|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Promoter hypermethylation of CDH1, FHIT, MTAP and PLAGL1 in gastric adenocarcinoma in individuals from Northern Brazil显示文摘AIM: To evaluate the methylation status of CDH1, FHIT, MTAP and PLAGL1 promoters and the association of these findings with clinico-pathological characteristics. METHODS: Methylation-specific PCR (MSP) assay was performed in 13 nonneoplastic gastric adenocarcinoma, 30 intestinal-type gastric adenocarcinoma and 35 diffuse- type gastric adenocarcinoma samples from individuals in Northern Brazil. Statistical analyses were performed using the chi-square or Fisher’s exact test to assess associations between methylation status and clinico- pathological characteristics. RESULTS: Hypermethylation frequencies of CDH1, FHIT, MTAP and PLAGL1 promoter were 98.7%, 53.9%, 23.1% and 29.5%, respectively. Hypermethylation of three or four genes revealed a significant association with diffuse-type gastric cancer compared with nonneoplastic cancer. A higher hypermethylation frequency wassignificantly associated with H pylori infection in gastric cancers, especially with diffuse-type. Cancer samples without lymph node metastasis showed a higher FHIT hypermethylation frequency. MTAP hypermethylation was associated with H pylori in gastric cancer samples, as well as with diffuse-type compared with intestinal-type. In diffuse-type, MTAP hypermethylation was associated with female gender. CONCLUSION: Our findings show differential gene methylation in tumoral tissue, which allows us to conclude that hypermethylation is associated with gastric carcinogenesis. MTAP promoter hypermethylation can be characterized as a marker of diffuse-type gastric cancer, especially in women and may help in diagnosis, prognosis and therapies. The H pylori infectious agent was present in 44.9% of the samples. This infection may be correlated with the carcinogenic process through the gene promoter hypermethylation, especially the MTAP promoter in diffuse-type. A higher H pylori infection in diffuse-type may be due to greater genetic predisposition. | Mariana Ferreira Leal Eleonidas Moura Lima Patrícia Natália Oliveira Silva Paulo Pimentel Assumpo Danielle Queiroz Calcagno Spencer Luiz Marques Payo Rommel Rodríguez Burbano Marília de Arruda Cardoso Smith | 2007 | World Journal of Gastroenterology2007，13，18： | 24 |
| 2 | MYC and gastric adenocarcinoma carcinogenesis显示文摘MYC is an oncogene involved in cell cycle regulation,cell growth arrest,cell adhesion,metabolism,ribosome biogenesis,protein synthesis,and mitochondrial function. It has been described as a key element of several carcinogenesis processes in humans. Many studies have shown an association between MYC deregulation and gastric cancer. MYC deregulation is also seen in gastric preneoplastic lesions and thus it may have a role in early gastric carcinogenesis. Several studies have suggested that amplification is the main mechanism of MYC deregulation in gastric cancer. In the present review,we focus on the deregulation of the MYC oncogene in gastric adenocarcinoma carcinogenesis,including its association with Helicobacter pylori (H pylori) and clinical applications. | Danielle Queiroz Calcagno Mariana Ferreira Leal Paulo Pimentel Assumpo Marília de Arruda Cardoso Smith Rommel Rodríguez Burbano | 2008 | World Journal of Gastroenterology2008，14，39： | 8 |
| 3 | Clinical implication of 14-3-3 epsilon expression in gastric cancer显示文摘AIM:To evaluate for the first time the protein and mRNA expression of 14-3-3εin gastric carcinogenesis.METHODS:14-3-3εprotein expression was determined by western blotting,and mRNA expression was examined by real-time quantitative RT-PCR in gastric tumors and their matched non-neoplastic gastric tissue samples.RESULTS:Authors observed a significant reduction of 14-3-3εprotein expression in gastric cancer(GC)samples compared to their matched non-neoplastic tissue.Reduced levels of 14-3-3εwere also associated with diffuse-type GC and early-onset of this pathology.Our data suggest that reduced 14-3-3εmay have a role in gastric carcinogenesis process.CONCLUSION:Our results reveal that the reduced 14-3-3εexpression in GC and investigation of 14-3-3ε interaction partners may help to elucidate the carcino-genesis process. | Mariana Ferreira Leal Danielle Queiroz Calcagno Smia Demachki Paulo Pimentel Assumpo Roger Chammas Rommel Rodríguez Burbano Marília de Arruda Cardoso Smith | 2012 | World Journal of Gastroenterology2012，18，13： | 6 |
| 4 | Use ofhandgrip strength in the as- sessment of the muscle function of chro- nic kidney disease patients on dialysis:a systematic review显示文摘 | Leal O | 2011 | Nephrology Dial- ysis Transplantation : Official P2011，26，4： | 1 |
| 5 | Muhisytinge flow injection system for total inorganic selenium determination by hydride generation-atomic fluorescence spectrometry显示文摘 | Sernenova N V Leal L O Forteza R | 2003 | Anal China Acta2003，486，： | 1 |
| 6 | The PTEN/PI3K/AKT signalling pathway in cancer,therapeutic implications显示文摘 | Carnero A Blanco-Aparicio C Renner O Link W Leal JF | 2008 | Curr Cancer Drug Targets2008，8，3： | 1 |
| 7 | Activation and early parthenogenesis of bovine oocytes treated with ethanol and strontium显示文摘 | Simone Cristina Méo Cláudia Lima Verde Leal Joaquim Mansano Garcia | 2004 | Animal Reproduction Science2004，81，： | 1 |
| 8 | Quercetin in- duces structural chromosomal aberrations and uncom- mon rearrangements in bovine cells transformed by the E7 protein of bovine papillomavirus type 4显示文摘 | Leal A M Ferraz O P Carvalho C | 2003 | Vet Comp Onco12003，1，1： | 1 |
| 9 | Potential antioxidant capacity of sulfated polysaccharides fi'om the edible marine brown seaweed Fucus vesiculosus 显示文摘 | Ruperez P Ahrazem O Leal JA | 2002 | J Agric Food Chem2002，50，4： | 1 |
| 10 | The hard choice for alternative biofuels to diesel in Brazil显示文摘 | Carioca J O B Hiluy Filho J J Leal M R L V | 2009 | Biotechnology Advances2009，27，6： | 1 |
| 11 | Envelope-related energy demand: A design indicator of energy performance for residential buildings in early design stages显示文摘 | Vasco Granadeiro Jo?o R. Correia Vítor M.S. Leal José P. Duarte | 2013 | Energy & Buildings2013，，： | 1 |
| 12 | PTEN, more than the AKT pathway显示文摘 | Blanco-Aparicio C Renner O Leal JF | 2007 | Carcinogenesis2007，28，7： | 1 |
| 13 | Speciation analysis of inorganic arsenic by a multisyringe flow injection system with hy dride generation-atomic fluorescence spectrometric detection显示文摘 | LEAL L O FORTEZA R CEAD'A V | 2006 | Talanta2006，69，： | 1 |
| 14 | PTEN,more than the AKT pathway显示文摘 | Blanco-Aparicio C Renner O Leal JF | 2007 | Carcinogenesis2007，28，7： | 1 |
| 15 | Potential antioxidant capacity of sulfated polysaccharides from the edible marine brown seaweed Fucus vesiculosus显示文摘 | Ruperez P Ahrazem O Leal JA | 2002 | J Agric Food Chem2002，50，： | 1 |
| 16 | The past is a foreign country'? Acculturation theory and the anthropology of Globalization显示文摘 | Jo(a)o Leal | 2011 | Etnogr áfica[online]2011，，02： | 1 |
| 17 | PTEN,more than the AKT pathway显示文摘 | Blanco-Aparicio C Renner O Leal JF | 2007 | Carcinogenesis2007，28，： | 1 |
| 18 | Synthesis of chalcone analogues with increased antileishmanial activity显示文摘 | Boeck P Bandeira Falcǎo C A Leal P C | | 0，，05： | 1 |
| 19 | Potential antioxidant capacity of sulfated polysaccharides from the cdible marine brown seaweed focuses vesiculosus显示文摘 | Ruperez P Ahrazem O Leal JA | 2002 | J Agric Food Chem2002，50，4： | 1 |
| 20 | Determination of mercury by multisyringe flow injection system with cold-vapor atomic absorption spectrometry 显示文摘 | Leal L O Elsholz O Forteza R | 2006 | Analytica Chimica Acta2006，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员