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| 1 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016，22，13： | 9 |
| 2 | Mechanism of dehydration inactivation of Lactobacillus plantarum显示文摘 | LIEVENSE L C VERBEEK M A M NOOMEN A | 2007 | Appl Microbiol Biotechnol2007，41，： | 1 |
| 3 | Prediction of bladder outlet obstruction in men with lower urinary tract symptoms using artificial neural networks显示文摘 | SONKE G S HESKES T VERBEEK A L | 2000 | J Urol2000，163，1： | 1 |
| 4 | Mechanism of dehydration inactivation of Lactobacillus plantaum显示文摘 | Lievense L C Verbeek M A M Noomen A | 1994 | Applied Microbiology and Biotechnology1994，41，： | 1 |
| 5 | Neovascular age-related maeular degeneration and its relationship to antioxidant intake 显示文摘 | SNELLEN E L VERBEEK A L van den HOOGEN G W | 2002 | Acta Ophthalmol Scand2002，80，： | 1 |
| 6 | Mortality and prehospital thrombolysis for acute myocardial infarction: A meta - analysis 显示文摘 | Morrison L J Verbeek PR McDonald Ac | 2000 | JAMA2000，283，20： | 1 |
| 7 | Do countries or industries explain momentum in Europe? 显示文摘 | Nijman T Swinkels L Verbeek M | 2004 | Journal of Empirical Fi- nance2004，11，4： | 1 |
| 8 | Experimental investigation of the pulse inver- sion technique for imaging ultrasound contrast agents 显示文摘 | VERBEEK X A A M LEDOUX L A F WILLIGERS J M | 2000 | J Acoust Soc Am2000，107，4： | 1 |
| 9 | Risk factors for ulnar nerve compression at the elbow:a case control study显示文摘 | Bartels R H Verbeek A L | | 0，，07： | 1 |
| 10 | Murine igGl complexes trigger immune effector functions predominantly via Fc gamma RⅢ(CD16显示文摘 | Hazenbos W L Heijnen I A Meyer D Hofhuis F M Renardel de Lavalette C R Schmidt R E Capel P J van de Winkel J G Gessner J E van den Berg T K Verbeek J S | | 0，，06： | 1 |
| 11 | Mechanism of dehydration inactivation of Lactobacillus plantaum显示文摘 | Lievense L C Verbeek M A M Noomen A | 1994 | Applied Microbiology and Biotechnology1994，41，： | 1 |
| 12 | Near‐infrared fluorescence‐guided resection of colorectal liver metastases显示文摘 | Joost R. van der Vorst Boudewijn E. Schaafsma Merlijn Hutteman Floris P. R. Verbeek Gerrit‐Jan Liefers Henk H. Hartgrink Vincent T. H. B. M. Smit Clemens W. G. M. L?wik Cornelis J. H. van de Velde John V. Frangioni Alexander L. Vahrmeijer | 2013 | Cancer2013，，18： | 1 |
| 13 | Random bladder biopsies and the risk of recurrent superficial bladder cancer: a prospective study in 1026 patients 显示文摘 | Witjes J A Kiemeney L A L M Verbeek A L M | 1992 | World J Urol1992，10，： | 1 |
| 14 | Pre- dictability of recurrent and progressive disease in individual- patients with primary superficial bladder cancer显示文摘 | Witjes J A Kiemeney L A L M Verbeek A L M etal | 1993 | J Urol1993，150，1： | 1 |
| 15 | The effect of tooth size discrepancy on occlusion: Am experimental study 显示文摘 | Heusdens M Dermaut L Verbeek R | 2000 | Angle Orthod Dentofac Orhod2000，117，： | 1 |
| 16 | The double explosive layer cylindrical compaction method显示文摘 | Stuivinga M Verbeek H l Carton E P | 1999 | Journal of Materials Processing Technology1999，85，： | 1 |
| 17 | Mortality and prehospital thrombolysis for acute myocardial infarction: a meta-analysis显示文摘 | Morrison L J Verbeek P R McDonald A C | 2000 | JAMA2000，283，20： | 1 |
| 18 | Serial prehospital 12-lead electrocardiograms increase identification of ST-segment elevation myocardial infarction显示文摘 | Verbeek PR Ryan D Turner L | 2012 | Prehosp Emerg Care2012，16，1： | 1 |
| 19 | Estimators for orientation and anisotropy in digitized images显示文摘 | VLIET L J V VERBEEK P W | 1995 | Proc First Conference of the Advanced School for Computing & Imaging1995，，： | 1 |
| 20 | The effect of tooth size discrepancy on occlusion:Am experimentM study显示文摘 | Heusdens M Dermaut L Verbeek R | 2000 | Angle Orthod Dentofac Orhod2000，117，： | 1 |
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