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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn’s disease patients显示文摘AIM:To investigate the interaction of interleukin-23 receptor(IL23R)(rs1004819 and rs2201841),autophagy-related 16-like 1(ATG16L1)(rs2241880), caspase recruitment domain-containing protein 15 (CARD15)genes,and IBD5 locus in Crohn's disease(CD) patients. METHODS:A total of 315 unrelated subjects with CD and 314 healthy controls were genotyped.Interactions and specific genotype combinations of a total of eight variants were tested.The variants of IBD5locus(IGR2198a_1 rs11739135 and IGR2096a_1 rs12521868),CARD15(R702W rs2066845 and L1007fs rs2066847),ATG16L1(rs2241880)and IL23R (rs1004819,rs2201841)genes were genotyped by PCR-RFLP,the G908R(rs2066844)in CARD15 was determined by direct sequencing. RESULTS:The association of ATG16L1 T300A with CD was confirmed[P=0.004,odds ratio(OR)=1.69, 95%CI:1.19-2.41],and both IL23R variants were found to represent significant risk for the disease(P= 0.008,OR=2.05,95%CI:1.20-3.50 for rs1004819 AA;P<0.001,OR=2.97,95%CI:1.65-5.33 for rs2201841 CC).Logistic regression analysis of pairwise interaction of the inflammatory bowel disease (IBD)loci indicated that IL23R,ATG16L1,CARD15 and IBD5(IGR2198a_1)contribute independently to disease risk.We also analysed the specific combina- tions by pair of individual ATG16L1,IL23R rs1004819, rs2201841,IGR2198a_1,IGR2096a_1 and CARD15 genotypes for disease risk influence.In almost all cases,the combined risk of susceptibility pairs was higher in patients carrying two different risk-associated gene variants together than individuals with just one polymorphism.The highest OR was found for IL23R rs2201841 homozygous genotype with combination of positive CARD15 status(P<0.001,OR=9.15,95% CI:2.05-40.74). CONCLUSION:The present study suggests a cumulative effect of individual IBD susceptibility loci. | Veronika Csngei Luca Járomi EnikSáfrány Csilla Sipeky Lili Magyari Bernadett Faragó Judit Bene Noémi Polgár Lilla Lakner Patrícia Sarlós Márta Varga Béla Melegh | 2010 | World Journal of Gastroenterology2010，16，2： | 2 |
| 3 | Determination of trace elements in human liver biopsy samples by ICP–MS and TXRF: hepatic steatosis and nickel accumulation显示文摘 | Imre Varga ágnes Szebeni Norbert Szoboszlai Béla Kovács | 2005 | Analytical and Bioanalytical Chemistry2005，，3： | 1 |
| 4 | Sarcoidosis显示文摘 | Newman LS Rose CS Maier LA | 1997 | N Engl J Med1997，336，17： | 1 |
| 5 | Office-based cryoablation of breast fibroadenomas with long-term follow-up显示文摘 | Kaufman CS Littrup PJ La FG | 2005 | Breast J2005，11，： | 1 |
| 6 | Exhaled breath condensate pH and childhood asthma: unselected birth cohort study显示文摘 | Nicolaou NC Lowe LA Murray CS | 2006 | Am J Respir Crit Care Med2006，174，3： | 1 |
| 7 | Lung Function at Age 3 Years :Effect of Pet Ownership and Exposure to Indoor Allergens 显示文摘 | Lowe LA Woodcock A Murray CS | 2004 | Arch Pediatr Adolesc Med2004，158，6： | 1 |
| 8 | Distraction osteogenesisfor reconstruction of mandibular symphyseal defects显示文摘 | Annino DJ Jr G oguen LA K armody CS | 1994 | Arch Otolar2yngol Head Neck Surg1994，120，5： | 1 |
| 9 | Distraction osteogensis for reconstruction of mandibular symphyseal defects显示文摘 | Annino DJ Goguen LA Karmody CS | 1994 | Arch Head Neck Surg1994，120，9： | 1 |
| 10 | Epoxidation of Thermally Degraded Poly (vinyl chloride) 显示文摘 | Tibor Szakács Béla Iván | 2004 | Polymer Degradation and Stability2004，85，3： | 1 |
| 11 | Changes in heart rate var- la billty under propofol anesthesia a possible explanation for propo- fol induced brady earidia 显示文摘 | Deutsehman CS Harris AP Fleisher LA | 1994 | Aresth Araly1994，79，2： | 1 |
| 12 | Poisoning mortality 1985-1995显示文摘 | Fingerhut LA Cox CS | 1998 | Public Health Rep1998，113，3： | 1 |
| 13 | Association of hemostatic factors with peripheral vascular disease显示文摘 | Philipp CS Cisar LA Kim HC | 1997 | Am Heart J1997，134，51： | 1 |
| 14 | Perioperative nutrition and postoperative complications in patients undergoing spinal surgery显示文摘 | Klein JD Hey LA Yu CS | 1996 | Spine1996，21，22： | 1 |
| 15 | Detection of human cytomegalovirus in normal and neoplastic breast epithelium 显示文摘 | Harkins LE Matlaf LA Soroceanu L Klemm K Britt WJ Wang W Bland KI Cobbs CS | 2010 | Herpesviridae2010，1，1： | 1 |
| 16 | Poisoning mortality 1985 - 1995 显示文摘 | Fingerhut LA Cox CS | 1998 | Public Health Rep1998，113，3： | 1 |
| 17 | Sarcoidosis显示文摘 | Newman LS Rose CS Maier LA | 1997 | New Engl J Med1997，336，： | 1 |
| 18 | Sclerokeratitis and facial skin leslons : a case report of pyoderma gangrenosum and its response to dapsone therapy 显示文摘 | Teasley LA Foster CS Bahatzis S | 2007 | Cornea2007，26，2： | 1 |
| 19 | Cutaneous vasoconstrictor responses to nor-epinephrine are attenuated in older humans显示文摘 | Thompson CS Holowatz LA Kenney WL | 2005 | Am J Physiol Regul Integr Comp Physiol2005，288，5： | 1 |
| 20 | Office-based cryoablation of breast fibroadenomas with long-term follow-up显示文摘 | Kaufman CS Littrup PJ Freeman-Gibb LA | 2005 | Breast J2005，11，5： | 1 |
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