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| 1 | Esophagus and regenerative medicine显示文摘In addition to squamous cell carcinoma,the incidence of Barrett's esophagus with high-grade dysplasia and esophageal adenocarcinoma is rapidly increasing worldwide.Unfortunately,the current standard of care for esophageal pathology involves resection of the affected tissue,sometimes involving radical esophagectomy.Without exception,these procedures are associated with a high morbidity,compromised quality of life,and unacceptable mortality rates.Regenerative medicine approaches to functional tissue replacement include the use of biological and synthetic scaffolds to promote tissue remodeling and growth.In the case of esophageal repair,extracellular matrix(ECM) scaffolds have proven to be effective for the reconstruction of small patch defects,anastomosis reinforcement,and the prevention of stricture formation after endomucosal resection(EMR).More so,esophageal cancer patients treated with ECM scaffolds have shown complete restoration of a normal,functional,and disease-free epithelium after EMR.These studies provide evidence that a regenerative medicine approach may enable aggressive resection of neoplastic tissue without the need for radical esophagectomy and its associated complications. | Ricardo Londono Blair A Jobe Toshitaka Hoppo Stephen F Badylak | 2012 | World Journal of Gastroenterology2012，18，47： | 4 |
| 2 | Aplastic anemia and severe pancytopenia during treatment with peg-interferon,ribavirin and telaprevir for chronic hepatitis C显示文摘Telaprevir and Boceprevir are the first direct acting antivirals approved for chronic hepatitis C in combination with peg-interferon alfa and ribavirin.Pancytopenia due to myelotoxicity caused by these drugs may occur,but severe hematological abnormalities or aplastic anemia(AA) have not been described.We collected all cases of severe pancytopenia observed during triple therapy with telaprevir in four Spanish centers since approval of the drug in 2011.Among 142 cirrhotic patients receiving treatment,7 cases of severe pancytopenia(5%) were identified and three were consistent with the diagnosis of AA.Mean age was 59 years,five patients had compensated cirrhosis and two patients had severe hepatitis C recurrence after liver transplantation.Severe pancytopenia was diagnosed a median of 10 wk after the initiation of therapy.Three patients had pre-treatment hematological abnormalities related to splenomegaly.In six patients,antiviral treatment was interrupted at the onset of hematological abnormalities.Two patients died due to septic complications and one patient due to acute alveolar hemorrhage.The remaining patients recovered.Severe pancytopenia and especially AA,are not rare during triple therapy with telaprevir in patients with advanced liver disease.Close monitoring is imperative in this setting to promptly detect serious hematological disorders and to prevent further complications. | Sabela Lens Jose L Calleja Ana Campillo Jose A Carrion Teresa Broquetas Christie Perello Juan de la Revilla Zoe Marino Maria-Carlota Londono Jose M Sanchez-Tapias Alvaro Urbano-Ispizua Xavier Forns | 2015 | World Journal of Gastroenterology2015，21，17： | 4 |
| 3 | Hyponatremia impairs early posttransplantation outcome in patients with cirrhosis undergoing liver transplantation显示文摘 | Londono MC Guevara M Rimola A | 2006 | Gastroenterology2006，130，4： | 1 |
| 4 | Nutritive value of tropical tree leaf meals in adult sows显示文摘 | LETERME P BOTERO M LONDONO A M | 2006 | Journal of Animal Science2006，82，2： | 1 |
| 5 | Therapeutic efficacy and safety of methotrexate + leflunomide in Colombian patients with ac- tive rheumatoid arthritis refractory to conventional treatment显示文摘 | Londono J Santos AM Santos PI | 2012 | Rev Bras Reumatol2012，52，6： | 1 |
| 6 | Extraction of a hydrophilic compound from water into liquid CO2 using dendritic surfactants显示文摘 | Londono J D Wignall G | 1997 | Nature1997，389，： | 1 |
| 7 | A network resource mapping service for distributed applications显示文摘 | Londono J Bestavros A | 2008 | IEEE International Symposium on IPDPS2008，，： | 1 |
| 8 | Insertion of FLT3 internal tandem duplication in the tyrosine kinase domain-1 is associated with resistance to chemotherapy and inferior outcome 显示文摘 | Kayser S Schlenk RF Londono MC | 2009 | Blood2009，114，12： | 1 |
| 9 | Con- trol of glycogen synthase through ADIPOR1 -AMPK pathway in renal distal tubules of normal and diabetic rats显示文摘 | CAMMISOTi-O PG LONDONO I GINGRAS D | 2008 | Am J Physiol Renal Physiol2008，294，4： | 1 |
| 10 | Maerophage phenotype as a predictor of constructive remodeling tolh)wing the implantation of biologically derived surgical mesh materials 显示文摘 | BROWN BN LONDONO R TOTTEY S | 2012 | Acta Biomater2012，8，3： | 1 |
| 11 | Chiari I malformation associated with syringomyelia and scoliosis 显示文摘 | Ghanem IB Londono C Delalande O | 1997 | Spine (Phila Pa 1976)1997，22，： | 1 |
| 12 | MELD score and serum with cirrhosis and ascites显示文摘 | Londono MC Cardenas A Guevara M | 2002 | Arch Interrn Med2002，162，： | 1 |
| 13 | Inhibition of Wnt/β-catenin pathway by niclosamide:a therapeutic target for ovarian cancer显示文摘 | AREND R C LONDONO JOSHI A I SAMANT RS | 2014 | Gynecol Oncol2014，134，1： | 1 |
| 14 | Influence of operating parameters on NOx and N2O axial profiles in a circulating fluidized bed combustor显示文摘 | Diego L F Londono C A Wang X S | 1996 | Fuel1996，，8： | 1 |
| 15 | Beneficial effect of and giotensin-blocking agents on graft fibrosis in hepatitis C recurrence after liver transp lantation显示文摘 | Rimola A Londono MC Guevara G | 2004 | Transp lantation2004，78，5： | 1 |
| 16 | Life table analysis of stomal complications following colostomy 显示文摘 | Londono -Schimmer EE Lrong Ap Phillips RK | 1994 | Dis Colon Rectum1994，37，： | 1 |
| 17 | Influence of Operating Parameters on NOx and N2O Axial Profiles in a Circulating Fluidized Bed Combustor显示文摘 | De Diego L F Londono C A Wang X S | 1996 | Fuel1996，75，8： | 1 |
| 18 | Extraction of a hydrophilic comp-ound from water into liquid CO2 using dendritic surfactants显示文摘 | Cooper A I Londono J D Wignaii G | 1997 | Nature1997，389，： | 1 |
| 19 | Isolation,characterization,and molecular cloning of a specific Mycobacterium tuberculosis antigen:identification of a species-specific sequence 显示文摘 | Londono L P Portillo P D | 1991 | Infect Immun1991，59，： | 1 |
| 20 | Heat shock protein 70 gene polymorphisms in Mexican patients with spondyloarthropathies 显示文摘 | Vargas-Alarcon G Londono J D Hemandez-Pacheco G | 2002 | Ann Rheum Dis2002，61，1： | 1 |
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