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| 1 | Proton nuclear magnetic resonance-based metabonomic models for non-invasive diagnosis of liver fibrosis in chronic hepatitis C:Optimizing the classification of intermediate fibrosis显示文摘AIM To develop metabonomic models(MMs), using 1 H nuclear magnetic resonance(NMR) spectra of serum, to predict significant liver fibrosis(SF: Metavir ≥ F2), advanced liver fibrosis(AF: METAVIR ≥ F3) and cirrhosis(C: METAVIR = F4 or clinical cirrhosis) in chronic hepatitis C(CHC) patients. Additionally, to compare the accuracy of the MMs with the aspartate aminotransferase to platelet ratio index(APRI) and fibrosis index based on four factors(FIB-4). METHODS Sixty-nine patients who had undergone biopsy in the previous 12 mo or had clinical cirrhosis were included. The presence of any other liver disease was a criterion for exclusion. The MMs, constructed using partial least squares discriminant analysis and linear discriminant analysis formalisms, were tested by cross-validation, considering SF, AF and C. RESULTS Results showed that forty-two patients(61%) presented SF, 28(40%) AF and 18(26%) C. The MMs showed sensitivity and specificity of 97.6% and 92.6% to predict SF; 96.4% and 95.1% to predict AF; and 100% and 98.0% to predict C. Besides that, the MMs correctly classified all 27(39.7%) and 25(38.8%) patients with intermediate values of APRI and FIB-4, respectively. CONCLUSION The metabonomic strategy performed excellently in predicting significant and advanced liver fibrosis in CHC patients, including those in the gray zone of APRI and FIB-4, which may contribute to reducing the need for these patients to undergo liver biopsy. | Andrea Dória Batista Carlos Jonnatan Pimentel Barros Tássia Brena Barroso Carneiro Costa Michele Maria Goncalves de Godoy Ronaldo Dionísio Silva Joelma Carvalho Santos Mariana Montenegro de Melo Lira Norma ThoméJucá Edmundo Pessoa de Almeida Lopes Ricardo Oliveira Silva | 2018 | World Journal of Hepatology2018，10，1： | 2 |
| 2 | Distinct subsets of microRNAs are expressed differentially in the human placentas of patients with preeclampsia 显示文摘 | Pineles BL Romero R Montenegro D | 2007 | Am J Obstet Gynecol2007，196，3： | 1 |
| 3 | Evidence for a stereotypic difference in post-transcriptional regulation of placental gene expression in preeclampsia and SGA:An explanation for the two different phenotypes? 显示文摘 | Pineles BL Romero R Montenegro D | 2006 | Am J Obstet Gynecol2006，195，6： | 1 |
| 4 | 6LoWPAN ad hoc on-demand distance vector routing (LOAD)显示文摘 | Kim K Park S D Montenegro G | 2007 | Network Working Group Internet Draff(work in progress)2007，802，1： | 1 |
| 5 | Neonatal lupus erythematosus: 4 cases and clinical review 显示文摘 | Penate Y Lujan D Rodriguez J Hemandez-Machin B Montenegro T Afonso JL | 2005 | Actas Dermosifiliogr2005，96，10： | 1 |
| 6 | Tensile strength of cementing agents on the CeraOne system of den- tal prosthesis on implants显示文摘 | Montenegro A C Machado A N Gouvea C V D | 2008 | Implant Dentistry2008，17，4： | 1 |
| 7 | Distinct subsets of microRNAs are expressed differentially in the human placentas of patients with preeclampsia显示文摘 | Pineles BL Romero R Montenegro D | | 0，，03： | 1 |
| 8 | Distinct subsets of microRNAs are expressed differentially in the human placentas of patients with preeclampsia显示文摘 | Pineles BL Romero R Montenegro D | | 0，，： | 1 |
| 9 | Distinct subseta of mi-croRNAs are expressed differentially in the human placentas of pa-tients with preeclampsia显示文摘 | Pineles BL Romero R Montenegro D | 2007 | Am J Obstet Gynecol2007，196，3： | 1 |
| 10 | The multicultural quality of life index in Argentina: a validation study显示文摘 | Jatuff D Zapata-Vega MI Montenegro R | 2007 | Actas Esp Psiquiatr2007，35，4： | 1 |
| 11 | The frequency of non-epileptic spells in children: Results of video-EEG moni- toring in a tertiary care center显示文摘 | Montenegro MA Sproule D Mandel A | 2008 | Seizure - European Journal of Epilepsy2008，17，7： | 1 |
| 12 | The frequency of non-epileptic spells in children:results of video-EEG monitoring in a tertiary care center显示文摘 | Montenegro M A Sproule D Mandela A | 2008 | Seizure2008，17，7： | 1 |
| 13 | Molecules with multiple light -emissive electronic excited states as a strategy toward molecular reversible logic gates显示文摘 | Pérez-Inostrosa E Montenegro J M Collado D | 2007 | J Phys Chem C2007，111，： | 1 |
| 14 | 如何确定妊娠早期稽留流产药物治疗成功的标准 | Reynolds A Ayres-De-Campos D Costa M.A Montenegro N. 张超 | 2005 | 世界核心医学期刊文摘(妇产科学分册)2005，0，5： | 1 |
| 15 | The mechanism for the cathodic reduction of sulphur in dimethylformamide: Low temperature voltammetry 显示文摘 | Evans A Montenegro M I Pletcher D | 2001 | Electrochem Commun2001，3，9： | 1 |
| 16 | Expression patterns of microRNAs in the chorioamniotic membranes:a role for microRNAs in human pregnancy and parturition显示文摘 | Montenegro D Romero R Kim SS | 2009 | J Pathol2009，217，1： | 1 |
| 17 | Detection of Epstein-Barr virus in tonsillar tissue of children and the relationship with recurrent tonsillitis显示文摘 | Endo LH Ferreira D Montenegro MC | | 0，，1： | 1 |
| 18 | Distinct subsets of microRNAs are expressed differentially in the human placentas of patients with preeclampsia 显示文摘 | Pineles BL Romero R Montenegro D | 2007 | Obstet Gynecol2007，196，： | 1 |
| 19 | Patterns of hippocampal abnormalities in malformations of cortical development显示文摘 | Montenegro MA Kinay D Cendes F | | 0，，03： | 1 |
| 20 | Clinical suspicion and parathyroid carcinoma management显示文摘 | Montenegro F L Tavares M R Durazzo M D | 2006 | Sao Paulo Med J2006，124，1： | 1 |
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