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| 1 | GYY4137 protects against myocardial ischemia and reperfusion injury by attenuating oxidative stress and apoptosis in rats显示文摘Hydrogen sulfide(H_2S) is a gasotransmitter that regulates cardiovascular functions.The present study aimed to determine the protective effect of slow-releasing H_2S donor GYY4137 on myocardial ischemia and reperfusion(I/R) injury and to investigate the possible signaling mechanisms involved.Male Sprague-Dawley rats were treated with GYY4137 at 12.5 mg/(kg·day),25 mg/(kg·day) or 50 mg/(kg·day) intraperitoneally for7 days.Then,rats were subjected to 30 minutes of left anterior descending coronary artery occlusion followed by reperfusion for 24 hours.We found that GYY4137 increased the cardiac ejection fraction and fractional shortening,reduced the ischemia area,alleviated histological injury and decreased plasma creatine kinase after myocardial I/R.Both H_2S concentration in plasma and cystathionine-γ-lyase(CSE) activity in the myocardium were enhanced in the GYY4137 treated groups.GYY4137 also decreased malondialdehyde and myeloperoxidase levels in serum,attenuated superoxide anion level and suppressed phosphorylation of mitogen activated protein kinases in the myocardium after I/R.Meanwhile,GYY4137 increased the expression of Bcl-2 but decreased the expression of Bax,caspase-3 activity and apoptosis in the myocardium.The data suggest that GYY4137 protects against myocardial ischemia and reperfusion injury by attenuating oxidative stress and apoptosis. | Guoliang Meng Jing Wang Yujiao Xiao Wenli Bai Liping Xie Liyang Shan Philip K Moore Yong Ji | 2015 | The Journal of Biomedical Research2015，29，3： | 18 |
| 2 | Magnetic resonance elastography is accurate in detecting advanced fibrosis in autoimmune hepatitis显示文摘To assess the value of magnetic resonance elastography(MRE) in detecting advanced fibrosis/cirrhosis in autoimmune hepatitis(AIH).METHODS In this retrospective study, 36 patients(19 treated and 17 untreated) with histologically confirmed AIH and liver biopsy performed within 3 mo of MRE were identified at a tertiary care referral center. Liver stiffness(LS) with MRE was calculated by a radiologist, and inflammation grade and fibrosis stage in liver biopsy was assessed by a pathologist in a blinded fashion. Two radiologistsevaluated morphological features of cirrhosis on conventional magnetic resonance imaging(MRI). Accuracy of MRE was compared to laboratory markers and MRI for detection of advanced fibrosis/cirrhosis.RESULTS Liver fibrosis stages of 0, 1, 2, 3 and 4 were present in 4, 6, 7, 6 and 13 patients respectively. There were no significant differences in distribution of fibrosis stage and inflammation grade between treated and untreated patient groups. LS with MRE demonstrated stronger correlation with liver fibrosis stage in comparison to laboratory markers for chronic liver disease(r = 0.88 vs-0.48-0.70). A trend of decreased mean LS in treated patients compared to untreated patients was observed(3.7 k Pa vs 3.84 k Pa) but was not statistically significant. MRE had an accuracy/sensitivity/specificity/positive predictive value/negative predictive value of 0.97/90%/100%/100%/90% and 0.98/92.3%/96%/92.3%/96% for detection of advanced fibrosis and cirrhosis, respectively. The performance of MRE was significantly better than laboratory tests for detection of advanced fibrosis(0.97 vs 0.53-0.80, P < 0.01), and cirrhosis(0.98 vs 0.58-0.80, P < 0.01) and better than conventional MRI for diagnosis of cirrhosis(0.98 vs 0.78, P = 0.002).CONCLUSION MRE is a promising modality for detection of advanced fibrosis and cirrhosis in patients with AIH with superior diagnostic accuracy compared to laboratory assessment and MRI. | Jin Wang Neera Malik Meng Yin Thomas C Smyrk Albert J Czaja Richard L Ehman Sudhakar K Venkatesh | 2017 | World Journal of Gastroenterology2017，23，5： | 15 |
| 3 | Repeatability and Reproducibility of Quantitative Assessment of the Retinal Microvasculature Using Optical Coherence Tomography Angiography Based on Optical Microangiography显示文摘Objective The aim of this study was to determine the repeatability and reproducibility of optical coherence tomography angiography(OCTA) based on optical microangiography(OMAG) measurements of macular vessels in normal eyes. Methods In this prospective cohort study, 40 eyes of 40 healthy volunteers underwent repeated OCTA(Cirrus HD-OCT 5000 angiography system, Carl Zeiss Meditec, Inc.) scans on two separate visit days. On each visit day, the eyes were scanned three times. The following parameters were used to quantitatively describe the OCTA images of the superficial vascular network: vessel area density(VAD), vessel skeleton density(VSD), vessel diameter index(VDI), vessel perimeter index(VPI), vessel complexity index(VCI), flux, and foveal avascular zone(FAZ). Coefficient of variation(CV) and intraclass correlation coefficient(ICC) were calculated for evaluating intravisit and intervisit repeatability, as well as interobserver reproducibility. Results The measurements showed high repeatability [CVs ≤ 4.2%(intravisit) and ≤ 4.6%(intervisit)] and interobserver reproducibility(ICCs ≥ 0.923) for all parameters. Conclusion This study demonstrated good repeatability and reproducibility of OCTA based on OMAG for the measurement of superficial vessel parameters in normal eyes. | ZHAO Qi YANG Wen Li WANG Xiao Na Ruikang K Wang YOU Qi Sheng CHU Zhong Di XIN Chen ZHANG Meng Yu LI Dong Jun WANG Zi Yang CHEN Wei LI Yi Feng CUI Rui SHEN Lin WEI Wen Bin | 2018 | Biomedical and Environmental Sciences2018，31，6： | 8 |
| 4 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 5 | 母亲妊娠期焦虑抑郁对孩子应激性心率及血压的影响显示文摘心理障碍,包括焦虑和抑郁在妊娠期间十分常见。该研究目的在于确定母亲的这些心理障碍是否会对后代的心血管反应产生影响。方法:对231名孕妇的心理状态进行评定,在其后代(n=216)7~9岁时进行视频压力反应测试。测定静息时、观看压力视频时和恢复期的心率及血压水平。 | 刘莉 叶鹏 Fan F Zou Y Tian H Zhang Y Zhang J Ma X Meng Y Yue Y Liu K Dart AM | 2015 | 中华高血压杂志2015，23，6： | 5 |
| 6 | No receptor stands alone: IgG B-cell receptor intrinsic and extrinsic mechanisms contribute to antibody memory显示文摘获得的免疫学的记忆是惹人注目的现象。致命的流行病通过 naï 扫; ve 人口,许多死但是幸存的那些从来不是 “攻击了 ― 两次;从未至少 fatally”,在 430 BCE 观察的历史学家修西得底斯。抗体记忆为对许多人的传染疾病的保护是批评的并且是的基础将近所有当前的人的疫苗。部分地,抗体记忆被编码为切换适应于不同地区生活的动物的免疫球蛋白(Ig ) 在对抗原的主要反应被产生并且产生的表示 G 记忆 B 房间快速,高亲密关系并且在有一样的抗原的挑战之上的 high-titered 抗体回答。IgG-B-cell 受体(BCR ) 并且导致抗原的 IgG-BCR 发信号怎么贡献记忆抗体回答,充分没被理解。在这评论,我们总结在抗体记忆在玩正在揭示细胞、分子的机制并且讨论怎么用不同试验性的途径学习的令人激动的新进展帮助将阐明 B 房间记忆的复杂现象。 | Yinsheng Xu Liling Xu Meng Zhao ChenGuang Xu Yilin Fan Susan K Pierce Wanli Liu | 2014 | Cell Research2014，24，6： | 4 |
| 7 | 混合润滑状态下表面织构的建模和设计研究显示文摘织构化技术指的是在微纳米尺度下,通过物理或化学方法在机械滑动支承表面加工凹坑、沟槽或凸起结构。近二十年来的研究表明,织构化表面可以显著改善机械配副的摩擦学特性,因此工程中得到了广泛应用。然而,现行的织构设计方法往往基于试错法或经验。对于织构设计准则,特别是在混合润滑状态下织构设计准则相当缺失。相关文献中几乎找不到公认的织构设计准则。因此,本文旨在于建立计算凹形织构在混合润滑状态下摩擦学特性的数学模型,进而研究织构非规则形状和排布对其摩擦学特性的影响。通过用平均流量雷诺方程和K-E弹塑性接触模型分别计算凹形织构化表面的流体动压作用和微凸体接触状态。 | 张辉 董光能 Meng HUA K S CHIN | 2018 | 机械工程学报2018，54，3： | 3 |
| 8 | Evidence for apoptosis after intercerebral hemorrhage in rat striatum显示文摘 | Matsushita K Meng W Wang X | | 0，，： | 2 |
| 9 | Decreased Endogenous Production of Hydrogen Sulfide Accelerates Atherosclerosis显示文摘 | Sarathi Mani Hongzhu Li Ashley Untereiner Lingyun Wu Guangdong Yang Richard C. Austin Jeffrey G. Dickhout ?árka Lhoták Qing H. Meng Rui Wang | 2013 | Circulation2013，，25： | 2 |
| 10 | 变载荷下摩擦磨损在线监测与磨损机理分析显示文摘选用阶梯加载、短时高载及有阻尼简谐激励动载(DHE)等加载方式,研究加载方式对球-盘配副的摩擦磨损的影响.采用测力传感器、在线可视铁谱传感器(OLVF)分别实现摩擦磨损实时监测,并分析盘试样磨损特征.与静载荷相比的结果显示:a.阶梯载荷可以减小磨合期的局部高磨损峰值;b.短时高载时,摩擦系数摩擦系数μ及百分覆盖面积比IIPCA结果显示球-盘配副有一定的承载能力,但加载时间超过60s后,磨损显著增加;c.在DHE载荷下,容易造成μ陡升.磨痕形貌分析表明:过载条件下,恒载和阶梯载荷造成的磨损以表面材料塑性流动为主,DHE载荷易造成表面疲劳;因此,球-盘配副能够承受一定的短时高载荷,阶梯载荷有利于改善配副的摩擦学性能,而DHE载荷对配副的损伤最大. | 袁伟 董光能 Chin K S Hua Meng | 2016 | 华中科技大学学报(自然科学版)2016，44，2： | 2 |
| 11 | Purification and characterization of intracellular toxin A of Clostridium difficile显示文摘 | Meng XQ Kamiya S Yamakawa K | 1993 | J Med Microbiol1993，38，： | 2 |
| 12 | 深部地球条件下铁和氧元素的化学变化显示文摘氧与铁分别为地球上丰度最高的元素与占地球质量最大的元素,它们所形成的化合物遍布我们的星球,具有-2价的氧控制着地球的氧逸度,随着深度的增加氧逸度逐渐降低,与铁所形成的氧化物中铁的价态也逐渐降低,O/Fe逐渐增加,近些年来科学家们发现深部地球条件下铁的一系列氧化物,其中具有高压黄铁矿结构的铁超氧化物FeO2具有最高的O/Fe,并且它还能够携带一定量的H(表示为Py-FeO2H,, x=0-1)。 | 夏群科 Liu J Hu Q Y Bi W L Yang L X Xiao Y M Chow P Meng Y.Prakapenka V B Mao H K Mao W L | 2019 | 矿物岩石地球化学通报2019，38，3： | 2 |
| 13 | Preparation and properties of poly(vinyl alcohol)-vermiculite nanocomposites显示文摘 | XU J MENG Y Z LI R K Y | 2003 | J Polym Sci B:Polym Phys2003，41，： | 1 |
| 14 | Evidence for apoposis after inracerebral hemorrhage in rat striatum显示文摘 | Matsushita K Meng W Wang X | 2000 | J Cereb Blood Flow Metab2000，20，2： | 1 |
| 15 | An overview of hydrogen production from biomass显示文摘 | Meng Ni Dennis Y C Leung Michael K H Leung Sumathy K | 2006 | Fuel Processing Technology2006，，87： | 1 |
| 16 | Promotion of seminomatous tumors by targeted overexpression of glial cell line - derived neurotrophic factor in mouse testis 显示文摘 | MENG X DeROOI J D G WESTERDAHL K | 2001 | Cancer Res2001，61，8： | 1 |
| 17 | Evidence for ap- optosis after intervertebral hemorrhage in rat striatum显示文摘 | Matsushita K Meng W Wang X | 2000 | J Cereb Blood Flow Metab2000，20，2： | 1 |
| 18 | Energy transfer mechanism in Yb3+∶Er3+-ZBLAN:macroand micro-parameters显示文摘 | MENG Z NAGAMATSU K HIGASHIHATA M | 2004 | Journal of luminescence2004，106，3： | 1 |
| 19 | Influence of ceramic thickness on mechanical properties and polymer structure of dual-cured resin luting agents显示文摘 | Meng X Yoshida K Atsuta M | | 0，，04： | 1 |
| 20 | Research on database显示文摘 | LI Y K MENG X F ZHANG X Y | | 0，，08： | 1 |
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