if previously treated for H. pylori infection or if they were taking a proton pump inhibitor (PPI), H2-receptor antagonist or antibiotics. Patients were assigned to receive one of the following therapies:(1) 7-d triple therapy (PPI plus clarithromycin and amoxicillin or metronidazole) plus L. reuteri supplementation dur- ing antibiotic treatment; (2) 7-d triple therapy plus L. reuteri supplementation after antibiotic treatment; (3) sequential regimen (5-d PPI plus amoxicillin therapy followed by a 5-d PPI, clarithromycin and tinidazole) plus L. reuteri supplementation during antibiotic treatment; and (4) sequential regimen plus L. reuteri supplementation after antibiotic treatment. Successful eradication therapy was defined as a negative urea breath test at least 4 wk following treatment. RESULTS:Ninety adult dyspeptic patients were en- rolled, and 83 (30 male, 53 female; mean age 57 ± 13 years) completed the study. Nineteen patients were administered a 7-d triple treatment:11 with L. reuteri supplementation during and 8 after therapy. Sixty-four patients were administered a sequential regimen:32 with L. reuteri supplementation during and 32 after therapy. The eradication rate was significantly higher in the sequential group compared with the 7-d triple regimen (88% vs 63%, P = 0.01). No difference was found between two types of PPI. No difference in erad- ication rates was observed between patients submitted to L. reuteri supplementation during or after antibiotic treatment. Compliance with therapy was excellent in all patients. No difference in adverse effects was observed between the different antibiotic treatments and between patients submitted to L. reuteri supplementation during and after antibiotic treatment. There was a low incidence of adverse effects in all groups of patients with sequential therapy, probably due to the presence of the L. reuteri supplementation. CONCLUSION:The sequential treatment regimen achieved a significantly higher eradication rate of H. pylori compared with standard 7-d regimen. L. reuteri supplementation could reduce the frequency and the intensity of antibiotic-associated side-effects. | Cesare Efrati Giorgia Nicolini Claudio Cannaviello Nicole Piazza O'Sed Stefano Valabrega | 2012 | World Journal of Gastroenterology2012，18，43： | 4 |
| 4 | Photonic implementation of boson sampling:a review显示文摘Boson sampling is a computational problem that has recently been proposed as a candidate to obtain an unequivocal quantum computational advantage.The problem consists in sampling from the output distribution of indistinguishable bosons in a linear interferometer.There is strong evidence that such an experiment is hard to classically simulate,but it is naturally solved by dedicated photonic quantum hardware,comprising single photons,linear evolution,and photodetection.This prospect has stimulated much effort resulting in the experimental implementation of progressively larger devices.We review recent advances in photonic boson sampling,describing both the technological improvements achieved and the future challenges.We also discuss recent proposals and implementations of variants of the original problem,theoretical issues occurring when imperfections are considered,and advances in the development of suitable techniques for validation of boson sampling experiments.We conclude by discussing the future application of photonic boson sampling devices beyond the original theoretical scope. | Daniel J.Brod Ernesto F.Galvão Andrea Crespi Roberto Osellame NicolòSpagnolo Fabio Sciarrino | 2019 | Advanced Photonics2019，1，3： | 3 |
| 5 | Neuroprotection mediated by glial cell line-derived neurotrophic factor:Involvement of a reduction of NMDA-induced calcium influx by the mitogen-activated protein kinase pathway显示文摘 | Nicole O Ali C Docagne F | 2001 | J Neurosci2001，21，9： | 1 |
| 6 | Histone Methyltransferase Activity of a Drosophila Polycomb Group Repressor Complex显示文摘 | Jürg Müller Craig M. Hart Nicole J. Francis Marcus L. Vargas Aditya Sengupta Brigitte Wild Ellen L. Miller Michael B. O’Connor Robert E. Kingston Jeffrey A. Simon | 2002 | Cell2002，，2： | 1 |
| 7 | Spontaneously hyper- tensive rats are highly vulnerable to AMPA-induced brain le- sions 显示文摘 | Lecrux C Nicole O Chaza'lviel L | 2007 | Stroke2007，38，11： | 1 |
| 8 | The proteolytic activity of tissue- plasmino- gen activator enhances NMDA receptor - mediated sighaling显示文摘 | Nicole O Doeaqne F | 2001 | Nature Medicine2001，7，1： | 1 |
| 9 | Activation of protease-activated receptor-1 triggers astrogliosis after brain injury显示文摘 | Nicole O Goldshmidt A Hamill CE | 2005 | J Neurosci2005，25，： | 1 |
| 10 | Genetic Polymorphisms in MTHFR (C677T, A1298C), MTR (A2756G) and MTRR (A66G) Genes Associated With Pathological Characteristics of Prostate Cancer in the Ecuadorian Population显示文摘 | Andrés López-Cortés Gabriela Jaramillo-Koupermann María J. Mu?oz Alejandro Cabrera Carolina Echeverría Felipe Rosales Nicolás Vivar César Paz-y-Mi?o | 2013 | The American Journal of the Medical Sciences2013，，： | 1 |
| 11 | B7-H1 (programmed death-1ligand) on dendritic cells is involved in the induction and maintenance of T cell anergy 显示文摘 | Nicole Selenko-Gebauer N Majdic O | 2003 | J Immunol2003，170，7： | 1 |
| 12 | Rheological behavior of poly(methyl methacrylate)/polystyrene (PMMA/PS) blends with the addition of PMMA-ran-PS显示文摘 | Márcio Yee Patrícia S. Calv?o Nicole R. Demarquette | 2007 | Rheologica Acta2007，，5： | 1 |
| 13 | Ischemia-induced interleukin-6 as a potential endogenous neuroprotective cytokine against NMDA receptormediated excitotoxicity in the brain显示文摘 | Ali C Nicole O Docagne F | 2000 | J Cereb Blood Flow Metab2000，20，6： | 1 |
| 14 | Activation of extrasynaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid beta production 显示文摘 | Bordji K Becerril-Ortega J Nicole O | 2010 | J Neurosci2010，30，15： | 1 |
| 15 | A Transforming growth factor-βt antagonist unmasks the neuroprotective role of this endogenous cytokine in excitotoxic and ischemic brain injury 显示文摘 | Ruocco A Nicole O Docayne F | 1999 | J Cereb Blood Flow Metab1999，19，12： | 1 |
| 16 | The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling显示文摘 | Nicole O Docagne F Ali C | 2001 | Nat Med2001，7，1： | 1 |
| 17 | Ischemia-indueed interleukin-6 as a potential endogenous neuroproteetive eytokine against NMDA receptor-mediated excitotoxicity in the brain 显示文摘 | Ali C Nicole O Docagne F | 2000 | J Cereh Blood Flow Metah2000，20，： | 1 |
| 18 | Neuroprotection mediated by glial cell line-derived neurotrophic factor:involvement of a reduction of NMDA-induced calcium influx by the mitogen-activated protein kinase pathway显示文摘 | Nicole O Ali C Docagne F | 2001 | Neurosci2001，21，9： | 1 |
| 19 | The proteolytic activity of tissueplasminogen activator enhances NMDA receptor-mediated signaling显示文摘 | Nicole O Docagne F Ali C | 2001 | Nature Med2001，7，： | 1 |
| 20 | Effects of the root lesion nematode, Pratylenchus thornei, on wheat yields in Mexico显示文摘 | Julie M Nicol Ivan O M | 2004 | Nernatology2004，6，4： | 1 |
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