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| 1 | Woofer–tweeter adaptive optical structured illumination microscopy显示文摘A woofer–tweeter adaptive optical structured illumination microscope(AOSIM) is presented. By combining a low-spatial-frequency large-stroke deformable mirror(woofer) with a high-spatial-frequency low-stroke deformable mirror(tweeter), we are able to remove both large-amplitude and high-order aberrations. In addition, using the structured illumination method, as compared to widefield microscopy, the AOSIM can accomplish highresolution imaging and possesses better sectioning capability. The AOSIM was tested by correcting a large aberration from a trial lens in the conjugate plane of the microscope objective aperture. The experimental results show that the AOSIM has a point spread function with an FWHM that is 140 nm wide(using a water immersion objective lens with NA=1.1) after correcting a large aberration(5.9 μm peak-to-valley wavefront error with 2.05 μm RMS aberration). After structured light illumination is applied, the results show that we are able to resolve two beads that are separated by 145 nm, 1.62× below the diffraction limit of 235 nm. Furthermore, we demonstrate the application of the AOSIM in the field of bioimaging. The sample under investigation was a green-fluorescentprotein-labeled Drosophila embryo. The aberrations from the refractive index mismatch between the microscope objective, the immersion fluid, the cover slip, and the sample itself are well corrected. Using AOSIM we were able to increase the SNR for our Drosophila embryo sample by 5×. | QINGGELE LI MARC REINIG DAICH KAMIYAMA BO HUANG XIAODONG TAO ALEX BARDALES JOEL KUBBY | 2017 | Photonics Research2017，5，4： | 3 |
| 2 | Efficient IL-2R signaling differentially affects the stability,function,and composition of the regulatory T-cell pool显示文摘Signaling via interleukin-2 receptor(IL-2R)is a requisite for regulatory T(Treg)cell identity and function.However,it is not completely understood to what degree IL-2R signaling is required for Treg cell homeostasis,lineage stability and function in both resting and inflammatory conditions.Here,we characterized a spontaneous mutant mouse strain endowed with a hypomorphic Tyr129His variant of CD25,theα-chain of IL-2R,which resulted in diminished receptor expression and reduced IL-2R signaling.Under noninflammatory conditions,Cd25Y129H mice harbored substantially lower numbers of peripheral Treg cells with stable Foxp3 expression that prevented the development of spontaneous autoimmune disease.In contrast,Cd25^(Y^(129H))Treg cells failed to efficiently induce immune suppression and lost lineage commitment in a T-cell transfer colitis model,indicating that unimpaired IL-2R signaling is critical for Treg cell function in inflammatory environments.Moreover,single-cell RNA sequencing of Treg cells revealed that impaired IL-2R signaling profoundly affected the balance of central and effector Treg cell subsets.Thus,partial loss of IL-2R signaling differentially interferes with the maintenance,heterogeneity,and suppressive function of the Treg cell pool. | Marc Permanyer Berislav Bošnjak Silke Glage Michaela Friedrichsen Stefan Floess Jochen Huehn Gwendolyn E.Patzer Ivan Odak Nadine Eckert Razieh Zargari Laura Ospina-Quintero Hristo Georgiev Reinhold Förster | 2021 | Cellular & Molecular Immunology2021，18，2： | 2 |
| 3 | Role of peroxisomes in ROS/RNS-metabolism:implications for human disease显示文摘 | Marc F Marcus N Bo Wang | 2012 | BBA-Mol Basis Dis2012，1822，： | 1 |
| 4 | Esophageal dilation显示文摘 | James V. Egan Todd H. Baron Douglas G. Adler Raquel Davila Douglas O. Faigel Seng-lan Gan William K. Hirota Jonathan A. Leighton David Lichtenstein Waqar A. Qureshi Elizabeth Rajan Bo Shen Marc J. Zuckerman Trina VanGuilder Robert D. Fanelli | 2006 | Gastrointestinal Endoscopy2006，，6： | 1 |
| 5 | Human Papillomavirus Prevalence and Type-Distribution, Cervical Cancer Screening Practices and Current Status of Vaccination Implementation in Central and Eastern Europe显示文摘 | Mario Poljak Katja Seme Polona J. Maver Bo?tjan J. Kocjan Kate S. Cuschieri Svetlana I. Rogovskaya Marc Arbyn Stina Syrj?nen | 2013 | Vaccine2013，，： | 1 |
| 6 | Thermal effects on hydrothermal biomass liquefaction显示文摘 | Zhang Bo Von Keitz Marc Valentas Kenneth | 2008 | Applied Biochemistry and Biotechnology2008，147，13： | 1 |
| 7 | Posterior Versus Anterior Circulation Infarction: How Different Are the Neurological Deficits?显示文摘 | Wen-Dan Tao Ming Liu Marc Fisher De-Ren Wang Jie Li Karen L Furie Zi-Long Hao Sen Lin Can-Fei Zhang Quan-Tao Zeng Bo Wu | 2012 | Stroke2012，，8： | 1 |
| 8 | Role of peroxisomes in ROS/RNS-metabolism: Implications for human disease显示文摘 | Marc Fransen Marcus Nordgren Bo Wang Oksana Apanasets | 2011 | BBA - Molecular Basis of Disease2011，，9： | 1 |
| 9 | ASGE guideline: modifications in endoscopic practice for the elderly显示文摘 | Waqar A. Qureshi Marc J. Zuckerman Douglas G. Adler Raquel E. Davila James V. Egan S. Ian Gan David R. Lichtenstein Elizabeth Rajan Bo Shen Robert D. Fanelli Trina Van Guilder Todd H. Baron | 2006 | Gastrointestinal Endoscopy2006，，4： | 1 |
| 10 | Dual role for atypical chemokine receptor 1 in myeloid cell hematopoiesis and distribution显示文摘Similar to conventional chemokine receptors,atypical chemokine receptors(ACKRs)are cell-surface receptors that possess a seven transmembrane domain structure and regulate immune responses by interacting with chemokines.However,ACKRs differ from conventional chemokine receptors because of their inability to couple to G proteins and therefore to transduce intracellular signals mediating leukocyte migration upon chemokine binding.Instead,ACKRs internalize,transport or scavenge chemokines,regulating their extracellular availability,and thus impacting homeostasis,inflammation and immune response. | Marc Permanyer Berislav Bošnjak Reinhold Förster | 2018 | Cellular & Molecular Immunology2018，15，4： | 0 |
| 11 | High rate of clinically relevant improvement following anatomical total shoulder arthroplasty for glenohumeral osteoarthritis显示文摘BACKGROUND The minimal clinically important difference(MCID)is defined as the smallest meaningful change in a health domain that a patient would identify as important.Thus,an improvement that exceeds the MCID can be used to define a successful treatment for the individual patient.AIM To quantify the rate of clinical improvement following anatomical total shoulder arthroplasty for glenohumeral osteoarthritis.METHODS Patients were treated with the Global Unite total shoulder platform arthroplasty between March 2017 and February 2019 at Herlev and Gentofte Hospital,Denmark.The patients were evaluated preoperatively and 3 months,6 months,12 months,and 24 months postoperatively using the Western Ontario Osteoarthritis of the Shoulder index(WOOS),Oxford Shoulder Score(OSS)and Constant-Murley Score(CMS).The rate of clinically relevant improvement was defined as the proportion of patients who had an improvement 24 months postoperatively that exceeded the MCID.Based on previous literature,MCID for WOOS,OSS,and CMS were defined as 12.3,4.3,and 12.8 respectively.RESULTS Forty-nine patients with a Global Unite total shoulder platform arthroplasty were included for the final analysis.Mean age at the time of surgery was 66 years(range 49.0-79.0,SD:8.3)and 65%were women.One patient was revised within the two years follow-up.The mean improvement from the preoperative assessment to the two-year follow-up was 46.1 points[95%confidence interval(95%CI):39.7-53.3,P<0.005]for WOOS,18.2 points(95%CI:15.5-21.0,P<0.005)for OSS and 37.8 points(95%CI:31.5-44.0,P<0.005)for CMS.Two years postoperatively,41 patients(87%)had an improvement in WOOS that exceeded the MCID,45 patients(94%)had an improvement in OSS that exceeded the MCID,and 42 patients(88%)had an improvement in CMS that exceeded the MCID.CONCLUSION Based on three shoulder-specific outcome measures we find that approximately 90%of patients has a clinically relevant improvement.This is a clear message when informing patients about their prognosis. | Marc Randall Kristensen Nyring Bo Sanderhoff Olsen Alexander Amundsen Jeppe Vejlgaard Rasmussen | 2024 | World Journal of Orthopedics2024，15，2： | 0 |
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