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| 1 | Burden of Clostridium difficile infection between 2010 and 2013:Trends and outcomes from an academic center in Eastern Europe显示文摘AIM:To analyze the incidence and possible risk factors in hospitalized patients treated with Clostridium difficile infection(CDI).METHODS:A total of 11751 patients were admitted to our clinic between 1 January 2010 and 1 May2013.Two hundred and forty-seven inpatients were prospectively diagnosed with CDI.For the risk analysis a 1:3 matching was used.Data of 732 patients matched for age,sex,and inpatient care period and unit were compared to those of the CDI population.Inpatient records were collected from an electronic hospital database and comprehensively reviewed.RESULTS:Incidence of CDI was 21.0/1000 admissions(2.1%of all-cause hospitalizations and 4.45%of total inpatient days).The incidence of severe CDI was 12.6%(2.63/1000 of all-cause hospitalizations).Distribution of CDI cases was different according to the unit type,with highest incidence rates in hematology,gastroenterology and nephrology units(32.9,25 and24.6/1000 admissions,respectively) and lowest rates in 1.4%(33/2312) in endocrinology and general internal medicine(14.2 and 16.9/1000 admissions)units.Recurrence of CDI was 11.3%within 12 wk after discharge.Duration of hospital stay was longer in patients with CDI compared to controls(17.6 ± 10.8d vs 12.4 ± 7.71 d).CDI accounted for 6.3%of allinpatient deaths,and 30-d mortality rate was 21.9%(54/247 cases).Risk factors for CDI were antibiotic therapy[including third-generation cephalosporins or fluoroquinolones,odds ratio(OR) = 4.559;P < 0.001],use of proton pump inhibitors(OR = 2.082,P< 0.001),previous hospitaiization within 12 mo(OR = 3.167,P < 0.001),previous CDI(OR = 15.32;P < 0.001),while presence of diabetes mellitus was associated with a decreased risk for CDI(OR = 0.484;P< 0.001).Treatment of recurrent cases was significantly different from primary infections with more frequent use of vancomycin alone or in combination(P < 0.001),and antibiotic therapy duration was longer(P < 0.02).Severity,mortality and outcome of primary infections and relapsing cases did not significantly differ.CONCLUSION:CDI was accounted for significant burden with longer hospitaiization and adverse outcomes.Antibiotic,PPI therapy and previous hospitaiization or CDI were risk factors for CDI. | Zsuzsanna Kurti Barbara D Lovasz Michael D Mandel Zoltan Csima Petra A Golovics Bence D Csako Anna Mohas Lorant Gnczi Krisztina B Gecse Lajos S Kiss Miklos Szathmari Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，21： | 6 |
| 2 | 动态增强磁共振成像对恶性血液病骨髓肿瘤浸润监测的初步研究显示文摘目的本研究旨在利用动态增强MR成像技术(DCE-MR)检测血液病患者骨髓强化特征变化,研究其与骨髓肿瘤细胞浸润状态的相关性。方法25例血液病经DCE-MR成像及髂嵴穿刺活检,测定骨髓灌注的最大强化率(PER),最大强化斜率值(Slopemax),峰值时间(TTP),平均时间(MT),以及骨髓活检分析肿瘤分数(TF)。结果肿瘤浸润组较缓解期组PER高(临床缓解期为0.252±0.156,肿瘤组为0.592±0.433),统计学上有显著性差异(P<0.05)。肿瘤浸润组较缓解期组的Slopemax高肿瘤组:(0.561±0.634)/s;缓解期组:(0.204±0.105)/s、TTP缩短肿瘤组:(68.12±42.18)s;缓解期组:(81.52±38.49)s,但统计学上无显著性差异(P>0.05),MT值两组差异不明显(P>0.05)。结论动态增强MR成像能够监测血液病骨髓肿瘤细胞浸润状态,为恶性血液病治疗随访提供了一种新的无创性监测手段。 | 张蕾 Catherine Mandel 杨振燕 Qing Yang Richard Nibbs David Westerman Alex G Pitman | 2006 | 中国医学影像技术2006，22，7： | 4 |
| 3 | 血液病骨髓动态增强MRI特征的初步研究显示文摘目的 探讨血液病患者骨髓动态增强MRI(DCE-MRI)与骨髓细胞构成的关系。方法对25例恶性血液病患者进行DCE-MRI检查,测定骨髓灌注的最大强化率(PER)、最大强化斜率(Slopemax)、峰值时间(哪)和平均时间(MT);30min后进行髂嵴穿刺活检,分析细胞构成。结果 25例血液病患者中,正常细胞数型骨髓20例,细胞数增多型骨髓3例,细胞数减少型骨髓2例。DCE-MRI骨髓时间.信号强度曲线(TIC)B型3例,C型7例,D型13例,E型2例。细胞数增多型骨髓PER、Slopemax均高于正常细胞数型骨髓和细胞数减少型骨髓;细胞数增多型骨髓,TTP短于正常细胞数型骨髓和细胞数减少型骨髓;细胞数减少型骨髓MT短于正常细胞数型骨髓和细胞数增多型骨髓。结论 DCE-MRI可以作为无创、有效监测血液病骨髓细胞构成变化的手段之一。 | 张蕾 Catherine Mandel 杨振燕 王培军 Alex G Pitman | 2007 | 中华肿瘤杂志2007，29，3： | 2 |
| 4 | Prognosis in childhood rhabdomyosarcoma of the extremity显示文摘 | Ghavimi F Mandell LR Heller G | 1989 | Cancer1989，64，11： | 1 |
| 5 | Uncoupling of the molecularfence'and paracellular'gate functions in epithelial tight junctions显示文摘 | Mandel LJ Baeallao R Zampighi G | 1993 | Nature1993，361，6412： | 1 |
| 6 | Independence fringes produced by superposition independent maser light beams显示文摘 | Magyar B G Mandel Dr L | 1963 | Nature1963，，4877： | 1 |
| 7 | Zinc Finger Tools:custom DNA-binding domains for transcription factors and nucleases显示文摘 | Mandell J G Barbas C F 3rd | 2006 | Nucleic Acids Res2006，34，： | 1 |
| 8 | Iron and alpha-synuclein in the substantia nigra of MPTP-treated mice:effect of neuroprotective drugs R-apomorphine and green tea polyphenol (-)-epigallocatechin-3-gallate显示文摘 | Mandel S Maor G Youdim MB | | 0，，： | 1 |
| 9 | Certain special features of the formation of welds made at high speeds显示文摘 | PATON E O MANDEL' BERG S L Sidorenko B G | 1971 | Autom Weld1971，24，8： | 1 |
| 10 | Polymorphonuclear neutrophils: an effeetive antimierobial force 显示文摘 | SAWYER D W ODNOVITZ G R MANDELL G L | 1989 | Rev Infect1989，11，15： | 1 |
| 11 | Designing marketplaces of the artificial with consumers in mind: Four ap proaches to understanding consumer behavior in electronic environments显示文摘 | Bellman S Johnson E Lohse G and Mandel N | 2006 | Journal of Interactive Marketing2006，20，1： | 1 |
| 12 | Fludarabine - based protocol for haploidentical peripheral blood stem cell transplantation in Hurler syndrome显示文摘 | Kapelushnik J Mandel H Varadi G | 2000 | J Pediatr Hematol Oncol2000，22，5： | 1 |
| 13 | Activation of mitogen-activate protein kinase associated with prostate cancer progression显示文摘 | Gioeli D Mandell J W Petroni G R | 1999 | Cancer Res1999，59，2： | 1 |
| 14 | The immunosuppressive effect of type Ⅱ mouse interferon preparations on antibody production显示文摘 | Sonnenfeld G Mandel A D Merigan T C | 1977 | Cell Immunol1977，34，2： | 1 |
| 15 | Time and dosage dependence of immunoenhancement by murine type Ⅱ interferon preparations显示文摘 | Sonnenfeld G Mandel A D Merigan T C | 1978 | Cell Immunol1978，40，2： | 1 |
| 16 | A new respiratory fluoroquinolone, oral gemifloxacin: a safety profile in context显示文摘 | Ball P Mandell L Patou G | 2004 | Int J Antimicrob Agent2004，23，： | 1 |
| 17 | Perioperative considerations in paients with cirrhotic cardiomypopathy显示文摘 | Biancofiore G Mandell MS Rocca GD | | Current Opinion in Anaesthesiology0，，： | 1 |
| 18 | Critical role of chromium(Cr)-DNA interactions in the formation of Cr-induced polymerase arresting lesions显示文摘 | O'Brien T Mandel H G Pritchard D E | 2002 | Biochemistry2002，41，12： | 1 |
| 19 | Effeet of epidural analgesia with ambulation on labor duration显示文摘 | Vallejo M C Firestone L L Mandell G L | 2001 | Anesthesiology2001，95，4： | 1 |
| 20 | Infectious Diseases Society of America/Amer- ican Thoracic Society consensus guidelines on the management of community-acquired pneumonia in a- dults显示文摘 | MANDELL L A WUNDERINK R G ANZUETO A | 2007 | Clin Infect Dis2007，44，： | 1 |
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