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| 1 | 胰腺的癌症病人的反应评估追随者 neoadjuvant 治疗显示文摘 Pancreatic ductal adenocarcinoma(PDAC) is one of the most aggressive human neoplastic entities,with a very poor prognosis characterized by a high mortality rate and short survival.This is due both to its aggressive biological behaviour and the high incidence of locally advanced stages at the time of the initial diagnosis.The limits of resectability and the role of neoadjuvant(radio) chemotherapy for PDAC management are still unclear.A recently published article by Kats et al compared the radiological,surgical and histopathological results of 129 patients with borderline resectable tumors undergoing neoadjuvant treatment followed by surgery.Although post-neoadjuvant treatment imaging implied a low response rate,a high rate of complete resections was achieved.This seems to confirm that,though radiology has made a significant progress in defining locally advanced PDAC,there is place for further improvement.In particular,the differentiation between radiotherapy-induced scarring/fibrosis and cancer-associated desmoplasia remains a clinical/radiological challenge.Though selection of patients with occult systemic disease is possible with neoadjuvant treatment,downstaging does not seem to occur frequently.Thus,development of novel,more aggressive(radio) chemotherapy regimens is required to improve prognosis of patients with locally unresectable but not systemically micro-metastasized tumors. | Chiara Tosolini Christoph W Michalski Jrg Kleeff | 2013 | World Journal of Gastrointestinal Surgery2013，5，2： | 7 |
| 2 | Update on surgical treatment of pancreatic neuroendocrine neoplasms显示文摘Pancreatic neuroendocrine neoplasms(PNENs) are rare and account for only 2%-4% of all pancreatic neoplasms. All PNENs are potential(neurendocrine tumors PNETs) or overt(neuroendocrine carcinomas PNECs) malignant,but a subset of PNETs is low-risk. Even in case of low-risk PNETs surgical resection is frequently required to treat hormone-related symptoms and to obtain an appropriate pathological diagnosis. Low-risk PNETs in the body and the tail are ideal for minimallyinvasive approaches which should be tailored to the individual patient. Generally,surgeons must aim for parenchyma sparing in these cases. In high-risk and malignant PNENs,indications for tumor resection are much wider than for pancreatic adenocarcinoma,in many cases due to the relatively benign tumor biology. Thus,patients with locally advanced and metastatic PNETs may benefit from extensive resection. In experienced hands,even multi-organ resections are accomplished with acceptable perioperative morbidity and mortality rates and are associated with excellent long term survival. However,poorly differentiated neoplasms with high proliferation rates are associated with a dismal prognosis and may frequently only be treated with chemotherapy. The evidence on surgical treatment of PNENs stems from reviews of mostly singlecenter series and some analyses of nation-wide tumor registries. No randomized trial has been performed to compare surgical and non-surgical therapies in potentially resectable PNEN. Though such a trial would principally be desirable,ethical considerations and the heterogeneity of PNENs preclude realization of such a study. In the current review,we summarize recent advances in the surgical treatment of PNENs. | Jan G D’Haese Chiara Tosolini Güralp O Ceyhan Bo Kong Irene Esposito Christoph W Michalski J?rg Kleeff | 2014 | World Journal of Gastroenterology2014，20，38： | 4 |
| 3 | Cancer-Stellate Cell Interactions Perpetuate the Hypoxia-Fibrosis Cycle in Pancreatic Ductal Adenocarcinoma显示文摘 | Mert Erkan Carolin Reiser-Erkan Christoph W. Michalski Stefanie Deucker Danguole Sauliunaite Sylvia Streit Irene Esposito Helmut Friess J?rg Kleeff | 2009 | Neoplasia2009，，： | 2 |
| 4 | All-weather model for sky luminance distribution-preliminary configuration and validation 显示文摘 | Perez R Seals R Michalsky J | 1993 | Solar Energy1993，50，3： | 1 |
| 5 | Second-generation recombination-based in vivo expression technology for large-scale screening for Vibrio cholerae genes induced during infection of the mouse small intestine显示文摘 | OSORIO C G CRAWFORD J A MICHALSKI J | 2005 | Infect Immun2005，73，2： | 1 |
| 6 | Systematic review and meta-analysis of standard and extended lymphadenectomy in pancreaticoduodenectomy for pancreatic cancer显示文摘 | Michalski CW Kleeff J Wente MN | | 0，，03： | 1 |
| 7 | Systematic review and meta- analysis of standard and extended lymphadenectomy in pancreaticoduodenectomy for pancreatic cancer 显示文摘 | Michalski CW Klceff J Wente MN | 2007 | Br J Surg2007，94，3： | 1 |
| 8 | Automated multifilter rotating shadow-band radiometer: an instrument for optical depth and radiation measurement显示文摘 | LEE H MICHALSKY J BERNDT J | 1994 | Applied Optics1994，33，22： | 1 |
| 9 | Quality of life and satisfaction with outcome among prostate-cancer survivors显示文摘 | Sanda MG Dunn RL Michalski J | | 0，，12： | 1 |
| 10 | Mass spectrometric approach for screening modifications of total serum N-glycome in human diseases:application to cirrhosis显示文摘 | MORELLE W FLAHAUT C MICHALSKI J C | 2006 | Glycobiology2006，16，4： | 1 |
| 11 | Pancreatic cancer: from bench to 5-year survival 显示文摘 | Kleeff J Michalski C Friess H | 2006 | Pancreas2006，33，2： | 1 |
| 12 | An all weather model for sky luminance distribution显示文摘 | Perez R Seals R Michalsky J Ineichen P | 1993 | Solar Energy1993，50，： | 1 |
| 13 | Vertical motion of spherical particles显示文摘 | Michalski J A | 1995 | Chem Eng Technol1995，18，6： | 1 |
| 14 | The ligament anatomy of the deltoid complex of the ankle: a qualitative and quantitative anatomical study显示文摘 | Campbell K J Michalski MP Wilson K J | 2014 | J Bone Joint Surg Am2014，96，8： | 1 |
| 15 | Inorganic,wet flue gas desulfurization(FGD)technologies-a review显示文摘 | Michalski J A | 2006 | Trends in Chemical Engineering2006，10，： | 1 |
| 16 | The problemsof pulse excitation in electromagnetic flowmeters显示文摘 | MICHALSKI A JAKUBOWSKI J WATRAL Z | 2013 | IEEEInstrumentation and Measurement Magazine2013，16，5： | 1 |
| 17 | Comparing symbolic and sub symbolic learning: three studies显示文摘 | Wnek J Michalski R | 1994 | Machine Learning1994，，4： | 1 |
| 18 | Isolation and characterisation of antibacterial peptides derived from the f(164-207) region of bovine aS2-casein显示文摘 | cCann K B Shiell B J Michalski W P | 2005 | Inte Dairy2005，15，2： | 1 |
| 19 | Prospective clinical evaluation of an electronic portal imaging device显示文摘 | Michalski J M Graham M V Bosch W R et ol | 1996 | Int J Radiat Biol Phys1996，34，4： | 1 |
| 20 | Optimal design of the coils of an electromagnetic flowmeter显示文摘 | MICHALSKI A STARZYNSKI J | 1998 | IEEE Transactions on Magnetics1998，34，5： | 1 |
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