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| 1 | Colonoscopic yield of colorectal neoplasia in daily clinical practice显示文摘AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per indication.METHODS:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or cancer.RESULTS:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients. | Jochim S Terhaar sive Droste Mike E Craanen Rene WM van der Hulst Joep F Bartelsman Dick P Bezemer Kim R Cappendijk Gerrit A Meijer Linde M Morsink Pleun Snel Hans ARE Tuynman Roy LJ van Wanrooy Eric IC Wesdorp Chris JJ Mulder | 2009 | World Journal of Gastroenterology2009，15，9： | 6 |
| 2 | Are faecal markers good indicators of mucosal healing in inflammatory bowel disease?显示文摘AIM: To review the published literature concerning the accuracy of faecal inflammatory markers for identifying mucosal healing. METHODS: Bibliographical searches were performed in MEDLINE electronic database up to February 2015,using the following terms: 'inflammatory bowel disease','Crohn′s disease','ulcerative colitis','faecal markers','calprotectin','lactoferrin','S100A12','endoscop*','mucosal healing','remission'. In addition,relevant references from these studies were also included. Data were extracted from the published papers including odds ratios with 95%CI,P values and correlation coefficients. Data were grouped together according to each faecal marker,Crohn's disease or ulcerative colitis,and paediatric compared with adult study populations. Studies included in this review assessed mucosal inflammation by endoscopic and/or histological means and compared these findings to faecal marker concentrations in inflammatory bowel diseases(IBD) patient cohorts. Articles had to be published between 1990 and February 2015 and written in English. Papers excluded from the review were those where the faecal biomarker concentration was compared between patients with IBD and controls or other disease groups,those where serum biomarkers were used,those with a heterogeneous study population and those only assessing post-operative disease. RESULTS: The available studies show that faecal markers,such as calprotectin and lactoferrin,are promising non-invasive indicators of mucosal healing. However,due to wide variability in study design,especially with regard to the definition of mucosal healing and evaluation of marker cut offs,the available data do not yet indicate the optimal roles of these markers. Thirty-six studies published between 1990 and 2014 were included. Studies comprised variable numbers of study participants,considered CD(15-164 participants) or UC(12-152 participants) separately or as a combined group(11-252 participants). Eight reports included paediatric patients. Several indices were used to document mucosal inflammation,encompassing elevenendoscopic and eight histologic grading systems. The majority of the available reports focused on faecal calprotectin(33 studies),whilst others assessed faecal lactoferrin(13 studies) and one study assessed S100A12. Across all of the biomarkers,there is a wide range of correlation describing the association between faecal markers and endoscopic disease activity(r values ranging from 0.32 to 0.87,P values ranging from < 0.0001 to 0.7815). Correlation coefficients are described in almost all studies and are used more commonly than outcome measures such as sensitivity,specificity,PPV and/or NPV. Overall,the studies that have evaluated faecal calprotectin and/or faecal lactoferrin and their relationship with endoscopic disease activity show inconsistent results. CONCLUSION: Future studies should report the results of faecal inflammatory markers in the context of mucosal healing with clear validated cut offs. | Gudula JAM Boon Andrew S Day Chris J Mulder Richard B Gearry | 2015 | World Journal of Gastroenterology2015，21，40： | 4 |
| 3 | Auto immune hepatitis显示文摘To provide an update of the latest trends in epidemiology, clinical course, diagnostics, complications and treatment of auto immune hepatitis(AIH). A search ofthe MEDLINE database was performed using the search terms: 'auto immune hepatitis', 'clinical presentation', 'symptoms', 'signs', 'diagnosis', 'auto antibodies', 'laboratory values', 'serology', 'histopathology', ' h i s t o l o g y ', ' g e n e t i c s ', 'HLA g e n e s ', 'non-HLA genes', 'environment', 'epidemiology', 'prevalence', 'incidence', 'demographics', 'complications', 'HCC', 'PBC', 'PSC', 'corticosteroid', 'therapy', 'treatment', 'alternative treatment'. English-language full-text articles and abstracts were considered. Articles included reviews, meta-analysis, prospective retrospective studies. No publication date restrictions were applied. AIH is an immune meditated progressive inflammatory liver disease that predominantly affects middle-aged females but may affect people of all ages. The clinical spectrum of AIH is wide, ranging from absent or mild symptoms to fulminant hepatic failure. The aetiology of AIH is still unknown, but is believed to occur as the consequence of an aberrant immune response towards an un-known trigger in a genetically susceptible host. In the absence of a gold standard, diagnosis is based on the combination of clinical, biochemical and histopathological criteria. Immunosuppressive treatment has been the cornerstone of treatment since the earliest description of the disease in 1950 by Waldenstr?m. Such treatment is often successful at inducing remission and generally leads to normal life expectancy. Nevertheless, there remain significant areas of unmet aetiological a clinical needs including fundamental insight in disease pathogenesis, optimal therapy, duration of treatment and treatment alternatives in those patients unresponsive to standard treatment regimens. | nicole mf van gerven ynto s de boer chris jj mulder carin mj van nieuwkerk gerd bouma | 2016 | World Journal of Gastroenterology2016，22，19： | 3 |
| 4 | Computing interface motion in compressible gas dynamics显示文摘 | Mulder W Osher S Sethian J | 1992 | Journal of Computational Physics1992，100，1： | 2 |
| 5 | the Panretinal photocoagulation in DR 显示文摘 | Mulders S | 1998 | Ophthamology1998，126，： | 1 |
| 6 | Activation in ventral prefrontal cortex is sensitive to genetic vulnerability for attention-deficit hyperactivity disorder显示文摘 | Durston S Mulder M Casey BJ | 2006 | Biol Psychiatry2006，60，10： | 1 |
| 7 | Extensive and specific responses of a eukaryote to bacterial quorum-sensing sig- nals 显示文摘 | MATHESIUS U MULDERS S GAO M S | 2003 | Proc Natl Acad Sci USA2003，100，： | 1 |
| 8 | Role of perceptions and knowledge in the impact assessment for the extension of Mainport Rotterdam显示文摘 | Hommes S Hulscher S Mulder J Otter H Bressers H | 2009 | 33(1):146-1552009，33，1： | 1 |
| 9 | Anti-M llerian hormone serum concentrations in normoovulatory and anovulatory Women of reproductive age显示文摘 | Laven J S Mulders A G Visser J A | 2004 | The Journal of Clinical EndocrinologyMetabolism2004，89，1： | 1 |
| 10 | Lobaplatin in advanced urothelial tract tumours显示文摘 | Sternburg CN De Mulder P Fossa S | 1997 | Ann Oncol1997，8，： | 1 |
| 11 | Mother- Infant Breastfeeding Progress Tool: a guide for education and support of the breastfeeding dyad显示文摘 | Johnson T S Mulder P J Strube K | 2007 | J Obstet Gynecol Neonatal Nurs2007，36，4： | 1 |
| 12 | Islet amyloid polypeptide in the islets ef langerhans: friend or foe? 显示文摘 | Gebre Medhin S Olefssen C Mulder H | 2000 | Diabetelegia2000，43，： | 1 |
| 13 | Robust flight control us- ing incremental nonlinear dynamic inversion and angular acceleration prediction 显示文摘 | SIEBERLING S CHU Q P MULDER J A | 2010 | Journal of Guidance Control and Dynamics2010，33，6： | 1 |
| 14 | Freeze-dried Poly (d, 1-lactic acid) Macro Porous Guidance Scaffolds Impregnated with Brain-derived Neurotrophic Factor in the Transected Adult Rat Thoracic Spinal Cord显示文摘 | Patist C M Mulder M B Gautier S E | 2004 | Biomaterials2004，25，： | 1 |
| 15 | Anti-Mullerian hormone serum concentrations in normoovulatory and anovulatory women of reproductive age显示文摘 | Laven J S Mulders A G Visser J A | 2004 | Clin Endocrinol Metab2004，8，9： | 1 |
| 16 | Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4 显示文摘 | Vermeulen M Mulder KW Denissov S | 2007 | Celt2007，131，1： | 1 |
| 17 | The epidemiology of hand injuries in the netherlands and denmark 显示文摘 | LARSEN CF MULDER S JOHANSEN AMT | 2004 | Eur J Epidemiol2004，19，4： | 1 |
| 18 | Postive coeliac se- rology in irritable bowel syndrome patients with normal duodenal diopsies: video capsule endoscopy findings and HLA - DQ typing may affect clinical management 显示文摘 | ADLER S N JACOB H MULDER C I | 2006 | J Gastrointestin Liver Dis2006，15，3： | 1 |
| 19 | Reentry flight clearance using interval analysis 显示文摘 | Juliana S Chu Q P Mulder J A | 2008 | Journal of Guidance Control and Dynamics2008，31，5： | 1 |
| 20 | Modulation of gluta- thione conjugation in vivo: how to decrease glutathione conju- gation in vivo or in intact cellular systems in vitro显示文摘 | Mulder G J Ouwerkerk - Mahadevan S | 1997 | Chemi- co - Biological Interactions1997，105，1： | 1 |
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