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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Anterior ankle arthrodesis显示文摘Ankle arthrodesis is a common procedure that resolves many conditions of the foot and ankle; however, complications following this procedure are often reported and vary depending on the fixation technique. Various techniques have been described in the attempt to achieve ankle arthrodesis and there is much debate as to the efficiency of each one. This study aims to evaluate the efficiency of anterior plating in ankle arthrodesis using customised and Synthes Tomo Fix plates. We present the outcomes of 28 ankle arthrodeses between 2005 and 2012, specifically examining rate of union, patient-reported outcomes scores, and complications. All 28 patients achieved radiographic union at an average of 36 wk; the majority of patients(92.86%) at or before 16 wk, the exceptions being two patients with Charcot joints who were noted to have bony union at a three year review. Patient-reported outcomes scores significantly increased(P < 0.05). Complications included two delayed unions as previously mentioned, infection, and extended postoperative pain. With multiple points for fixation and coaxial screw entry points, the contoured customised plate offers added compression and provides a rigid fixation for arthrodesis stabilization. | Gordon L Slater Stephanie C Sayres Martin J O'Malley | 2014 | World Journal of Orthopedics2014，5，1： | 5 |
| 3 | High gain GaAs potoconductive semiconductor switches for impulse sources显示文摘 | LOUBREIL G M ZUTAVERN F J O'MALLEY M W | 1994 | SPIE1994，2343，： | 2 |
| 4 | Patients'priorities for medical care显示文摘 | Fletcher R H O'Malley M S Earp J A | 1983 | Medical Care1983，21，2： | 1 |
| 5 | Advances in pulsed power-driven radiography systems显示文摘 | Maenchen J Cooperstein G O'Malley J | 2004 | Proc of the IEEE2004，92，7： | 1 |
| 6 | Impact of heavy metals on enzymatic activity of substrate and on composting worms Eiseniafetida 显示文摘 | Malley C Nair J Ho G | 2006 | Bioresurce Technology2006，97，13： | 1 |
| 7 | Transoral robotic surgery: supraglottic laryngectomy in a canine model 显示文摘 | Weinstein GS O' Malley B J Hockstein NG | 2005 | Laryngoscope2005，115，7： | 1 |
| 8 | A study of principal component analysis applied to spatially distributed wind power显示文摘 | BURKE D J O'MALLEY M J | 2011 | IEEE Trans on Power Systems2011，26，4： | 1 |
| 9 | Listening coprehension strategies in secondlanguage acquisition 显示文摘 | | 1989 | Applied Linguistics1989，11，： | 1 |
| 10 | Augmented Hopfield Network for Unit Commitment and Economic Dispatch显示文摘 | Walsh M P O'Malley M J | 1997 | IEEE Trans on Power Systems1997，12，4： | 1 |
| 11 | Listening comprehension strategies in second language acquisition 显示文摘 | O'Malley J M Chamot A U & Kupper L | 1989 | Applied Linguistics1989，，10： | 1 |
| 12 | Interleukin-6 modulates colonic transepithelial ion transport in the stress-sensitive wistar kyoto rat 显示文摘 | O'Malley D Dinan T G Cryan J F | 2012 | Front Pharmacol2012，3，： | 1 |
| 13 | Surface studies on multicomponent polymer systems by X-ray photoelectron spectroscopy:Polystyrene/poly(ethylene oxide) homopolymer blends显示文摘 | Thomas H R O'Malley J J | 1981 | Macromolecules1981，14，： | 1 |
| 14 | Enzyme-linked immunosorbent assay to assess respiratory syncytial virus concentration and correlate results with inflammatory mediators in tracheal secrations显示文摘 | Malley R Vernacchio L Devincenzo J | 2000 | The Pediatric Infectious Disease Journal2000，19，1： | 1 |
| 15 | Advancesin pulsed power-driven radiography systems显示文摘 | Maenchen J Cooperstein G Malley J | | 0，，07： | 1 |
| 16 | Factors affecting the outcome in patients with gastroschisis:How important is immediate repair显示文摘 | Alali JS Tander B Malleis J | 2011 | Eur J Pediatr Surg2011，21，2： | 1 |
| 17 | Dippers and non-dippers显示文摘 | Sheriden J O'Malley K | 1988 | Lancet1988，2，： | 1 |
| 18 | Learning strategy applications with students of English as a second language 显示文摘 | O'Malley J M & Chamot A U | 1985 | TESOL Quarterly1985，19，3： | 1 |
| 19 | Determination of the C-13, C-12 rations of individual PAH from environmental samples: can PAH sources be apportioned显示文摘 | O'malley VP Abrajano TA Hellou J | 1994 | Organic Geochemistry1994，21，67： | 1 |
| 20 | Parabolic and hyperbolic flexure hinges: flexibility, mo- tion precision and stress characterization based on compliance closed-form equations 显示文摘 | LOBONTIU N PAINE J S N MALLEY E O | 2002 | Precis Eng2002，26，： | 1 |
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