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| 1 | Phase angle obtained by bioelectrical impedance analysis independently predicts mortality in patients with cirrhosis显示文摘AIM To evaluate the prognostic value of the phase angle(PA)obtained from bioelectrical impedance analysis(BIA) for mortality prediction in patients with cirrhosis. METHODS In total, 134 male cirrhotic patients prospectively completed clinical evaluations and nutritional assessment by BIA to obtain PAs during a 36-mo follow-up period. Mortality risk was analyzed by applying the PA cutoff point recently proposed as a malnutrition marker(PA ≤ 4.9°) in Kaplan-Meier curves and multivariate Cox regression models. RESULTS The patients were divided into two groups according to the PA cutoff value(PA > 4.9°, n = 73; PA ≤ 4.9°, n = 61). Weight, height, and body mass index were similar in both groups, but patients with PAs > 4.9° were younger and had higher mid-arm muscle circumference, albumin, and handgrip-strength values and lower severe ascites and encephalopathy incidences, interleukin(IL)-6/IL-10 ratios and C-reactive protein levels than did patients with PAs ≤ 4.9°(P ≤ 0.05). Forty-eight(35.80%) patients died due to cirrhosis, with a median of 18 mo(interquartile range, 3.3-25.6 mo) follow-up until death. Thirty-one(64.60%) of these patients were from the PA ≤ 4.9° group. PA ≤ 4.9° significantly and independently affected the mortality model adjusted for Model for End-Stage Liver Disease score and age(hazard ratio = 2.05, 95%CI: 1.11-3.77, P = 0.021). In addition, Kaplan-Meier curves showed that patients with PAs ≤ 4.9° were significantly more likely to die. CONCLUSION In male patients with cirrhosis, the PA ≤ 4.9° cutoff was associated independently with mortality and identified patients with worse metabolic, nutritional, and disease progression profiles. The PA may be a useful and reliable bedside tool to evaluate prognosis in cirrhosis. | Giliane Belarmino Maria Cristina Gonzalez Raquel S Torrinhas Priscila Sala Wellington Andraus Luiz Augusto Carneiro D'Albuquerque Rosa Maria R Pereira Valéria F Caparbo Graziela R Ravacci Lucas Damiani Steven B Heymsfield Dan L Waitzberg | 2017 | World Journal of Hepatology2017，9，7： | 11 |
| 2 | Aquaporins:Their role in cholestatic liver disease显示文摘This review focuses on current knowledge on hepato-cyte aquaporins(AQPs)and their significance in bile formation and cholestasis.Canalicular bile secretion results from a combined interaction of several solute transporters and AQP water channels that facilitate water flow in response to the osmotic gradients created. During choleresis,hepatocytes rapidly increase their canalicular membrane water permeability by modulating the abundance of AQP8.The question was raised as to whether the opposite process,i.e.a decreased canalicular AQP8 expression would contribute to the development of cholestasis.Studies in several experimental models of cholestasis,such as extrahepatic obstructive cholestasis,estrogen-induced cholestasis, and sepsis-induced cholestasis demonstrated that the protein expression of hepatocyte AQP8 was impaired. In addition,biophysical studies in canalicular plasma membranes revealed decreased water permeability associated with AQP8 protein downregulation.The combined alteration in hepatocyte solute transporters and AQP8 would hamper the efficient coupling of osmotic gradients and canalicular water flow.Thus cholestasis may result from a mutual occurrence of impaired solute transport and decreased water permeability. | Guillermo L Lehmann Maria C Larocca Leandro R Soria Raúl A Marinelli | 2008 | World Journal of Gastroenterology2008，14，46： | 8 |
| 3 | Pneumo-CT assessing response to neoadjuvant therapy in esophageal cancer: Imaging-pathological correlation显示文摘Pneumo-computed tomography (PnCT) is a technique primarily developed and used to study stenotic lesions of the esophagus, gastroesophageal junction and stom-ach for pre-surgical planning. It helps to define both upper and lower borders of neoplasms located in the aforementioned areas. It achieves maximum lumen distension with CO2 highlighting thickened areas of the esophageal wall, thus allowing an accurate quantifica-tion of their extents. Although there are other alterna-tives for distension (oral contrast agents, water and ef-fervescent granules), they may be suboptimal. Patients with locally advanced esophageal cancer have a dismal prognosis despite surgical resection. Therefore, neo-adjuvant treatment strategies using radiation therapy and chemotherapy were developed to improve sur-vival. Neoadjuvant therapy improves esophageal tumor prognosis in a substantial proportion of patients, and the use of imaging techniques is mandatory to detect their response. PnCT combined with virtual endoscopy and multiplanar reconstruction enhances morphologic details in esophageal cancer, and thus would allow animproved assessment of response to neoadjuvant treat-ment. Therefore, more information could be provided to assess the efficacy of pre-surgical treatment. We de-scribe the potential use of PnCT to assess the response to neoadjuvant therapy in esophageal cancer with an imaging pathologic correlation. | Marina Ulla Ernestina Gentile Ezequiel Levy Yeyati Maria L Diez Demetrio Cavadas Ricardo D Garcia-Monaco Pablo R Ros | 2013 | World Journal of Gastrointestinal Oncology2013，5，12： | 3 |
| 4 | Comparative Advertising:Effects of Structural Alignability on Target Brand Evaluations显示文摘 | Zhang Shi Frank R Kardes Maria L Cronley | 2002 | Journal of Consumer Psychology2002，12，4： | 1 |
| 5 | Polymorphisms of platelet membrane glycoprotein Iba associated with arterial thrombolic disease显示文摘 | Rocio GC Maria L Jose R | 1998 | Blood1998，92，： | 1 |
| 6 | Car- diovagal response to acute mild exercise in young healthy subjects显示文摘 | Gizegore R Gian D P Maria T L R | 2005 | Circ J2005，69，： | 1 |
| 7 | Understanding the plasticity of the alph~beta hydrolase fold: lid swapping on the C~mdida tmtarctica lipase B results in chimeras with interesting biocatalytic properties显示文摘 | Skjot M Maria L Chatterjee R | 2009 | Chem Bio Chem2009，10，： | 1 |
| 8 | Cytomegalovirus Pneu- monia in AIDS Patients Value of Cytomegalovirus Culture From BAL Fluid and Correlation With Lung Disease显示文摘 | Caterina UF Flavia L Maria R | 1998 | Chest1998，113，： | 1 |
| 9 | Screening analysis of beer ageing using near infrared spectroscopy and the successive projections algorithm for variable selection显示文摘 | MAHDI G V SEYED S M MARIA L R M | 2012 | Talanta2012，89，1： | 1 |
| 10 | Inhibition of Desuvovibrio gigas hydrogenase with copper salts and other metalions显示文摘 | VICTOR M F MARIA L R PRESENTACION R | 1989 | European Journal of Biochemistry1989，185，2： | 1 |
| 11 | Effect of com- bined treatment with hot air and UV-C on senescence and quality parameters of minimally processed broccoli( Bras- sica oleracea L var Italica) 显示文摘 | Maria L L Pedro M C Alicia R C | 2008 | Postharvest Biology and Technology2008，48，1： | 1 |
| 12 | Postharvest treatment with(-)and(+)methyl jasmonate stimulates anthocyanin accumulation in grapes显示文摘 | GEMA F GRACIA P B MARIA L R | 2015 | LWT-Food Science and Technology2015，62，1： | 1 |
| 13 | Requirement for GD3 ganglioside in CD95 and ceramide-induced apoptosis 显示文摘 | De Maria R Lentil L Malisan F | 1997 | Science1997，277，5332： | 1 |
| 14 | Plastic mulching and availability of soil nutrients in cucumber crop显示文摘 | Quezada M Maria R Munguia L Juan P | 1995 | TERRA(Mexico)1995，13，： | 1 |
| 15 | Three-dimensional model of the melt blowing process显示文摘 | Maria V T Shambaugh R L | 2003 | Industrial & Engineering Chemistry Research2003，42，26： | 1 |
| 16 | 限饲和再投喂对不同日龄鸡消化酶促反应的影响显示文摘试验旨在评价限饲和再投喂对两个不同日龄(7和35d)鸡酶活性和胃肠道器官重量的影响,在每种日龄下,鸡被限饲70%(30%自由采食)7d,然后自由采食3d。对照组自由采食10d。对胰腺中糜蛋白酶、胰蛋白酶、淀粉酶、脂肪酶活性和小肠中蔗糖酶、麦芽糖酶的活性进行分析,并且测量了腺胃、肌胃、小肠和大肠的重量。在14d,与对照组相比,限饲组的胰蛋白酶、淀粉酶活性均降低,但在42d,与对照组相比,限饲组蔗糖酶活性降低,表明限饲对酶活性的影响与日龄有关。限饲可以降低完成期(42d)各器官的重量。日龄35~42d的鸡,在再投喂后,器官重量增加,并且达到与对照组一致。在起始期(14d),腺胃和肌胃受限饲的影响很小,在完成期,肌胃也是受影响最小的器官,而小肠时受影响最严重。限饲的所有影响在恢复饲喂3d后被逆转,表明这种改变时快速且可逆的,并且限饲和再投喂与年龄有关。 | Cristiane R A Duarte Maria L M Vicentini P Pinheiro D F | 2014 | 饲料博览2014，0，10： | 1 |
| 17 | 5-Arylidene-2-imino-4-thiazolidones:design and synthesis of novel anti-inflammatory agents显示文摘 | Rosaria O Maccari R Maria L B | 2005 | Bioorg Med Chem2005，13，13： | 1 |
| 18 | High Temperature Mechanical Behavior of a 30% Ni - 19% Cr Steel 显示文摘 | Jose A J Oscar A R Maria T L | 2003 | ISIJ International2003，，12： | 1 |
| 19 | Chemical modification of cross-linked resinbased on acrylonitrile for anchoring metal ions 显示文摘 | de Santa Maria L C Amorim M C V Aguiar M R M P | 2001 | Reactive and Functional Polymers2001，49，2： | 1 |
| 20 | In vitro propagation of the endangered plant Centaurea ultreiae : assessment of genetic stability by cytological studies, flow cytometry and RAPD analysis显示文摘 | Ruben M Juan R Maria L G | 2010 | Plant Cell Tiss Org2010，101，1： | 1 |
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