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| 1 | Community structure and elevational diversity patterns of soil Acidobacteria显示文摘Acidobacteria is one of the most dominant and abundant phyla in soil,and was believed to have a wide range of metabolic and genetic functions. Relatively little is known about its community structure and elevational diversity patterns. We selected four elevation gradients from 1000 to 2800 m with typical vegetation types of the northern slope of Shennongjia Mountain in central China. The vegetation types were evergreen broadleaved forest,deciduous broadleaved forest,coniferous forest and sub-alpine shrubs. We analyzed the soil acidobacterial community composition,elevational patterns and the relationship between Acidobacteria subdivisions and soil enzyme activities by using the 16 S rRNA meta-sequencing technique and multivariate statistical analysis. The result found that 19 known subdivisions as well as an unclassified phylotype were presented in these forest sites,and Subdivision 6 has the highest number of detectable operational taxonomic units(OTUs). A significant single peak distribution pattern(P < 0.05) between the OTU number and the elevation was observed. The Jaccard and Bray–Curtis index analysis showed that the soil Acidobacteria compositional similarity significantly decreased(P < 0.01) with the increase in elevation distance. Mantel test analysis showed the most of the soil Acidobacteria subdivisions had the significant relationship(P < 0.01) with different soil enzymes. Therefore,soil Acidobacteria may be involved in different ecosystem functions in global elemental cycles. Partial Mantel tests and CCA analysis showed that soil pH,soil temperature and plant diversity may be the key factors in shaping the soil Acidobacterial community structure. | Yuguang Zhang Jing Cong Hui Lu Guangliang Li Yuanyuan Qu Xiujiang Su Jizhong Zhou Diqiang Li | 2014 | Journal of Environmental Sciences2014，26，8： | 17 |
| 2 | A BAC clone of MDV strain GX0101 with REV-LTR integration retained its pathogenicity显示文摘The complete genome of Marek's disease virus (MDV) strain GX0101, which was integrated with the LTR sequences of REV, was cloned in Escherichia coli as a bacterial artificial chromosome (BAC). BAC vector sequences were introduced into the US2 locus of the MDV genome by homologous recombination. The viral DNA containing the BAC vector was used to transform Escherichia coli strain of DH10B. Then the recombinant virus was successfully rescued by transfection of the recombinant BAC DNA into primary chicken embryo fibroblast (CEF). This BAC viral clone was named bac-GX0101. When the reconstituted virus was inoculated into 1-day-old birds, visceral tumors could be detected as early as 62 d post infection. There was no difference in growth ability and pathogenicity to birds between the BAC derived virus and its parental virus. The BAC derived virus maintained its oncogenicity and immunosuppressive effects. In conclusion, the complete genome of GX0101 strain was successfully cloned into BAC and the infectious clone was rescued. With the powerful BAC manipulation system, the infectious clone will provide a useful tool for further understanding the functional roles of the inserted REV-LTR sequence in the GX0101 strain of MDV. | SUN AiJun LAWRENCE Petherbridge ZHAO YuGuang LI YanPeng NAIR Venugopal K CUI ZhiZhong | 2009 | Chinese Science Bulletin2009，54，15： | 15 |
| 3 | Effect of composite supports on the methanation activity of Co-Mo-based sulphur-resistant catalysts显示文摘The effects of composite supports of CeO2-Al2O3,MgO-Al2O3,TiO2-Al2O3 or ZrO2-Al2O3 on the methanation activity of supported Co-Mo-based sulphur-resistant catalysts were investigated.The catalysts were further characterized by nitrogen adsorption measurement,X-ray diffraction and X-ray photoelectron spectroscopy.The catalyst of 5%CoO-15%MoO3 supported on CeO2-Al2O3,MgO-Al2O3,TiO2-Al2O3 or ZrO2-Al2O3 composite oxides,respectively,showed different catalytic performances of syngas methanation in the presence of hydrogen sulphide as compared with that of the 5%CoO-15%MoO3/Al2O3 catalyst.The Co-Mo/CeO2-Al2O3 catalyst shows the highest methanation activity among the tested catalysts.The enhanced methanation activity may be attributed to the improvement of the dispersion of active metal species and the inhibition of the formation of S6+. | Haiyang Wang Zhenhua Li Erdong Wang Can Lin Yuguang Shang Guozhong Ding Xinbin Ma Shaodong Qin Qi Sun | 2012 | Journal of Natural Gas Chemistry2012，21，6： | 15 |
| 4 | Combination of ribavirin and reduning protects mice against severe pneumonia induced by H1N1 influenza a virus显示文摘OBJECTIVE:To investigate the effects of ribavirin administration combined with Reduning in a mouse model of influenza A(H1N1)-induced severe pneumonia.METHODS:Influenza A/Beijing/501/2009(H1N1)-infected C57BL/6 mice were randomly divided into four experimental groups treated with either a mock injection of phosphate-buffered saline(PBS),ribavirin(66.6 mg/kg daily)or Reduning(86.6 mg/kg daily),or a combination of both,for 7 days.Mice were monitored for clinical signs and survival,and body weight was measured daily for 14 days.Virus titer,lung wet-to-dry ratios,pathology and cytokines including interleukin(IL)-6,IL-10,and interferon(IFN)-γwere assayed on different days.RESULTS:In the untreated group injected with phosphate buffer saline,all the mice died of the infection.The survival rate of mice treated with Reduning was only 10%,whereas 100%of the ribavirin-and the combination-treated mice survived.Low lung viral loads indicated that ribavirin significantly inhibited virus replication,whereas Reduning did not.Lung wet-to-dry ratios demonstrated that both ribavirin and Reduning,administered together or separately,reduced acute lung edema compared with results in the untreated group.Pathology analyses also showed that treatment with a combination of both drugs relieved pathological lesions,whereas the single drug treatment did not.Levels of IL-6,IL-10 and IFN-γin mice treated with ribavirin or the combination of both ribavirin and Reduning were all significantly lower than in the untreated group,especially in the combination-treated group.In addition,Reduning administration significantly decreased both IL-6 and IL-10production but had no effect on IFN-γ.CONCLUSION:Due to the synergistic effect of antiviral and antiinflammation,the combination of ribavirin and Reduning could be an effective treatment for severe H1N1 which was considered to be significant to delayed antiviral and drug resistant. | Ma Yuexia Zhang Wei Zhao Zhongpeng Li Min Liu Jian Wang Yuguang | 2016 | Journal of Traditional Chinese Medicine2016，36，2： | 13 |
| 5 | An Important Ornithischian Tracksite in the Early Jurassic of the Shenmu Region,Shaanxi,China显示文摘A large track site with multiple, well-preserved trackways of an Early Jurassic quadrupedal ornithischian dinosaur is the first report of Moyenisauripus-like trackways from Asia, herein named Shenmuichnus youngteilhardorum. The tracks occur in a clastic fluvial sequence in the Fuxian Formation in Shenmu County, Shaanxi Province, which is in the same general region as the discovery site of Sinoichnites,the first dinosaur track reported from China. Based on size and morphology, it is likely that Sinoichnites, which is now lost, also represents an ornithischian. The Shenmuichnus youngteilhardorum trackways show two modes of preservation: the first representing deeper tracks, with sediment rims, results in Deltapodus-like tracks, with indistinct pes digit traces and sub-circular manus traces, the second produces Moyenosauripus-like tracks, with clear tridactyl and pentadactyl digit traces in the pes and manus respectively. Thus the Shenmu trackways play a key role in resolving globally significant ichnotaxonomic problems surrounding the nomenclature of Sinoichnites, Moyenosauripus, Deltapodus and other named (Ravatichnus) and unnamed trackways from Asia, Africa and Europe. In addition they shed important light on the paleogeographical and paleoecological distribution of quadrupedal ornithischians in the Early Mesozoic. The track site has been the focus of a major excavation to transfer the trackways from their original remote location to the new Shenmu Museum, in Shenmu City. Other tracksites in the area which reveal Anomoepus, Grallator and the Deltapodus morphotype, together with Shenmuichnus and plant fossil evidence, suggest an Early Jurassic age for the tracksite. | LI Jianjun Martin G.LOCKLEY ZHANG Yuguang HU Songmei MATSUKAWA Masaki BAI Zhiqiang | 2012 | Acta Geologica Sinica(English Edition)2012，86，1： | 11 |
| 6 | A New Species of Cathayornis from the Lower Cretaceous of Inner Mongolia,China and Its Stratigraphic Significance显示文摘摘要:不完全的 postcranial 鸟的骨骼从西方的内部蒙古的 Otog 旗帜的更低的白垩纪 Jingchuan 形成被描述并且指了 Cathayornis 的新种, C。chabuensis sp。nov。这是从外面的辽宁省的 Cathayornis 的第一份报告。新发现显示 Cathayornis 与 Otogornis genghisi 共存了,并且更多详细说明了在 Otogornis 代表的这二 enantiornithine 类表演之间的比较一个更原始的类比 Cathayornis。我们的分析进一步显示 Cathayornis 是一只树木的鸟。从这个区域的 Cathayornis 的发现也证实鸟的忍受石块的 Jingchuan 形成比得上在西方的辽宁的上面的 Jehol 组的 Jiufotang 形成,并且应该被指中间迟了的早白垩纪。 | LI Jianjun LI Zhiheng ZHANG Yuguang ZHOU Zhonghe BAI Zhiqiang ZHANG Lifu BA Tuya | 2008 | Acta Geologica Sinica(English Edition)2008，82，6： | 11 |
| 7 | Ultrasound-Guided Transmuscular Quadratus Lumbar Block Reduces Opioid Consumption after Laparoscopic Partial Nephrectomy显示文摘Objectives Transmuscular quadratus lumborum block(TQLB)may provide postoperative analgesia in patients undergoing intraperitoneal surgeries.The purpose of this study was to examine the potential efficacy of TQLB among patients undergoing retroperitoneal procedures,such as the laparoscopic partial nephrectomy(LPN).Methods This prospective,randomized,controlled study was conducted from August 2017 to November 2018 at Peking Union Medical College Hospital(Beijing,China).Patients who were scheduled for a LPN,aged 18・70 years old with an ASA physical status score of I-II were randomly assigned to receive either TQLB with 0.6 ml/kg of 0.5%ropivacaine plus general anesthesia(TQLB group)or general anesthesia alone(control group).Patient-controlled intravenous analgesia with morphine was initiated immediately upon surgery completion.The primary outcome was the cumulative consumption of morphine within 8 h after surgery.The secondary outcome included postoperative consump廿ons of morphine at other time points,pain score at rest and during activity,postoperative nausa and vomitting(PONV),and recovery related parameters.Results Totally 30 patients per group were recruited in the study.The 8 h consumption of morphine was lower in theTQLB group than in the control group(median,0.023 mg/kg vs.0.068 mg/kg,U=207.5,P<0.001).No significant differences were observed in postoperative pain scores between the two groups.Patients in the TQLB group had fewer episodes of PONV(20%vs.47%,χ2=4.&P=0.028)in the first 24 h after surgery and higher scores for quality of recovery(mean,13&6 vs.131.9,t=-2.164,P=0.035)120 h after surgery than the controls.Conclusions TQLB resulted in an opioid-sparing effect during the early postoperative period following LPN,as well as a lower incidence of PONV and improved quality of recovery. | Xulei Cui Xu Li Minna Li Yuelun Zhang Yi Xie Weigang Yan Yushi Zhang Zhigang Ji Yuguang Huang | 2020 | Chinese Medical Sciences Journal2020，35，4： | 10 |
| 8 | Expression of human cytomegalovirus components in the brain tissues of patients with Rasmussen's encephalitis显示文摘Rasmussen's encephalitis(RE) is a rare and severe progressive epileptic syndrome with unknown etiology. Infection by viruses, including human cytomegalovirus(HCMV), has been speculated to be a potential trigger for RE. However, no viral antigens have been detected in the brains of patients with RE; thus, a possible clinical linkage between viral infections and RE has not been firmly established. In this study, we evaluated the expression of HCMV pp65 antigen in brain sections from 26 patients with RE and 20 non-RE patients by immunohistochemistry and in situ hybridization, and assessed the associations between HCMV infection and clinical parameters.Elevated expression of HCMV pp65 protein and DNA was observed in 88.5%(23/26) and 69.2%(18/26) of RE cases, respectively. In the non-RE group, HCMV pp65 antigen was detected only in two cases(10%), both of which were negative for DNA staining. Additionally, the intensity of HCMV pp65 staining was correlated with a shorter duration of the prodromal stage, younger age of seizure onset, and more severe unilateral cortical atrophy. Elevated expression of HCMV pp65 was observed in RE brain tissue and was correlated with the clinical features of RE disease. In summary, our results suggested that HCMV infection may be involved in the occurrence and progression of RE disease. Thus, further studies are needed to determine whether early treatment with anti-HCMV antibodies could modulate the course of RE. | Yao Zhang Yisong Wang Sichang Chen Shuai Chen Yuguang Guan Changqing Liu Tianfu Li Guoming Luan Jing An | 2017 | Virologica Sinica2017，32，2： | 9 |
| 9 | Influence of foraminifera on formation and occurrence characteristics of natural gas hydrates in fine-grained sediments from Shenhu area, South China Sea显示文摘Marine gas hydrates accumulate primarily in coarse-grained, high-permeability layers; however, highly saturated natural gas hydrates have been discovered in the fine-grained sediments of Shenhu area, South China Sea(SCS). This may be explained by key factors, such as the great abundance of foraminifera shells. In this paper, by analyzing the SCS foraminifera structure and performing hydrate formation experiments in the foraminifera shells, the contribution of foraminifera to hydrate accumulation in the SCS was investigated from a microscopic point of view. Simulations of hydrate formation were carried out in both pure SCS foraminifera shells and the host sediments. Pore structures in typical foraminifera were studied by use of micro-focus X-ray computed tomography(CT) and scanning electron microscopy(SEM). Hydrate growth and occurrence characteristics in the foraminifera shells were observed in-situ. The results showed that the presence of foraminifera significantly enhanced the effective porosity of the SCS sediments. Moreover, while the hydrates grew preferentially in the chambers of the coarse-grained foraminifera by adhering to the inner walls of the foraminifera shells, no apparent hydrate accumulation was observed in the fine-grained or argillaceous matrix. These findings provide a basis for further studies on the accumulation mechanism of hydrates and physical properties of hydrate reservoir in the South China Sea. | LI ChengFeng HU GaoWei ZHANG Wei YE YuGuang LIU ChangLing LI Qing SUN JianYe | 2016 | Science China Earth Sciences2016，59，11： | 7 |
| 10 | ~1H nuclear magnetic resonance-based metabolomic study on efficacy of Qingrehuatan decoction against abundant phlegm-heat syndrome in young adults with essential hypertension显示文摘OBJECTIVE: To observe the influence of Qingrehuatan decoction(QRHT) on serum metabolic profile in young essential hypertension(YEH) patients with abundant phlegm-heat syndrome and provide a basis for treatment with the decoction.METHODS: Twelve male YEH patients were randomly selected and serum samples were collected for examination before and after 4 weeks of thetreatment with QRHT. Twelve healthy males were randomly selected and their serum samples were collected as a control. All serum samples were detected using metabolomic technology with1 H nuclear magnetic resonance. Differences in metabolites were studied by principal component analysis and partial least squares-discriminate analysis,which produced scores and loadings plots.RESULTS: After 4 weeks of treatment, serum substances could be distinguished between the YEH patients with abundant phlegm-heat syndrome and the control patients. The specific serum endogenous metabolites tended to improve after the treatment. QRHT can appropriately increase the levels of glucose, lactic acid, citric acid, high-density lipoprotein, phosphatidylcholine, glycerophosphate choline, hydroxybutyrate, alanine, and glutamate.QRHT could also decrease the levels of low-density lipoprotein/very low-density lipoprotein, lipids,N-acetyl glycoprotein, and O-acetyl glycoprotein.CONCLUSION: QRHT can effectively ameliorate metabolic disorders in YEH Patients with abundant phlegm- heat syndrome.1H NMR-based metabolomic technology can provide an objective basis for the treatment of YEH patients with abundant phlegm-heat syndrome using QRHT. | Feng Xuanchao Yang Zheng Chu Yuguang Du Bai Su Mei Li Yi Wang Yinghong Jiang Chunying Hu Yuanhui | 2015 | Journal of Traditional Chinese Medicine2015，35，1： | 6 |
| 11 | Quantum network communication: a discrete-time quantum-walk approach显示文摘We study the problem of quantum multi-unicast communication over the butterfly network in a quantum-walk architecture, where multiple arbitrary single-qubit states are transmitted simultaneously between multiple source-sink pairs. Here, by introducing quantum walks, we demonstrate a quantum multiunicast communication scheme over the butterfly network and the inverted crown network, respectively,where the arbitrary single-qubit states can be efficiently transferred with both the probability and the state fidelity one. The presented result concerns only the butterfly network and the inverted crown network, but our techniques can be applied to a more general graph. It paves a way to combine quantum computation and quantum network communication. | Yuguang YANG Jiajie YANG Yihua ZHOU Weimin SHI Xiubo CHEN Jian LI Huijuan ZUO | 2018 | Science China(Information Sciences)2018，61，4： | 5 |
| 12 | Ichnofabrics and Their Environmental Interpretation from the Fluvial Deposits of the Middle Triassic Youfangzhuang Formation in Western Henan, Central China显示文摘Fluvial deposits from the Middle Triassic Youfangzhuang Formation in Henan Province, China contain a low-diversity trace fossils. Vertical dwelling burrows of opportunists dominate in active channel, whereas horizontal deposit-feeding, grazing, and vertical dwelling burrows occur in overbank deposits. Seven recurrent ichnofabrics were distingushed. The Palaeophycus tubularis ichnofabric preserves below scour interface between two fluvial cycles. The Skolithos linearis ichnofabric forms in middle to high-energy, soft substrates in the middle and upper parts of active channel deposits under semi-arid climate. The Skolithos linearis-Planolites montanus ichnofabric occurs in the sediments just a little above the Skolithos linearis ichnofabric and is formed in middle-energy, soft substrates in the upper part of active channel deposits. The Planolites montanus ichnofabric is mostly preserved in association with medium- to thick-bedded brown-red silty mudstones or siltstones in low-energy, perennial muddy bottom ponds in overbank settings. The Taenidium barretti ichnofabric is interpreted as periodically exposed ephemeral ponds or low-energy distal floodplain. The Skolithos isp. ichnofabric commonly occurs in middle to high-energy firm ground of proximal foodplain or crevasse-splay deposits. The root trace ichnofabric occurs in the crevasse splay deposits. The presence of thin palaeosols and the abundance of calcretization in mudstones indicate a seasonal climate ranging from humid to semi-arid, with high temperature, rainfall, and well-defined dry and wet seasons. | Min Wang Yongan Qi Da Li Mingyue Dai Yuguang Chang | 2014 | Journal of Earth Science2014，25，4： | 5 |
| 13 | An 84-month observational study of the changes in CD4 T-lymphocyte cell count of 110 HIV/AIDS patients treated with traditional Chinese medicine显示文摘这研究试图由与病毒(HIV )/acquired 免疫不全症候群(爱滋病) 与 TCM 连续地对待 84 个月的人的免疫不全在 110 个盒子的 CD4 T 淋巴细胞房间计数观察变化评估繁体中文药(TCM ) 的治疗学的效果。从从 2004 ~ 2013 与 TCM 对待的 19 个省和城市的 110 个 HIV/AIDS 病人的信息是镇定的。在 CD4 计数的索引的变化( 200 , 201350 , 351500 并且> 500 房间/公里<啜class=“ a-plus-plus ”>在五次的 3 )指( 0 , 12 , 36 , 60 和 84 个月)并且不同治疗[加 antiretroviral 治疗(艺术)的 TCM 和 TCM ]被比较。重复措施测试没显示在组和时间之间的相互作用(P > 0.05 ) 。在四个不同框架增加和二个组的减少的 CD4 计数的学位与基线相比是统计上重要的。在二个组之间的 CD4 计数不是统计上重要的。为 200 房间 / 公里的 CD4 计数 < 啜 class= “ a-plus-plus ” > 吝啬的 CD4 计数改变的 3 , 是 21 和 28 房间 / 公里 < 啜 class= “ a-plus-plus ” > 每为 TCM 的年,加艺术的组和 TCM 分别地组织的 3 。为 201350 房间 / 公里的 CD4 计数 < 啜 class= “ a-plus-plus ” > 吝啬的 CD4 计数改变的 3 , 是 6 和 25 房间 / 公里 < 啜 class= “ a-plus-plus ” > 每为 TCM 的年,加艺术的组和 TCM 分别地组织的 3 。为 351500 房间 / 公里的 CD4 计数 < 啜 class= “ a-plus-plus ” > 吝啬的 CD4 计数改变的 3 , 是 13 和 7 房间 / 公里 < 啜 class= “ a-plus-plus ” > 每为 TCM 的年,加艺术的组和 TCM 分别地组织的 3 。为 CD4 计数 > 500 房间 / 公里 < 啜 class= “ a-plus-plus ” > 吝啬的 CD4 计数改变的 3 , 是 34 和 17 房间 / 公里 < 啜 class= “ a-plus-plus ” > 每为 TCM 的年,加艺术的组和 TCM 分别地组织的 3 。TCM 的长期的使用能与 HIV/AIDS 在病人维持或变慢,并且可以完成持续有效性衰退 CD4 计数的步。 | Jian Wang Biyan Liang Xiaoping Zhang Liran Xu Xin Deng Xiuhui Li Lu Fang Xinghua Tan Yuxiang Mao Guoliang Zhang Yuguang Wang | 2014 | Frontiers of Medicine2014，8，3： | 5 |
| 14 | 800 Gbit/s transmission over 1 km single-mode fiber using a four-channel silicon photonic transmitter显示文摘We demonstrate the optical transmission of an 800 Gbit/s(4×200 Gbit/s)pulse amplitude modulation-4(PAM-4)signal and a 480 Gbit/s(4×120 Gbit/s)on–off-keying(OOK)signal by using a high-bandwidth(BW)silicon photonic(SiP)transmitter with the aid of digital signal processing(DSP).In this transmitter,a four-channel SiP modulator chip is co-packaged with a four-channel driver chip,with a measured 3 dB BW of 40 GHz.DSP is applied in both the transmitter and receiver sides for pre-/post-compensation and bit error rate(BER)calculation.Back-to-back(B2B)BERs of the PAM-4 signal and OOK signal are first measured for each channel of the transmitter with respect to a variety of data rates.Similar BER performance of four channels shows good uniformity of the transmitter between different channels.The BER penalty of the PAM-4 and OOK signals for 500 m and 1 km standard single-mode fiber(SSMF)transmission is then experimentally tested by using one channel of the transmitter.For a 200 Gbit/s PAM-4 signal,the BER is below the hard-decision forward error correction(HD-FEC)threshold for B2B and below the soft-decision FEC(SD-FEC)threshold after 1 km transmission.For a 120 Gbit/s OOK signal,the BER is below SD-FEC threshold for B2B.After 500 m and 1 km transmission,the data rate of the OOK signal shrinks to 119 Gbit/s and 118 Gbit/s with the SD-FEC threshold,respectively.Finally,the 800 Gbit/s PAM-4 signal with 1 km transmission is achieved with the BER of all four channels below the SD-FEC threshold. | Hongguang Zhang Miaofeng Li Yuguang Zhang Di Zhang Qiwen Liao Jian He Shenglei Hu Bo Zhang Lei Wang Xi Xiao Nan Qi Shaohua Yu | 2020 | Photonics Research2020，8，11： | 5 |
| 15 | Comparative study on thermal cracking characteristics and bio-oil production from different microalgae using Py-GC/MS显示文摘The yield and chemical composition of pyrolysis products of Chlorella pyrenoidosa and Schizochytrium limacinum were determined using thermogravimetric analyzer(TGA)and pyrolysis-gas chromatographic mass spectrometry(Py-GC/MS)by varying the temperature ranges.After further analysis of the total ion current(TIC)diagrams of Chlorella pyrenoidosa and Schizochytrium limacinum,it was concluded that both the pyrolysis products of each sample were mainly comprised of hydrocarbons,aromatics,fatty acids,nitrogen compounds,PAHs,phenols,etc,however,the relative content of each compound from Chlorella pyrenoidosa and Schizochytrium limacinum was different.The pyrolysis of Chlorella pyrenoidosa and Schizochytrium limacinum at 350℃ produced a maximum yield of bio-oil production(44.32%and 60.99%);moreover,Chlorella pyrenoidosa could lead to more pollutants(nitrogen compounds and PAHs)release(2.71%)compared to that of Schizochytrium limacinum(0.7%).Considering the reasonable bio-oil production and minimum release of pollutants,Schizochytrium limacinum was found to be superior for producing biofuel against Chlorella pyrenoidosa. | Gang Li Fang Ji Xue Bai Yuguang Zhou Renjie Dong Zhigang Huang | 2019 | International Journal of Agricultural and Biological Engineering2019，12，1： | 5 |
| 16 | Nutrients removal and biomass production from anaerobic digested effluent by microalgae: A review显示文摘This article summarizes the recent progress of nutrient removal from wastewater via microalgae.Removal of nitrogen and phosphorous compounds from wastewater are of great importance,while those compounds are suitable for growth of some microalgae species.Such a combination provides more opportunities for anaerobic digestion facilities,which are producing large amount of wastewater with high nitrogen and phosphorous contents.However,in order to optimize and maximize the performance and durability of the nutrient removal process,it is suggested that the basic principles about nitrogen and phosphorous migration should be investigated thoroughly,especially from the fundamentals of substance transfer mechanism between water environment and algal cells. | Gang Li Xue Bai Huan Li Zhitao Lu Yuguang Zhou Yingkuan Wang Jinxin Cao Zhigang Huang | 2019 | International Journal of Agricultural and Biological Engineering2019，12，5： | 5 |
| 17 | The diversity of denitrifying bacteria in the alpine meadow soil of Sanjiangyuan natural reserve in Tibet Plateau显示文摘This is the first time to describe the diversity of denitrifying bacteria in Sanjiangyuan natural reserve in Tibet Plateau by investigating the molecular diversity and phylogenetic analysis of nirK and nosZ genes using PCR-RFLP and sequencing. Four soil samples were collected from alpine meadow communities from over an altitude of 4600 m which had different physicochemical properties by principal component analysis (PCA). For the genes fragment of nirK and nosZ, the diverse PCR products were characterized by cloning, restriction fragment length polymorphism (RFLP) analysis and sequenced. A total of 253 nirK clones and 283 nosZ clones were received in four samples, and 78 operational taxonomic units (OTUs) of nirK and 120 OTUs of nosZ by the restriction enzymes MspI and RsaI digested. The analysis of environmental factors showed that altitude and C/N ratio in soil may be the key factors to the denitrifying bacteria community. 36 nirK clones and 17 nosZ clones were sequenced, and their levels of nucleotide identity were from 69% to 98% and 57% to 97%, respectively. The phylogenetic tree was constructed using the Clustal W and Mega softwares, and all the sequenced clones could be subdivided into 4 groups. Some of clone sequences were related to the nirK and nosZ genes belonging to three phylogenetic subdivisions (α-, β- and γ subclasses of the Proteobacteria), while most of the clones were closely related to the genes of the uncultured bacteria. The sequence distributions were not clear relating to the sample sites in the tree. | ZHANG Yuguang LI Diqiang WANG Huimin XIAO Qiming LIU Xueduan | 2006 | Chinese Science Bulletin2006，51，10： | 4 |
| 18 | Detection of EBV and HHV6 in the Brain Tissue of Patients with Rasmussen's Encephalitis显示文摘Rasmussen's encephalitis (RE) is a rare pediatric neurological disorder, and the exact etiology is not clear. Viral infection may be involved in the pathogenesis of RE, but conflicting results have reported. In this study, we evaluated the expression of both Epstein-Barr virus (EBV) and human herpes virus (HHV) 6 antigens in brain sections from 30 patients with RE and16 control individuals by immunohistochemistry. In the RE group, EBV and HHV6 antigens were detected in 56.7% (17/30) and 50% (15/30) of individuals, respectively. In contrast, no detectable EBV and HHV6 antigen expression was found in brain tissues of the control group. The co-expression of EBV and HHV6 was detected in 20.0% (6/30) of individuals. In particular, a 4-year-old boy had a typical clinical course, including a medical history of viral encephalitis,intractable epilepsy, and hemispheric atrophy. The co-expression of EBV and HHV6 was detected in neurons and astrocytes in the brain tissue, accompanied by a high frequency of CD8?T cells. Our results suggest that EBV and HHV6 infection and the activation of CD8?T cells are involved in the pathogenesis of RE. | Dong Liu Xin Wang Yisong Wang Peigang Wang Dongying Fan Sichang Chen Yuguang Guan Tianfu Li Jing An Guoming Luan | 2018 | Virologica Sinica2018，33，5： | 4 |
| 19 | Analysis of characteristics and predictive factors of immune checkpoint inhibitor-related adverse events显示文摘Objective:We aimed to retrospectively analyze the toxicity profiles and predictors of immune-related adverse events(irAEs)as well as the correlation between irAEs and the clinical efficacy of multi-type immune checkpoint inhibitors(ICIs)in patients with advanced pan-cancer in a real-world setting.Methods:We retrospectively analyzed data from 105 patients with advanced pan-cancer treated with multi-type ICIs at the First Hospital of Jilin University between January 1,2016 and August 1,2020.We used logistic regression analyses to investigate the associations of irAEs with clinical baseline characteristics,blood count parameters,and biochemical indicators during treatment.Receiver operating characteristic curves were used to determine cutoff values for parameters and area under the curve values.Kaplan–Meier and Cox multivariate regression analyses were performed to estimate the relationships of baseline characteristics and irAEs with progression-free survival(PFS)and overall survival(OS).Results:A lower relative lymphocyte count(cutoff=28.5%),higher albumin level(cutoff=39.05 g/L),and higher absolute eosinophil count(AEC)(cutoff=0.175×10^(9)/L)were significantly associated with the occurrence of irAEs,among which a higher AEC(cutoff=0.205×10^(9)/L)was strongly associated with skin-related irAEs[odds ratios(ORs)=0.163,P=0.004].Moreover,a higher lactate dehydrogenase level(cutoff=237.5 U/L)was an independent predictor of irAEs of grade≥3(OR=0.083,P=0.023).In immune cell subgroup analysis,a lower absolute count of CD8+CD28−suppressor T cells(OR=0.806;95%confidence interval:0.643–1.011;P=0.062),which are regulatory T lymphocytes,was associated with the occurrence of irAEs,although the difference was not statistically significant.Furthermore,a higher percentage of CD19+B cells was associated with the occurrence of irAEs of grade≥3(P=0.02)and grade≥2(P=0.051).In addition,patients with any grade of irAE had a significantly high PFS(8.37 vs.3.77 months,hazard ratios(HR)=2.02,P=0.0038)and OS(24.77 vs.13.83 months,HR=1.84;P=0.024).Conclusions:This retrospective study reports clinical profile data for irAEs in unselected patients in a real-world setting and explored some parameters that may be potential predictive markers of the occurrence,type,or grade of irAEs in clinical practice.Evidence of a correlation between safety and efficacy may facilitate a complete assessment of the risk-benefit ratio for patients treated with ICIs. | Rilan Bai Naifei Chen Xiao Chen Lingyu Li Wei Song Wei Li Yuguang Zhao Yongfei Zhang Fujun Han Zheng Lyu Jiuwei Cui | 2021 | Cancer Biology & Medicine2021，18，4： | 4 |
| 20 | Life cycle assessment of biofuel production from microalgae cultivated in anaerobic digested wastewater显示文摘The whole process of biofuel production from Desmodesmus sp.EJ 8-10 cultivated in anaerobic digested wastewater(ADW)under the optimal temperature was evaluated by using the method of Life Cycle Assessment(LCA).The energy efficiency and environment emissions were under considerable for the corresponding parametric study.The functional unit was 1 kg microalgae.It was concluded that the harvest stage was responsible for the main energy consumption during the microalgal whole pyrolysis process.The energy conversion efficiency of the whole process was larger than 1,which indicated that the process was profitable.The environmental impact of the whole process was 1165.67 mPET2000,among which the primary impact on the environment was eutrophication that accounts for 57.36%,followed by photochemical ozone synthesis(22.56%),acidification(17.36%);and global warming(2.73%),respectively. | Gang Li Zhitao Lu Jiang Zhang Huan Li Yuguang Zhou Ali Mohammed Ibrahim Zayan Zhigang Huang | 2020 | International Journal of Agricultural and Biological Engineering2020，13，1： | 4 |
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