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| 1 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 2 | Induction, localization and metal content of hydrogenase in green alga Chlamydomonas reinhardtii显示文摘 | Happe T Mosler B Naber J D | 1994 | Eur J Biochem1994，222，： | 1 |
| 3 | Treatment of severe agintation with olanzapine in 166 patientswith sehizoaffeetive, or bipolar I diaorder显示文摘 | Lambert M Huber CG Naber D etal | 2008 | Pharmaeopsyehat2008，41，5： | 1 |
| 4 | Subjective well - being un- der neuroleptic treatment and its relevance for compliance 显示文摘 | Naber D Karow A lambert M | 2005 | Act a Psychiatrica Scandinavica2005，111，427： | 1 |
| 5 | Aripiprazole:a new atypical antipsychotic with a different pharmacological mechanism显示文摘 | Naber D Lambert M | 2004 | Progress in Neuro-Psychopharmacology and Biological Psychiatry2004，28，8： | 1 |
| 6 | Combustion of n-butanol in aspark-ignition IC engine 显示文摘 | Szwaja S Naber J D | 2010 | Fuel2010，89，7： | 1 |
| 7 | A self-rating to measure subjective effects of neuroleptic drugs, relationships to objective psychopatholo- gy, quality of life, compliance and other clinical variables 显示文摘 | Naber D | 1995 | Int Clin Psyehopharmacol1995，10，3： | 1 |
| 8 | Modeling engine spray/wall impingement显示文摘 | Naber J D Reitz R D | 1989 | Transaction of the SAE1989，97，6： | 1 |
| 9 | Combustion of n-butanol in a spark-ignition IC engine显示文摘 | Szwaja S Naber J D | 2010 | Fuel2010，89，7： | 1 |
| 10 | Improvement of schizophrenic patients' subjective well-being under atypical antipsychotic drugs 显示文摘 | Naber D Moritz S Lambert M | 2001 | Schizophr Res2001，50，12： | 1 |
| 11 | Comparison of electrically evoked cortical potential thresholds generated with subretinal or suprachoroidal placement of a microelectrode array in the rabbit显示文摘 | Yamauchi Y Franco LM Jackson D J Naber JF Ziv RO Rizzo JF et ol | 2005 | J Neural Eng2005，2，1： | 1 |
| 12 | Subjective well--being under neu roleptic treatment and its relevance for compIianee显示文摘 | Naber D Karow A Lambert M | 2005 | Acta Psychi-attica Scandinavca2005，111，427： | 1 |
| 13 | Current issues in schizophrenia: overview of patient acceptability, functioning capacity and quality of life显示文摘 | Lambert E Naber D | 2004 | CNS Drugs2004，18，2： | 1 |
| 14 | Rates and predictors of re- mission and recovery during 3 years in 392 never--treated patients with schizophrenia 显示文摘 | M Lambert D Naber A Schacht | 2008 | Acta psychiatrica scandinavica2008，118，： | 1 |
| 15 | Role of the eNOS Glu298Asp variant on the GNB3825T allele dependent determination of alpha-adrenergic coronary constriction 显示文摘 | Naber C K Baumgart D Heusch G | 2003 | Pharmaeogenetics2003，13，5： | 1 |
| 16 | Combustion of n-butanol in a spark-ignition IC engine显示文摘 | Szwaja S Naber J D | 2010 | Fuel2010，89，7： | 1 |
| 17 | Comparison of electrically evoked cortical potential thresholds generated with subretinal or suprachoroidal place- ment of a microelectrode array in the rabbit显示文摘 | Yamauchi Y Franco LM Jackson D J Naber JF Ziv RO Rizzo JF | 2005 | J Neural Eng2005，2，1： | 1 |
| 18 | Comparisons of hydrogen and gasoline combustion knock in a spark igni tion engine显示文摘 | Szwaja S Bhandary K R Naber J D | 2007 | International Journal of Hydrogen Energy2007，32，18： | 1 |
| 19 | Combustion of n-butanol in a Spark- ignition IC Engine显示文摘 | SZWAJA S NABER J D | 2010 | Fuel2010，89，7： | 1 |
| 20 | Psychopathological and neuropsychological effects of 8-days' cortieosteroid treatment:a prospective study显示文摘 | Naber D Sand P Heigl B | 1996 | Psychoneuroendocrinology1996，21，1： | 1 |
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