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| 1 | Formation history and protolith characteristics of granulite facies metamorphic rock in Central Cathaysia deduced from U-Pb and Lu-Hf isotopic studies of single zircon grains显示文摘The petrochemical as well as zircon U-Pb and Lu-Hf isotopic studies of granulite facies metamorphic rock from the Taoxi Group in eastern Nanling Range, Central Cathaysia indicate that its protolith is the sedimentary rock with low maturation index. The clastic materials are mostly from middle Neoproterozoic (~736 Ma) granitoid rocks with minor Neoarchaean and Paleoproterozoic rocks. The timing of this Neoproterozoic magmatism is in agreement with the second period of magmatism widespread surrounding the Yangtze Block. Hf isotopic data indicate that the Neoproterozoic granitoids resulted from the recycled Paleoproterozoic mantle-derived crustal materials. The sedimentary rock was deposited in Late Neoproterozoic Era, and carried into low crust in Early Paleozoic. The partial melting of the meta-sedimentary rock took place at about 480 Ma and subsequently granulite facies metamorphism occurred at ca. 443 Ma. The zircons forming during this time interval (Early Paleozoic) show large Hf isotope variations, and their -Hf(t) values increase from -13.2 to +2.36 with decreasing age, suggesting the injection of mantle-derived materials during partial melting and metamorphism processes in the Early Paleozoic. Calculation results show that this metamorphic rock, if evolved to Mesozoic, has similar isotopic composition to the nearby Mesozoic high Si peraluminous granites, implying that this kind of granulite facies metamorphic rock is probably the source material of some Mesozoic peraluminous granitoids in eastern Nanling Range. | YU Jinhai ZHOU Xinmin Y. S. O'Reilly ZHAO Lei W. L. Griffin WANG Rucheng WANG Lijuan CHEN Xiaomin | 2005 | Chinese Science Bulletin2005，50，18： | 35 |
| 2 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 3 | Driving vascular endothelial cell fate of human multipotent Isl1 heart progenitors with VEGF modified mRNA显示文摘multipotent 心祖先的不同家庭在哺乳动物的 cardiogenesis 期间在多样的心脏的、光滑的肌肉和 endothelial 房间系的产生起一个中央作用。驾驶这些 multipotent 祖先的房间命运决定的精确 paracrine 信号的鉴定,和小说的开发来临在 vivo 交付这些信号,是向开他们的再生治疗学的潜力的关键步。此处,我们识别了位于早人的胎儿的心(OFT-ECs ) 的流出道的人的心脏的 endothelial 中介的一个家庭,由 Isl1 和 CD144/vWF 的 coexpression 描绘了。由比较人的 OFT-ECs 和非心脏的 EC 表示的 angiocrine 因素,脉管的 endothelial 生长因素( VEGF ) A 作为最富有地表示的因素被识别,并且同种细胞的试金记录了它的能力驱使人的胚胎的干细胞(转换字符)的 endothelial 说明以一种 VEGF 受体依赖者方式导出 Isl1 +祖先。人的 Isl1-ECs (区分开来与导出 hESC 的 ISL1 + 祖先的 endothelial 房间) 以心脏的 endothelial 祖先的表示类似于 OFT-ECs -- 并且 endocardial 房间特定的基因,证实他们的机关特性。决定是否 VEGF -- A 可能是服务一在里面为人的导出转换字符的 Isl1-ECs 的 vivo 房间命运开关,我们证实化学上使用的一条新奇途径作为一个平台修改了 mRNA 为短暂,还在心血管的祖先的 paracrine 因素的高度有效的表示。VEGF 的 Overexpression -- A 支持在 vivo 的人的 Isl1 + 祖先的不仅 endothelial 说明而且嫁接,增长和幸存(减少的 apoptosis ) 。从人的 pluripotent 干细胞的心脏特定的人的 Isl1-ECs 的大规模推导,结合了能力驾驶跟随移植的 endothelial 说明,嫁接,和幸存,在心为脉管的新生建议新奇策略。 | Kathy O Lui Llor Lang Eduardo A Silva Lei Bu Makoto Sahara Ronald A Li David J Mooney Kenneth R Chien | 2013 | Cell Research2013，23，10： | 6 |
| 4 | Preparation and hybridization analysis of DNA/RNA from E. coli on microfabricated bioelectronic chips显示文摘 | Cheng Jing Sheldon E L Wu Lei Uribe A Gerrue L O Carrino J Heller M J O'Connell J P | | 0，，： | 2 |
| 5 | Modelling low carbon transition and economic impacts under SSPs and RCPs based on GTIMES显示文摘The simulation of global and regional energy system transition and its potential mitigation cost could intuitively reflect the need for earlier climate mitigation actions. To explore the possible transitions of global and regional energy system, this study applied a 14-region energy system model (GTIMES) with scenarios designed using Shared Socio-economic Pathways (SSPs) with Representative Concentration Pathways (RCPs), and detailed depicts the quantification of SSPs trajectories into GTIMES model. Modeling results show that: 1) Global energy-related CO_(2) emissions will reach 37–74 Gt by 2050 under reference scenarios, while they will decrease to 12–14 Gt under higher possibility pathways to reach 2 ℃ target, with ratios of non-fossil fuel round to 42%–46%. 2) Electrification level has to increase noticeably in regional transition with a global average level of about 44% to achieve significant emission reduction. 3) Higher level of mitigation cost would happen with the constraint mitigation target, as well as social and economic trajectories chosen. Therefore, following trajectories of sustainable development is necessary. | YANG Lei SHI Jing-Cheng CHEN Wen-Ying James GLYNN Brian O GALLACHOIR | 2021 | Advances in Climate Change Research2021，12，6： | 2 |
| 6 | Dietary supplemen- tation with to-3 PUFA increases adiponeetin and attenuates ventrieular remodeling and dysfunction with pressure overload 显示文摘 | DUDA M K O'SHEA K M LEI B | 2007 | Cardiovascular Research2007，76，2： | 1 |
| 7 | Estimation and defect assessment for combined residual stress and mechanical loading 显示文摘 | Lei Y O'Dowd N P Webster G A | 2000 | International Journal of Pressure Vessels and Piping2000，77，： | 1 |
| 8 | Effect of grain size on fractal structure of acousticemissionhypocenterdistributioningranitic rock显示文摘 | KUSUNOSE K LEI X L NISHIZAWA O | 1991 | Physicsofthe Earthand Planetary Interiors1991，67，12： | 1 |
| 9 | Early predictors of deathand disability after acute cerebral ischemic event显示文摘 | Henon H Godefroy O Leys D | 1995 | Stroke1995，26，： | 1 |
| 10 | A research microstructure and properties of(Ti,A1)N coatings显示文摘 | Wang Y K Xiao L F Lei T O | 1995 | Surface and Coatings Technology1995，72，： | 1 |
| 11 | Sox2 ex- pression in breast tumours and activation in breast cancer stem cells显示文摘 | Leis O Eguiara A Lopez-Arribillaga E | 2012 | Oncogene2012，31，11： | 1 |
| 12 | Cognitive decline and dementia in the elderly hypertensive 显示文摘 | Hanon O Leys D | 2002 | J Renin Angiotensin Aldosterone Syst2002，3，1： | 1 |
| 13 | A new application of molecularly imprinted materials 显示文摘 | LEI Ye RAMSTROM O MANSSON M O | 1998 | Jour- nal of Molecular Recognition1998，11，： | 1 |
| 14 | Early predictors of death and disubility after acute cerebra ischemic event显示文摘 | Henon H Godegroy O Leys D | 1995 | Stroke1995，26，： | 1 |
| 15 | Effect of grain size on fractal structure of acoustic emission hypocenter distribution in granitic rock 显示文摘 | Kusunose K Lei X Nishizawa O | 1991 | Physics of the Earth and Planetary Interiors1991，67，1： | 1 |
| 16 | Ventilation and performance in office work 显示文摘 | SEPPANEN O FISK W J LEI Q H | 2006 | Indoor Air2006，16，： | 1 |
| 17 | VEGF - induced vascular permeability is mediated by FAK 显示文摘 | CHEN Xiao - lei NAM J O JEAN C | 2012 | Developmental Cell2012，22，1： | 1 |
| 18 | New modified Saleh models for memoryless nonlinear power amplifier behavioural modeling 显示文摘 | DROMA M O MEZA S LEI YIMING | 2009 | IEEE Communications Letters2009，13，6： | 1 |
| 19 | Bone-resorbing activity of thyroid hormones is related to prostaglandin production in cultured neonatal mouse calvaria显示文摘 | Klaushofer K Hoffmann O Gleispach H Leis HJ Czerwenka E Koller K Peterlik M | | 0，，： | 1 |
| 20 | A Research on Microstructure and Properties of ( Ti, A1 ) N Coating 显示文摘 | WANG Y K XIA L F LEI T O | 1995 | Surf & Coat Technol1995，72，： | 1 |
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