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| 1 | WJSC 6^(th) Anniversary Special Issues(2):Mesenchymal stem cells Progress of mesenchymal stem cell therapy for neural and retinal diseases显示文摘Complex circuitry and limited regenerative power make central nervous system(CNS)disorders the most challenging and difficult for functional repair.With elusive disease mechanisms,traditional surgical and medical interventions merely slow down the progression of the neurodegenerative diseases.However,the number of neurons still diminishes in many patients.Recently,stem cell therapy has been proposed as a viable option.Mesenchymal stem cells(MSCs),a widely-studied human adult stem cell population,have been discovered for more than 20 years.MSCs have been found all over the body and can be conveniently obtained from different accessible tissues:bone marrow,blood,and adipose and dental tissue.MSCs have high proliferative and differentiation abilities,providing an inexhaustible source of neurons and glia for cell replacement therapy.Moreover,MSCs also show neuroprotective effects without any genetic modification or reprogramming.In addition,the extraordinary immunomodulatory properties of MSCs enable autologous and heterologous transplantation.These qualities heighten the clinical applicability of MSCs when dealing with the pathologies of CNS disorders.Here,we summarize the latest progress of MSC experimental research as well as human clinical trials for neural and retinal diseases.This review article will focus on multiple sclerosis,spinal cord injury,autism,glaucoma,retinitis pigmentosa and age-related macular degeneration. | Tsz Kin Ng Veronica R Fortino Daniel Pelaez Herman S Cheung | 2014 | World Journal of Stem Cells2014，6，2： | 13 |
| 2 | Inflammatory bowel disease serology in Asia and the West显示文摘AIM:To study serological antibodies in Caucasians and Asians,in health and inflammatory bowel disease(IBD),in Australia and Hong Kong(HK).METHODS:Anti-glycan antibodies[anti-chitobioside(ACCA),anti-laminaribioside(ALCA)],and anti-mannobioside(AMCA),anti-Saccharomyces cervisiae(gASCA);and atypical perinuclear anti-neutrophil cytoplasmic antibody(pANCA)were tested in IBD patients,their unaffected relatives,and healthy controls in Australia and HK(China).Antibody status(positive or negative)and titre was compared between subjects of different geography,ethnicity and disease state.RESULTS:Ninety subjects were evaluated:21 Crohn’s disease(CD),32 ulcerative colitis(UC),29 healthy controls,and 8 IBD patient relatives.Forty eight subjects were Australian(29 Caucasian and 19 ethnic Han Chinese)and 42 were from HK(all Han Chinese).Caucasian CD patients had a significantly higher antibody prevalence of gASCA(67%vs 3%,P<0.001),ALCA(44%vs 6%,P=0.005),and AMCA(67%vs 15%,P=0.002),whereas HK CD patients had a higher prevalence of only AMCA(58%vs 25%,P=0.035),when compared with UC and healthy subjects in both countries.Caucasian CD had significantly higher gASCA prevalence(67%vs 0%,P<0.001)and titre(median59 vs 9,P=0.002)than HK CD patients.Prevalence and titres of ALCA,ACCA and AMCA did not differ between CD in the two countries.Presence of at least one antibody was higher in Caucasian than HK CD patients(100%vs 58%,P=0.045).pANCA did not differ between countries or ethnicity.CONCLUSION:Serologic CD responses differ between HK Asian and Australian Caucasian patients.Different genetic,environmental or disease pathogenic factors may account for these differences. | Lani Prideaux Michael A Kamm Peter De Cruz Daniel R van Langenberg Siew C Ng Iris Dotan | 2013 | World Journal of Gastroenterology2013，19，37： | 10 |
| 3 | Comparison of antioxidant activity of clove ( Eugenia caryophylata Thunb) buds and lavender ( Lavandula stoechas L.)显示文摘 | ìlhami Gül?in ?. Güng?r ?at ?ükrü Beydemir Mahfuz Elmasta? ?. ?rfan Küfrevio?lu | 2004 | Food Chemistry2004，，3： | 3 |
| 4 | Plasma and aqueous humor levels of adiponutrin and pannexin 1 in patients with and without diabetic retinopathy显示文摘AIM: To evaluate plasma and aqueous levels of adiponutrin and pannexin 1 in patients with and without diabetic retinopathy.METHODS: The study included three age and gendermatched groups of 20 cataract patients with no diabetes or additional disease(Group C), 20 cataract patients with diabetes and no retinopathy(Group DM+C), and 20 cataract patients with diabetic retinopathy(Group DR+C).All the patients were examined with respect to body mass index(BMI), fasting plasma glucose, hemoglobin A1c(HbA1c), and lipid profile.Phacoemulsification and intraocular lens(Phaco+IOL) implantation were performed to all patients in all the groups, and aqueous samples were taken during the operation.The plasma and aqueous adiponutrin and pannexin 1 levels were analyzed using enzyme-linked immunosorbent assays.RESULTS: A statistically significant difference was determined between the groups with respect to BMI, fasting plasma glucose, and HbA1c levels(P<0.05 for all parameters tested).The plasma adiponutrin levels of Group DR+C were statistically significantly lower than those of Group C and Group DM+C(P<0.001, P=0.004).No statistically significant difference was determined in the aqueous adiponutrin levels in three groups.The plasma pannexin 1 levels of Groups DM+C and DR+C were statistically significantly lower than those of Group C(both P=0.001).The aqueous pannexin 1 levels of Group DR+C were statistically significantly higher than those of Group C and Group DM+C(P=0.001, P<0.001).CONCLUSION: Adiponutrin and pannexin 1, which play an important role in the pathophysiology of diabetes and obesity, and have a regulatory role in hyperglycemia and insulin resistance.The measurement of adiponutrin and pannexin 1 levels may support clinicians in determining the risk of DR development. | Fatih Cem Gül Sabiha Güngör Kobat FatihÇelik Süleyman Aydin Ramazan Fazil Akkoç | 2022 | International Journal of Ophthalmology(English edition)2022，15，3： | 3 |
| 5 | An unusual case of incidental rupture of liver hemangioma during labor显示文摘Cavernous hemangiomas are the most common benign tumors of the liver and are found in about 2% of autopsy patients. 1,2 The vast majority of these tumors are small and asymptomatic; however, there have been a few reported cases in which these lesions led to spontaneous fatal hemorrhage. 1,2 Although liver hemangiomas occur in both sexes, most studies point to a female predominance; one study reported a ratio of female predominance of 4. 5: 1.3 It has been suggested that estrogen may be associated with the growth of liver hemangiomas, but the incidence of these lesions in pregnancy and the effect on them of the increased estrogen levels during pregnancy are unknown. 2 Symptomatic liver hemangiomas have been treated by steroids, radiation therapy, surgical resection and recently embolization, but surgeons may sometimes be confronted with intraabdominal hemorrhage originating from rupture of asymptomatic liver hemangiomas. This case describes an incidental intraabdominal hemorrhage originating from a liver hemangioma in a 36 weeks twin pregnancy being delivered emergently by Cesarean section due to fetal distress. | TayfunGüng(o|¨)r Hakan Aytan (O|¨)merLütfiTapisiz Sema Zergeroglu | 2004 | Chinese Medical Journal2004，17，2： | 2 |
| 6 | Role of β-microseminoprotein from prostate cancer initiationto recurrence: A mini-review显示文摘Medline/Pubmed articles relevant to this topic were considered using the search terms ?-microseminoprotein, MSMB, prostate secretory protein of 94 amino acids and PSP94. Full articles were retrieved when the abstract was considered relevant. In addition, other data related to this topic including our own are discussed. Summary of fi ndings-?-microseminoprotein(MSMB) is increasingly being considered as a marker for prostatecancer, as reduced levels have been associated with the disease. Here we review various aspects of this protein including its biological and physiological variants, binding proteins and immune modulation; its importance as a marker for biochemical recurrence of prostate cancer; prostate cancer related splice variants and its therapeutic utility. Two of the most important properties of MSMB are related to anticancer functions and immune modulation. Predominant expression of two(short and full-length) splice variants of MSMB has been observed from normal prostate and several other tissues. In benign prostate hyperplasia the short isoform is dominant, constituting 98% of this isoform, whereas in prostate cancer 96% constitute the fulllength isoform. The MSMB promoter single nucleotide polymorphism rs10993994 with the C allele functions as an activated cyclic adenosine monophosphate response element binding protein binding site. This C variant of rs10993994 could be responsible for the production of splice variants under variable conditions. MSMB has binding motifs to a few known proteins including immunoglobulin G and several Cysteine-rich secretory proteins family proteins. MSMB bound to these proteins is considered as immune modulating. Use of MSMB as a urinary marker for detecting aggressive prostate cancers that could resist radiation and surgical treatments, seems possible, but needs further investigation. The ratio of MSMB splice variants could also be a possible approach in understanding prostate cancers, with higher ratios indicating severe disease. | Nishi Karunasinghe Karen Bishop Pamela Murray Yuanye Xu Megan Goudie Lance Ng Shuotun Zhu Dug Yeo Han Lynnette R Ferguson Jonathan Masters Benji Benjamin Michael Holmes | 2014 | World Journal of Clinical Urology2014，3，1： | 2 |
| 7 | 前房注射头孢呋辛对术后眼内炎的预防作用(英文)显示文摘目的:研究前房注射头孢呋辛对术后眼内炎的预防作用。方法:回顾性研究6 099例行超声乳化白内障手术的年龄相关性白内障患者。对照组,2001-10/2004-05,3 075例3 075眼行白内障手术未用眼内抗生素,实验组,2004-06/2007-04,3 024例3 024眼术中前房用0.1mL含1mg的头孢呋辛。两组的术前预防措施和手术步骤相同。结果:对照组和实验组分别有13(0.42%)和4(0.13%)例患者发生术后眼内炎[P=0.031;OR =3.20(1.04-9.84)]。两组发生术后眼内炎的平均时间分别是术后30(3 ~75)d和25(2 ~35)d(P=0.35)。研究细菌感染,实验组,烟曲菌和铜绿假单胞菌对头孢呋辛耐药,而肺炎链球菌对头孢呋辛敏感。未发现前房运用头孢呋辛的毒性和过敏性症状。结论:预防性前房运用头孢呋辛是安全的,可以预防术后细菌性眼内炎。然而抗生素抗菌谱窄和抗生素耐药性的可能性需要考虑。 | Güngr Sobaci Yusuf Uysal Fatih M Mutlu Atilla Bayer Rιza Gungor Suat Karagul | 2009 | 国际眼科杂志2009，9，8： | 2 |
| 8 | Algorithms for mining distance based outliers in large data sets 显示文摘 | E Knorr and R Ng | 1998 | VLDB Conference Proceedings1998，，： | 2 |
| 9 | Pancreatic cancer显示文摘 | C Güng?r B T Hofmann G Wolters‐Eisfeld M Bockhorn | 2014 | Br J Pharmacol2014，，4： | 2 |
| 10 | Malingering or simulation in ophthalmology-visual acuity显示文摘Simulation can be defined as malingering,or sometimes functional visual loss(FVL).It manifests as either simulating an ophthalmic disease(positive simulation),or denial of ophthalmic disease(negative simulation).Conscious behavior and compensation or indemnity claims are prominent features of simulation.Since some authors suggest that this is a manifestation of underlying psychopathology,even conversion is included in this context.In today's world,every ophthalmologist can face with simulation of ophthalmic disease or disorder.In case of simulation suspect,the physician's responsibility is to prove the simulation considering the disease/disorder first,and simulation as an exclusion.In simulation examinations,the physician should be firm and smart to select appropriate test(s) to convince not only the subject,but also the judge in case of indemnity or compensation trials.Almost all ophthalmic sensory and motor functions including visual acuity,visual field,color vision and night vision can be the subject of simulation.Examiner must be skillful in selecting the most appropriate test.Apart from those in the literature,we included all kinds of simulation in ophthalmology.In addition,simulation examination techniques,such as,use of OCT(optical coherence tomography),frequency doubling perimetry(FDP),and modified polarization tests were also included.In this review,we made a thorough literature search,and added our experiences to give the readers up-to-date information on malingering or simulation in ophthalmology. | Ali Ihsan Incesu Güngr Sobaci | 2011 | International Journal of Ophthalmology(English edition)2011，4，5： | 2 |
| 11 | Comparison of Grid Laser, Intravitreal Triamcinolone, and Intravitreal Bevacizumab in the Treatment of Diffuse Diabetic Macular Edema显示文摘 | Sobaci Güng?r ?zge G?khan Erdurman Cüneyt Durukan Hakan A Bayraktar Zeki M | 2012 | Ophthalmologica2012，，2： | 2 |
| 12 | On the utility of gambling: extending the approach of meginniss 显示文摘 | Ng C T Luce R D Marley A A J | 2008 | Aequationes Mathematicae2008，76，： | 1 |
| 13 | Imaging and staging of transitional cell carcinoma:part 2,upper urinary tract显示文摘 | Vikram R Sandier CM Ng CS | 2009 | AJR2009，192，6： | 1 |
| 14 | Caspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis显示文摘 | JANICKE R U NG P SPRENGART M L | 1998 | J Biol Chem1998，273，15： | 1 |
| 15 | 显示文摘 | Heganaars M NG Ensink R Koelemu | 1998 | Int J Cancer1998，75，： | 1 |
| 16 | Malignant transformation of osteoblastoma显示文摘 | Merryweather R Middlemiss JH SanerKin NG | 1980 | Bone Joint Surg1980，62，3： | 1 |
| 17 | Computer graphics techniques for modelingcloth显示文摘 | NG H N Grimsdale R L | 1996 | IEEE Computer Graphics and Applications1996，，： | 1 |
| 18 | Numerical simulations of LNG vapor dispersion in brayton fire training field tests with ANSYS CFX显示文摘 | Qi R F Ng D Cormier B R | 2010 | Journal of Hazardous Materials2010，183，13： | 1 |
| 19 | Near- infrared spectro- scopic determination of degradation in vegetable oils used to fry various foods 显示文摘 | Ng C L Wehling R L Cuppet S L | 2011 | Journal of Agricultural and Food Chem- istry2011，59，12： | 1 |
| 20 | Low levels of p53 protein and chromatin silencing of p53 target genes repress apoptosis in Drosophila endocycling cells显示文摘 | Zhang B Mehrotra S Ng W L Calvi B R | 2014 | PLoS Genet2014，10，10： | 1 |
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