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| 1 | Safety and success of precut biliary sphincterotomy: Is it linked to experience or expertise?显示文摘瞄准:决定成功的率和按规格裁切的复杂并发症胆汁的括约肌切开术(PBS ) 基于优先的经验并且到比较在 PBS 和标准内视镜的括约肌切开术(ES ) 之间的复杂并发症率。方法:回顾的评估有希望地在一个学术第三级的工作分派中心收集了非使随机化的数据。包括的学习没有 formal 在 PBS 训练的由单个 endoscopist 经历了 PBS 和 ES 的在一个八年的时期的所有病人。学习的主要结果措施是有到 ES 的复杂并发症的比较的 PBS 的成功和复杂并发症。结果:一个总数 2939 内视镜后退 cholangiopancreatographies (ERCP ) 在学习时期期间被执行,包括 818 (28%) ES 并且 150 (5%) PBS 过程。经由 PBS 的选择胆汁的管子在在 75% 病人的第一次尝试是成功的。管子被完成在一另外在一次随后的尝试(总数 87%) 的 13% 病人。从 PBS 的复杂并发症率比 ES 高是 45% ,但是没显著地不同[7%(10/50 ) 对 5%(38/818 ) , P = 0.29 ] 。任何一个从 PBS 的复杂并发症都不是严重的。向增加成功的一个重要趋势关于 endoscopist 存在 ?ˉs 在按规格裁切的第一次尝试(P = 0.0393,为趋势的 Cochran-Armitage 准确测试, Z =-1.7588) 。结论:尽管有在这种技术的特定的训练的缺乏, PBS 从另外的富有经验的中心与高成功率和类似于的复杂并发症率或不到报告被执行。这些结果建议内视镜的经验和也许天生的内视镜的技巧可以在这个过程的结果起一个重要作用。 | Lindsay S Robison Shyam Varadarajulu C Mel Wilcox | 2007 | World Journal of Gastroenterology2007，13，15： | 10 |
| 2 | Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment显示文摘The tumor microenvironment(TME) is complex and constantly evolving. This is due, in part, to the crosstalk between tumor cells and the multiple cell types that comprise the TME, which results in a heterogeneous population of tumor cells and TME cells. This review will focus on two stromal cell types, the cancerassociated adipocyte(CAA) and the cancer-associated fibroblast(CAF). In the clinic, the presence of CAAs and CAFs in the TME translates to poor prognosis in multiple tumor types. CAAs and CAFs have an activated phenotype and produce growth factors, inflammatory factors, cytokines, chemokines, extracellular matrix components, and proteases in an accelerated and aberrant fashion. Through this activated state, CAAs and CAFs remodel the TME, thereby driving all aspects of tumor progression, including tumor growth and survival, chemoresistance, tumor vascularization, tumor invasion, and tumor cell metastasis. Similarities in the tumorpromoting functions of CAAs and CAFs suggest that a multipronged therapeutic approach may be necessary to achieve maximal impact on disease. While CAAs and CAFs are thought to arise from tissues adjacent to the tumor, multiple alternative origins for CAAs and CAFs have recently been identified. Recent studies from our lab and others suggest that the hematopoietic stem cell, through the myeloid lineage, may serve as a progenitor for CAAs and CAFs. We hypothesize that the multiple origins of CAAs and CAFs may contribute to the heterogeneity seen in the TME. Thus, a better understanding of the origin of CAAs and CAFs, how this origin impacts their functions in the TME, and thetemporal participation of uniquely originating TME cells may lead to novel or improved anti-tumor therapeutics. | Ying Xiong Lindsay T Mc Donald Dayvia L Russell Ryan R Kelly Katie R Wilson Meenal Mehrotra Adam C Soloff Amanda C LaRue | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 3 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet2009，，9666： | 5 |
| 4 | Preoperative immunonutrition in patients undergoing liver resection:A prospective randomized trial显示文摘BACKGROUND Preoperative supplementation with immunonutrients, including arginine and n-3 fatty acids, has been shown in a number of systematic reviews to reduce infectious complications in patients who have undergone gastrointestinal surgery. Limited information, however, is available on the benefits of nutritional supplementation enriched with arginine and n-3 fatty acids in patients undergoing liver resection.AIM To evaluate the effects of preoperative nutritional supplementation enriched with arginine and n-3 fatty acids on inflammatory and immunologic markers and clinical outcome in patients undergoing liver resection.METHODS Thirty-four patients undergoing liver resection were randomized to either five days of preoperative Impact? [1020 kcal/d, immunonutrition(IMN) group], or standard care [no supplementation, standard care(STD) group]. Nutritional status was measured at study entry by subjective global assessment(SGA).Functional assessments(grip strength, fatigue and performance status) were carried out at study entry, on the day prior to surgery, and on postoperative day(POD) 7 and 30. Inflammatory and immune markers were measured at study entry, on the day prior to surgery, and POD 1, 3, 5, 7, 10 and 30. Postoperative complications were recorded prospectively until POD30.RESULTS A total of 32 patients(17 IMN and 15 STD) were analysed. All except four patients were SGA class A. The plasma ratio of(eicosapentaenoic acid plus docosahexaenoic acid) to arachidonic acid was higher in IMN patients on the day prior to surgery and POD 1, 3, 5 and 7(P < 0.05). Plasma interleukin(IL)-6 concentrations were elevated in the IMN group(P = 0.017 for POD7). No treatment effect was detected for functional measures, immune response(white cell count and total lymphocytes) or markers of inflammation(C-reactive protein,tumour necrosis factor-α, IL-8, IL-10). There were 10 patients with infectious complications in the IMN group and 4 in the STD group(P = 0.087). Median hospital stay was 9(range 4–49) d in the IMN group and 8(3-34) d in the STD group(P = 0.476).CONCLUSION In well-nourished patients undergoing elective liver resection, this study failed to show any benefit of preoperative immunonutrition. | Kylie Russell Han-Guang Zhang Lyn K GillANDers Adam SJR Bartlett Helena L Fisk Philip C Calder Peter J Swan Lindsay D Plank | 2019 | World Journal of Hepatology2019，11，3： | 3 |
| 5 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet2009，，9666： | 3 |
| 6 | 将安装于CON EDISON电网的带故障限流功能的高温超导电缆现状和进展显示文摘介绍了Hydra超导电缆项目的总体目标、设计准则、现状和进展,重点介绍了25 m原型电缆的结构设计、生产制造及型式试验。 | Maguire J Folts D Yuan J Henderson N Lindsay D Knoll D Rey C Duckworth R Gouge M Wolff Z Kurtz S | 2011 | 电网与清洁能源2011，27，5： | 3 |
| 7 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet . 2009 (9666)2009，，9666： | 3 |
| 8 | Variations in Wool Growth with Nutrient Supply in Northern China显示文摘Field studies on essessment of nutritional status of the grazing sheep were carried out in each of the three major grassland regions, the eastern Inner Mongolia and beyond grassland, the Inner Mongolia - Ningxia - Gansu grassland and the Xinjiang grassland, in northern China. The results obtained showed that the wool production of fine wool sheep in these regions varied between regions and seasons, with similar seasonal patterns in all regions and that reducing the seasonal variations in nutrient supply would enhance wool production substantially. Nutritional limitations to wool growth of the grazing sheep in these regions were suggested, those were: the shortage of protein supply in winter and early spring; the poor quality of much of the pasture and the hay used as supplements, the low energy intake during winter which probably necessitated the use of body stores to maintain body temperature. | D X Lu,Iner(Mongolia Academy of Animal Sciences.Hohhot City.Inner Mongolia Autgolia Autonmous Region.PRC)Z C Feng,(Mongolia Academy of Animal Sciences.Hohhot City.Inner Mongolia Autgolia Autonmous Region.PRC)H R Wang,(Mongolia Academy of Animal Sciences.Hohhot City.Inner Mongolia Autgolia Autonmous Region.PRC)R Z Yang,(Xinjiang Institute of Animal Science.Xinjiang Academy of Animal Science.Yiu Hou Road.Urumqi.Xinjiang Uygur Autonomous Region PRC)C T Ma,(Chinese Academy of Agricultural Sciences.Lanzhou.Gansu.PRC)D B Purser,(CSIRO Division of Animal Production.Laboratory for Rural Research.Private Bag.P.O.Wembley.Western Australia 6014)J R Lindsay(CSIRO Division of Animal Production.Laboratory for Rural Research.Private Bag.P.O.Wembley.Western Australia 6014)D W Peter(CSIRO Division of Animal Production.Laboratory for Rural Research.Private Bag.P.O.Wembley.Western Australia 6014) | 1997 | 畜牧与饲料科学1997，22，S1： | 3 |
| 9 | Occurrence and properties of flavor-related bromophenols found in the marine environment: a review 显示文摘 | Boyle J L Lindsay R C Stuiber D A | 1993 | J Aquat Food Prod Technol1993，2，： | 2 |
| 10 | Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial显示文摘 | Matthew T Seymour Lindsay C Thompson Harpreet S Wasan Gary Middleton Alison E Brewster Stephen F Shepherd M Sinead O’Mahony Timothy S Maughan Mahesh Parmar Ruth E Langley | 2011 | The Lancet2011，，9779： | 2 |
| 11 | Chemical reactions on rutile TiO2(110)显示文摘 | Lun Pang C Lindsay R Thomton G | 2008 | Chem Soc Rev2008，37，10： | 1 |
| 12 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 13 | Volatile compounds characterizing the aroma of fresh Atlantic and Pacific oysters显示文摘 | JOSEPHSON D B LINDSAY R C STUIBER D A | 1987 | J Food Sci1987，50，： | 1 |
| 14 | Comparison of the stimulatory sffects of ovine,porcine and human follicle-stimulating hormone and of ovine and human luteinizing hormone on the accumulation of cyclic AMP by porcine granulosa cells显示文摘 | Lindsay A M Channing C P | 1979 | Journal of Endocrinology1979，80，： | 1 |
| 15 | The effects of potential neuroprotective agents on rat facial function recovery following facial nerve injury显示文摘 | Vakharia KT Lindsay RW Knox C | 2011 | Otolaryngology-Head and Neck Surgery2011，144，1： | 1 |
| 16 | Structure of Toxoplasma gondii tachyzoites,bradyzoites and spo- rozoites,and biology and development of tissue cysts 显示文摘 | DUBEY J P LINDSAY S SPEER C A | 1998 | Clin Microbiol Rev1998，11，2： | 1 |
| 17 | Preference evaluation of foods prepared with imitation cheeses显示文摘 | Lindsay R C Hargett S M Graf T F | 1980 | Food Products Development1980，14，： | 1 |
| 18 | High white blood cell count is associated with a worsening of insulin sensitivity and predicts the development of type 2 diabetes显示文摘 | VOZAROVA B WEYER C LINDSAY R S | 2002 | Diabetes2002，51，： | 1 |
| 19 | Local delivery of adenoviral vectors encoding murine interleukin 10 induces colonic interleukin 10 production and is therapeutic for murine colitis 显示文摘 | Lindsay J O Ciesielski C J Scheinin T | 2003 | Gut2003，52，3： | 1 |
| 20 | Outcrop studies of shale smear on fault-surface显示文摘 | Lindsay N C Murphy F C | 1993 | Special Publication of International Association of Sedimentologist1993，15，： | 1 |
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