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| 1 | 幽门螺杆菌粪便抗原试验的多中心研究显示文摘目的:评估幽门螺杆菌(H.pylori)粪便抗原(HpSA)试验诊断H.pylori感染的准确性。方法:应用酶免疫反应原理进行HpSA试验,在大样本、多中心研究中进行HpSA试验的评估。995例因消化不良症状接受胃镜检查者纳入本研究,所有患者均以HpSA试验、快速尿素酶试验(RUT)和组织学(或培养)方法检测H.pylori。以RUT和组织学(或培养)联合检测作为“金标准”,两项试验均阳性者定为H.pylori感染。结果:以光密度值≥0.16为阳性,HpSA检测诊断H.pylori感染的敏感性为93.5%(478/511),特异性为94.2%(456/484),阳性预测值为94.5%(478/506),阴性预测值为93.3%(456/489),总的检测准确性为93.9%(934/995)。结论:HpSA试验是一种简便、准确的非侵入性H.pylori感染检测方法。 | 刘文忠 萧树东 王吉耀 赵志泉 钱家鸣 胡伏莲 胡品津 Many Vazquez Michael Boieraguel James R Leroy | 2002 | 胃肠病学2002，7，3： | 26 |
| 2 | FibroSURE^(TM) and FibroScan~ in relation to treatment response in chronic hepatitis C virus显示文摘AIM:To compare histological endpoint assessment using noninvasive alternatives to biopsy during treatment in a chronic hepatitis C virus(HCV)cohort.METHODS:Patients with chronic HCV were randomized to receive interferon-based therapy for 24(genotypes 2/3)or 48(genotype 1)wk.FibroSURE~TM(FS)was assessed at baseline and at week-12 post-treatment follow-up.Baseline biopsy for METAVIR was assessed by a single pathologist.FibroScan~ transient elastogra-phy(TE)was performed during treatment in a patient subset.RESULTS:Two thousand and sixty patients(n = 253 in Asia)were classif ied as METAVIR F0-1(n = 1682)or F2-4(n = 378).For F2-4,FS(n = 2055)had sensitiv-ity and specif icity of 0.87 and 0.61,respectively,with area under the receiver-operating curve of 0.82;corre-sponding values for TE(n = 214)and combined FS/TE(n = 209)were 0.77,0.88 and 0.88,and 0.93,0.68 and 0.88.Overall FS/TE agreement for F2-4 was 71%(κ = 0.41)and higher in Asians vs non-Asians(κ = 0.86 vs 0.35;P < 0.001).Combined FS/TE had 97% accuracy in Asians(n = 33).Baseline FS(0.38 vs 0.51,P < 0.001)and TE(8.0 kPa vs 11.9 kPa,P = 0.006)scores were lower in patients with sustained virological response than in nonresponders,and were maintained through follow-up.CONCLUSION:FS and TE may reliably differentiate mild from moderate-advanced disease,with a potential for high diagnostic accuracy in Asians with chronic HCV. | Keyur Patel Mireen Friedrich-Rust Yoav Lurie Mircea Grigorescu Carol Stanciu Chuan-Mo Lee Eugene R Schiff Dieter Hussinger Michael P Manns Guido Gerken Isabelle Colle Michael Torbenson Erik Pulkstenis G Mani Subramanian John G McHutchison Stefan Zeuzem | 2011 | World Journal of Gastroenterology2011，17，41： | 4 |
| 3 | 热应激和低营养摄入对猪肠道完整性和功能的影响显示文摘热应激会损害肠道完整性,并诱发肠渗漏。因此,本试验研究了直接或间接热应激(通过减少采食量)对生长猪肠道通透性的影响。选用体重(43±4)kg的杂交后备母猪(n=48),分别安置在以下控制环境中:热中性(TN)环境(20℃,湿度35%~50%,自由采食)、热应激(HS)环境(35℃,湿度20%~35%,自由采食)、热中性环境配对饲喂(PFTN,以消除不同采食量的交互影响)。第1、3、7天使猪只安乐死,采集的空肠样品被安装到尤式灌流室,测定跨膜电阻抗值(TER)和异硫氰基荧光标记的脂多糖(LPS)渗透性(APP,表示为表观渗透系数)。此外,评估肠道完整性以及应激基因和蛋白标志物。结果表明,不考虑热应激天数,HS组与TN组猪相比,血浆内毒素水平增加45%(P〈0.05),空肠TER降低30%(P〈0.05),LPS渗透率增加2倍(P〈0.01)。此外,与PFTN组相比,HS组第7天的猪LPS渗透性有增加的趋势(P=0.06)。整个试验阶段HS组溶菌酶和碱性磷酸酶活性下降,分别下降46%和59%(P〈0.05);然而,3 d和7 d空肠免疫细胞标记物——髓过氧化物酶活性增加(P〈0.05)。由此可见,热应激和减少采食量都会降低肠道完整性,并增加内毒素渗透性。推测这可能会导致炎症加重,在炎热的夏季可能是导致猪生长性能降低的原因。 | Pearce S C Mani V Weber T E Rhoads R P Patience J F Baumgard L H Gabler N K | 2016 | 中国饲料2016，，3： | 3 |
| 4 | Pentoxifylline plus prednisolone versus pentoxifylline only for severe alcoholic hepatitis: A randomized controlled clinical trial显示文摘 | B De S Mandal D Sau S Mani S Chatterjee S Mondal K Bhattacharya K Sil R Bhattacharya | 2014 | Annals of Medical and Health Sciences Research2014，，5： | 2 |
| 5 | Exploring a new twist on tumor metastasis显示文摘 | YANG J MANI S A WEINBERG R A | 2006 | Cancer Res2006，66，9： | 1 |
| 6 | Glil protein reguates ti S-phase checkpoint in tumor cells via Bid protein, and its inhibitior sensitizes to DNA topoisomerase I inhibitors显示文摘 | Tripathi K Mani C Barnett R | 2014 | J Biol Chem2014，289，31： | 1 |
| 7 | Evaluation of plant leaves, oil cakesand agroindustrial wastes as substrates for mass multiplica-tion of the nematophagous fungus, Paecilomyces Lilacinus显示文摘 | Mani A Anandam R J | 1989 | Journal of Biological Control1989，3，1： | 1 |
| 8 | Effects of wildfire and permafrost on soil organic matter and soil climate in interior Alaska 显示文摘 | Harden J W Manies K L Turetsky M R | 2006 | Global Change Biology2006，12，12： | 1 |
| 9 | The frequency and tim- ing of epileptiform activity on continuous electroencephalo- gram in comatose post cardiac arrest syndrome? patients treated with therapeutic hypothermia 显示文摘 | Mani R Schmitt S E Mazer M | 2012 | Resuscitation2012，83，7： | 1 |
| 10 | Hyperuricemia and xanthine oxidase in preeclampsis,revisited显示文摘 | Many A Hubel R Roberts JM | 1996 | Am J Obetet Cynecol1996，174，： | 1 |
| 11 | Performance of aluminium anodes under heat treatment显示文摘 | ASHOK S R VENKATARAMANI A PARTHIBAN G T SRINWASAN S PALANISWAMY N MANI A RAGHAVAN M | 2002 | Corrosion on Prevention & Control2002，49，2： | 1 |
| 12 | Active control of unsteady com- bustion-induced oscillations显示文摘 | GULATI A MANI R | 1992 | Journal of Propulsion and Power1992，8，5： | 1 |
| 13 | Optimization of solvent extraction of moringa (Moringa oleifera ) seed kernel oil using response surface methodology 显示文摘 | MANI S JAYA S VADIVAMBAL R | 2007 | Food and Bioproducts Processing2007，85，4： | 1 |
| 14 | Induced chromosomal proximity and gene fusions in prostate cancer显示文摘 | MANI R S TOMLINS S A CALLAHAN K | 2009 | Science2009，326，5957： | 1 |
| 15 | Development of a high- level of resistance to Bacillus sphaericus in a field population of Culex quinquefasciatus from Kochi, India显示文摘 | Rao DR Mani TR Rajendran R | 1995 | J Am Mosq Control Assoc1995，11，1： | 1 |
| 16 | Long-term stability of self-assembled monolayers on316L stainless steel 显示文摘 | KAUFMANN C R MANI G MARTON D | 2010 | Biomed Mater2010，5，02： | 1 |
| 17 | Role of the aphelinid parasitoid Encorsia guadeloupae in the suppression of the exotic spiraling whitefly Aleurodicus disperses on banana in India显示文摘 | Mani M Krishnamoorthy A Venugopalan R | 2004 | Biocontrol Science and Technology2004，14，6： | 1 |
| 18 | Diabetic foot infection in the world:we need ways forward显示文摘 | Xie T Lu S Mani R | 2010 | Int J Low Extrem Wounds2010，9，1： | 1 |
| 19 | Heat stress reduces barrier function and alters intestinal metabolism in growing pigs 显示文摘 | Pearce S C Mani V Boddicker R L et o/ | 2012 | Joumal of Animal Science2012，90，： | 1 |
| 20 | Kinetic faceting of multiply twinned diamond crystals during vapor phase synthesis显示文摘 | Mani R C Sunkara M K | 2003 | Diamond Relat Mater2003，12，： | 1 |
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