维普期刊资源整合服务平台（V6.5）

1432篇 您的检索式：作者名="LEE MK"

选中清除导出查看参考文献查看引证文献引用追踪共72页首页上一页第1页下一页末页 /72 跳转

	题名	作者	年代	出处	被引量
1	Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides.	John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin	2015	World Journal of Gastroenterology2015，21，35：	3
2	New quantitative and qualitative measures on functional mobility prediction for stroke patients显示文摘	Lee MY Wong MK Tang FT	1998	J Med Eng Technol1998，22，1：	2
3	Cornuside suppresses cytokine-induced proinflammatory and adhesion molecules in the human umbilical vein endothelial cells 显示文摘	Kang DG Moon MK Lee AS	2007	Biol Pharm Bull2007，30，9：	1
4	Crystal structure of visfatin/pre-B cell colony-enhancing factor 1/nicotinamide phosphoribosyltransferase,free and in complex with the anti-cancer agent FK-866显示文摘	Kim MK Lee JH Kim H	2006	Journal of Molecular Biology2006，362，1：	1
5	Human mesenchymal stem cells maintain transgene expression during expansion and differentiation显示文摘	Lee K Majumdar MK Buyaner D	2001	Mol Ther2001，3，6：	1
6	The role of virus specific CD8+ cells in liver damage and viral control during persistent hepatitis B virus infection 显示文摘	Maini MK Boni C Lee CK	2000	J Experimental Medicine2000，191，8：	1
7	Comparative epidemiological studies on vector/reservoir animals of tsutsugamushi disease between high and low endemic areas in Korea显示文摘	Ree HI Cho MK Lee IY	1995	Korean J Parasitol1995，33，1：	1
8	Late stent malapposition after drug-eluting stent implantation:an intravascular ultrasound analysis with long-term follow-up显示文摘	Hong MK Mintz GS Lee CW	2006	Circulation2006，，3：	1
9	Recombinant polioviruses expres-sing hepatitis B virus-specific cytotoxic T-lymphocyte epito-pes显示文摘	Cho SP Lee B Min MK	2000	Vaccine2000，18，25：	1
10	Early changes in incretin secretion after laparoscopic duodenal-jejunal bypass surgery in type 2 diabetic patients显示文摘	Lee HC Kim MK Kwon HS	2010	Obese Surg2010，20，11：	1
11	Role of naringin supplement in regulation of lipid and ethanol metabolism in rats 显示文摘	Seo HJ Jeong KS Lee MK	2003	Life Sciences2003，73，：	1
12	Assessment of risk factors for Korean children with Kawasaki dis- ease显示文摘	Kim JJ Hong YM Yun SW Han MK Lee KY Song MS	2012	Pediatr Cardiol2012，33，4：	1
13	Contralateral acupuncture versus ipsilateral acupuncture in the rehabilitation of post- stroke hemiplegic patients: a systematic review显示文摘	Kim MK Choi TY Lee MS	2010	BMC Complementary and Alternative Medicine2010，10，：	1
14	Elective stenting of unprotected left main coronary artery stenosis:effect of debulking before stentiug and intravascular ultrasound guidance显示文摘	Park SJ Hong MK Lee CW	2001	J Am Coll Cardiol2001，38，4：	1
15	Seroprevalence of tissue invading parasitic infections diagnosed by ELISA in Korea显示文摘	Lee MK Hong SJ Kim HR	2010	J Korean Med Sci2010，25，9：	1
16	The effects of proteinuria on urinary cystatin-C and glomerular filtration rate calculated by serum cystatin-C显示文摘	Kim JS Kim MK Lee JY	2012	Ren Fail2012，34，6：	1
17	Neutralization epitopes on the antigenic domain U of the Orientia tsutsugamushi 56-kDa protein revealed by monoclonal antibodies显示文摘	Seong SY Kim MK Lee SM	2000	Vaccine2000，19，1：	1
18	The role of vlrus specific CD8 + cells in liver damage and viral control during persistent hepatitis B vires infection显示文摘	Maini MK Boni C Lee CK	2000	J Experimental Medicine2000，191，8：	1
19	Preoperative C-reactive protein levels are associated with tumor size and lymphovascular invasion in resec- ted non-small cell lung cancer显示文摘	Lee JG Cho BC Bae MK	2009	Lung Cancer2009，63，：	1
20	The effectiveness of syringe irrigation and ultrasonics to remove debris from simulated irregularities within prepared root canal walls显示文摘	Lee SJ Wu MK Wesselink PR	2004	Int Ended J2004，37，10：	1

返回顶部每页显示：

共72页首页上一页第1页下一页末页 /72 跳转

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

用户提示