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| 1 | Flow Characteristics Diagnosis and Optimization for Dust Collectors Inflow Duct in Thermal Power Plants显示文摘火电厂烟风道用于输送烟气、冷风等介质,其设计优化水平不但影响火电厂烟风系统阻力的大小,而且影响与烟风道直接相连的各个设备的运行状态。某600MW机组除尘器前烟道设计不合理,存在磨损严重、进入除尘器烟气分配不均等问题,文中采用标准缸￡模型,利用Fluent求解器对该部分烟道的流场进行数值计算,诊断分析其存在的主要问题,提出的3个改造方案均可使烟道阻力大幅度下降、烟道磨损减轻、进入除尘器烟气分配均匀。同时,研究了缓转半径及烟气流速对该段烟道阻力和烟气分配的影响情况,计算结果表明该段烟道缓转半径宜选在0.875以上,烟气流速对该段烟道的性能基本没有影响。 | LIU Ming MENG Guixiang YAN Junjie CHEN Weixiong LI Weidong CHONG Daotong LIU Jiping | 2013 | 中国电机工程学报2013，33，11： | 22 |
| 2 | Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencing显示文摘Hepatocellular 癌(HCC ) 是癌症实质词法,基因并且 phenotypic 差异。然而,我们不理解在 intratumor 异质和肿瘤的联系词法 / 组织学的特征之间的关系。用介绍 96 个肿瘤房间(30-36 各个) 和 15 个正常的肝房间(5 各个) 的单个房间的整个染色体的定序,与联系 HBV 的 HCC 从三个男病人收集了,我们证实拷贝数字变化在 hepatocarcinogenesis 早发生,但是此后在整个肿瘤仍然保持相对稳定前进。重要地,我们证明特定的 HCC 能具有 monoclonal 或 polyclonal 起源。有汇合的 multinodular 形态学的肿瘤是典型 polyclonal 肿瘤并且显示最高的 intratumor 异质。除了 mutational 和拷贝数字侧面,我们把了用导出 HBV 的外国 genomic 标记的 HCC 的同种细胞的起源。在 monoclonal HCC,所有肿瘤单身者房间展出一样的 HBV 集成,显示 HBV 集成是一个早司机事件并且在肿瘤前进期间仍然保持极其稳定。另外,我们的结果显示那两个都转移,迟了的传播并且早播种当模特儿,在 HCC 有一个角色前进。尤其是,开始的克隆传播的早 intrahepatic 导致同步 multifocal 肿瘤的形成。同时,我们在 HCC 识别了潜在的司机基因 ZNF717,它展出变化的高频率在单个房间并且人口铺平,,通过调整 IL-6/STAT3 小径行动的肿瘤 suppressor。这些调查结果热点多重不同肿瘤在 HCC 的进化机制,它为特定的处理策略建议需要。 | Meng Duan, Shu Zhang, Zhichao Wang, Jieyi Shi, Longzi Liu, Xiaoying Wang, Aiwu Ke, Jian Zhou, Jia Fan, Qiang Gao Junfeng Hao, Chong Li Sijia Cui Daniel L Worthley Ya Cao Ruibin Xi Xiaoming Zhang Jian Zhou, Jia Fan Qiang Gao | 2018 | Cell Research2018，28，3： | 21 |
| 3 | Imaging in detecting sites of pulmonary fibrosis induced by paraquat显示文摘 | Xiao-li Xu Wei Wang Zu-jun Song Hong Ding Xiao-hong Duan Huan-cheng Meng Jian Chong | 2011 | World Journal of Emergency Medicine2011，2，1： | 19 |
| 4 | Antioxidant and Anti-inflammatory Capacity of Ferulic Acid Released from Wheat Bran by Solid-state Fermentation of Aspergillus niger显示文摘Objective A strain of Aspergillus niger(A. niger), capable of releasing bound phenolic acids from wheat bran, was isolated. This strain was identified by gene sequence identification. The antioxidant and anti-inflammatory capacity of ferulic acid released from wheat bran by this A. niger strain(FA-WB) were evaluated. Methods Molecular identification techniques based on PCR analysis of specific genomic sequences were conducted; antioxidant ability was examined using oxygen radical absorbance capacity(ORAC), cellular antioxidant activity(CAA) assays, and erythrocyte hemolysis assays. RAW264.7 cells were used as a model to detect anti-inflammatory activity. Results The filamentous fungal isolate was identified to be A. niger. ORAC and CAA assay showed that FA-WB had better antioxidant activity than that of the ferulic acid standard. The erythrocyte hemolysis assay results suggested that FA-WB could attenuate AAPH-induced oxidative stress through inhibition of reactive oxy gen species(ROS) generation. FA-WB could significantly restore the AAPH-induced increase in intracellular antioxidant enzyme activities to normal levels as well as inhibit the intracellular malondialdehyde formation. TNF-?, IL-6, and NO levels indicated that FA-WB can inhibit the inflammation induced by lipopolysaccharide(LPS). Conclusion Ferulic acid released from wheat bran by a new strain of A. niger had good anti-inflammatory activity and better antioxidant ability than standard ferulic acid. | YIN Zhi Na WU Wen Jia SUN Chong Zhen LIU Hui Fan CHEN Wen Bo ZHAN Qi Ping LEI Zhuo Gui XIN Xuan MA Juan Juan YAO Kun MIN Tian ZHANG Meng Meng WU Hui | 2019 | Biomedical and Environmental Sciences2019，32，1： | 14 |
| 5 | Value of fasting plasma glucose to screen gestational diabetes mellitus before the 24th gestational week in women with different pre-pregnancy body mass index显示文摘Background:Gestational diabetes mellitus(GDM)is usually diagnosed between 24th and 28th gestational week using the 75-g oral glucose tolerance test(OGTT).It is difficult to predict GDM before 24th gestational week because fast plasma glucose(FPG)decreases as the gestational age increases.It is controversial that if FPG≥5.1 mmol/L before 24th gestational week should be intervened or not.The aim of this study was to evaluate the value of FPG to screen GDM before 24th gestational week in women with different pre-pregnancy body mass index(BMI).Methods:This was a multi-region retrospective cohort study in China.Women who had a singleton live birth between June 20,2013 and November 30,2014,resided in Beijing,Guangzhou and Chengdu,and received prenatal care in 21 selected hospitals,were included in this study.Pre-pregnancy BMI,FPG before the 24th gestational week,and one-step GDM screening with 75 g-OGTT at the 24th to 28th gestational weeks were extracted from medical charts and analyzed.The pregnant women were classified into four groups based on pre-pregnancy BMI:Group A(underweight,BMI<18.5 kg/m^2),Group B(normal,BMI 18.5-23.9 kg/m^2),Group C(overweight,BMI 24.0-27.9 kg/m^2)and Group D(obesity,BMI≥28.0 kg/m^2).The trend of FPG before 24th week of gestation was described,and the sensitivity and specificity of using FPG before the 24th gestational week to diagnose GDM among different pre-pregnancy BMI groups were reported.Differences in the means between groups were evaluated using independent sample t-test and analysis of variance.Pearson Chi-square test was used for categorical variables.Results:The prevalence of GDM was 20.0%(6806/34,087)in the study population.FPG decreased gradually as the gestational age increased in all pre-pregnancy BMI groups until the 19th gestational week.FPG was higher in women with higher pre-pregnancy BMI.FPG before the 24th gestational week and pre-pregnancy BMI could be used to predict GDM.The incidence of GDM in women with FPG≥5.10 mmol/L in the 19th to 24th gestational weeks and pre-pregnancy overweight or obesity was significantly higher than that in women with FPG≥5.10 mmol/L and pre-pregnancy BMI<24.0 kg/m^2(78.5%[62/79]vs.52.9%[64/121],χ^2=13.425,P<0.001).Conclusions:FPG decreased gradually as the gestational age increased in all pre-pregnancy BMI groups until the 19th gestational week.Pre-pregnancy overweight or obesity was associated with an increased FPG value before the 24th gestational week.FPG≥5.10 mmol/L between 19 and 24 gestational weeks should be treated as GDM in women with pre-pregnancy overweight and obesity. | Yu-Mei Wei Xin-Yue Liu Chong Shou Xing-Hui Liu Wen-Ying Meng Zi-Lian Wang Yun-Feng Wang Yong-Qing Wang Zhen-Yu Cai Li-Xin Shang Ying Sun Hui-Xia Yang | 2019 | Chinese Medical Journal2019，，8： | 13 |
| 6 | 亚洲近视管理共识显示文摘指南的目标本指南是从国际近视研究所(IMI)白皮书中提取出来的有关近视管理方面的建议[1,2]。本指南所提供的内容都是根据现有最新数据(截至2022年3月)而来,其治疗可行性和执业范围因地区而异,应根据实际情况做调整。眼保健专家组通过对现有最优科学数据进行分析诠释,从而形成了本指南。在工作中,近视管理从业者应该将患者需求放在首位,全面考虑患者具体情况后再提出合适的处理意见。 | Monica Jong Serge Resnikoff Kah Ooi Tan 吕帆 Kah Meng Chung 胡楚南 Ian Morgan Oliver Kam Tong Woo 蓝卫忠 齐备 瞿佳 杨智宽 樊志诚 吴佩昌 Ian Flitcroft Murphy Hian Kee Chan Thok Chuan Tan Charlie Ho David Chai Wong Chong Liang Hwee Koh Olivia Qian Ru Cheng | 2022 | 中华眼视光学与视觉科学杂志2022，24，3： | 11 |
| 7 | Wheat genomic study for genetic improvement of traits in China显示文摘Bread wheat(Triticum aestivum L.)is a major crop that feeds 40%of the world’s population.Over the past several decades,advances in genomics have led to tremendous achievements in understanding the origin and domestication of wheat,and the genetic basis of agronomically important traits,which promote the breeding of elite varieties.In this review,we focus on progress that has been made in genomic research and genetic improvement of traits such as grain yield,end-use traits,flowering regulation,nutrient use efficiency,and biotic and abiotic stress responses,and various breeding strategies that contributed mainly by Chinese scientists.Functional genomic research in wheat is entering a new era with the availability of multiple reference wheat genome assemblies and the development of cutting-edge technologies such as precise genome editing tools,highthroughput phenotyping platforms,sequencing-based cloning strategies,high-efficiency genetic transformation systems,and speed-breeding facilities.These insights will further extend our understanding of the molecular mechanisms and regulatory networks underlying agronomic traits and facilitate the breeding process,ultimately contributing to more sustainable agriculture in China and throughout the world. | Jun Xiao Bao Liu Yingyin Yao Zifeng Guo Haiyan Jia Lingrang Kong Aimin Zhang Wujun Ma Zhongfu Ni Shengbao Xu Fei Lu Yuannian Jiao Wuyun Yang Xuelei Lin Silong Sun Zefu Lu Lifeng Gao Guangyao Zhao Shuanghe Cao Qian Chen Kunpu Zhang Mengcheng Wang Meng Wang Zhaorong Hu Weilong Guo Guoqiang Li Xin Ma Junming Li Fangpu Han Xiangdong Fu Zhengqiang Ma Daowen Wang Xueyong Zhang Hong-Qing Ling Guangmin Xia Yiping Tong Zhiyong Liu Zhonghu He Jizeng Jia Kang Chong | 2022 | Science China(Life Sciences)2022，65，9： | 9 |
| 8 | Dynamic characteristics of lime-treated expansive soil under cyclic loading显示文摘To better understand the dynamic properties of expansive clay treated with lime, a series of laboratory tests were conducted using a dynamic triaxial test system. The influential factors, including moisture content, confining pressure, vibration frequency, consolidation ratio, and cycle number on the dynamic characteristics were discussed. Experimental results indicate that specimens at low moisture contents tend to damage along the 30° shear plane and they present brittle failure, while saturated specimens show swelling phenomenon and plastic failure. A reduction in cohesion has been observed for unsaturated samples at large number of cycles, while it is opposite for the internal friction angle. For the saturated specimens, both the cohesion and internal friction angle decrease with increasing number of cycles. | Min Wang Lingwei Kong Chong Zhao Meng Zang | 2012 | Journal of Rock Mechanics and Geotechnical Engineering2012，4，4： | 8 |
| 9 | 雷帕霉素对小鼠百草枯中毒导致肺纤维化的治疗作用(英文)显示文摘目的:评估雷帕霉素(RAPA)对小鼠百草枯(PQ)中毒导致肺纤维化的治疗作用,并初步探讨其作用机制。创新点:首次在小鼠PQ中毒的模型中证明RAPA可明显抑制肺纤维化,且此作用与转化生长因子-β1(TGF-β1)的抑制相关。方法:将C57BL/6J雄鼠分为对照组(腹腔注射生理盐水)和实验组(腹腔注射10 mg/kg PQ)。实验组根据采用的治疗不同,可分为以下四组:PQ组、PQ+RAPA组、PQ+MP(甲强龙)组和PQ+MP+RAPA组。用苏木精-伊红染色法(H&E)和马松(Masson)三色染色法观察肺组织病理结构变化,用酶联免疫吸附测定(ELISA)试剂盒检测肺组织中的羟脯氨酸(HYP)含量,用免疫组化和免疫印迹的方法检测TGF-β1和α-平滑肌肌动蛋白(α-SMA)的表达水平。结论:本实验中小鼠的肺组织病理染色结果显示,RAPA治疗能缓解肺纤维化导致的病理改变(图3)。ELISA实验结果显示,RAPA治疗28天后可显著降低肺组织中HYP的含量(图4)。免疫组化和免疫印迹实验结果显示,RAPA治疗能明显下调肺组织中TGF-β1和α-SMA的高表达(图5和6)。综上所述,RAPA在治疗PQ中毒导致的肺纤维化中有重要价值。 | Xue SHAO Meng LI Chong LUO Ying-ying WANG Ying-ying LU Shi FENG Heng LI Xia-bing LANG Yu-cheng WANG Chuan LIN Xiu-jin SHEN Qin ZHOU Hong JIANG Jiang-hua CHEN | 2015 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2015，16，1： | 7 |
| 10 | Efficient generation of homozygous substitutions in rice in one generation utilizing an rABE8e base editor显示文摘A new deaminase,TadA8e,was recently evolved in the laboratory.TadA8e catalyzes DNA deamination over 1,000 times faster than ABE7.10.We developed a high-efficiency adenine base editor,rABE8e(rice ABE8e),combining monomeric TadA8e,bis-bpNLS and codon optimization.rABE8e had substantially increased editing efficiencies at NG-protospacer adjacent motif(PAM)and NGG-PAM target sequences compared with ABEmax.For most targets,rABE8e exhibited nearly 100%editing efficiency and high homozygous substitution rates in the specific editing window,especially at Positions A5 and A6.The ability to rapidly generate plant materials with homozygous base substitutions will benefit gene function research and precision molecular breeding. | Chuang Wei Chong Wang Meng Jia Hong-Xuan Guo Peng-Yu Luo Mu-Gui Wang Jian-Kang Zhu Hui Zhang | 2021 | Journal of Integrative Plant Biology2021，63，9： | 7 |
| 11 | Research progress on microstructure evolution of semi-solid aluminum alloys in ultrasonic field and their rheocasting显示文摘The effects of ultrasonic vibration(UV)treatment on microstructure of semi-solid aluminum alloys and the application of UV in rheocasting process are reviewed.Good semi-solid slurry can be produced by high-intensity UV process for aluminum alloys.The microstructures of Al-Si,Al-Mg and Al-Cu alloys produced by rheocasting assisted with UV are compact and with fine grains.The mechanical properties of the UV treated alloys are increased by about 20%-30%.Grain refinement of the alloys is generally considered because of cavitation and acoustic streaming caused by UV.Apart from these mechanisms,a hypothesis of the fuse of dendrite root caused by capillary infiltration in the ultrasonic field,as well as a mechanism of crystallites falling off from the mould-wall and crystal multiplication by mechanical vibration effect in indirect ultrasonic vibration are proposed to explain the microstructure evolution of the alloys. | Wu Shusen Lin Chong Lü Shulin Sha Meng | 2014 | China Foundry2014，11，4： | 7 |
| 12 | Importance of identifying tropical cyclone tornadoes in typhoon warning and defense systems显示文摘Tornadoes are highly localized severe weather phenomena and have been of increasing concern in China [1] in recent years, especially after the sinking of the Oriental Star in 2015 [2] and severe tornado damage in Yancheng in 2016 (3)Tornadoes induced by tropical cyclones, however, have received little attention.A recent study has shown that a large number of tornado-scale vortices can be produced at the inner edge of the intense eyewallconvection of tropical cyclones [4]. | Dan Yao Xudong Liang Qing Meng Jian Li Chong Wu Zhengshuai Xie Dandan Chen Jianping Guo | 2019 | Science Bulletin2019，64，3： | 7 |
| 13 | Design and physical model experiment of an attitude adjustment device for a crawler tractor in hilly and mountainous regions显示文摘To address the problems of difficult leveling and poor stability of hill crawler tractors,an attitude adjustment device based on a parallel four-bar mechanism was designed,and the mechanical reasons for the sideslip instability of hill crawler tractors were analyzed.On this basis,a posture adjustment mechanism based on a parallel four-bar mechanism was proposed,and the structure of the complete attitude adjustment device was designed.To ensure that this device meets the strength requirements during operation,a mechanical analysis of the key components(active rocker and slave rocker)was carried out to accommodate the load during leveling.Based on ANSYS software,a finite element simulation analysis was used to determine the maximum stress position of the active and slave rockers.Finally,to verify the accuracy of the above simulation analysis results and determine the influence rules of the lateral slope angle,longitudinal slope angle and loading quality on the abovementioned maximum stress,a physical model test bench of the attitude adjustment device was built.An orthogonal regression experiment was carried out with the maximum stresses of the active and slave rockers as the test indices.The experimental data were analyzed by Design-Expert 10 software,and the results show that the order of the primary and secondary factors influencing the maximum stress of the active rocker was the loading mass,lateral slope angle and longitudinal slope angle.The order of the factors influencing the maximum stress of the slave rocker was the longitudinal slope angle,lateral slope angle and loading mass.The active and slave rockers meet the strength requirements.This work provides technical support for the production of hill crawler tractor physical prototypes. | Jingbin Sun Chong Meng Yazhou Zhang Guoping Chu Yanjie Zhang Fuzeng Yang Zhijie Liu | 2020 | Information Processing in Agriculture2020，7，3： | 5 |
| 14 | Smoking and Its Relation to Metabolic Status among Chinese Adults: Analysis of a Nationwide Survey显示文摘Objective To update the estimated prevalence rates of smoking and examine major metabolic diseases associated with smoking status in Chinese adults. Methods Using a complex, multistage, probability sampling design, we recruited a nationally representative sample of 98,658 Chinese adults aged ≥18 years in 2010. Information on current, former, never, and passive smoking status was obtained using a standard questionnaire. All estimates were weighted to represent the overall Chinese adult population. Results The estimated proportion of current smokers was 28.3% for Chinese adults aged ≥18 years. The corresponding values of former and passive smokers were 5.1% and 21.4%, respectively. Additionally, former smokers were found to have a less favorable metabolic risk profile among all categories of smoking status in both men and women. The prevalence of metabolic diseases such as diabetes and hypertension also increased with a greater number of smoking pack-years in men. Conclusion The prevalences of current smoking and passive smoking remain high in Chinese adults. | DING Lin XU Yu WANG Li Min JIANG Yong ZHANG Mei LI Yi Chong LU Jie Li XU Min WANG Tian Ge LI Mian ZHAO Zhi Yun DAI Meng WANG Wei Qing ZHAO Wen Hua WANG Lin Hong BI Yu Fang NING Guang 无 | 2016 | Biomedical and Environmental Sciences2016，29，9： | 5 |
| 15 | A transcription factor STOP1-centered pathway coordinates ammonium and phosphate acquisition in Arabidopsis显示文摘Phosphorus(P)is an indispensable macronutrient required for plant growth and development.Natural phosphate(Pi)reserves are finite,and a better understanding of Pi utilization by crops is therefore vital for worldwide food security.Ammonium has long been known to enhance Pi acquisition efficiency in agriculture;however,the molecular mechanisms coordinating Pi nutrition and ammonium remains unclear.Here,we reveal that ammonium is a novel initiator that stimulates the accumulation of a key regulatory protein,STOP1,in the nuclei of Arabidopsis root cells under Pi deficiency.We show that Pi deficiency promotes ammonium uptake mediated by AMT1 transporters and causes rapid acidification of the root surface.Rhizosphere acidification-triggered STOP1 accumulation activates the excretion of organic acids,which help to solubilize Pi from insoluble iron or calcium phosphates.Ammonium uptake by AMT1 transporters is downregulated by a CIPK23 protein kinase whose expression is directly modulated by STOP1 when ammonium reaches toxic levels.Taken together,we have identified a STOP1-centered regulatory network that links external ammonium with efficient Pi acquisition from insoluble phosphate sources.These findings provide a framework for developing possible strategies to improve crop production by enhancing the utilization of non-bioavailable nutrients in soil. | Wen Hao Tian Jia Yuan Ye Meng Qi Cui Jun Bo Chang Yu Liu GuiXin Li Yun Rong Wu Ji Ming Xu Nicholas P.Harberd Chuan Zao Mao Chong Wei Jin Zhong Jie Ding Shao Jian Zheng | 2021 | Molecular Plant2021，14，9： | 5 |
| 16 | Separation and enrichment of trace ractopamine in biological samples by uniformly-sized molecularly imprinted polymers显示文摘In order to prepare a high capacity packing material for solid-phase extraction with specific recognition ability of trace ractopamine in biological samples, uniformly-sized, molecularly imprinted polymers (MIPs) were prepared by a multi-step swelling and polymerization method using methacrylic acid as a functional monomer, ethylene glycol dimethacrylate as a cross-linker, and toluene as a porogen respectively. Scanning electron microscope and specific surface area were employed to identify the characteristics of MIPs. Ultraviolet spectroscopy, Fourier transform infrared spectroscopy, Scatchard analysis and kinetic study were performed to interpret the specific recognition ability and the binding process of MIPs. The results showed that, compared with other reports, MIPs synthetized in this study showed high adsorption capacity besides specific recognition ability. The adsorption capacity of MIPs was 0.063 mmol/g at 1 mmol/L ractopamine concentration with the distribution coefficient 1.70. The resulting MIPs could be used as solid-phase extraction materials for separation and enrichment of trace ractopamine in biological samples. | Ya Li Qiang Fu Meng Liu Yuan-Yuan Jiao Wei Du Chong Yu Jing Liu Chun Chang Jian Lu | 2012 | Journal of Pharmaceutical Analysis2012，2，6： | 4 |
| 17 | Malnutrition Increases the Risk of Mortality in Hospitalized Lung Cancer Patients显示文摘Background The Global Leadership Initiative on Malnutrition(GLIM)recently developed a new set of diagnostic criteria for identifying patients with malnutrition.Because the GLIM criteria were only introduced a little over 3 years ago,additional validation and reliability testing are needed in a variety of populations.Methods We performed an observational,multicenter cohort study.From July 2013 to October 2018,lung cancer patients were recruited from the Daping Hospital of Army Medical University and the First Hospital of Jilin University as part of the INSCOC project.Previously-established cut-off values for the calf circumference(CC,male<30 cm,female<29.5 cm)were applied as the reduced muscal mass of phenotypic criteria to establish the GLIM diagnosis.Multivariate Cox regression analyses were performed to analyze the association between the GLIM criteria and survival.Results A total of 1219 patients with lung cancer were studied as subjects.Their age was 58.81±9.92 years old,and 820 were male and 399 were female.According to the GLIM diagnostic criteria using the CC as a muscle mass measurement,303 patients(24.9%)were categorized as malnourished,142 patients(23.1%)in the adult group(18≤age<60)and 161 patients(26.7%)in the older group(age≥60 years).The patients with malnutrition had a higher incidence of anemia than the nourished patients(P=0.012).The QLQ-C30 score and KPS score indicating that the malnourished patients had a consistently worse quality of life compared to the nourished group(all P<0.001).The median survival of the malnutrition group was 42(95%CI:34-50)months,which was much shorter than the 62(95%CI:57-66)months in the nourished group(P<0.001).In the adult group,the median survival decreased from 65(95%CI:55-72)months in nourished group to 34(95%CI:25-48)months in the patients with malnutrition(P<0.001).In the older group,it decreased from 61(95%CI:55-67)months to 48(95%CI:39-59)months(P=0.001).A Cox regression analysis showed that GLIM-diagnosed malnutrition was associated with an increased risk of death among adult group(HR=1.670,95%CI:1.29-2.16),older group(HR=1.332,95%CI:1.05-1.69)and overall(HR=1.453,95%CI:1.22-1.72).Conclusion All of these results demonstrate that GLIM-diagnosed malnutrition is associated with a poorer survival for all lung cancer patients,independent of age. | Fei Fei Chong Liang Yu Yin Jie Liu Na Li Jing Guo Yang Fan Meng Yuan Zhang Ling Zhang Xiu Mei He Hong Mei Zhang Mu Li Shi Wei Li Hong Xia Xu | 2022 | Journal of Nutritional Oncology2022，7，1： | 4 |
| 18 | Prevalence and risk factors of methotrexate hepatoxicity in Asian patients with psoriasis显示文摘AIM: To establish the prevalence of liver fibrosis and to evaluate the possible risk factors for fibrosis and progression in Asian with psoriasis treated with methotrexate (MTX) based on liver histology. METHODS: Patients with psoriasis treated with MTX referred to the Department of Gastroenterology, Tan Tock Seng Hospital for liver biopsy were identified and retrospectively studied. Patient case notes and electronic records were retrieved from the hospital database and relevant data collated. Histological changes of liver biopsies were staged according to Roengik score. The factors assessed were age, gender, ethnicity, cumulative dose of MTX, presence of comorbid conditions such as diabetes, hypertension, hyperlipidemia, and ethanol use. We also assessed the histological change in those with multiple liver biopsies. Statistical analysis was performed using Stata V.9.2. RESULTS: There were altogether 59 patients (median age 50 years old, range 22-81 years old, male, 88%) with 98 biopsies liver biopsies; 6 normal [median cumulative dose (MCD), 2285 mg]; 62 gradeⅠ (MCD 2885 mg), 23 grade Ⅱ (MCD 1800 mg) and 7 grade Ⅲ (MCD 1500 mg). There was no grade Ⅳ or cirrhosis. The prevalence of liver fibrosis (grade Ⅲ) was 12%. Of the factors assessed, diabetes (P=0.001) and hypertension (P=0.003) were significant for fibrosis on univariate analysis but not on multivariate analysis. Of the 26 patients who had more than one biopsy (median 2, range 2-6), 57.7% (n=15) were stable, 34.6% (n=9) had progression and 7.7% (n=2) had regression of histological grades. On univariate analysis, nonChinese ethnicity (P=0.031), diabetes (P=0.018), and hyperlipidemia (P=0.011) were predictive of progression of grades, but these were not significant on multivariate analysis. CONCLUSION: Liver fibrosis in Asian psoriatic population on MTX is comparable to the West. Cumulative dose was not associated with liver fibrosis. Metabolic syndrome is important factors. | Chong Meng Yeo Vui Heng Chong Arul Earnest Wei Lyn Yang | 2013 | World Journal of Hepatology2013，5，5： | 3 |
| 19 | Microstructures and mechanical properties of a newly developed high-pressure die casting Mg-Zn-RE alloy显示文摘A newly developed Mg-4Zn-2La-3Y alloy with high strength was fabricated by high-pressure die casting method,and its microstructures were thoroughly studied using transmission electron microscopy.The results demonstrate that it owns fine grains and approximately highly interconnected intermetallic phase skeletons,and exhibits ultra-high strength at both room and high temperatures.Interestingly,the eutectic intermetallic skeleton of this alloys is consisted of numerous fine particles,which are mainly consisted of two intermetallic phases,namely W and Mg12RE.Multiple{101}twins and SFs were found in the Mg12RE phase while a few of SFs in the W phase.Additionally,minor long-period stacking ordered phase was observed in the eutectoid phase,and it probably nucleated on the Mg12RE phase following a certain OR as(0002)14H//(110)Mg12REand[1120]14H//[111]Mg12RE,or(0002)14H//(211)Mg12REand[1120]14H//[111]Mg12RE.This special intermetallic skeleton with many interfaces and planar faults can efficiently transfer dislocations across grain boundaries,and this is the key factor for the outstanding mechanical properties of the studied alloy. | Xiru Hua Qiang Yang Dongdong Zhang Fanzhi Meng Chong Chen Zihao You Jinghuai Zhang Shuhui Lv Jian Meng | 2020 | Journal of Materials Science & Technology2020，52，18： | 3 |
| 20 | 铜引线键合中影响焊球硬度因素的研究(英文)显示文摘铜丝球焊由于其经济优势和优越的电气性能近来得到了普及,然而,在引线键合工艺中用铜丝取代金丝面临着一些技术上的挑战。多年来,IC芯片焊盘结构已经逐步适应了金丝球焊。铜在本质上比金硬度高,因此以铜线取代金线便引出了有关硬度的问题。研究了用25.4μm铜丝球焊中与键合机参数有关的铜焊球硬度特性。采用电子打火系统不同的电流和打火时间设置,用5%氢气和95%氮气组成的惰性保护气体形成了一个典型的25.4μm大小的铜焊球,研究了维氏硬度的焊球。用实验设计建立了第一和第二键合参数,进行了无空气焊球基本数据调整。通过改变电子打火系统参数,对硬度特性进行了进一步的测试。典型的键合球的大小和厚度的第一键合响应证实铜键合球的生产实力与电子打火系统的电流和打火时间有关。 | Hong Meng Ho Yee Chen Tan Heng Mui Goh Wee Chong Tan Boon Hoe Toh Jonathan Tan Zhao Wei Zhong | 2009 | 电子工业专用设备2009，，11： | 3 |
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