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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | Explanation in Recommender Systems 显示文摘 | David McSherry | 2005 | Artificial Intelligence Review2005，24，： | 1 |
| 3 | Jirstromexpression posi-tively ct)iTelates with poor prognosis in breast cancer patients显示文摘 | McSherry EA McGee SF | 2009 | lnt JCancer2009，125，6： | 1 |
| 4 | Effect of age on mortality, hospitalizations and response to digoxin in patients with heart failure: the DIG study显示文摘 | Rich MW McSherry F Williford WO | 2001 | J Am Coll Cardiol2001，38，3： | 1 |
| 5 | Land suitability analysis for the upper Gila River watershed显示文摘 | Steiner F McSherry L Jill Cohen | 2000 | Landscape and Urban Planning2000，50，： | 1 |
| 6 | JAM-A expression positively correlates with poor prognosis in breast cancer patients显示文摘 | McSherry EA McGee SF Jirstrom K | 2009 | Int J Cancer2009，125，6： | 1 |
| 7 | ClassⅡcorrection-reducing patient compliance:a review of the available techniques显示文摘 | Mcsherry PF Bradley H | 2000 | J Orthod2000，27，3： | 1 |
| 8 | The incidence and causes of death following surgery for nonmalignant biliary tract disease显示文摘 | McSherry C K Glenn F | 1980 | Ann Surg1980，131，： | 1 |
| 9 | Privacy integrated queries: an extensible platform for privacy-preserving data analysis显示文摘 | MCSHERRY F | 2010 | Communication of the ACM2010，53，9： | 1 |
| 10 | Sense of coherence: its effects on psychological and physiological processes prior to, during, and after a stressful situation显示文摘 | McSherry WC Holm JE | 1994 | J Clin Psychol1994，50，4： | 1 |
| 11 | Knowledge discovery by inspection显示文摘 | Mcsherry D | 1997 | Decision Support Systems1997，21，： | 1 |
| 12 | The reflective diary: An aid to practice - based learning显示文摘 | Marland G McSherry W | 1997 | Nurs Stand1997，12，5： | 1 |
| 13 | Class Ⅱ correction-reducing patient compliance:a review of the available techniques显示文摘 | McSherry PF Bradley H | 2000 | J Orthod2000，27，3： | 1 |
| 14 | Knowledge Discovery by Inspection 显示文摘 | MCSHERRY D | 1997 | Decision Support Systems1997，21，： | 1 |
| 15 | Calibrating Noise to Sensitivity in Private Data Analysis显示文摘 | Dwork C McSherry F Nissim K | 2006 | Theory of Cryptog- raphy2006，25，20： | 1 |
| 16 | The Mirizzi syndrome:suggested classification and surgical therapy显示文摘 | McSherry CK Tsuge S Pessagno DJ | 1982 | Surg Gastroenterol1982，1，2： | 1 |
| 17 | Land Suitability analysis for the upper Gila River watershed显示文摘 | Steiner F McSherry L Cohen J | 2000 | Landscape and Urban Planning2000，50，4： | 1 |
| 18 | Evidence-based nursing:clarifying the concepts for nurses in practice显示文摘 | Scott K McSherry R | 2009 | J Clin Nurs2009，18，8： | 1 |
| 19 | The Mirrizzi syndrome : suggested classification and surgical therapy 显示文摘 | McSherry CK Ferstenberg H Virshup M | 1982 | Surg Gastroentero1982，1，： | 1 |
| 20 | The ectopic maxillary canine: a review显示文摘 | McSherry PF | 1998 | Br J Orthod1998，25，3： | 1 |
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