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| 1 | Lactic acid bacteria as antigen delivery vehicles for oral immunization perposes 显示文摘 | Pouwels PH Leer RJ Shaw M | 1998 | Int J Food Microbiol1998，41，： | 1 |
| 2 | Apaptosis bcl-2 expression, and proliferation in benign and malignant endometrial epithelium: An approach using multiparameter flow cytometry显示文摘 | Morsi H M Leers M P Radespiel Troger M | 2000 | GynecolOncol2000，77，1： | 1 |
| 3 | Engineering the microflora to vaccinate the mucosa: serum immunoglobulin G responses and activated draining cervical lymph nodes following mucosal application of tetanus toxin fragment C-expressing Lactobacilli显示文摘 | Shaw D M Gaerthe B Leer R J | 2000 | Immunology2000，100，： | 1 |
| 4 | Reduced E-cadherin expression is associated with increased lymph node metastasis and unfavorable prognosis in non-small cell lung cancer显示文摘 | Sulzer M Leers M Bollen E | 1998 | Am J Respir Crit Care Med1998，157，4： | 1 |
| 5 | Distribution and modeling of rare earth elements in Chinese river sediments 显示文摘 | Zhu W Kennedy M de Leer E W B Zhou H Alaerts G J R | 1997 | The Science of the Total Environment1997，204，： | 1 |
| 6 | Effect of along distance run on cardiac markers in healthy athletes显示文摘 | LEERS M P SCHEPERS R BAUMGARTEN R | 2006 | Clin Chem Lab Med2006，144，： | 1 |
| 7 | Incompatibility of Lactobacilluz vectors with replicons derived from small cryptic Lactobacillus plasmids and segregational instability of the introduced vectors 显示文摘 | Posno M Leer R J van Luijk N | 1991 | Appl Environ Microbiol1991，57，6： | 1 |
| 8 | Engineering the microflora to vaccinate the mucosa: serum immunoglobulin G responses and activated draining cervical lymph nodes following mucosal application of tetanus toxin fragment C-expressing lactobacilli显示文摘 | Shaw D M Gaerthe B Leer R J | 2000 | Immunology2000，100，： | 1 |
| 9 | Engineering the microflora to vaccinate the mucosa:serum immunoglobulin G responses and activated draining cervical lymph nodes following mucosal application of tetanus toxin fragment C-expressing lactobacillus显示文摘 | Gaerthe B Leer R J | 2000 | Immunology2000，100，： | 1 |
| 10 | Aylmer's Library: Transcendental Alchemy in Hawthorne's The Birth-Mark 显示文摘 | Van Leer David M | 1976 | ESQ1976，22，1976： | 1 |
| 11 | Lactic acid bacteria as an- tigen delivery vehicles for oral immunization purposes 显示文摘 | Pouwels P H Leer R J Shaw M | 1998 | Inter J Food Microbiol1998，41，2： | 1 |
| 12 | Immunocytochemical detection and mapping of a cytokeratin 18 neo-epitope exposed during early apoptosis显示文摘 | Leers M P Kolgen W Bjorklund V | 1999 | J Pathol1999，187，： | 1 |
| 13 | Lactic Acid Bacteria as Antigen Delivery Vehicles for Oral Immunization Purposes显示文摘 | POUWELS P H LEER R J SHAW M | 1998 | International Journal of Food Microbiology1998，41，： | 1 |
| 14 | Complete genome sequence of Lactobacillus plantarum WCFS1 显示文摘 | Kleerebezem M Boekhorst J van Kranenburg R Molenaar D Kuipers O P Leer R Tarchini R Peters SA Sandbrink H M Fiers M W E J Stiekema W Lankhorst R M K Bron P A Hoffer S M Groot M N N Kerkhoven R de Vries M Ursing B de Vos W M Siezen R J | 2003 | Proceedings of the National Academy of Sciences2003，100，4： | 1 |
| 15 | Engineering the mi- croflora to vaccinate the mucosa: serum immunoglobulin G response and activated draining cervical lymph nodes following mucosal appli- cation of tetanus toxin fragment C 7 experssing Lactobacilli 显示文摘 | SHAW D M GAERTHE B LEER R J | 2000 | Im- munology2000，100，4： | 1 |
| 16 | Software improvement for evaluation of laryngopharyngeal pH testing(Restech)——a comparison between Data View 3 and 4显示文摘BACKGROUND When gastroesophageal reflux contents reach above the upper esophageal sphincter,patients may,in addition to typical reflux symptoms,present with atypical,extraesophageal symptoms related to laryngopharyngeal reflux(LPR).Surgical treatment of LPR has shown to lead to 70%symptom improvement,however no gold standard for the diagnosis of LPR exists.In 2007,the Restech Dx-pH was released as a valid method to measure acid exposure above the upper esophageal sphincter.Recently,a new software update was introduced for analysis of measured pH data and calculation of composite scores.The effect of the changes applied to the new software version have not yet been analyzed.AIM To compare results generated by Data View 3 to the most recently released Data View 4.METHODS All patients with gastroesophageal reflux disease symptoms were seen in a specialized surgical outpatient clinic for gastrointestinal function testing.Retrospective chart review was performed of all patients presenting with suspected gastroesophageal reflux disease and extraesophageal reflux symptoms,who underwent laryngopharyngeal pH monitoring using the Restech Dx-pH system(Respiratory Technology Corp.,Houston,TX,United States)and simultaneous esophageal pH monitoring.Data View 3 and Data View 4 were used to evaluate Restech studies obtained.Diary entries such as mealtimes,supine and upright periods,and symptoms were entered manually to ensure accuracy and precise conversion of data between both software versions.Paired t test was performed for statistical analysis of results.RESULTS A total of 174 patients(63.8%female)met inclusion criteria,all suffering from extraesophageal reflux symptoms as well as typical gastroesophageal reflux disease symptoms.Mean RYAN score upright was 48.77 in Data View 3 compared to 22.17 in Data View 4,showing a significant difference(~aP=0.0001).Similar results were shown for supine period(mean RYAN Score Data View 35.29 vs 1.42 in Data View 4,~cP=0.0001).For upright periods 80 patients showed a decrease of value of the RYAN score with a mean of-58.9(mean 51.1%decrease).For supine position 25 patients showed a decrease of value of the RYAN score with a mean of-15.13[range(-153.44)–(-0.01)],which equals a mean decrease of value of 44.5%.Ten patients showed no oropharyngeal acid exposure in Data View 3,but mild/moderate(n=7)or severe(n=3)acid exposure in Data View 4.Correlation with positive esophageal pH measurement was improved in all 10 patients.CONCLUSION Results of both software versions cannot be compared to each other.However,our data suggests that Data View 4 may be an improvement of the Restech pH measurement in the evaluation of LPR. | Dolores Thea Müller Elena Schulte Benjamin Babic Laura Knepper Claudia Fuchs Wolfgang Schroder Christiane J Bruns Jessica M Leers Hans Friedrich Fuchs | 2020 | World Journal of Gastrointestinal Surgery2020，12，5： | 1 |
| 17 | The expression of beta catenin in non-small-cell lung cancer: a clinicopathological study 显示文摘 | Leers MP Sulzer MA | 1998 | Clin Pathol1998，51，12： | 1 |
| 18 | Development and validation of a new in vitro assay for selection of probiotic bacteria that express immunestimulating properties in chickens in vivo显示文摘 | Koenen M E van der Hulst R Leering M | 2004 | FEMS Immunol Med Microbiol2004，40，： | 1 |
| 19 | Regulation of expression of the Lactobacillus pentosus xylAB operon 显示文摘 | LOKMAN B C HEERIKHUISEN M LEER R J | 1997 | J Bacteriol1997，179，17： | 1 |
| 20 | Lactic acid bacteria as antigen delivery vehicles for oral immunization purposes显示文摘 | Pouwels P H Leer R J Shaw M | 1998 | Int J Food Microbiol1998，41，2： | 1 |
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