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49篇 您的检索式：作者名="LENGYEL P"

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	题名	作者	年代	出处	被引量
1	Relevance of α-defensins(HNP1-3) and defensin β-1 in diabetes显示文摘AIM: To investigate the genetic background of human defensin expression in type 1 and 2 diabetes.METHODS: Associations between DEFA1/DEFA3 gene copy number polymorphism and diabetes as well as between the promoter polymorphisms of DEFB1 and diabetes were studied. The copy number variation of the DEFA1/DEFA3 genes was determined in 257 diabetic patients(117 patients with type 1 and 140 with type 2 diabetes). The control group consisted of 221 age- and gender-matched healthy blood donors. The cumulative copy numbers of the DEFA1/DEFA3 genes were detected by using quantitative PCR analysis. To evaluate the HNP 1-3(human neutrophil peptide 1-3 or α-defensin) levels in the circulation, plasma HNP 1-3 concentrations were measured by ELISA. The expression of DEFA1/A3 in peripheral leukocytes of the diabetic patients was measured by quantitative RT PCR analysis. Three SNPs of the human DEFB1(human defensin β-1) gene: DEFB1 G-20A(rs11362), DEFB1 C-44G(rs1800972) and DEFB1 G-52A(rs1799946) were genotyped by Custom TaqMan? Real Time PCR assay.RESULTS: Significant differences were observed in HNP1-3 levels between the healthy subjects and both groups of diabetic patients. The mean ± SE was 28.78 ± 4.2 ng/mL in type 1 diabetes, and 29.82 ± 5.36 ng/mL in type 2 diabetes, vs 11.94 ± 2.96 ng/mL in controls; P < 0.01 respectively. There was no significant difference between patients with type 1 and type 2 diabetes in the high plasma concentrations of HNP1-3. The highest concentrations of α-defensin were found in diabetic patients with nephropathy(49.4 ± 4.8 ng/mL), neuropathy(38.7 ± 4.8 ng/mL) or cardiovascular complications(45.6 ± 1.45 ng/L). There was no significant difference in the cumulative copy numbers of DEFA1/DEFA3 genes between controls and patients, or between patients with the two types of diabetes. Comparisons of HNP 1-3 plasma level and DEFA1/A3 copy number of the same patient did not reveal significant relationship between defensin-α levels and the gene copy numbers(r2 = 0.01). Similarly, no positive correlation was observed between the copy numbers and the mRNA expression levels of DEFA1/A3. Regarding the C-44G polymorphism of DEFB1, the GG 'protective' genotype was much less frequent(1%-2%) among both groups of patients than among controls(9%).CONCLUSION: Elevated HNP1-3 levels in diabetes are independent of DEFA1/DEFA3 copy numbers, but GG genotype of C-44G SNP in DEFB1 gene may result in decreased defensin β-1 production.	Balázs Csaba Németh Tamás Várkonyi Ferenc Somogyvári Csaba Lengyel Katalin Fehértemplomi Szabolcs Nyiraty Péter Kempler Yvette Mándi	2014	World Journal of Gastroenterology2014，20，27：	4
2	Interferon action: nucleolar and nucleoplasmic localization of the interferon-inducible 72 kDa protein that is encoded by the Ifi204 gene from the gene 200 cluster显示文摘	Choubey D Lengyel P	1992	J Cell Biol1992，116，6：	1
3	Chronic aluminum treatment results in aluminum depostis and affects M1 muscarinic receptors in rat brain显示文摘	Lengyel Z Kasa P	1996	Neurobiology Bp1996，4，12：	1
4	Tumor suppressor genes: news about the interferon connection显示文摘	Lengyel P	1993	PNAS1993，90，：	1
5	Accumulation of an mRNA and protein in interferon-treated Ehrlich ascites tumour cells显示文摘	Farrell P J Broeze R J Lengyel P	1979	Nature1979，279，5713：	1
6	Increased short - term variability of the RT interval in professional soccer players: possible implications for arrhythmia prediction显示文摘	Lengyel C Orosz A Hegyi P	2011	PLoS ONE2011，6，4：	1
7	Albuminuria after fetal pancreatic islet transplantation:a 10-year follow-up显示文摘	V(o)r(o)s P Farkas G Lengyel Z		0，，：	1
8	Biochemstry of interferons and their action显示文摘	Lengyel P	1982	Annu Rev Biochem1982，51，2：	1
9	Chronic aluminum treatment results in aluminum depostis and affects M1 muscarinic receptors in rat brain 显示文摘	Harkany T Lengyel Z Kasa P	1996	Neurobiology Bp1996，4，：	1
10	Assessment of the effica- cy of the rectovaginal button fistula plug for the treatment of ile- al pouch-vaginal and rectovaginal fistulas 显示文摘	Gonsalves S Sagar P Lengyel J	2009	Dis Colon Rec- tum2009，52，11：	1
11	Chronic aluminum treatment result in aluminum deposits and affects M1 muscarinic receptors in rat brain 显示文摘	Harkany T Lengyel Z Kasa P Gluya K	1996	Neurobiology1996，4，12：	1
12	The interferon-inducible nucleolar p204 protein binds the ribosomal RNA transcription显示文摘	Liu CJ Wang H Lengyel P	1999	EMBOJ1999，18，10：	1
13	The P200 family protein P204 as a modulator of cell proliferation and differentiation:a brief survey显示文摘	Lengyel P Liu CJ	2010	Cell Mol Life Sci2010，67，：	1
14	The p200 family protein p204 as a modulator of cell proliferation and differentiation:a brief survey显示文摘	Lengyel P Liu CJ	2010	Cell Mol Life Sci2010，67，3：	1
15	Synapses with short- term plasticity are optimal estimators of presynaptic membrane potentials 显示文摘	Pfister J P Dayan P Lengyel M	2010	Nature Neuroseience2010，13，：	1
16	Gallbladder hypomotility in diabetic polyneuropathy显示文摘	Tamás T. Várkonyi M.D. Csaba Lengyel M.D. László Madácsy M.D. Borbála Vel?sy M.D. Ph.D. Péter Kempler M.D. Ph.D. D.Sc. Tamás Fazekas M.D. Ph.D. D.Sc. László Pávics M.D. Ph.D. László Csernay M.D. Ph.D. D.Sc. János Lonovics M.D. Ph.D	2001	Clinical Autonomic Research2001，，6：	1
17	Interferon action: RNA cleavage pattern of a (2' -5' ) oligoadenylate-dependent endonuclease 显示文摘	Floyd-Smith G Slattery E Lengyel P	1981	Science1981，212，4498：	1
18	Interferon action: RNA cleavage pattern of a (2'-5') oligoadenylate-dependent endonuclease 显示文摘	Floyd-Smith G Slattery E Lengyel P	1981	Science1981，212，4498：	1
19	Chronic aluminum treatment results in aluminum depostis and affects M1 muscarinic receptors in rat brain 显示文摘	Harkany Lengyel Z Kasa P	1996	Neurobiology Bp1996，4，：	1
20	Tumor suppressor genes:news about the interferon connection显示文摘	Lengyel P	1993	PNAS1993，90，：	1

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