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| 1 | Device-associated infection rates, mortality, length of stay and bacterial resistance in intensive care units in Ecuador: International Nosocomial Infection Control Consortium's findings显示文摘AIM To report the results of the International Nosocomial Infection Control Consortium(INICC) study conducted in Quito, Ecuador.METHODS A device-associated healthcare-acquired infection(DAHAI) prospective surveillance study conducted from October 2013 to January 2015 in 2 adult intensive care units(ICUs) from 2 hospitals using the United States Centers for Disease Control/National Healthcare Safety Network(CDC/NHSN) definitions and INICC methods. RESULTS We followed 776 ICU patients for 4818 bed-days. The central line-associated bloodstream infection(CLABSI) rate was 6.5 per 1000 central line(CL)-days, the ventilator-associated pneumonia(VAP) rate was 44.3 per 1000 mechanical ventilator(MV)-days, and the catheterassociated urinary tract infection(CAUTI) rate was 5.7 per 1000 urinary catheter(UC)-days. CLABSI and CAUTI rates in our ICUs were similar to INICC rates [4.9(CLABSI) and 5.3(CAUTI)] and higher than NHSN rates [0.8(CLABSI) and 1.3(CAUTI)]- although device use ratios for CL and UC were higher than INICC and CDC/NSHN's ratios. By contrast, despite the VAP rate was higher than INICC(16.5) and NHSN's rates(1.1), MV DUR was lower in our ICUs. Resistance of A. baumannii to imipenem and meropenem was 75.0%, and of Pseudomonas aeruginosa to ciprofloxacin and piperacillin-tazobactam was higher than 72.7%, all them higher than CDC/NHSN rates. Excess length of stay was 7.4 d for patients with CLABSI, 4.8 for patients with VAP and 9.2 for patients CAUTI. Excess crude mortality in ICUs was 30.9% for CLABSI, 14.5% for VAP and 17.6% for CAUTI. CONCLUSION DA-HAI rates in our ICUs from Ecuador are higher than United States CDC/NSHN rates and similar to INICC international rates. | Estuardo Salgado Yepez Maria M Bovera Victor D Rosenthal Hugo A González Flores Leonardo Pazmino Francisco Valencia Nelly Alquinga Vanessa Ramirez Edgar Jara Miguel Lascano Veronica Delgado Cristian Cevallos Gasdali Santacruz Cristian Pelaéz Celso Zaruma Diego Barahona Pinto | 2017 | World Journal of Biological Chemistry2017，8，1： | 23 |
| 2 | 气象卫星云图的多分辨小波分解及人工神经网络降水估计研究显示文摘采用多分辨小波分析对卫星图象进行预处理 ,在保留其特征信息的同时 ,减小了数据量 ,改善了神经网络训练过程的收敛性能 ,提高了处理速度。采用这一方法根据 GOES- 8的红外亮温图象和气象雷达资料对巴西圣保罗州中部的降水量估计进行了试验 ,取得了良好的效果。 | 李伟钢 Maria C V Ramirez Nelson J Ferreira 石立华 Leonardo D de A Sá | 2000 | 南京气象学院学报2000，23，2： | 13 |
| 3 | Management of oligometastatic non-small cell lung cancer patients:Current controversies and future directions显示文摘Oligometastatic non-small cell lung cancer(NSCLC)describes an intermediate stage of NSCLC between localized and widely-disseminated disease.This stage of NSCLC is characterized by a limited number of metastases and a more indolent tumor biology.Currently,the management of oligometastatic NSCLC involves radical treatment(radiotherapy or surgery)that targets the metastatic lesions and the primary tumor to achieve disease control.This approach offers the potential to achieve prolonged survival in patients who,in the past,would have only received palliative measures.The optimal therapeutic strategies for the different scenarios of oligometastatic disease(intracranial vs extracranial disease,synchronous vs metachronous)remain undefined.Given the lack of head-to-head studies comparing radiotherapy to surgery in these patients,the decision to apply surgery or radiotherapy(with or without systemic treatment)must be based on prognostic factors that allow us to classify patients.This classification will allow us to select the most appropriate therapeutic strategy on an individualized basis.In the future,the molecular or microRNA profiles will likely improve the treatment selection process.The objective of the present article is to review the most relevant scientific evidence on the management of patients with oligometastatic NSCLC,focusing on the role of radiotherapy and surgery.We also discuss areas of controversy and future directions. | Felipe Counago Javier Luna Luis Leonardo Guerrero Blanca Vaquero María Cecilia Guillén-Sacoto Teresa González-Merino Begona Taboada Verónica Díaz Belén Rubio-Viqueira Ana Aurora Díaz-Gavela Francisco JoséMarcos Elia del Cerro | 2019 | World Journal of Clinical Oncology2019，10，10： | 5 |
| 4 | Effect of electrical stimulation of the lower esophageal sphincter in gastroesophageal reflux disease patients refractory to proton pump inhibitors显示文摘AIM: To evaluate the efficacy of lower esophageal sphincter(LES)-electrical stimulation therapy(EST) in a subgroup of patients that reported only partial response to proton pump inhibitors(PPIs) therapy, compared to a group of patient with complete response.METHODS: Bipolar stitch electrodes were laparoscopically placed in the LES and connected to an implantable pulse generator(EndoS tim BV, the Hague, the Netherlands), placed subcutaneously in the anterior abdominal wall. Stimulation at 20 Hz, 215 μsec, 3-8 m Amp in 30 min sessions was delivered starting on day 1 post-implant. Patients were evaluated using gastroesophageal reflux disease(GERD)-HRQL, symptom diaries; esophageal p H and esophageal manometry before and up to 24 mo after therapy and results were compared between partial and complete responders.RESULTS: Twenty-three patients with GERD on LESEST were enrolled and received continuous per-protocol stimulation through 12 mo and 21 patients completed 24 mo of therapy. Of the 23 patients, 16(8 male, mean age 52.1 ± 12 years) had incomplete response to PPIs prior to LES-EST, while 7 patients(5 male, mean age 52.7 ± 4.7) had complete response to PPIs. In the sub-group with incomplete response to PPIs, median(IQR) composite GERD-HRQL score improved significantly from 9.5(9.0-10.0) at baseline on-PPI and 24.0(20.8-26.3) at baseline off-PPI to 2.5(0.0-4.0) at 12-mo and 0.0(0.0-2.5) at 24-mo follow-up(P < 0.05 compared to on-and off-PPI at baseline). Median(IQR) % 24-h esophageal pH < 4.0 at baseline in this sub-group improved significantly from 9.8%(7.8-11.5) at baseline to 3.0%(1.9-6.3) at 12 mo(P < 0.001) and 4.6%(2.0-5.8) at 24 mo follow-up(P < 0.01). At their 24-mo follow-up, 9/11 patients in this sub-group were completely free of PPI use. These results were comparable to the sub-group that reported complete response to PPI therapy at baseline. No unanticipated implantation or stimulation-related adverse events, or any untoward sensation due to stimulation were reported in either group and LES-EST was safely tolerated by both groups. CONCLUSION: LES-EST is safe and effective in controlling symptoms and esophageal acid exposure in GERD patients with incomplete response to PPIs. These results were comparable to those observed PPI responders. | Edy Soffer Leonardo Rodríguez Patricia Rodriguez Beatriz Gómez Manoel G Neto Michael D Crowell | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，1： | 4 |
| 5 | Anatomical and functional changes after dexamethasone implant and ranibizumab in diabetic macular edema: a retrospective cohort study显示文摘AIM: To investigate the efficacy and safety of ranibizumab(RZB group) and dexamethasone implant(DEX group) intravitreal treatments in patients with treatment-na?ve center involved diabetic macular edema(DME) by means of functional and morphological assessments.METHODS: This retrospective cohort study included 50 eyes of 50 patients with DME treated either with RBZ or DEX. Best-corrected visual acuity(BCVA) and microperimetry were evaluated at baseline and during a 6-month follow-up. In addition, central macular thickness(CMT) by means of structural optical coherence tomography(OCT) and retinal capillary plexus density and choriocapillary density by means of OCT angiography were assessed in all cases.RESULTS: Functional and morphological parameters significantly improved during the study period in both groups. BCVA improved significantly in both groups witha greater increase in the DEX group compared to the RBZ group(P=0.030). Microperimetry significantly differed during follow-up between the two treatments(P=0.031). In both groups CMT significantly decreased(P<0.001) without statistically significant differences between the two groups. A statistically significant increase of deep capillary plexus density was detected in both groups at 30 d after therapy. The retreatment rate was 0.70±0.10 and 0.65±0.10 in the RBZ group and 0.65±0.10 and 0.50±0.11 in DEX group at 120 and 180 d respectively. Two out of 25 patients in DEX group showed intraocular pressure increase requiring hypotonic eye drops.CONCLUSION: Both treatments are very effective for DME treatment during 6 mo of follow-up with a lower retreatment rate in DEX group. | Leonardo Mastropasqua Silvio Di Staso Rossella D’Aloisio Alessandra Mastropasqua Luca DiAntonio Alfonso Senatore Marco Ciancaglini Marta Di Nicola Giuseppe Di Martino DanieleTognetto Lisa Toto | 2019 | International Journal of Ophthalmology(English edition)2019，12，10： | 2 |
| 6 | Early elevation of interleukin-1β and interleukin-6 levels after bare or drug-eluting stent implantation in patients with stable angina显示文摘 | Gennaro Sardella Paola Mariani Mariadomenica D’Alessandro Leonardo De Luca Marianna Pierro Massimo Mancone Alessandro Porretta Daniele Accapezzato Francesco Fedele Marino Paroli | 2005 | Thrombosis Research2005，，6： | 2 |
| 7 | Video-assisted thoracic surgery versus pleural drainage in the management of the first episode of primary spontaneous pneumothorax显示文摘 | Divisi D Di Leonardo G Crisci R | 2015 | American journal of surgery2015，210，1： | 1 |
| 8 | P5-HT1 A receptors in mood and anxiety:recent insights into autoreceptor versus heteroreceptor function显示文摘 | Garcia-Garcia A L Newman-Tancredi A Leonardo E D | 2013 | Psyc hopharmac ology (Berl)2013，15，： | 1 |
| 9 | Speciation of phosphorus fractionation in river sediments by explanatory data analysis显示文摘 | KATSAOUOS C Z GIOKAS D L LEONARDOS I D | 2007 | Water Research2007，41，2： | 1 |
| 10 | Interdependent response of networked systems 显示文摘 | Leonardo D James I Barry J | 2007 | Journal of Infrastructure System2007，，10： | 1 |
| 11 | Odor threshold determination of 53 odorant chemicals显示文摘 | LEONARDOS G KENDALL D BARNARD N | 1969 | Journal of the Air Pollution Control Association1969，19，2： | 1 |
| 12 | Protein secretion in Pichia pastoris and advances in protein production显示文摘 | Leonardo M D ChungJ H Carl A B | 2012 | Appl Microbiol Biotechnol2012，，： | 1 |
| 13 | Characterization of genes associated with induced resistance against Penicillium expansum in apple fruit treated with quercetin显示文摘 | SIMONA M S LEONARDO S ANNALISA D G | 2010 | Postharvest Biology and Technology2010，56，1： | 1 |
| 14 | Effects of nitrogen source,N∶P ratio and N-pulse concentration and frequency on the growth of Gracilaria cornea(Gracilariales,Rhodophyta) in culture显示文摘 | Leonardo N A Robledo D | 1999 | Hydrobiologia1999，，： | 1 |
| 15 | SBAS-based satellite orbit correction for the generation of DInSAR timeseries:application to RADARSAT-1 data显示文摘 | PEPE A BERARDINO P MANUELA B LEONARDO D E LANARI R SANSOSTI E | 2011 | IEEE2011，49，12： | 1 |
| 16 | Persistent Coronary No Flow After Wire Insertion Is an Early and Readily Available Mortality Risk Factor Despite Successful Mechanical Intervention in Acute Myocardial Infarction显示文摘 | Marco Valgimigli Gianluca Campo Patrizia Malagutti Maurizio Anselmi Leonardo Bolognese Flavio Ribichini Giacomo Boccuzzi Nicoletta de Cesare Alfredo E. Rodriguez Filippo Russo Raul Moreno Giuseppe Biondi-Zoccai Carlo Penzo José F. Díaz Fernández Giovanni | 2011 | JACC: Cardiovascular Interventions2011，，1： | 1 |
| 17 | Vats versus pleu- ral drainage in the management of the first episode of prima- ry spontaneous pneumothorax 显示文摘 | DIVIS! D DI LEONARDO G CRISCI R | 2015 | The American Journal of Surgery2015，30，15： | 1 |
| 18 | Assay of sudan Icontamination of foodstuff by atmospheric pressure chemicalionization tandem mass spectrometry and isotope dilution显示文摘 | Leonardo D D Loredana M Fabio M | 2004 | Anal Chem2004，76，51： | 1 |
| 19 | Real-time digital holographic microscopy of multiple and arbitrarily oriented planes 显示文摘 | CAVALLINI L BOLOGNESI G LEONARDO R D | 2011 | Optics Letters2011，36，17： | 1 |
| 20 | Estimating photosynthesis and concurrent export rates in C3 and C4 species at ambient and elevated CO2显示文摘 | Grodzinski B Jiao J Leonardos E D | 1998 | Plant Physiol1998，117，1： | 1 |
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