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| 1 | 血管内超声去肾交感神经术治疗高血压:一项多中心,国际,单盲,随机,假手术对照试验显示文摘早期研究表明,基于射频的去肾交感神经术可降低中度高血压患者的血压。研究者研究了在没有使用抗高血压药物的情况下,使用血管内超声去。肾交感神经术是否会降低高血压患者的动态血压。 | 刘青 叶鹏 Azizi M Schmieder RE Mahfoud F Weber MA Daemen J Davies J Basile J Kirtane AJ Wang Y Lobo MD Saxena M Feyz L Rader F Lurz P Sayer J Sapoval M Levy T Sanghvi K Abraham J Sharp ASP Fisher NDL Bloch MJ Reeve-Stoffer H Coleman L Mullin C Mauri L | 2018 | 中华高血压杂志2018，26，10： | 27 |
| 2 | 非维生素K拮抗与维生素K拮抗口服抗凝剂与脑出血患者住院死亡之间的关系显示文摘尽管非维生素K拮抗口服抗凝剂(non-vitamin K antagonist oral anticoagulants, NOACs)越来越多地应用于预防血栓栓塞性疾病,但关于NOACs相关性脑出血的数据仍然有限。 | 刘青 叶鹏 Inohara T Xian Y Liang L Matsouaka RA Saver JL Smith EE Schwamm LH Reeves MJ Hernandez AF Bhatt DL Peterson ED Fonarow GC | 2018 | 中华高血压杂志2018，26，2： | 16 |
| 3 | Predictors of spine deformity progression in adolescent idiopathic scoliosis: A systematic review with meta-analysis显示文摘AIM: To evaluate published data on the predictors of progressive adolescent idiopathic scoliosis(AIS) in order to evaluate their efficacy and level of evidence. METHODS: Selection criteria:(1) study design: randomized controlled clinical trials, prospective cohort studies and case series, retrospective comparative and none comparative studies;(2) participants: adolescents with AIS aged from 10 to 20 years; and(3) treatment: observation, bracing, and other. Search method: Ovid MEDLINE, Embase, the Cochrane Library, Pub Medand patent data bases. All years through August 2014 were included. Data were collected that showed an association between the studied characteristics and the progression of AIS or the severity of the spine deformity. Odds ratio(OR), sensitivity, specificity, positive and negative predictive values were also collected. A metaanalysis was performed to evaluate the pooled OR and predictive values, if more than 1 study presented a result. The GRADE approach was applied to evaluate the level of evidence.RESULTS: The review included 25 studies. All studies showed statistically significant or borderline association between severity or progression of AIS with the following characteristics:(1) An increase of the Cobb angle or axial rotation during brace treatment;(2) decrease of the rib-vertebral angle at the apical level of the convex side during brace treatment;(3) initial Cobb angle severity(> 25o);(4) osteopenia;(5) patient age < 13 years at diagnosis;(6) premenarche status;(7) skeletal immaturity;(8) thoracic deformity;(9) brain stem vestibular dysfunction; and(10) multiple indices combining radiographic, demographic, and physiologic characteristics. Single nucleotide polymorphisms of the following genes:(1) calmodulin 1;(2) estrogen receptor 1;(3) tryptophan hydroxylase 1;(3) insulin-like growth factor 1;(5) neurotrophin 3;(6) interleukin-17 receptor C;(7) melatonin receptor 1B, and(8) Scoli Score test. Other predictors included:(1) impairment of melatonin signaling in osteoblasts and peripheral blood mononuclear cells(PBMC);(2) G-protein signaling dysfunction in PBMC; and(3) the level of platelet calmodulin. However, predictive values of all these findings were limited, and the levels of evidence were low. The pooled result of brace treatment outcomes demonstrated that around 27% of patents with AIS experienced exacerbation of the spine deformity during or after brace treatment, and 15% required surgical correction. However, the level of evidence is also low due to the limitations of the included studies.CONCLUSION: This review did not reveal any methods for the prediction of progression in AIS that could be recommended for clinical use as diagnostic criteria. | Andriy Noshchenko Lilian Hoffecker Emily M Lindley Evalina L Burger Christopher MJ Cain Vikas V Patel Andrew P Bradford | 2015 | World Journal of Orthopedics2015，6，7： | 4 |
| 4 | 失眠在创伤后应激障碍与高血压关系中的作用显示文摘创伤后应激障碍(posttraumatic stress disorder,PTSD)与高血压发病相关。PTSD还与失眠症相关,尽管对两者关系知之甚少,但它会增加高血压患病风险。失眠是否会增加PTSD相关的高血压风险目前仍是未知的。方法:研究者检索了1109名女性退伍军人队列研究(women veterans cohort study)参与者[平均年龄为(43.8±10.9)岁;52%为女性,81%为白人]的问卷调查和电子健康记录数据,评估其PTSD症状严重程度、近期失眠症状与高血压的横断面关系。 | 周卫(译) 袁源(审校) Gaffey AE Redeker NS Rosman L Mullington MJ Brandt CA Haskell SG Burg MM | 2020 | 中华高血压杂志2020，28，9： | 3 |
| 5 | p53/microRNA-214/ULK1信号通路调控的自噬在糖尿病肾病中的作用机制显示文摘目前有多个研究证实糖尿病肾病中存在自噬失调,但其潜在的病理机制并不清楚。该研究通过对糖尿病小鼠及糖尿病患者肾脏组织分析发现,自噬反应在肾脏中均明显被抑制。特异性敲除小鼠肾脏近端小管的自噬相关基因Atg6后可抑制自噬作用,导致糖尿病小鼠肾脏肥大,加重小管损伤、炎症反应及纤维化,最终导致蛋白尿增加,说明自噬在糖尿病肾病中起保护作用。与此同时,研究发现糖尿病组织中小RNA214(miR-214)表达上调,从而抑制下游unc-51样自噬相关激活酶(ULK1)的表达,最终导致自噬表达降低。特异性沉默肾脏近端小管miR-214的表达可减少对ULK1的抑制,阻止了糖尿病肾病肾脏体积的增大,降低了蛋白尿水平。 | Ma Z Li L Livingston MJ 梅淑钦(编译) | 2021 | 中华医学杂志2021，101，42： | 2 |
| 6 | Anesthsia by n-alkane not consistent with the Meyer-Overton hypothesis:Determination of the solubilities of alkanes in saline and various lipids显示文摘 | Taheri S Laster MJ Jin L | 1993 | Anesth Analg1993，77，1： | 2 |
| 7 | Cloning and functional expression of a htunan liver organic cation transporter 显示文摘 | Zhang L Dresser MJ Gray AT | 1997 | Mol Pharmacol1997，51，： | 1 |
| 8 | Acceptability and impact of zidovudine for prevention of mother-to-child human immunodeficiency virus-1 transmission in France 显示文摘 | Mayaux MJ Teglas JP Mandelbrot L | 1997 | J Pecliatr1997，131，6： | 1 |
| 9 | Expanding the phenotypic spectrum of LICAM- associated disease 显示文摘 | Basel- Vanagaite L Straussberg R Friez MJ | 2006 | Clin Genet2006，69，5： | 1 |
| 10 | The role of corticotrophin releasing factor in depress andanxiety disorder显示文摘 | Owens MJ Plotsky PM | 1999 | J Endocrinol1999，160，1： | 1 |
| 11 | Genome remodelling in a basal-like breast cancer metastasis and xenograft显示文摘 | Ding L Ellis MJ Li S Larson DE | 2010 | Nature2010，464，7291： | 1 |
| 12 | Impaired allocentric spatial working memory and intact retrograde memory after thalamic damage caused by thiamine deficiency in rats显示文摘 | Mumby DG Cameli L Glenn MJ | 1999 | Behav Neurosci1999，113，1： | 1 |
| 13 | Treatment of node-negative infra-centimetric HER2+ invasive breast carcinomas:a joint AERIO/REMAGUS study显示文摘 | Rodrigues MJ Wassermann J Albiges-Sauvin L | 2009 | J Clin Onco12009，27，15： | 1 |
| 14 | The role of RhoA/Rho kinase pathway in endothelial dysfunction显示文摘 | Yao L Romero MJ Toque HA | 2010 | J Card-iovasc Dis Res2010，1，4： | 1 |
| 15 | Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx 1 显示文摘 | Pierani A Moran-Rivard L Sunshine MJ | 2001 | Neuron2001，29，： | 1 |
| 16 | Determination of Nacetylcysteine using RPHPLC and post-column derivatization with 5,5, -dithiobis- (2-nitrobenzoic acid ) 显示文摘 | Nozal MJ Bernal JL Toribio L | 1997 | J Chromatogr A1997，778，12： | 1 |
| 17 | Separable noradrenergie and dopaminergie regulation of prepulse inhibition in rats: implications for predictive validity and Tourette Syndrome显示文摘 | Swerdlow NR Bongiovanni MJ Tochen L | 2006 | Psychophamacology( Berl)2006，186，2： | 1 |
| 18 | The importance of expectations on participatory sport event satisfaction: An exploration into the effect of athlete skill level on service expectations显示文摘 | BERNTHAL MJ SAWYER L | 2004 | Sport J2004，7，19： | 1 |
| 19 | Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion显示文摘 | Schreiber RD Old L J Smyth MJ | 2011 | Science2011，331，6024： | 1 |
| 20 | Melanin as an adsorbent for drug residues 显示文摘 | Howells L Godfrey M Saner MJ | 1994 | Analyst1994，119，： | 1 |
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