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| 1 | Calcitriol analog ZK191784 ameliorates acute and chronic dextran sodium sulfate-induced colitis by modulation of intestinal dendritic cell numbers and phenotype显示文摘AIM: To investigate the effects of ZK1916784, a low calcemic analog of calcitriol on intestinal inflammation. METHODS: Acute and chronic colitis was induced by dextran sodium sulfate (DSS) according to standard procedures. Mice were treated intraperitoneally with ZK1916784 or placebo and colonic inflammation was evaluated. Cytokine production by mesenterial lymph node (MLN) cells was measured by ELISA. Immunohistochemistry was performed to detect intestinal dendritic cells (DCs) within the colonic tissue, and the effect of the calcitriol analog on DCs was investigated. RESULTS: Treatment with ZK191784 resulted in significant amelioration of disease with a reduced histological score in acute and chronic intestinal inflammation. In animals with acute DSS colitis, down- regulation of colonic inflammation was associated with a dramatic reduction in the secretion of the proinflammatory cytokine interferon (IFN)-γ and a significant increase in intereleukin (IL)-10 by MLN cells. Similarly, in chronic colitis, IL-10 expression in colonic tissue increased 1.4-fold when mice were treated with ZK191784, whereas expression of the Th1-specific transcription factor T-beta decreased by 81.6%. Lower numbers of infiltrating activated CD11c+ DCs were found in the colon in ZK191784-treated mice with acute DSScolitis, and secretion of proinflammatory cytokines by primary mucosal DCs was inhibited in the presence of the calcitriol analog. CONCLUSION: The calcitriol analog ZK191784 demonstrated significant anti-inflammatory properties in experimental colitis that were at least partially mediated by the immunosuppressive effects of the derivate on mucosal DCs. | Ulrike G Strauch Florian Obermeier Nicole Grunwald Nadja Dunger Heiko C Rath Jürgen Schlmerich A Steinmeyer U Zügel HH Herfarth | 2007 | World Journal of Gastroenterology2007，13，48： | 4 |
| 2 | Loss of CD103^+ intestinal dendritic cells during colonic inflammation显示文摘AIM:To investigate possible differences in dendritic cells(DC)within intestinal tissue of mice before and after induction of colitis. METHODS:Mucosal DC derived from intestinal tissue,as well as from mesenteric lymph nodes and spleen,were analyzed by fluorescence activated cell sorting(FACS) analysis.Supernatants of these cells were analyzed for secretion of different pro-and anti-inflammatory cytokines. Immunohistochemistry and immunofluorescence were performed on cryosections of mucosal tissue derived from animals with colitis as well as from healthy mice. RESULTS:It was shown that DC derived from healthy intestinal lamina propria(LP)represented an immature phenotype as characterized by low-level expression of costimulatory cytokines.In contrast to DC from spleen and mesenteric lymph nodes(MLN)that secreted proinflammatory cytokines,LP-DC produced high levels of the anti-inflammatory cytokine IL-10.After induction of mu-rine colitis in a CD4 + CD62L + transfer model or in chronic Dextran sulfate sodium-colitis,a marked increase of activated CD80 + DC could be observed within the inflamed colonic tissue.Interestingly,in contrast to splenic DC,a significant population of DC within MLN and colonic LP expressed the mucosal integrin CD103 which was lost during colitis. CONCLUSION:The constitutive secretion of antiinflammatory cytokines by immature DC within the intestinal LP might regulate the homeostatic balance between mucosal immunity and tolerance.CD103 + DC could mediate this important function. | Ulrike G Strauch Nicole Grunwald Florian Obermeier Sonja Gürster Heiko C Rath | 2010 | World Journal of Gastroenterology2010，16，1： | 2 |
| 3 | Central line-associated bloodstream infection among children with biliary atresia listed for liver transplantation显示文摘BACKGROUND Pre-transplant nutrition is a key driver of outcomes following liver transplantation in children.Patients with biliary atresia(BA) may have difficulty achieving satisfactory weight gain with enteral nutrition alone,and parenteral nutrition(PN) may be indicated.While PN has been shown to improve anthropometric parameters of children with BA listed for liver transplantation,less is known about the risks,particularly infectious,associated with this therapy among this specific group of patients.AIM To describe the incidence,microbiology,and risk factors of central line-associated bloodstream infection(CLABSI) among children with BA listed for liver transplantation.METHODS Retrospective review of children aged ≤ 2-years of age with BA who were listed for primary liver transplantation at Texas Children's Hospital from 2008 through2015(n = 96).Patients with a central line for administration of PN(n = 63) were identified and details of each CLABSI event were abstracted.We compared the group of patients who experienced CLABSI to the group who did not,to determine whether demographic,clinical,or laboratory factors correlated with development of CLABSI.RESULTS Nineteen of 63 patients(30%,95%CI:19,43) experienced 29 episodes of CLABSI during 4800 line days(6.04 CLABSI per 1000 line days).CLABSI was predominantly associated with Gram-negative organisms(14/29 episodes,48%)including Klebsiella spp.,Enterobacter spp.,and Escherichia coli.The sole polymicrobial infection grew Enterobacter cloacae and Klebsiella pneumoniae.Grampositive organisms(all Staphylococcus spp.) and fungus(all Candida spp.)comprised 9/29(31%) and 6/29(21%) episodes,respectively.No demographic,clinical,or laboratory factors were significantly associated with an increased risk for the first CLABSI event in Cox proportional hazards regression analysis CONCLUSION There is substantial risk for CLABSI among children with BA listed for liver transplantation.No clinical,demographic,or laboratory factor we tested emerged as an independent predictor of CLABSI.While our data did not show an impact of CLABSI on the short-term clinical outcome,it would seem prudent to implement CLABSI reduction strategies in this population to the extent that each CLABSI event represents potentially preventable hospitalization,unnecessary healthcare dollar expenditures,and may exact an opportunity cost,in terms of missed allograft offers. | Nicole D Triggs Stacey Beer Sonam Mokha Kat Hosek Danielle Guffey Charles G Minard Flor M Munoz Ryan W Himes | 2019 | World Journal of Hepatology2019，11，2： | 2 |
| 4 | 显示文摘 | Bos G W Nicole M | 1999 | Biomed Mater Res1999，44，： | 1 |
| 5 | activity and temperature responses of ammonia-oxidizing archaea and bacteria in soil microcosms 显示文摘 | Tourna M Freitag T E Nicol G W | 2008 | Environmental Microbiology2008，10，5： | 1 |
| 6 | Is the world's economic center of gravity ] l already in Asia? 显示文摘 | Jean M G Nicole A M | 2010 | AREA2010，42，1： | 1 |
| 7 | Fluid Stochastic Petri Nets: Theory, Applications and Solution 显示文摘 | G Horton V G Kulkami D M Nicol K S Trivedi | 1998 | European Journal of Operations Research (S0377-2217)1998，105，1： | 1 |
| 8 | Structural features of prolactins and growth hormones that can be related to their biological properties显示文摘 | Nicoll C S Mayer G L Russell S M | 1986 | Endocr Rev1986，7，： | 1 |
| 9 | Seed banks of a southern Australian wetland : the influence of water regime on the final floristic composition显示文摘 | Nicol J M Ganf G G Pehon G A | 2003 | Plant Ecology2003，，168： | 1 |
| 10 | The effects of integrated care on quality of work in nursing homes:A quasi-experiment显示文摘 | Nicolle P G Boumans Afke J M B Berkhout | 2008 | International Journal of Nursing Studies2008，45，8： | 1 |
| 11 | Formation of crystalloid inclusions in the small intestine of neonatal pigs:an immunocytochemical study using colloidal gold显示文摘 | Komüves L G Nicols B L Hutchens T W | 1993 | Histochemical Journal1993，25，1： | 1 |
| 12 | Effects of vent ducts on the reduced pressure from explosion in dust collectors显示文摘 | Lunn G A Nicol A M Coliins P D | 1998 | Journal of Loss Prevention in the Process Industries1998，11，： | 1 |
| 13 | Temperature step changes: a novel approach to control biofilms of Streptococcus thermophilus in a pilot plant- scale cheesemilk pasteurization plant显示文摘 | Knight G C Nicol R S Mcmeekin T A | 2004 | International Journal of Food Microbiology2004，93，： | 1 |
| 14 | Homologues of nitrite reductases in ammonia-oxidizing archaea:diversity and genomic context 显示文摘 | Bartossek R Nicol G W Lanzen A | 2010 | Environ Microbiol2010，12，4： | 1 |
| 15 | The importance of the ni- trous oxide pathway to NOx in lean-premixed combustion显示文摘 | Nicol D G Steele R C Marinov N M | 1995 | Journal of Engineering for Gas Turbine and Power1995，117，： | 1 |
| 16 | Chlorobenzenes in sediments,water and selected fish from Lakes Superior,Huson,Erie and Ontario显示文摘 | Barry G Oliver Karen D Nicol | 1982 | Environ Sci Tehnol1982，，16： | 1 |
| 17 | Hepatic iodo- thyronine 5'-deiodinase: The role of selenium 显示文摘 | ARTHUR J R NICOL F BECKETr G J | 1990 | Bio- chem J1990，272，2： | 1 |
| 18 | Peroxisome proliferator-activated receptor beta/delta regulatesvery low density lipoprotein production and catabolism in mice on a Western diet 显示文摘 | Akiyama T E Lambert G Nicol C J | 2004 | Biol Chem2004，279，20： | 1 |
| 19 | Temperature step changes: a novel approach to control biofilms of Streptococcus thermophilus in a pilot plant- scale cheesemilk pasteurization plant 显示文摘 | Knight G C Nicol R S Mcmeekin T A | 2004 | International Journal of Food Microbiology2004，，93： | 1 |
| 20 | Temperature step changes: a novel approach to control biofilms of Streptococcus thermophiles in a pilot plant-scale cheese-milk pasteurization plant 显示文摘 | KNIGHT G NICOL R MCMEEK1N T | 2004 | Int J Food Mi- crobiol2004，93，3： | 1 |
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