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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Nitrogen and phosphorus removal from urban wastewater by the microalga Scenedesmus obliquus显示文摘 | M.E Mart??nez S Sánchez J.M Jiménez F El Yousfi L Mu?oz | 2000 | Bioresource Technology2000，，3： | 2 |
| 3 | Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patients显示文摘 | Manuel Romero-Gómez Maria Del Mar Viloria Raúl J. Andrade Javier Salmerón Moisés Diago Conrado M. Fernández-Rodríguez Raquel Corpas Marina Cruz Lourdes Grande Luis Vázquez Paloma Mu?oz-de-Rueda Pilar López-Serrano Ana Gila María L. Gutiérrez Celia Pérez A | 2005 | Gastroenterology2005，，3： | 2 |
| 4 | The integrin alpha(v)beta8mediates epithelial homeostasis through MT1-MMP-dependent activationof TGF-betal显示文摘 | Mu D Cambier S Fjellbirkeland L | 2002 | J Cell Biol2002，157，3： | 1 |
| 5 | A microRNA polycistron as a potential human oncogene显示文摘 | He L Thomson JM Hemann MT Hernando-Monge E Mu D Goodson S Powers S Cordon-Cardo C.Lowe SW Hannon GJ | | 0，，： | 1 |
| 6 | The outcome of poskrolater al fusion in highly sekeiod patients with diseogenie low back pain显示文摘 | PARKER L M MU NELL S E BODEN S D | 1996 | Spine1996，21，16： | 1 |
| 7 | Fabrication,characterization and in vitro release of paclitaxel (Taxol) loaded poly (lactic-co-glycolic acid) microspheres prepared by spray drying technique with lipid / cholesterol emulsifiers 显示文摘 | Mu L Feng S S | 2001 | J Control Release2001，76，： | 1 |
| 8 | Chromosome number reports LXXXIX 显示文摘 | Mu S M Shue L R | 1985 | Taxon1985，34，4： | 1 |
| 9 | Online dual updating with recursive PLS model and its application in predicting crystal size of purified terephthalie acid (PTA) process 显示文摘 | Mu S J Zeng Y Z Liu R L | 2006 | Journal of Process Control2006，16，6： | 1 |
| 10 | Nanoparticles of biode- gradable polymers for clinical administration of paclitaxel 显示文摘 | Feng S S Mu L Win K Y | 2004 | Curr Med Chem2004，11，4： | 1 |
| 11 | Phase I / II trial of melanoma therapy with dendritic cells transfected with autologous tumor - mRNA 显示文摘 | Kyte JA Mu L Aamdal S | 2006 | Cancer Gene Ther2006，13，10： | 1 |
| 12 | Phase Ⅰ/Ⅱ trial of melanoma therapy with dendritic ceils transfected with autologons tumormRNA显示文摘 | Kyte JA Mu L Aamdal S et:al | 2006 | CancerGeneTherapy2006，13，10： | 1 |
| 13 | Spectroscopic study onacid-induced unfolding and refolding of apo-neuroglobin显示文摘 | Mu J S Li L Z Guo Y J | 2010 | Spectrochim Acta A2010，75，： | 1 |
| 14 | Deformationmechanisms of closed-cell aluminum foam in compression显示文摘 | Mu Y L Yao G C Liang L S | 2010 | Scripta Mate rial ia2010，63，6： | 1 |
| 15 | A cytogenetic study of blue grained wheat显示文摘 | LI Z MU S JIANG L | 1983 | Z Pflanzeiicntg (Wheat Journal of Plant Breeding)1983，90，： | 1 |
| 16 | Microscopic morphology and elemental composition of size distributed atmospheric particulate matter,in Urumqi, China显示文摘 | Yin H Mu S Y Zhao L | 2013 | Environmental Earth Sciences2013，69，： | 1 |
| 17 | Low-valent titanium induced reductive cyclization of 4,4-dicyano-1,3-diaryl-1-butanone: application to the synthesis of 1-amino-2-cyano-eyclopentene derivatives显示文摘 | Shi D Q Mu L L Lu Z S | 1997 | Synth Commun1997，27，23： | 1 |
| 18 | Genetic Polymorphisms in MTHFR (C677T, A1298C), MTR (A2756G) and MTRR (A66G) Genes Associated With Pathological Characteristics of Prostate Cancer in the Ecuadorian Population显示文摘 | Andrés López-Cortés Gabriela Jaramillo-Koupermann María J. Mu?oz Alejandro Cabrera Carolina Echeverría Felipe Rosales Nicolás Vivar César Paz-y-Mi?o | 2013 | The American Journal of the Medical Sciences2013，，： | 1 |
| 19 | Transcatheter aortic valve implantation in very elderly patients: immediate results and medium term follow-up显示文摘ObjectiveTo 评估立即的 transcatheter 在有严重、征兆的大动脉的狭窄的很老的病人的大动脉的阀门培植(TAVI ) 结果和中期的后续(作为).MethodsThis multicenter,观察、未来的学习在三所医院里被执行。我们包括了连续很老(>85 年) 病人与作为严重由 TAVI 对待。主要端点是在包括的二 years.ResultsThe 研究从任何原因评估死亡率有一个平均数的 160 个连续病人 87 ± 变老;2.1 年(从 85 ~ 94 年的范围) 和 18.8%± 的吝啬的逻辑 EuroSCORE;11.2% 与 57 (35.6%) 病人得分 ≥20% 。程序的成功率是 97.5% ,与 25 (15.6%) 与主要流血经历尖锐复杂并发症的病人(最经常) 。全球死亡率在住院期间是 8.8%(n = 14 ) 并且 30 天的死亡率是 10%(n = 16 ) 。中部在时期上面列在后面是 252.24 ±232.17 天。在后续时期期间, 28 (17.5%) 病人们死了(他们中的 17 个由于心脏的原因) 。估计的二年全面、心脏的幸存率使用 Kaplan-Meier 方法分别地是 71% 和 86.4% 。比例的危险回归给看了的考克斯可变 EuroSCORE ≥20 是与全面 mortality.ConclusionsTAVI 联系的唯一的变量在很老的病人的一张选择人口安全、有效。我们的调查结果支持在病人的这个复杂的组的这个新过程的采纳。 | Isaac Pascual Antonio J Mu oz-García Diego López-Otero Pablo Avanzas Manuel F Jimenez-Navarro Belén Cid-Alvarez Raquel del Valle Juan H Alonso-Briales Raimundo Ocaranza-Sanchez José M Hemández Ramiro Trillo-Nouche César Morís | 2015 | Journal of Geriatric Cardiology2015，12，4： | 1 |
| 20 | The integrin αvβ8 mediates epithelia homeostasis through MT1-MMP-dependent activation of TGF-β1 显示文摘 | Mu D Cambier S Fjellbirkelan L | 2002 | J Cell Biol2002，157，3： | 1 |
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