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| 1 | Effects of Helicobacterpyloriinfection on gastric emptying rate in patients with non-ulcer dyspepsia显示文摘AIM: The pathogenesis of delayed gastric emptying in patients with non-ulcer dyspepsia (NUD) remains unclear. We aimed to examine whether gastric emptying rate in NUD patients was associated with Helicobacterpylori(Hpylori) infection and whether it was affected by eradication of the infection. METHODS: Gastric emptying rate of a mixed solid-liquid meal was assessed by the paracetamol absorption method in NUD patients and asymptomatic controls (n=-17). Hpylori status was assessed by serology and biopsy urease test. Hpylori-positive NUD patients (n=-23) received 10-day triple eradication therapy. H pylori status was re-assessed by biopsy urease test four weeks later, and if eradication was confirmed, gastric emptying rate was re-evaluated. RESULTS: Thirty-three NUD patients and 17 controls were evaluated. NUD patients had significantly delayed gastric emptying compared with controls. The mean maximum plasma paracetamol concentration divided by body mass (Cmax/BM) was 0.173 and 0.224 mg/L.kg respectively (P=0.02), the mean area under plasma paracetamol concentration-time curve divided by body mass (AUC/BM) was 18.42 and 24.39 mg.min/L.kg respectively (P=-0.01). Gastric emptying rate did not differ significantly between H pylori-positive and H pylori-negative NUD patients. The mean Cmax/BM was 0.172 and 0.177 mg/Ukg respectively (P=-0.58), the mean AUC/BM was 18.43 and 18.38 rag.min/L.kg respectively (P=0.91). Among 14 NUD patients who were initially H pylori-positive, confirmed eradication of the infection did not significantly alter gastric emptying rate. The mean Cmax/BM was 0.171 and 0.160 mg/Ukg before and after Hp eradication, respectively (P=0.64), the mean AUC/BM was 17.41 and 18.02 mg.min/Ukg before and after eradication, respectively (P=-0.93). CONCLUSION: Although gastric emptying is delayed in NUD patients compared with controls, gastric emptying rate is not associated with H pylori status nor it is affected by eradication of the infection. | Grigoris I Leontiadis George I Minopoulos Efstratios Maltezos Stamatia Kotsiou Konstantinos I Manolas Konstantinos Simopoulos Dimitrios Hatseras | 2004 | World Journal of Gastroenterology2004，10，12： | 9 |
| 2 | Consensus Statements on the Risk, Prevention, and Treatment of Venous Thromboembolism in Inflammatory Bowel Disease: Canadian Association of Gastroenterology显示文摘 | Geoffrey C. Nguyen Charles N. Bernstein Alain Bitton Anthony K. Chan Anne M. Griffiths Grigorios I. Leontiadis William Geerts Brian Bressler J. Decker Butzner Marc Carrier Nilesh Chande John K. Marshall Chadwick Williams Clive Kearon | 2014 | Gastroenterology2014，，3： | 2 |
| 3 | Recent Safety Concerns With Proton Pump Inhibitors显示文摘 | Joan Chen Yuhong Cathy Yuan Grigorios I. Leontiadis Colin W. Howden | 2012 | Journal of Clinical Gastroenterology2012，，2： | 2 |
| 4 | A meta-analysis of the yield of capsule endoscopy compared to other diagnostic modalities in patients with non-stricturing small bowel Crohn's disease显示文摘 | Triester SL Leighton JA Leontiadis GI | 2006 | Am J Gastroenterol2006，101，5： | 1 |
| 5 | Meta - analysis : the ef- ficacy of intravenous H2 - receptor antagonists in bleeding peptic ulcer 显示文摘 | Levine JE Leontiadis GI Sharma VK | 2002 | Aliment Pharmacol Ther2002，16，6： | 1 |
| 6 | Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding显示文摘 | Leontiadis GI Sreedharan A Dorward S | 2007 | Health Technol Assess2007，11，51： | 1 |
| 7 | Proton pump inhibitor treatment initiated prior to endoscopic diagnosis in upper gastrointestinal bleeding 显示文摘 | Sreedharan A Martin J Leontiadis GI | 2010 | Cochrane Database Syst Rev2010，，00： | 1 |
| 8 | A meta- analysis of the yield of capsule endoscopy compared to other diagnostic modalities in patients with obscure gastro- intestinal bleeding 显示文摘 | Triester SL Leighton JA Leontiadis GI | 2005 | Am J Gastroenterol2005，100，11： | 1 |
| 9 | Proton pumpinhibitor treatment initiated prior to endoscopic diagnosis in uppergastrointestinal bleeding 显示文摘 | Sreedharan A Martin J Leontiadis GI | 2010 | Cochrane Database Syst Rev2010，7，00： | 1 |
| 10 | A meta-analysis of the yield of capsule endoscopy compared to other diagnostic modalities in patients with obscure gastrointestinal bleeding 显示文摘 | Triester SL Leighton JA Leontiadis GI | 2005 | Am J Gastro- enterol2005，100，11： | 1 |
| 11 | Systematic review and meta -analysis of proton pump inhibitor therapy in peptic ulcer bleeding 显示文摘 | Leontiadis GI Sharma VK Howden CW | 2005 | BMJ2005，330，7491： | 1 |
| 12 | A hybrid approach for con- tent-based publish/subscribe in vehicular networks 显示文摘 | Leontiadis I Costa P Mascoloc C | 2009 | Perva- sive and Mobile Computing2009，5，6： | 1 |
| 13 | A meta - analysis of the yield of capsule endoscopy compared other diagnostic modalitie- sin patients with non--stficturing small bowel Crohn'S disease显示文摘 | Triester SL Leighton J A Leontiadis G I | 2006 | Am J Gastroenterol2006，101，95： | 1 |
| 14 | A meta-analysis of the yield of capsule endoscopy compared to other diagnostic modalities in patients with obscure gastrointestinal bleeding显示文摘 | Triester SL Leighton JA Leontiadis GI | 2005 | Am J Gastroenterel2005，100，： | 1 |
| 15 | Meta-analysis: the efficacy of intravenous H2-receptor antagonists in bleeding peptic ulcer显示文摘 | Levine J Leontiadis G Sharma V Howden C | 2002 | Aliment Pharmacol Ther2002，16，6： | 1 |
| 16 | A meta-anaIysis of the yield of capsule endoscopy compared to other diagnostic modalities in patients with obscure gastrointestinal bleeding显示文摘 | Triester SL Leighton JA Leontiadis GI | 2005 | The American Journal of Gastroenterology2005，100，1： | 1 |
| 17 | On the effectiveness of an opportunistic traffic management system for vehicular networks显示文摘 | Leontiadis I Marfia G Mack D | 2011 | IEEE Transactions on Intelligent Transportation Systems2011，12，4： | 1 |
| 18 | Systematic review and meta-analysis:enhanced efficacy of proton-pump inhibitor therapy for peptic ulcer bleeding in Asia-a post hoc analysis from the Cochrane Collaboration显示文摘 | Leontiadis UI Sharma VK Howden CW | 2010 | Aliment Pharmacol Ther2010，21，9： | 1 |
| 19 | The risks of PPI therapy显示文摘 | Moayyedi P Leontiadis G I | 2012 | Nat Rev Gastroentero| Hepatol2012，9，3： | 1 |
| 20 | High-dose versus low-dose intravenous proton pump inhibitor treatment for bleeding peptic ulcers显示文摘 | Leontiadis OI Howden CW Barkun AN | 2012 | Expert Rev Gastroenterol Hepatol2012，6，6： | 1 |
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