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| 1 | Liver transplantation and alcoholic liver disease:History,controversies,and considerations显示文摘Alcohol consumption accounts for 3.8% of annual global mortality worldwide, and the majority of these deaths are due to alcoholic liver disease(ALD), mainly alcoholic cirrhosis. ALD is one of the most common indications for liver transplantation(LT). However, it remains a complicated topic on both medical and ethical grounds, as it is seen by many as a 'self-inflicted disease'. One of the strongest ethical arguments against LT for ALD is the probability of relapse. However, ALD remains a common indication for LT worldwide. For a patient to be placed on an LT waiting list, 6 mo of abstinence must have been achieved for most LT centers. However, this '6-mo rule' is an arbitrary threshold and has never been shown to affect survival, sobriety, or other outcomes. Recent studies have shown similar survival rates among individuals who undergo LT for ALD and those who undergo LT for other chronic causes of end-stage liver disease. There are specific factors that should be addressed when evaluating LT patients with ALD because these patients commonly have a high prevalence of multisystem alcohol-related changes. Risk factors for relapse include the presence of anxiety or depressive disorders, short pre-LT duration of sobriety, and lack of social support. Identification of risk factors and strengthening of the social support system may decrease relapse among these patients. Family counseling for LT candidates is highly encouraged to prevent alcohol consumption relapse. Relapse has been associated with unique histopathological changes, graft damage, graft loss, and even decreased survival in some studies. Research has demonstrated the importance of a multidisciplinary evaluation of LT candidates. Complete abstinence should be attempted to overcome addiction issues and to allow spontaneous liver recovery. Abstinence is the cornerstone of ALD therapy. Psychotherapies, including 12-step facilitation therapy, cognitive-behavioral therapy, and motivational enhancement therapy, help support abstinence. Nutritional therapy helps to reverse muscle wasting, weight loss, vitamin deficiencies, and trace element deficiencies associated with ALD. For muscular recovery, supervised physical activity has been shown to lead to a gain in muscle mass and improvement of functional activity. Early LT for acute alcoholic hepatitis has been the subject of recent clinical studies, with encouraging results in highly selected patients. The survival rates after LT for ALD are comparable to those of patients who underwent LT for other indications. Patients that undergo LT for ALD and survive over 5 years have a higher risk of cardiorespiratory disease, cerebrovascular events, and de novo malignancy. | Claudio Augusto Marroni Alfeu de Medeiros Fleck Jr Sabrina Alves Fernandes Lucas Homercher Galant Marcos Mucenic Mario Henrique de Mattos Meine Guilherme Mariante-Neto Ajacio Bandeira de Mello Brandao | 2018 | World Journal of Gastroenterology2018，24，26： | 7 |
| 2 | Lymphocyte subsets predictive value and possible involvement of human papilloma virus infection on breast cancer molecular subtypes显示文摘AIM To detect human papilloma virus(HPV) presence and to characterize cellular immune response in breast cancer patients. METHODS A total of 74 women were included, of which 48 samples were from patients diagnosed with breast cancer and 26 patients with benign pathology of the breast. Molecular subtype classification was performed based on the immunohistochemical reports of the tumor piece. HPV genome detection and genotyping from fresh breast biopsies was performed using the INNO-LIPA HPV Genotyping Extra test(Innogenetics, Ghent, Belgium). CD3+, CD4+, CD8+ and natural killer(NK)+ cells levels from peripheral blood samples from patients with breast cancer and benign pathology were measured by flow cytometry. RESULTS Luminal A was the most frequent breast cancer molecular subtype(33.33%). HPV was detected in 25% of the breast cancer patients, and genotype 18 was the most frequent in the studied population. The mean of CD3+, CD4+ and CD8+ subpopulations were decreased in patients with breast cancer, in relation to those with benign pathology, with a statistically significant difference in CD8+ values(P = 0.048). The mean of NK+ cells was increased in the benign pathology group. The average level of CD3+, CD4+, CD8+ and NK+ cells decreased as the disease progressed. HER2+ and Luminal B HER2+ tumors had the lowest counts of cell subsets. HPV breast cancer patients had elevated counts of cellular subsets. CONCLUSION Determining level changes in cellular subsets in breast cancer patients is a useful tool to evaluate treatment response. | Andreína Fernandes Adriana Pesci-Feltri Isabel García-Fleury Marco López Vincent Guida Marisol De Macedo María Correnti | 2018 | World Journal of Clinical Oncology2018，9，7： | 5 |
| 3 | Role of sex hormones in gastrointestinal motility in pregnant and non-pregnant rats显示文摘AIM: To correlate gastric contractility, gastrointestinal transit, and hormone levels in non-pregnant(estrous cycle) and pregnant rats using noninvasive techniques. METHODS: Female rats(n = 23) were randomly divided into(1) non-pregnant,(contractility, n =6; transit, n = 6); and(2) pregnant(contractility, n = 5; transit, n = 6). In each estrous cycle phase or at 0, 7, 14, and 20 d after the confirmation of pregnancy, gastrointestinal transit was recorded by AC biosusceptometry(ACB), and gastric contractility was recorded by ACB and electromyography. After each recording, blood samples were obtained for progesterone and estradiol determination. RESULTS: In the estrous cycle, despite fluctuations of sex hormone levels, no significant changes in gastrointestinal motility were observed. Days 7 and 14 of pregnancy were characterized by significant changes in the frequency of contractions(3.90 ± 0.42 cpm and 3.60 ± 0.36 cpm vs 4.33 ± 0.25 cpm) and gastric emptying(168 ± 17 min and 165 ± 15 min vs 113 ± 15 min) compared with day 0. On these same days, progesterone levels significantly increased compared with control(54.23 ± 15.14 ng/m L and 129.96 ± 30.52 ng/mL vs 13.25 ± 6.31 ng/mL). On day 14, we observed the highest level of progesterone and the lowest level of estradiol compared with day 0(44.3 ± 15.18 pg/mL vs 24.96 ± 5.96 pg/mL). CONCLUSION: Gastrointestinal motility was unaffected by the estrous cycle. In our data, high progesterone and low estradiol levels can be associated with decreased contraction frequency and slow gastric emptying. | Juliana Fernandes Matos Madileine Francely Americo Yuri Karen Sinzato Gustavo Tadeu Volpato Luciana Aparecida Corá Marcos Felipe Freitas Calabresi Ricardo Brandt Oliveira Debora Cristina Damasceno Jose Ricardo Arruda Miranda | 2016 | World Journal of Gastroenterology2016，22，25： | 5 |
| 4 | Evaluation of Physicochemical,Microbiological and Sensory Stability of Frozen Stored Vacuum-Packed Lamb Meat显示文摘Nowadays,lamb meat represents only 7%of all meat produced in the world.In recent years the demand for standardized lamb meat cuts has been considered of great importance and the marketing occurs predominantly in the form of frozen cuts.Herewith,the main of this work was to evaluate the stability and safety of lamb meat during frozen storage.Meats were vacuum packed in high barrier multilayer plastic films and stored during 12 mon at(-18±1)oC.The meat stability was assessed by physical and chemical(lipid oxidation,objective color,pH value,cooking losses and instrumental texture),microbiological(total count of psychrotrophic,coliform count at 45°C,coagulase-positive staphylococci and the presence of Salmonella)and sensory analysis(acceptance test and visual evaluation).The vacuum packed lamb meat remained stable as to most physical and chemical indexes.Microbiological indexes showed good stability throughout the storage period according to Brazilian legislation standards to pathogenic microorganisms.Although a significant reduction in tenderness(shear force increase from 3 to 8 kg),it showed a good sensorial acceptance for all attributes tested,including texture,with scores of around 7(like moderately)during the 12 mon of storage.Therefore,it can be concluded that,under the conditions applied in this study,lamb meat presents a shelf life of at least 12 mon when stored at-18°C. | Rafaella de Paula Paseto Fernandes Maria Teresa de Alvarenga Freire Celso da Costa Carrer Marco Antonio Trindade | 2013 | Journal of Integrative Agriculture2013，12，11： | 4 |
| 5 | Detection of contaminants in cell cultures, sera and trypsin显示文摘 | Tatiana Flávia Pinheiro de Oliveira Ant?nio Augusto Fonseca Marcelo Fernandes Camargos Anapolino Macedo de Oliveira Ana Cláudia Pinto Cottorello Antonizete dos Reis Souza Iassudara Garcia de Almeida Marcos Bryan Heinemann | 2013 | Biologicals2013，，6： | 2 |
| 6 | Genetic polymorphisms involved in folate metabolism and concentrations of methylmalonic acid and folate on plasma homocysteine and risk of coronary artery disease显示文摘 | Patrícia Matos Biselli Alexandre Rodrigues Guerzoni Moacir Fernandes Godoy Marcos Nogueira Eberlin Renato Haddad Valdemir Melechco Carvalho Hélio Vannucchi érika Cristina Pavarino-Bertelli Eny Maria Goloni-Bertollo | 2010 | Journal of Thrombosis and Thrombolysis2010，，1： | 1 |
| 7 | Red blood cell transfusion does not increase oxygen consumption in criti- cally ill septic patients显示文摘 | Fernandes CJ Jr Akamine N De Marco FV | 2001 | Crit Care2001，5，6： | 1 |
| 8 | Influence of peanut skin extract on shelf-life of sheep patties显示文摘Objective: To evaluate the phenolic profile and antioxidant activity in vitro of peanut skin extract(PSE) and effect of PSE on characteristics of sheep patties during storage.Methods: PSE phenolic profile was evaluated in LC–MS analysis and by total phenolic content, 1,1-diphenyl-2-picrylhydrazyl radical scavenging capacity and ferric reducing/antioxidant power. Patties elaborated with sheep meat were packaged in modified atmosphere and storage at(2 ± 1)C. The analyses were performed every 5 days for 20 days on microbial counts, physico-chemical properties, lipid oxidation, protein stability and sensory characteristics.Results: The major group of phenolic compounds in PSE was the proanthocyanidins followed by other flavonoids, which are related to potential phenolic content and antioxidant activity. The addition of PSE and butyl hydroxytoluene(BHT) reduced the microbial counts during the storage time, caused reduction on the loss of redness and sensory properties over time. The lipid and protein oxidation in sheep patties was effectively inhibited by PSE and BHT.Conclusions: The present results showed the potential application of PSE as a natural alternative to replace synthetic antioxidants(BHT) for increasing the quality and extending the shelf-life of sheep patties. | Paulo Eduardo Sichetti Munekata Rafaella de Paula Paseto Fernandes Mariza Pires de Melo Marco Antonio Trindade Jose Manuel Lorenzo | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，7： | 1 |
| 9 | Growth inhibition of Staphylococcus aureus by chicken egg yolk antibodies显示文摘 | Marco Cesar Cunegundes Guimar?es Lívia Gomes Amaral Letícia Batista Azevedo Rangel Ian Victor Silva Claudia Gomes Fernandes Matta Marcos Fernando Rezende Matta | 2009 | Archivum Immunologiae et Therapiae Experimentalis2009，，5： | 1 |
| 10 | Low birth weight in Silo Luis, northeastern Brazil, trends and associated factors 显示文摘 | Helma Jane Ferreira Veloso Ant6nio Augusto Moura da Silva Helolsa Bettiol Marcelo Zubarin Goldani Fernando Lamy Filho Vanda Maria Ferreira Sim6es Rosgmgela Fernandes Lucena Batista Marco Ant6nio Barbieri | 2014 | BMC Pre Child2014，14，1： | 1 |
| 11 | A comprehensive chemical kinetic combustion model for the four butanol isomers显示文摘 | S. Mani Sarathy Stijn Vranckx Kenji Yasunaga Marco Mehl Patrick O?wald Wayne K. Metcalfe Charles K. Westbrook William J. Pitz Katharina Kohse-H?inghaus Ravi X. Fernandes Henry J. Curran | 2011 | Combustion and Flame2011，，6： | 1 |
| 12 | Treatment of pulp mill wastewater by Cryptococcus podzolicus and solar photo?Fenton: A case study显示文摘 | Lisete Fernandes Marco S Lucas Manuel I Maldonado | 2014 | Chemical Engineering Joumal2014，245，： | 1 |
| 13 | Maternal mental disorders in pregnancy and the puerperium and risks to infant health显示文摘Prenatal and postnatal period presents the highest prevalence of mental disorders in women's lives and depression is the most frequent one,affecting approximately one in every five mothers.The aggravating factor here is that during this period psychiatric symptoms affect not only women's health and well-being but may also interfere in the infant's intra and extra-uterine development.Although the causes of the relationship between maternal mental disorders and possible risks to a child's health and development remain unknown,it is suspected that these risks may be related to the use of psychotropic drugs during pregnancy,to substance abuse and the mother's lifestyle.Moreover,after delivery,maternal mental disorders may also impair the ties of affection(bonding) with the newborn and the ma-ternal capacity of caring in the post-partum period thus increasing the risk for infant infection and malnutrition,impaired child growth that is expressed in low weight and height for age,and even behavioral problems and vulnerability to presenting mental disorders in adulthood.Generally speaking,research on this theme can be divided into the type of mental disorder analyzed: studies that research minor mental disorders during pregnancy such as depression and anxiety find an association between these maternal disorders and obstetric complications such as prematurity and low birth weight,whereas studies that evaluate severe maternal mental disorders such as schizophrenia and bipolar disorder have found not only an association with general obstetric complications as well as with congenital malformations and perinatal mortality.Therefore,the success of infant growth care programs also depends on the mother's mental well being.Such findings have led to the need for new public policies in the field of maternal-infant care geared toward the population of mothers.However,more research is necessary so as to confirm the association between all factors with greater scientific rigor. | Priscila Krauss Pereira Lúcia Abelha Lima Letícia Fortes Legay Jacqueline Fernandes de Cintra Santos Giovanni Marcos Lovisi | 2012 | World Journal of Clinical Pediatrics2012，1，4： | 1 |
| 14 | Genetic polymorphisms involved in folate metabolism and concentrations of methylmalonic acid and folate on plasma homocysteine and risk of coronary artery disease显示文摘 | Patrícia Matos Biselli Alexandre Rodrigues Guerzoni Moacir Fernandes Godoy Marcos Nogueira Eberlin Renato Haddad Valdemir Melechco Carvalho Hélio Vannucchi érika Cristina Pavarino-Bertelli Eny Maria Goloni-Bertollo | 2010 | Journal of Thrombosis and Thrombolysis2010，，1： | 1 |
| 15 | Taurine attenuates cardiac remodeling after myocardial infarction显示文摘 | Lidiane P. Ardisson Bruna P.M. Rafacho Priscila P. Santos Heloísa Assalin Andréa F. Gon?alves Paula S. Azevedo Marcos F. Minicucci Bertha F. Polegato Katashi Okoshi Julio Sergio Marchini Luis F. Barbisan Ana Angélica H. Fernandes Fabio R.F. Seiva Sergio A | 2013 | International Journal of Cardiology2013，，： | 1 |
| 16 | Contrast-Enhanced Multidetector Computed Tomography Viability Imaging After Myocardial Infarction: Characterization of Myocyte Death, Microvascular Obstruction, and Chronic Scar显示文摘 | Albert C. Lardo Marco A.S. Cordeiro Caterina Silva Luciano C. Amado Richard T. George Anastasios P. Saliaris Karl H. Schuleri Veronica R. Fernandes Menekhem Zviman Saman Nazarian Henry R. Halperin Katherine C. Wu Joshua M. Hare Joao A.C. Lima | 2006 | Circulation2006，，3： | 1 |
| 17 | Red blood cell transfusion does not increase oxygen consumption in critically ill septic patients显示文摘 | Fernandes J CJ Akamine N de Marco FV | 2001 | Crit Care2001，5，6： | 1 |
| 18 | Infrared spectroscopy: A potential tool in huanglongbing and citrus variegated chlorosis diagnosis显示文摘 | Marcelo Camponez do Brasil Cardinali Paulino Ribeiro Villas Boas Débora Marcondes Bastos Pereira Milori Ednaldo José Ferreira Marina Fran?a e Silva Marcos Antonio Machado Barbara Sayuri Bellete Maria Fatima das Gra?as Fernandes da Silva | 2012 | Talanta2012，，： | 1 |
| 19 | Distribution of non-native invasive species and soil properties in proximity to paved roads and unpaved roads in a quartzitic mountainous grassland of southeastern Brazil (rupestrian fields)显示文摘 | Newton P. U. Barbosa G. Wilson Fernandes Marco A. A. Carneiro Lélis A. C. Júnior | 2010 | Biological Invasions2010，，11： | 1 |
| 20 | Sustainable airport environments: A review of water conservation practices in airports显示文摘 | Isabella de Castro Carvalho Maria Lúcia Calijuri Paula Peixoto Assemany Marcos Dornelas Freitas Machado e Silva Ronan Fernandes Moreira Neto Aníbal da Fonseca Santiago Mauro Henrique Batalha de Souza | 2013 | Resources, Conservation & Recycling2013，，： | 1 |
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