|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Opioid growth factor and the treatment of human pancreatic cancer:A review显示文摘Opioid growth factor(OGF),chemically termed[Met5]-enkephalin,and its receptor,OGF receptor(OGFr),form a biological axis that tonically regulates cell proliferation by delaying the G1/S interface of the cell cycle under homeostatic conditions or in neoplasia.Modulation of the OGF-OGFr pathway mediates the course of pancreatic cancer,with exogenous OGF or upregulation of OGFr repressing growth of human pancreatic cancer cells in culture and in nude mice.OGF therapy alone or in combination with standard chemotherapies such as gemcitabine and 5-fluorouracil results in enhanced inhibition of DNA synthesis and tumor growth.Molecular manipulation of OGFr confirms that the receptor is specific for OGF’s inhibitory action.Preclinical studies have warranted PhaseⅠand PhaseⅡclinical trials using OGF infusions as a treatment for patients with advanced,unresectable pancreatic cancers.OGF,an endogenous neuropeptide,is a safe,non-toxic,and effective biotherapy that utilizes the OGF-OGFr axis to mediate pancreatic tumor progression. | Ian S Zagon Patricia J McLaughlin | 2014 | World Journal of Gastroenterology2014，20，9： | 4 |
| 2 | Celiac disease:Management of persistent symptoms in patients on a gluten-free diet显示文摘AIM:To investigate all patients referred to our center with non-responsive celiac disease (NRCD),to establish a cause for their continued symptoms.METHODS:We assessed all patients referred to our center with non-responsive celiac disease over an 18-mo period.These individuals were investigated to establish the eitiology of their continued symptoms.The patients were first seen in clinic where a thorough history and examination were performed with routine blood work including tissue transglutaminase antibody measurement.They were also referred to a specialist gastroenterology dietician to try to identift any lapses in the diet and sources of hidden gluten ingestion.A repeat small intestinal biopsy was also performed and compared to biopsies from the referring hospital where possible.Colonoscopy,lactulose hydrogen breath testing,pancreolauryl testing and computed tomography scan of the abdomen were undertaken if the symptoms persisted.Their clinical progress was followed over a minimum of 2 years.RESULTS:One hundred and twelve consecutive patients were referred with NRCD.Twelve were found not to have celiac disease (CD).Of the remaining 100 patients,45% were not adequately adhering to a strict gluten-free diet,with 24 (53%) found to be inadvertently ingesting gluten,and 21 (47%) admitting noncompliance.Microscopic colitis was diagnosed in 12% and small bowel bacterial overgrowth in 9%.Refractory CD was diagnosed in 9%.Three of these were diagnosed with intestinal lymphoma.After 2 years,78 patients remained well,eight had continuing symptoms,and four had died.CONCLUSION:In individuals with NRCD,a remediable cause can be found in 90%:with continued gluten ingestion as the leading cause.We propose an algorithm for investigation. | David H Dewar Suzanne C Donnelly Simon D McLaughlin Matthew W Johnson H Julia Ellis Paul J Ciclitira | 2012 | World Journal of Gastroenterology2012，18，12： | 2 |
| 3 | Aerosol particle deposition in numerically simulated channel flow 显示文摘 | McLaughlin J B | 1989 | Physics of Fluids A1989，1，： | 1 |
| 4 | Microdialysis sampling with online microbore HPLC for the determination of tirapazamine and its reduced metabolites in rats显示文摘 | McLaughlin K J Faibushevich A A Lunte C E | 2000 | Analyst2000，125，1： | 1 |
| 5 | Rituxmab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program显示文摘 | Mclaughlin P Grillo Lopez A J Link B K | 1998 | J Clin Oncol1998，16，8： | 1 |
| 6 | Review: the behavior and environmental impact of contaminants in fertilizers显示文摘 | MCLAUGHLIN M J TILLER KG NAIDU R | 1996 | Aust J Soil Res1996，34，： | 1 |
| 7 | Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells显示文摘 | Radu C G Nijagal A McLaughlin J | 2005 | Proc Natl Acad Sci USA2005，102，5： | 1 |
| 8 | Fludarabine, mitoxantrone and dexamethasone: an effective new regimen for indolent lymphoma 显示文摘 | MCLAUGHLIN P HAGEMEISTER F B ROMAGUERA J E | 1996 | J Clin Oncol1996，14，： | 1 |
| 9 | Increased salinity causes elevated cadmium concentrations in field-grown potato tubers 显示文摘 | MCLAUGHLIN M J PALMER L T TILLER K G | 1994 | Journal of Environmental Quality1994，23，： | 1 |
| 10 | Fetal growth indicators and perfluorinated chemicals: a study in the Danish National Birth Cohort 显示文摘 | Fei C McLaughlin J K Tarone R E | 2008 | American journal of epidemiology2008，168，1： | 1 |
| 11 | Randomized study of adding inhaled iloprost to existing bosentan in pulmonary arterial hypertension显示文摘 | McLaughlin VV Oudiz R J Frost A | 2006 | Am J Respir Crit Care Med2006，174，： | 1 |
| 12 | Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells显示文摘 | Radu CG Nijagal A McLaughlin J | | 0，，： | 1 |
| 13 | Performance of the GLRT for adaptive vector subspace detection显示文摘 | Raghavan R S Pulsone N and McLaughlin D J | 1996 | IEEE Transactions on Aerospace and Electronic Systems1996，32，4： | 1 |
| 14 | High diversity andwidespread occurrence of mitotic spore mats in ectomycorrhizalPezizales显示文摘 | Healy R A Smith M E Bonito G M Pfister D H Ge Z W Guevara G G ’ Williams G Stafford K Kumar L Lee T HobartC Trappe J Vilgalys R McLaughlin D J | 2013 | Molecular Ecology2013，22，： | 1 |
| 15 | Strategies for globalizing service operations 显示文摘 | McLaughlin C P Fitzsimmons J A | 1996 | International Journal of Service Industry1996，7，4： | 1 |
| 16 | Preoperative status and risk of complications in patients with hip fracture显示文摘 | McLaughlin MA Orosz GM Magaziner J | 2006 | J Gen Intern Med2006，21，3： | 1 |
| 17 | Experiments on the instabilitiesof a swirling jet显示文摘 | Panda J McLaughlin D K | 1994 | Physics of Fluids1994，6，1： | 1 |
| 18 | Effect of Cl on Cd uptake by swiss chard in nutrient solutions显示文摘 | SMOLDERS E MCLAUGHLIN M J | 1996 | Plant and Soil1996，179，： | 1 |
| 19 | Metals and micronutrients-food safety issues显示文摘 | McLaughlin M J Parker D R Clarke J M | 1999 | Field Crops Research1999，60，： | 1 |
| 20 | The use of a modified Multimode Sample Introduction System for the simple and rapid determination of cadmium by chemical vapourgeneration atomic absorption spectrometry显示文摘 | Eric T Ritschdorff Neil Fitzgerald Roger L J Mclaughlin | | 0，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员