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| 1 | 在有类型 2 糖尿病的病人的 nephropathy 的管理。 | Critchley JA Zhao HL Tomlinson B Leung W Thomas GN Chan JC Cockram CS | 2002 | Chinese Medical Journal2002，，1： | 12 |
| 2 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 3 | Obesity-induced sperm DNA methylation changes at satellite repeats are reprogrammed in rat offspring显示文摘现在有充分证据,对在使肥沃的后代显型的父亲的贡献多于公平 DNA。然而,这 nongenetic 继承的身份和机制糟糕被理解。在这个研究区域的更重要的问题之一是:在精子 DNA methylation 的变化为后代有 phenotypic 后果吗?我们以前报导了肥胖的雄的老鼠的后代与控制相比改变了葡萄糖新陈代谢并且这效果通过 nongenetic 工具被继承。这里,我们用一样的协议在一个新队描述调查进精子 DNA methylation。在高脂肪的节食的雄的老鼠是 30% 比喂控制的男性重在交配的时候(16-19 星期旧, n = 14/14 ) 。一小(0.25%) 在全部的 5-methyl-2 ’ 增加; -deoxycytidine 被液体层析双人脚踏车团 spectrometry 在肥胖的老鼠精子检测。那 retrotransposon DNA methylation 在精子说的有定序的充实蛋白质的染色体(MBD-Seq ) 和 pyrosequencing 揭示了的 methyl-CpG 绑定领域的染色体的重复部分的检查没被肥胖,而是 methylation 在整个染色体在卫星重复影响被增加。然而,从男 27-week-old 后代从的肌肉,肝,和精子的检查肥胖并且控制父亲(从 8 生的 n = 的两个组) 表明正常 DNA methylation 层次在后代开发期间被恢复。而且,没有变化在肥胖的老鼠精子在三个 genomic 印记被发现。我们的调查结果为 transgenerational epigenetic reprogramming 有含意。他们建议 postfertilization 机制为使导致 environmentally 的 DNA methylation 在精子房间改变的一些正常化存在。 | Neil A Youngson Virginie Lecomte Christopher A Maloney Preston Leung Jia Liu Luke B Hesson Fabio Luciani Lutz Krause Margaret J Morris | 2016 | Asian Journal of Andrology2016，18，6： | 3 |
| 4 | Sedation-risk-free colonoscopy for minimizing the burden of colorectal cancer screening显示文摘Unsedated colonoscopy is available worldwide,but is not a routine option in the United States(US).We conducted a literature review supplemented by our experience and expert commentaries to provide data to support the use of unsedated colonoscopy for colorectal cancer screening.Medline data from 1966 to 2009 were searched to identify relevant articles on the subject.Data were summarized and co-authors provided critiques as well as accounts of unsedated colonoscopy for screening and surveillance.Diagnostic colonoscopy was initially dev eloped as an unsedated procedure.Procedure-re lated discomfort led to wide adoption of sedation in the US,although unsedated colonoscopy remains the usual practice elsewhere.The increased use of colonoscopy for colorectal cancer screening in healthy,asymptomatic individuals suggests a reass-essment of the burden of sedation in colonoscopy for screening is appropriate in the US for lowering costs and minimizing complications for patients.A water method developed to minimize discomfort has shown promise to enhance outcomes of unsedated colonoscopy.The use of scheduled,unsedated colono scopy in the US appears to be feasible for colorectal cancer screening.Studies to assess its applicability in diverse practice settings deserve to be conducted and supported. | Felix W Leung Abdulrahman M Aljebreen Emilio Brocchi Eugene B Chang Wei-Chih Liao Takeshi Mizukami Melvin Schapiro Konstantinos Triantafyllou | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，3： | 3 |
| 5 | 羟基磷灰石溶解度等温线的测定显示文摘目的:应用微量添加固体滴定和激光散射法测定HA(37℃ )溶解度等温线。方法:滴定物为HA。半导体二极管激光为发射光源,散射光源探测器用于监测超过溶解平衡点出现的沉淀。微量添加固体滴定所引发的沉淀引起散射光源显著且恒定地高于基线,由此判断溶液已处于过饱和状态,该固体滴定总量用于代表溶解度等温线的数据点。结果:HA溶解度等温线(37℃ )由6次滴定合共50个滴定终点构成。与传统方法所得结果比较,本实验所得HA的溶解度约为过往结果的百份之一。结论:微量添加固体滴定和激光散射法利于研究HA的溶解平衡且能得到准确的HA溶解度等温线。 | 陈卓凡 B W Darvell VW-H Leung | 2003 | 中国口腔种植学杂志2003，8，4： | 3 |
| 6 | Karaoke Theory in the Rehabilitation of mental patient显示文摘 | CM Leung Lee G Cheung B | 1998 | Singapore Medical Journal1998，4，： | 2 |
| 7 | Comparison of killer Ig-like receptor genotyping and phenotyping for selection of allogeneic blood stem cell donors显示文摘 | Leung W Iyengar R Triplett B | 2005 | J Immunol2005，174，10： | 1 |
| 8 | Size distributions of maternal and fetal DNA in maternal plasma显示文摘 | Chan K C ZhangJ Hui A B Wong N Lau T K Leung T N | 2004 | Clin Chem2004，50，： | 1 |
| 9 | Stochastic spline ritz method based on stochastic variational principle 显示文摘 | Yang L F Leung A Y T Yan L B | 2005 | Engineering Structures2005，27，3： | 1 |
| 10 | Reliability analysis for rotor rubbing 显示文摘 | Zhang Y M Wen B C Leung Y T | 2002 | ASME Journal for Vibration and Acoustics2002，124，1： | 1 |
| 11 | Man portable power needs of the 21st century显示文摘 | Atwater T B Cygan P J Leung F C | 2000 | J Power Sources2000，91，1： | 1 |
| 12 | Gene expression of the renin-angiotensin system in human kidney显示文摘 | Lai K N Leung J C Lai K B | 1998 | J Hypertens1998，16，： | 1 |
| 13 | A social network analysis of overseas tourist movement patterns in Beijing: The impact of the Olympic games 显示文摘 | Leung X Y Wang F Wu B H Stahura K A Xie Z H | 2012 | International Journal of Tourism Research2012，14，5： | 1 |
| 14 | Pseudolaric acids:isolation,bioactivity and synthetic studies显示文摘 | Chiu P Leung L T Ko B C | | 0，，07： | 1 |
| 15 | Glioblastoma cells deficient in DNA-dependent protein kinase are resistant to cell death显示文摘 | Chen G Sin F Leung B | 2005 | J Cell Physiol2005，203，1： | 1 |
| 16 | Aquiledine and isoaquiledine, novel flavonoid alkaloid from Aquilegia ecalcarata 显示文摘 | Chen S B Gao G Y Leung H Y | 2001 | J Nat Prod2001，64，1： | 1 |
| 17 | Hippocampal CA1 kindling but not long-term potentiation disrupts spatial memory performance显示文摘 | Leung L S Shen B | 2006 | Learn Mem2006，13，1： | 1 |
| 18 | Construction of the Chinese University Prognostic Index for hepatocellular carcinoma and comparison with the TNM staging system, the Okuda staging system, and the Cancer of the Liver Italian Program staging system: a study based on 926 patients 显示文摘 | Leung TW Tang AM Zee B | 2002 | Cancer2002，94，： | 1 |
| 19 | Using a dedicated lung-marker system for localization of pulmonary nodules before thoracoscopic surgery 显示文摘 | PARTIK B L LEUNG A N MULLER M R | 2003 | Am J Roentgenol2003，180，： | 1 |
| 20 | Distribution,fate and risk assessment of antibiotics in sewage treatment plants in Hong Kong,South China显示文摘 | Leung H W Minh T B Murphy M B | | 0，，： | 1 |
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