|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 在中国使用左乙拉西坦和卡马西平单药治疗部分性癫痫发作的比较:一项开放性、非劣效性试验的主要结果显示文摘目的针对≥16岁、新诊断或最近诊断为部分性癫痫发作的中国患者,比较左乙拉西坦和速释卡马西平(CBZ-IR)单药治疗的疗效。方法在Ⅲ期、随机分配、开放性试验N01364(NCT01954121)中,患者按1∶1的比例随机分配接受左乙拉西坦1 000 mg/d或CBZ-IR 400 mg/d,记录6个月无癫痫发作的患者比例及患者保留率、首次癫痫发作的时间、因不良事件或缺乏疗效导致首次癫痫发作/中止试验的时间、安全性和耐受性。结果在对符合方案集进行的分析中,接受左乙拉西坦治疗的186例患者中有88例(47.3%),接受CBZ-IR治疗的171例患者中有117例(68.4%)达到6个月无癫痫发作;校正后绝对差值为-22.9%(95%CI:-33.1%,-12.6%),其下限低于非劣效性界值-20%。左乙拉西坦组的患者保留率为48.4%,CBZ-IR组为70.2%。对于评估期首次癫痫发作时间,左乙拉西坦与CBZ-IR的风险比为2.686(95%CI:1.838,3.927);对于因不良事件或缺乏疗效导致首次癫痫发作/中止试验的时间,风险比为2.338(95%CI:1.629, 3.356)。使用左乙拉西坦在治疗中出现的不良事件(61.9%)略低于CBZ-IR(67.9%)。结论在低剂量单药治疗下,无法确定左乙拉西坦的疗效不低于CBZ-IR。左乙拉西坦的安全性/耐受性情况优于CBZ-IR。 | 廖卫平 周东 Toru Osakabe Christian Loesch 杜新鲁 Frank Tennigkeit 王学峰 | 2020 | 临床神经病学杂志2020，33，5： | 8 |
| 2 | Microbiology and treatment of halitosis 显示文摘 | Loesche W J KazorC | 2000 | Periodonto12000，28，： | 1 |
| 3 | Eribulin monotherapy versus treatment of physician's choice in patients with metastatic breast cancer (EMBRACE): a phase 3 open-label randomised study显示文摘 | Cortes J O'Shaughnessy J Loesch D | 2011 | Lancet2011，377，9769： | 1 |
| 4 | Mitochon-drial nitric oxide synthase-a ubiquitous regulator of oxidative phosphorylation显示文摘 | Bates TE Loesch A Burnstock G | 1996 | Biochem Biophys Res Commun1996，218，： | 1 |
| 5 | Cramer-rao bound for circular and noncircular complex independent component analysis 显示文摘 | Loesch B Yang B | 2013 | IEEE Transactions on Signal Processing2013，61，2： | 1 |
| 6 | Steric Effects in the State Spe- cific ReactionLi + HF (v=1, j=1,m=0) → LiF +H显示文摘 | LOESCH H J STIENKEMEIER F | 1993 | Journal of Chemical Physics1993，98，12： | 1 |
| 7 | Endothelium of human umbilical blood vessels: Ultrastructure immunolocalization of neuropeptides显示文摘 | Cai WQ Bodin P Loesch A | 1993 | J Vase Res1993，30，2： | 1 |
| 8 | Comparative resistance of opaque-2 and normal inbred lines of maize to ear-rotting pathogens 显示文摘 | Loesch P J Jr Foley D C Cox D F | 1976 | Crop Sci1976，16，6： | 1 |
| 9 | Personal oral hygiene and chronic periodontitis:a systematic review显示文摘 | Hujoel PP Cunha-Cruz J Loesche WJ | 2005 | Periodontol2005，37，2： | 1 |
| 10 | Spectral evolution of a blocking episode and comparison with wave interaction theory显示文摘 | COLUCCI S J LOESCH A Z BOSART L F | 1981 | JAS1981，38，： | 1 |
| 11 | Role of Streptococcus nuuans in human dental decay 显示文摘 | Loesche WJ | 1986 | Microbiol Rev1986，50，4： | 1 |
| 12 | Three-dimensional quantum mechanical study of the Li + HF→LiF + H process: Calculation of integral and differential cross sections显示文摘 | BAERr M LAST I LOESCH H J | 1994 | J Chem Phys1994，101，11： | 1 |
| 13 | Rapid release of endothelin and ATP from isolated aortic endothelial cells exposed to increased flow显示文摘 | Milner P Bodin P Loesch A | 1990 | Biochem Biophys Res Commun1990，170，2： | 1 |
| 14 | Microbiology and treatment of halitosis显示文摘 | Loesche WJ Kazor C | 2002 | Periodontol 20002002，28，： | 1 |
| 15 | Treatment of Perioddontal infections due to anaerobeic with short - term treatment with metronidazole显示文摘 | | 1981 | J Clin Periodontal1981，8，： | 1 |
| 16 | Periodontal disease as a specific, albeit chronic, infection : diagnosis and treatment 显示文摘 | Loesche WJ Grossman NS | 2001 | Clin Micro- biol Rev2001，14，4： | 1 |
| 17 | Treatment of Periodont Infections Due to Anaerobic Bacteria with Short-term Treatment with Metronidazole显示文摘 | Loesche W J Syed S A Morrison E C | 1981 | J Clin Periodontol1981，8，： | 1 |
| 18 | Personal oral hygiene and chronic periodontitis:a systematic review显示文摘 | Hujoel PP Cunha-Ciuz J Loesche WJ | 2005 | Periodontol2005，37，2： | 1 |
| 19 | Role of Streptococcus mutans in human dental decay显示文摘 | Loesche W J | | 0，，04： | 1 |
| 20 | Steric effects in the state specific reaction Li+HF (v=1,j=1, m=0)→LiF+H显示文摘 | LOESCH H J STIENKEMEIER F | 1993 | J Chem Phys1993，98，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员