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| 1 | Stenting for symptomatic intracranial arterial stenosis in China:1-year outcome of a multicentre registry study显示文摘background and purpose A multicentre prospective registry study of individually tailored stenting for a patient with symptomatic intracranial atherosclerotic stenosis(ICAS)combined with poor collaterals in China showed that the short-term safety and efficacy of stenting was acceptable.However,it remained uncertain whether the low event rate could be of a long term.We reported the 1-year outcome of this registry study to evaluate the long-term efficacy of individually tailored stenting for patients with severe symptomatic ICAS combined with poor collaterals.Methods Patients with symptomatic ICAS caused by 70%-99% stenosis located at the intracranial internal carotid,middle cerebral,intracranial vertebral or basilar arteries combined with poor collaterals were enrolled.Balloon-mounted stent or balloon plus self-expanding stent were selected based on the ease of vascular access and lesion morphology determined by the operators.The primary outcome was the rate of 30-day stroke,transient ischaemic attack and death,and 12-month ischaemic stroke within the same vascular territory,haemorrhagic stroke and vascular death after stenting.results From September 2013 to January 2015,300 patients(ages 58.3±9.78 years)were recruited.Among them,159 patients were treated with balloon-mounted stent and 141 with balloon plus self-expanding stent.During the 1-year follow-up,25 patients had a primary end point event.The probability of primary outcome at 1 year was 8.1%(95% CI 5.3% to 11.7%).In 76 patients with digital subtraction angiography follow-up,27.6%(21/76)had re-stenosis≥50% and 18.4%(14/76)had re-stenosis≥70%.No baseline characteristic was associated with the primary outcome.Conclusion The event rate remains low over 1 year of individually tailored stenting for patients with severe symptomatic ICAS combined with poor collaterals.Further randomised trial of comparing individually tailored stenting with best medical therapy is needed. | Ning Ma Yong Zhang Jie Shuai Changchun Jiang Qiyi Zhu Kangning Chen Li Liu Baomin Li Xiangqun Shi Lianbo Gao Yajie Liu Feng Wang Yongli Li Tieyan Liu Hongbo Zheng Dapeng Mo Feng Gao Yilong Wang Yongjun Wang Lei Feng Zhongrong Miao | 2018 | Stroke & Vascular Neurology2018，3，3： | 29 |
| 2 | FGF21 treatment ameliorates alcoholic fatty liver through activation of AMPK-SIRT1 pathway显示文摘成纤维细胞生长因素 21 (FGF21 ) , FGF 总科的一个最近识别的成员,主要从肝和脂肪质的纸巾被分泌并且在改进新陈代谢的症候群和动态平衡起一个重要作用。这研究的目的是在含酒精的脂肪肝疾病(AFLD ) 评估 FGF21 的角色并且决定它是否在 AFLD 上有治疗学的效果。在这份报纸,我们在长期的乙醇 gavage 和对待白酒的 HepG2 房间的一个鼠科的模型在导致白酒的肝损害上测试了 FGF21 的效果。男千米;公里老鼠每天收到了 5 g/kg 乙醇 gavage 的单个剂量 6 个星期,它导致了重要脂肪肝和肝损害。导致白酒的脂肪肝房间模型被在 75 公里的最后的集中增加乙醇进 HepG2 房间文化的媒介 9 天完成。结果与 recombinant FGF21 显示出那个处理在长期的乙醇 gavage 和对待白酒的 HepG2 房间的一个鼠科的模型的改善含酒精的脂肪肝和肝损害。另外, FGF21 处理下面调整丰满的酸的肝的表示合成的关键酶,激活的肝的 AMPK-SIRT1 小径和显著地下面调整的肝的氧化压力蛋白质。一起拿, FGF21 由 AMPK-SIRT1 小径的激活在 vitro 并且在 vivo 改正 AFLD 的多重新陈代谢的参数。 | Shenglong Zhu Lei Ma Yunzhou Wu Xianlong Ye Tianyuan Zhang Qingyang Zhang Lubna Muhi Rasoul Yunye Liu MO Guo Bing Zhou Guiping Ren Deshan Li | 2014 | Acta Biochimica et Biophysica Sinica2014，46，12： | 11 |
| 3 | Abnormal strain changes observed at Guza before the Wenchuan earthquake显示文摘An YRY-4 type borehole strainmeter at Guza station on the southwest end of the Longmenshan fault zone recorded anomalous changes from time to time since about one year before the Wenchuan earthquake.The anomaly is characterized by steps and/or asymmetrical pulses of short-periods(minutes-hours).Among about one hundred stations over the mainland of China,only Guza,the nearest one to the seismic area,observed such changes.A self-check function of the strainmeter helps confirm the credibility of the observation.The anomalous signals do not correspond to seasonal changes.The consistency in the sense of strain among long-term,anomalous interfering and coseismic changes suggests that they all resulted from the background tectonic movement.Results of an Overrun Rate Analysis further illustrate a close temporal relevance of the anomaly to the Wenchuan earthquake:its increase before,and decrease after the biggest changes during the main shock.The abnormal changes are attributed to local small-scale fractures with an evidential clue that the only Ms4.5 foreshock near Guza station on February 27,2008 produced the biggest anomalous change.By means of Wavelet Decomposition,it is revealed that longer period portion of the anomaly took place later before the main shock,consistent with the idea that scales of small fractures increase during earthquake preparation process.The anomalous strain changes are analogous to the stress changes observed before the 1976 Tangshan earthquake. | QIU ZeHua ZHANG BaoHong CHI ShunLiang TANG Lei SONG Mo | 2011 | Science China Earth Sciences2011，54，2： | 10 |
| 4 | Typical atmospheric haze during crop harvest season in northeastern China:A case in the Changchun region显示文摘This study presents the mass concentrations of PM_(2.5),O_3,SO_2 and NOxat one urban,one suburban and two rural locations in the Changchun region from September 25 to October 272013. Major chemical components of PM_(2.5)at the four sites were daily sampled and analyzed. Most of daily concentrations of SO_2(7–82 μg/m^3),O_3(27–171 μg/m^3) and NOx(14–213 μg/m^3) were below the limits of the National Ambient Air Quality Standard(NAAQS)in China. However,PM_(2.5)concentrations(143–168 μg/m^3) were 2-fold higher than NAAQS.Higher PM_(2.5)concentrations(~ 150 μg/m^3) were measured during the pre-harvest and harvest at the urban site,while PM_(2.5)concentrations significantly increased from 250 to400 μg m^(-3) at suburban and rural sites with widespread biomass burning. At all sites,PM_(2.5)components were dominated by organic carbon(OC) and followed by soluble component sulfate(SO_4^(2-)),ammonium(NH_4^+) and nitrate(NO_3^-). Compared with rural sites,urban site had a higher mineral contribution and lower potassium(K^+and K) contribution to PM_(2.5).Severe atmospheric haze events that occurred from October 21 to 23 were attributed to strong source emissions(e.g.,biomass burning) and unfavorable air diffusion conditions.Furthermore,coal burning originating from winter heating supply beginning on October 18 increased the atmospheric pollutant emissions. For entire crop harvest period,the Positive Matrix Factorization(PMF) analysis indicated five important emission contributors in the Changchun region,as follows: secondary aerosol(39%),biomass burning(20%),supply heating(18%),soil/road dust(14%) and traffic(9%). | Wei Wei Chen Daniel Q.Tong Mo Dan Shi Chun Zhang Xue Lei Zhang Yue Peng Pan | 2017 | Journal of Environmental Sciences2017，29，4： | 10 |
| 5 | Effect of repaglinide and gliclazide on glycaemic control, early-phase insulin secretion and lipid profiles in newly diagnosed type 2 diabetics显示文摘repaglinide 和 gliclazide 是的背景广泛地在类型 2 diabetes.They 的治疗使用的胰岛素促泌素通过不同机制刺激胰岛素分泌物并且可以从学习是在 glycaemic 控制上评估 repaglinide 或 gliclazide 的效果的在场的不同 aspects.The 有益于病人,胰岛素分泌物,并且类脂化合物在 47 全部的 A 最新诊断了的类型 2 糖尿病 patients.Methods 介绍打 2 个糖尿病病人被使随机化与 repagl 接受4星期的治疗的 | ZHANG Hong BU Ping XIE Yan-hong LUO Juan LEI Min-xiang MO Zhao-hui LIAO Er-yuan | 2011 | Chinese Medical Journal2011，，2： | 10 |
| 6 | Locoregional extension patterns of nasopharyngeal carcinoma and suggestions for clinical target volume delineation显示文摘Clinical target volume (CTV) delineation is crucial for tumor control and normal tissue protection. This study aimed to define the locoregional extension patterns of nasopharyngeal carcinoma (NPC) and to improve CTV delineation. Magnetic resonance imaging scans of 2366 newly diagnosed NPC patients were reviewed. According to incidence rates of tumor invasion, the anatomic sites surrounding the nasopharynx were classified into high-risk (>30%), medium-risk (5%-30%), and low-risk (<5%) groups. The lymph node (LN) level was determined according to the Radiation Therapy Oncology Group guidelines, which were further categorized into the upper neck (retropharyngeal region and level Ⅱ), middle neck (levels Ⅲ and Va), and lower neck (levels Ⅳ and Vb and the supraclavicular fossa). The high-risk anatomic sites were adjacent to the nasopharynx, whereas those at medium- or low-risk were separated from the nasopharynx. If the high-risk anatomic sites were involved, the rates of tumor invasion into the adjacent medium-risk sites increased; if not, the rates were significantly lower (P < 0.01). Among the 1920 (81.1%) patients with positive LN, the incidence rates of LN metastasis in the upper, middle, and lower neck were 99.6% , 30.2%, and 7.2%, respectively, and skip metastasis happened in only 1.2% of patients. In the 929 patients who had unilateral upper neck involvement, the rates of contralateral middle neck and lower neck involvement were 1.8% and 0.4%, respectively. Thus, local disease spreads stepwise from proximal sites to distal sites, and LN metastasis spreads from the upper neck to the lower neck. Individualized CTV delineation for NPC may be feasible. | Wen-Fei Li Ying Sun Mo Chen Ling-Long Tang Li-Zhi Liu Yan-Ping Mao Lei Chen Guan-Qun Zhou Li Li Jun Ma | 2012 | Chinese Journal of Cancer2012，31，12： | 10 |
| 7 | Mesoscopic Simulation Assistant Design of Immiscible Polyimide/BN Blend Films with Enhanced Thermal Conductivity显示文摘The mesoscopic simulation technique was applied to describe the phase separation behavior of polyimide blends and used for design of immiscible polyimide/BN blend films with enhanced thermal conductivity. The simulation equilibrium morphologies of different poly(amic acid)(PAA) blend systems were investigated and compared with optical images of corresponding polyimide blend films obtained by experiment. The immiscible polyimide blend films containing nano-/micro-sized BN with vertical double percolation structure were prepared. The result indicated that the thermal conductivity of polyimide blend film with 25 wt% nano-sized BN reached1.16 W/(m·K), which was 236% increment compared with that of the homogenous film containing the same BN ratio. The significant enhancement in thermal conductivity was attributed to the good phase separation of polyimide matrix, which made the inorganic fillers selectively localized in one continuous phase with high packing density, consequently, forming the effective thermal conductive pathway. | Guo-Dong Zhang Lin Fan Lan Bai Min-Hui He Lei Zhai Song Mo | 2018 | Chinese Journal of Polymer Science2018，36，12： | 9 |
| 8 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 9 | The role of climate factors in geographic variation in body mass and wing length in a passerine bird显示文摘Background: Geographic variation in body size is assumed to reflect adaptation to local environmental conditions. Although Bergmann's rule is usually sufficient to explain such variation in homeotherms, some exceptions have been documented. The relationship between altitude, latitude and body size, has been well documented for some vertebrate taxa during the past decades. However, relatively little information is available on the effects of climate variables on body size in birds.Methods: We collected the data of 267 adult Eurasian Tree Sparrow(Passer montanus) specimens sampled at 48 localities in China's mainland, and further investigated the relationships between two response variables, body mass and wing length, as well as a suit of explanatory variables, i.e. altitude, latitude, mean annual temperature(MAT), annual precipitation(PRC), annual sunshine hours(SUN), average annual wind speed(WS), air pressure(AP) and relative humidity(RH).Results: Our study showed that(1) although the sexes did not differ significantly in body mass, males had longer wings than females;(2) body mass and wing length were positively correlated with altitude but not with latitude;(3) body mass and wing length were negatively correlated with AP and RH, but not significantly correlated with WS. Body mass was positively correlated with SUN and inversely correlated with MAT. Wing length was not correlated with MAT in either sex, but was positively correlated with SUN and negatively correlated with PRC in male sparrows;(4) variation in body mass could be best explained by AP and SUN, whereas variation in wing length could be explained by RH and AP in both sexes. In addition, variation in male sparrows can be explained by SUN, WS and PRC but not in females.Conclusions: Two different proxies of body size, body mass and wing length, correlated with same geographic factors and different climate factors. These differences may reflect selection for heat conservation in the case of body mass, and for efficient flight in the case of wing length. | Yanfeng Sun Mo Li Gang Song Fumin Lei Dongming Li Yuefeng Wu | 2017 | Chinese Birds2017，，1： | 7 |
| 10 | Autonomic Disturbances in Acute Cerebrovascular Disease显示文摘Autonomic disturbances often occur in patients with acute cerebrovascular disease due to damage of the central autonomic network. We summarize the structures of the central autonomic network and the clinical tests used to evaluate the functions of the autonomic nervous system.We review the clinical and experimental findings as well as management strategies of post-stroke autonomic disturbances including electrocardiographic changes, cardiac arrhythmias, myocardial damage, thermoregulatory dysfunction, gastrointestinal dysfunction, urinary incontinence, sexual disorders, and hyperglycemia. The occurrence of autonomic disturbances has been associated with poor outcomes in stroke patients. Autonomic nervous system modulation appears to be an emerging therapeutic strategy for stroke management in addition to treatments for sensorimotor dysfunction. | Jun Mo Lei Huang Jianhua Peng Umut Ocak Jianmin Zhang John H.Zhang | 2019 | Neuroscience Bulletin2019，35，1： | 6 |
| 11 | Clinical Characteristics of Hospitalized Patients with SARS-CoV-2 and Hepatitis B Virus Co-infection显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)is a global pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2).SARS-Co V-2 infection was first detected in Wuhan,China in late December 2019.The virus was spreading rapidly to other cities of China and accumulating cases had been reported(Li et al.2020). | Xiaoping Chen Qunqun Jiang Zhiyong Ma Jiaxin Ling Wenjia Hu Qian Cao Pingzheng Mo Lei Yao Rongrong Yang Shicheng Gao Xien Gui Wei Hou Yong Xiong Jinlin Li Yongxi Zhang | 2020 | Virologica Sinica2020，35，6： | 6 |
| 12 | The Role of OsMSH5 in Crossover Formation during Rice Meiosis显示文摘MSH5,傻瓜相当或相同的事物家庭的一个成熟分裂特定的成员,在开始发育的酵母,老鼠, Caenorhabditis elegans,和 Arabidopsis 为再结合的正常水平被要求。这里,我们报导它的米饭相当或相同的事物的鉴定和描述, OsMSH5,并且在米饭表明它的功能成熟分裂。五独立 Osmsh5 异种展出了正常植物的生长和严重绝育。当交叉频率极大地被归结为观察了在那中的约 10% 个时, synaptonemal 建筑群很好在 Osmsh5 被安装野类型,导致相应不分离和完全的无菌的显型。OsMSH5 主要在圆锥花序被表示。Immunofluorescence 研究显示 OsMSH5 chromosomal 本地化限于早 meiotic 前期我。OsMSH5 能在 Oszip4, Osmer3,和 hei10 被装载到 meiotic 染色体上。然而,那些 ZMM 蛋白质不能当 OsMSH5 不在时通常是局部性的。而且,剩余 chiasmata 被显示在 zmm 异种之中最不经常,包括 Osmer3, Oszip4, hei10,和 Osmsh5。一起拿,我们建议 OsMSH5 工作在一级转线路的 OsZIP4, OsMER3,和 HEI10 在上游形成。 | Qiong Luo Ding Tang MO Wang Weixiong Luo Lei Zhang Baoxiang Qin Yi Shen Kejian Wang Yafei Li Zhukuan Cheng | 2013 | Molecular Plant2013，6，3： | 5 |
| 13 | Utility of MtCOI polymerase chain reaction-restriction fragment length polymorphism in differentiating between Q and B whitefly Bemisia tabaci biotypes显示文摘侵略,杀虫药剂抵抗, Q 白苍蝇遗传因子型,逐渐地经由植物材料的调停人的运动包括 US 传播了到另外的国家。我们估计了基于 VspI 的 mtCOI 的用途(线粒体细胞色素 oxidase 我) 是的聚合酶链反应限制碎片长度多型性(PCR-RFLP ) 技术为在亚利桑那把 Q 区分开来与主导的 B 遗传因子型的一种快速、划算、可靠的选择。用定序的标准 mtCOI 基因和 mtCOI PCR-RFLP 技术,我们八个白苍蝇五个个人拉紧的 biotyped 各在亚利桑那在不同地点从一品红和棉花收集了。完全的词语索引在二个方法之间被观察,与作为象 B 遗传因子型的 Q 遗传因子型和五件样品被识别的三紧张。我们也在在 GenBank 数据库当前可得到的 B 和 Q 遗传因子型白人苍蝇为 VspI 多型性扫描了 mtCOI 基因序列。这全球屏蔽分别地为 Q 和 B 遗传因子型揭示了三和四种 VspI 多态的类型的存在。不过,所有三个 VspI 多态的 Q 遗传因子型白人苍蝇分享了能被用来把 Q 遗传因子型区分开来与识别的四个 VspI 多态的 B 遗传因子型白人苍蝇的一个普通、唯一的 VspI 地点。这些结果证明基于 VspI 的 mtCOI 基因 PCR-RFLP 为区分白色在 US 并且在其它地方飞的 Q 和 B 遗传因子型提供一个可靠诊断工具。 | Wei-Hua Ma Xian-Chun Li Timothy J. Dennehy Chao-Liang Lei Mo Wang Benjamin A. Degain Robert L. Nichols | 2009 | Insect Science2009，16，2： | 5 |
| 14 | Inducing Flow Velocities to Manage Fish Reproduction in Regulated Rivers显示文摘Conservation of endangered or economic fish and control of invasive fish is a great challenge of hydraulic engineering worldwide.Flow velocity has been recognized to affect the spawning of fishes delivering drifting eggs in rivers.However,solid scientific supports and associated mechanisms to establish quantitative relations between flow velocity and fish reproduction,taking into account spawning,fertilizing,hatching,as well as surviving,are lacking.In this paper,we quantified the relationship between flow velocity and reproduction of Chinese carps through both lab and field experiments.The results showed that a minimum velocity was required to trigger Hypophthalmichthys molitrix(H.molitrix)releasing eggs,and a velocity range was preferred to sustain spawning activity.However,the embryo incubation and larvae development of H.molitrix were found to be inhibited with the increase in flow velocity.Considering the requirements of spawning and hatching,as well as larvae surviving,an optimized flow velocity processes was identified for the reproduction of H.molitrix in rivers.These findings were of great significance to the adaptive operation of reservoirs to create reasonable and precise ecological flows for managing fish reproduction,as shown by the promising results in the engineering application to the Three Gorges Reservoir. | Qiuwen Chen Jianyun Zhang Yuchen Chen Kangle Mo Jun Wang Lei Tang Yuqing Lin Lei Chen Yong Gao Wei Jiang Yuxin Zhang | 2021 | Engineering2021，7，2： | 4 |
| 15 | Thermal Expansion Behavior of Poly(amide-imide)Films with Ultrahigh Tensile Strength and Ultralow CTE显示文摘A series of novel poly(amide-imide)(PAl)films with different amide contents were prepared from pyromellitic dianhydride and four amide-containing diamines.These PAl films exhibited excellent mechanical and thermal properties with tensile strength of 203.7-297.4 MPa and Tg above 407℃.The rigid backbone structures combined with strong intermolecular interactions provided PAl films with ultralow in-plane CTE values from-4.17 ppm/℃to-0.39 ppm/℃in the temperature range of 30-300℃.The correlation between thermal expansion behavior and aggregation structures of PAl film was investigated.The results suggested that hydrogen bonding interactions could be maintained even at high temperature,thus resulting in good dimension reversibility of films in multiple heating-cooling cycles.It is demonstrated that dimensional stabilities of PAl films are determined by the rigidity,orientation,and packing of molecular chains.Heat-resistant PAl films with ultralow CTE can be developed as flexible substrates by regulating backbones and aggregation structures for optoelectronic application. | Lan Bai Lei Zhai Min-Hui He Chang-Ou Wang Song Mo Lin Fan | 2020 | Chinese Journal of Polymer Science2020，38，7： | 4 |
| 16 | Nitrogen deposition and its ecological impact in China: An overview显示文摘 | Xuejun Liu Lei Duan Jiangming Mo Enzai Du Jianlin Shen Xiankai Lu Ying Zhang Xiaobing Zhou Chune He Fusuo Zhang | 2010 | Environmental Pollution2010，，10： | 4 |
| 17 | Ethyl Acetate Fraction of Dicliptera chinensis(L.)Juss.Ameliorates Liver Fibrosis by Inducing Autophagy via PI3K/AKT/m TOR/p70S6K Signaling Pathways显示文摘Objective:To investigate the molecular mechanism underlying the anti-hepatic fibrosis activity of ethyl acetate fraction Dicliptera chinensis(L.)Juss.(EDC)in human hepatic stellate cells(HSCs)in vitro and in a carbon tetrachloride(CCl4)-induced hepatic fibrosis mouse model in vivo.Methods:For in vitro study,HSCs were pre-treated with platelet-derived growth factor(10 ng/mL)for 2 h to ensure activation and treated with EDC for 24 h and 48 h,respectively.The effect of EDC on HSCs was assessed using cell counting kit-8 assay,EdU staining,transmission electron microscopy,immunofluorescence staining,and Western blot,respectively.For in vivo experiments,mice were intraperitoneally injected with CCl4(2μL/g,adjusted to a 25%concentration in olive oil),3 times per week for 6 weeks,to develop a hepatic fibrosis model.Forty 8-week-old male C57 BL/6 mice were divided into 4 groups using a random number table(n=10),including control,model,positive control and EDC treatment groups.Mice in the EDC and colchicine groups were intragastrically administered EDC(0.5 g/kg)or colchicine(0.2 mg/kg)once per day for 6 weeks.Mice in the control and model groups received an equal volume of saline.Biochemical assays and histological examinations were used to assess liver damage.Protein expression levels ofα-smooth muscle actin(α-SMA)and microtubule-associated protein light chain 3 B(LC3 B)were measured by Western blot.Results:EDC reduced pathological damage associated with liver fibrosis,downregulated the expression ofα-SMA and upregulated the expression of LC3 B(P<0.05),both in HSCs and the CCl4-induced liver fibrosis mouse model.The intervention of bafilomycin A1 and rapamycin in HSCs strongly supported the notion that inhibition of autophagy enhancedα-SMA protein expression levels(P<0.01).The results also found that the levels of phosphoinositide(PI3 K),p-PI3 K,AKT,p-AKT,mammalian target of rapamycin(mTOR),p-mTOR,and p-p70 S6 K all decreased after EDC treatment(P<0.05).Conclusion:EDC has anti-hepatic fibrosis activity by inducing autophagy and might be a potential drug to be further developed for human liver fibrosis therapy. | LIU Yuan BI Yan-meng PAN Ting ZENG Ting MO Chan SUN Bing GAO Lei LYU Zhi-ping | 2022 | Chinese Journal of Integrative Medicine2022，28，1： | 3 |
| 18 | Dopamine Agonists Exert Nurrl-inducing Effect in Peripheral Blood Mononuclear Cells of Patients with Parkinson's Disease显示文摘 | Li-Min Zhang Cong-Cong Sun Ming-Shu Mo Luan Cen Lei Wei Fei-Fei Luo Yi Li Guo-Fei Li Si-Yun Zhang Li Yi Wei Huang Zhuo-Lin Liu Wei-Dong Leg Ping-Yi Xu | 2015 | Chinese Medical Journal2015，，13： | 3 |
| 19 | Trending IC design directions in 2022显示文摘For the non-stop demands for a better and smarter society, the number of electronic devices keeps increasing exponentially;and the computation power, communication data rate, smart sensing capability and intelligence are always not enough. Hardware supports software, while the integrated circuit(IC) is the core of hardware. In this long review paper, we summarize and discuss recent trending IC design directions and challenges, and try to give the readers big/cool pictures on each selected small/hot topics. We divide the trends into the following six categories, namely, 1) machine learning and artificial intelligence(AI) chips, 2) communication ICs, 3) data converters, 4) power converters, 5) imagers and range sensors, 6) emerging directions. Hope you find this paper useful for your future research and works. | Chi-Hang Chan Lin Cheng Wei Deng Peng Feng Li Geng Mo Huang Haikun Jia Lu Jie Ka-Meng Lei Xihao Liu Xun Liu Yongpan Liu Yan Lu Kaiming Nie Dongfang Pan Nan Qi Sai-Weng Sin Nan Sun Wenyu Sun Jiangtao Xu Jinshan Yue Milin Zhang Zhao Zhang | 2022 | Journal of Semiconductors2022，43，7： | 3 |
| 20 | The biomarkers of immune dysregulation and inflammation response in Parkinson disease显示文摘Parkinson’s disease(PD)is referring to the multi-systemicα-synucleinopathy with Lewy bodies deposited in midbrain.In ageing,the environmental and genetic factors work together and overactive major histocompatibility complex pathway to regulate immune reactions in central nerve system which resulting in neural degeneration,especially in dopaminergic neurons.As a series of biomarkers,the human leukocyte antigen genes with its related proteomics play cortical roles on the antigen presentation of major histocompatibility complex molecules to stimulate the differentiation of T lymphocytes and i-proteasome activities under their immune response to the PD-related environmental alteration and genetic variation.Furthermore,dopaminergic drugs change the biological characteristic of T lymphatic cells,affect theα-synuclein presentation pathway,and inhibit T lymphatic cells to release cytotoxicity in PD development.Taking together,the serum inflammatory factors and blood T cells are involved in the immune dysregulation of PD and inspected as the potential clinic biomarkers for PD prediction. | Li Chen Mingshu Mo Guangning Li Luan Cen Lei Wei Yousheng Xiao Xiang Chen Shaomin Li Xinling Yang Shaogang Qu Pingyi Xu | 2016 | Translational Neurodegeneration2016，5，1： | 3 |
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