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| 1 | Sorption kinetics and impact of temperature,ionic strength and colloid concentration on the adsorption of plutonium-239 by inorganic colloids显示文摘 | Reimus Lu N Parker PW Conca G R | 2003 | Radiochimica Acta2003，，91： | 1 |
| 2 | Motion of a rigid body in a viscous fluid显示文摘 | Carlos Conca Jorge San Martín H. Marius Tucsnak | 1999 | Comptes Rendus de l’Academie des Sciences Series I Mathematics1999，，6： | 1 |
| 3 | Penile prosthesis: Patient satisfaction, use and preference for malleable vs inflatable显示文摘AIM: To evaluate and compare long-term patient satisfaction and use after either malleable penile prosthesis(MPP) or inflatable penile prosthesis(IPP) implantation. METHODS: we present a retrospective unicenter study of 108 patients implanted with either 2 or 3-piece American Medical System^(TM)(AMS^(TM)) or Coloplast^(TM) inflatable penile prosthesis(AMS 700CX^(TM), AMS 700CXR^(TM), AMS Ambicor^(TM) or Coloplast TITAN^(TM)) or malleable(AMS Spectra^(TM) or Coloplast Genesis^(TM)) in our Centre between 1993 and 2011. We collected data from the medical record including follow-up, age and type of prosthesis. We used a four-question telephone surveydesigned ad hoc by urologist in our Department, with three multiple choice questions and a grading answer. After verbal consent was obtained, proposed questions concerned global satisfaction regarding to the procedure, quality of sexual intercourses graded from 0 to 10, frequency of sexual intercourse and about undergoing the same procedure again. SPSS^(TM) version 20.0 was used for the descriptive analysis of the data. RESULTS: Sixty seven(64%) patients underwent a MPP and 41(36%) an IPP. The mean age was 52.6 ± 3.6 years in the MPP group and 57.2 ± 2.8 years in the IPP group(P = 0.02). Total respond rate was 55.5%(60/108). Twenty six out of 33 MPP patients(78.9%) and 19 of the 27 IPP subjects(70.3%) were satisfied or very satisfied with the procedure. The quality of sexual intercourse was rated 7.13 ± 0.39 points in the MPP group and 6.16 ± 0.47 points in the IPP group. Frequency of sexual intercourse was 1 or more times per week in 15(46.9%) patients with MPP and in 12(46.1%) of the IPP patients. Twenty-eight(84.9%) patients who received a MPP would undergo the procedure for the same device again as well as 24(88.9%) of the IPP group. There were no statistical differences between groups regarding the four items in the survey.CONCLUSION: Patients show high satisfaction rate and no statistical differences exist regarding to global satisfaction, use of the device and quality of sexual intercourse depending on the type of penile prosthesis. | Ramón Rogel Bertó Jose Daniel López-Acón Saturnino Luján Marco Domingo Guzmán Ordaz Jurado Francisco Delgado Oliva María Angeles Conca Baenas Francisco Boronat Tormo | 2014 | World Journal of Clinical Urology2014，3，2： | 0 |
| 4 | AGNP精神科治疗药物监测共识指南:2011显示文摘治疗药物监测(Therapeutic drug monitoring,TDM),如通过定量测定血清或血浆药物浓度指导用药剂量优化,已经成为对患者进行精神药物治疗的很有价值的工具。在患者用药依从性难以判断、药物耐受性不佳、治疗剂量下无效以及可能存在药代动力学药物-药物相互作用等情况下,测定药物浓度是很有用的。在精神科,有可能明显获益于TDM的主要患者群体包括儿童、孕妇、老年患者、智力障碍患者、涉及司法的患者、已知或怀疑携带药代动力学相关基因变异的患者,以及合并躯体疾病影响药代动力学的患者。然而,只有将TDM充分整合到临床治疗过程中去,才能发挥其优化药物治疗的潜在优势。为了促进TDM的合理应用,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie,AGNP)的TDM专家组在2004年发表了精神药物治疗药物监测指南。之后,随着知识不断更新,又有许多可能需要进行TDM的新药上市。因此,本次更新将神经精神药物的种类扩展到了128种,并将其TDM必要性划分为从'强烈推荐'到'可能有用'的四个等级。经过大量细致且全面的文献检索与分门别类的汇总整理,将基于循证医学理念的'治疗参考浓度范围'和'剂量相关参考浓度范围'呈现给大家。本共识指南引入了'实验室警戒浓度'的新概念,即实验室需要马上告知治疗医生的药物浓度上限。本共识指南还给出了诸如药物作为细胞色素P450酶的底物和抑制剂的性质,代谢物与母药浓度比值的常见范围,以及与结果解释相关的内容,还提供了何时将TDM与遗传药理学检测相结合的建议。遵循本指南,有助于改善许多患者精神药物治疗的效果,特别是那些存在药代动力学异常的患者。TDM是一门交叉学科,有时针对看起来不一致的数据,需要多学科坦诚地讨论,只有这样,患者才能从这种合作中获益。 | Hiemke C Baumann P Bergemann N Conca A Dietmaier O Egberts K Fric M Gerlach M Greiner C Gründer G Haen E Havemann-Reinecke U Jaquenoud Sirot E Kirchherr H Laux G Lutz UC Messer T Müller MJ Pfuhlmann B Rambeck B Riederer P Schoppek B Stingl J Uhr M Ulrich S Waschgler R Zernig G 李文标(译) 果伟(译) 阮灿军(译) 贺静(译) 汤宜朗(审校) 王传跃(审校) | 2016 | 实用药物与临床2016，19，10： | 37 |
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