|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 中国西南地区晚二叠世泥炭地净初级生产力及其控制因素显示文摘米兰科维奇旋回理论是古环境研究中重要的时间'度量'工具。文中以贵州普安糯东17号煤层和云南富源天佑10号煤层为例,对晚二叠世煤层的地球物理测井信号进行频谱分析,以获得其中的米兰科维奇轨道周期参数。研究发现,测井信号所反映出的煤层灰分含量变化受泥炭地发育时期的米兰科维奇轨道周期(123ka(偏心率):35.6ka(斜率):21.2ka(岁差))驱动。以煤层剖面中的轨道周期为时间尺度,进一步计算出晚二叠世泥炭地的碳聚集速率为54.3~77.0gC/(m2.a),对应的净初级生产力(NPP)为543~1540gC/(m2.a)。基于晚二叠世、晚石炭世和现代热带泥炭地的NPP与各个时期大气成分的对比结果显示,大气中的二氧化碳和氧气含量对陆相生态系统的净初级生产力具有关键性的控制作用。 | 邵龙义 汪浩 Large D J | 2011 | 古地理学报2011，13，5： | 14 |
| 2 | 早白垩世泥炭地净初级生产力及其控制因素——来自二连盆地吉尔嘎郎图凹陷6号煤的证据显示文摘现代泥炭地中蕴藏着巨量的碳,泥炭地生产力的高低会影响全球碳循环及全球气候变化。前人对全新世以来泥炭地生产力做了大量研究,但对前第四纪的'深时'阶段的泥炭地生产力则极少涉及,其主要原因是缺少精确的定年方法。以二连盆地吉尔嘎郎图凹陷早白垩世6号煤为例,利用地球物理测井信号进行频谱分析并获得煤层中米兰科维奇旋回周期参数(123 ka(偏心率):38.1 ka(斜率):22.1 ka(岁差)),将米兰科维奇旋回作为'深时'地层时间的'度量'工具,计算出6号煤层碳的聚集速率为35.1~38.9 gC/(m^2·a),进一步推算出其所代表的泥炭地的碳聚集速率为46.2~51.2 gC/(m^2·a),净初级生产力(NPP)为231~256 gC/(m^2·a)。将该计算结果与全新世同一纬度带泥炭地生产力水平比较,并结合前人研究成果综合分析影响因素,得出早白垩世泥炭地生产力水平主要受温度和大气中二氧化碳含量控制,而这两种因素又与气候相关联,则泥炭地生产力的研究可能对进一步了解古气候提供帮助。 | 闫志明 邵龙义 王帅 Large D J 汪浩 孙钦平 | 2016 | 沉积学报2016，34，6： | 8 |
| 3 | Three-dimensional perfused human in vitro model of nonalcoholic fatty liver disease显示文摘AIM To develop a human in vitro model of non-alcoholic fatty liver disease(NAFLD), utilising primary hepatocytes cultured in a three-dimensional(3D) perfused platform. METHODS Fat and lean culture media were developed to directly investigate the effects of fat loading on primary hepatocytes cultured in a 3D perfused culture system. Oil Red O staining was used to measure fat loading in the hepatocytes and the consumption of free fatty acids(FFA) from culture medium was monitored. Hepatic functions, gene expression profiles and adipokine release were compared for cells cultured in fat and lean conditions. To determine if fat loading in the system could be modulated hepatocytes were treated with known anti-steatotic compounds. RESULTS Hepatocytes cultured in fat medium were found to accumulate three times more fat than lean cells and fat uptake was continuous over a 14-d culture. Fat loading of hepatocytes did not cause any hepatotoxicity and significantly increased albumin production. Numerous adipokines were expressed by fatty cells and genes associated with NAFLD and liver disease were upregulated including: Insulin-like growth factorbinding protein 1, fatty acid-binding protein 3 and CYP7A1. The metabolic activity of hepatocytes cultured in fatty conditions was found to be impaired and the activities of CYP3A4 and CYP2C9 were significantlyreduced, similar to observations made in NAFLD patients. The utility of the model for drug screening was demonstrated by measuring the effects of known antisteatotic compounds. Hepatocytes, cultured under fatty conditions and treated with metformin, had a reduced cellular fat content compared to untreated controls and consumed less FFA from cell culture medium.CONCLUSION The 3D in vitro NAFLD model recapitulates many features of clinical NAFLD and is an ideal tool for analysing the efficacy of anti-steatotic compounds. | Tomasz Kostrzewski Terri Cornforth Sophie A Snow Larissa Ouro-Gnao Cliff Rowe Emma M Large David J Hughes | 2017 | World Journal of Gastroenterology2017，23，2： | 6 |
| 4 | FOLFIRINOX and translational studies: Towards personalized therapy in pancreatic cancer显示文摘Pancreatic cancer is an extremely aggressive disease; although progress has been made in the last few years, the prognosis of these patients remains dismal. FOLFIRINOX is now considered a standard treatment in first-line setting, since it demonstrated an improved overall and progression-free survival vs gemcitabine alone. However, the enthusiasm over the benefit of this three-drug regimen is tempered by the associated increased toxicity profile, and many efforts have been made to improve the feasibility of this schedule. After a more recent phase Ⅲ trial showing an improved outcome over gemcitabine, the combination of gemcitabine/nab-paclitaxel emerged as another standard first-line treatment. However, this treatment is also associated with more side effects. In addition, despite initial promising data on the predictive role of SPARClevels, recent studies showed that these levels are not associated with nab-paclitaxel efficacy. The choice to use this treatment over FOLFIRINOX is therefore a topic of debate, also because no validated biomarkers to guide FOLFIRINOX treatment are available. In the era of actionable mutations and target agents it would be desirable to identify molecular factors or biomarkers to predict response to therapy in order to maximize the efficacy of treatment and avoid useless toxic effects for non-responding patients. However, until today the milestone of treatment for pancreatic cancer remains chemotherapy combinations, without predictive or monitoring tools existing to optimize therapy. This review analyzes the state-of-the-art treatments, promises and limitations of targeted therapies, ongoing trials and future perspectives, including potential role of microR NAs as predictive biomarkers. | Chiara Caparello Laura L Meijer Ingrid Garajova Alfredo Falcone Tessa Y Le Large Niccola Funel Geert Kazemier Godefridus J Peters Enrico Vasile Elisa Giovannetti | 2016 | World Journal of Gastroenterology2016，22，31： | 4 |
| 5 | Suppression of host immune response by the core protein of hepatitis C virus: possible implications for hepatiits C virus persistence显示文摘 | Large M K Kittlesen D J Hahn Y S | 1999 | J Immunol1999，162，2： | 2 |
| 6 | Oceanic vertical mixing: a review and a model with a nonlocal boundary layer parameteriza tion显示文摘 | LARGE W MCWILLIAMS J DONEY S | 1994 | Rev Geophys1994，32，4： | 1 |
| 7 | Gold and trace element zonation in pyrite using a laser imaging technique: Implications for the timing of gold in orogenic and Carlin- style sediment- hosted deposits 显示文摘 | R R Large L Danyushevsky C Hollit V Maslennikov S Meffer S Gilbert S Bull R Scott P Emsbo H Thomas B Singh J Foster | 2009 | Economic Geology2009，104，5： | 1 |
| 8 | Ocean general circulation model sensitivity to forcing from scatterometer winds显示文摘 | Milliff R F Large W G Morzel J | 1999 | Journal of Geophysical Research1999，104，11： | 1 |
| 9 | Silica-volatile interaction and the geological cause of the Xuan Wei lung cancer epidemic显示文摘 | Large D J Baruchspiro S K Tian L W | 2009 | Environmental Science and Technology2009，43，： | 1 |
| 10 | Myristoylated alanine-rich C kinase substrate coordinates native TRPC1 channel activation by phosphatidylinositol 4, 5-bisphosphate and protein kinase C in vascular smooth muscle 显示文摘 | Shi J Birnhaumer L Large WA | 2014 | The FASEB Journal2014，28，1： | 1 |
| 11 | Silica-volatile interaction and the geological cause of the Xuan Wei lungcancer epidemic显示文摘 | LARGE D J BARUCHSPIHO S K TIAN Linwei | 2009 | Environ Sci Technol2009，43，23： | 1 |
| 12 | Factors affecting the yield of cardiac valve allografts from living unrelated donors 显示文摘 | Hunt C J Caffey EA Large SR | 1998 | Eur J Cardiothorac Surg1998，13，1： | 1 |
| 13 | Biases and heuristics in Difference between entrepreneurs organizations 显示文摘 | Busenitz L W Barney strategic decision-making : and managers in large Business venturing 1997 J B | 1997 | Journal of1997，12，1： | 1 |
| 14 | Oceanic vertical mixing: a review and a model with a nonlocal boundary layer parameterization显示文摘 | LARGE W G MCWILLIAMS J C DONEY S C | 1994 | Reviews of Geophysics1994，32，4： | 1 |
| 15 | Impedance analysis of polymer film electrode显示文摘 | Larg G Bacskai J Inzelt G | 1993 | Electochem Acta1993，，38： | 1 |
| 16 | Large eddy simulation of the equatorial ocean boundary layer: diurnal cycle, eddy viscosity and horizontal rotation 显示文摘 | WANG D LARGE W G MCWILLIAMS J C | 1996 | Journal of Geophysical Research1996，101，2： | 1 |
| 17 | Multilayer Reflectors in Animals Using Green and Gold Beetles as Con- trasting Examples显示文摘 | PARKER A R MCKENZIE D R LARGE M C J | 1998 | J Exp Biol1998，201，： | 1 |
| 18 | Littering in context:Personal and environmental predictors of littering behavior显示文摘 | Schultz P W Bator R Tabanico J Bruni C Large L B | 2013 | Environment and Behavior2013，45，： | 1 |
| 19 | ion networks 显示文摘 | Bond J and Peyrat C Diameter vulnnerability of some large interconnect | 1988 | Congressus Numerantium1988，66，： | 1 |
| 20 | Gender differences in collaborative Web searching behavior:an elementary school study显示文摘 | Large A L Beheshti J Rahman T | 2002 | Information Processing and Management2002，38，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员