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| 1 | Umbelliferone ameliorates renal function in diabetic nephropathy rats through regulating inflammation and TLR/NF-κB pathway显示文摘Diabetic nephropathy(DN) is a leading cause of renal failure, contributing to severe morbidity and mortality in diabetic patients. Umbelliferae(Umb) has been well characterized to exert protective effects in diabetes. However, the action and mechanism of Umb in DN remains unclear. In this work, we studied the effect of Umb in a streptozotocin(STZ)-induced DN rat model and explore its underlying mechanism. DN rats were treated with Umb(20, 40 mg·kg^(-1)) or irbesartan(15 mg·kg^(-1)) for 4 weeks. Levels of serum glucose, insulin, blood uric acid, creatinine, triglycerides(TG) and total cholesterol(TC) were measured by commercial assay kits,respectively. Histopathological changes and inflammatory cytokine levels including IL-6, IL-1β and TNF-α in the kidney were also evaluated. Alterations in the expression of podocin, CD2 AP and TLR/NF-κB were assessed by western blotting. Our results showed that Umb reduced renal injury in DN rat model, as evidenced by the decrease in blood glucose, 24 h urinary protein, serum creatinine,and blood uric acid. Umb also significantly ameliorated the renal histopathological alteration, and down-regulated the expression of epithelial-to-mesenchymal transition-related molecular markers podocin and CD2AP. Moreover, Umb inhibited TLR2, TLR4, MyD88 expressions, NF-κB activation and considerably reduced levels of other downstream inflammatory molecules(TNF-α, IL-6, IL-1β).These findings indicated that Umb improved renal function through regulating inflammation and TLR/NF-κB pathway, suggesting the potential efficacy of Umb in DN treatment. | WANG Han-Qing WANG Sha-Sha Chiufai Kuok WANG Qi CHENG Xiao-Lan | 2019 | Chinese Journal of Natural Medicines2019，17，5： | 14 |
| 2 | SnSb@carbon nanocable anchored on graphene sheets for sodium ion batteries显示文摘有唯一的 nanostructures 的材料的开发是为在钠离子电池的钠存储的改进的有效策略完成稳定的骑车的性能和好率能力。在这个工作, SnSbcore/carbon-shell nanocables 直接在 graphene 表(GS ) 上抛锚了被热水的技术和化学蒸汽免职综合。同时的碳涂层和 SnSb 合金的封装为在钠离子电池减轻卷变化问题是有效的。在在钠离子电池为 SnSb 优化电解质以后,优化同轴的 SnSb/carbon nanocable/GS (SnSb/CNT@GS ) nanostructure 在 1 M NaClO 表明了稳定的骑车的能力和率性能 < 潜水艇 class= “ a-plus-plus ” > 有丙烯碳酸盐(PC ) 的 4 +5% fluoroethylene 碳酸盐(FEC ) 。SnSb/CNT@GS 电极能为多达 100 个周期保留 360 mAh/g 的一个能力,它是 71% 理论能力。这比在测试的另外的三电解质高( 1 M NaClO <潜水艇class=“ a-plus-plus ”> 4 在 PC , 1 M NaClO <潜水艇class=“ a-plus-plus ”>在 PC/FEC ( 1:1 v/v )和 1 M NaPF 的 4 <潜水艇class=“ a-plus-plus ”> 6 + PC ),并且比没有 graphene 的增加的样品的高。好电气化学的性能能被归因于禁止 SnSb 粒子,以及它的高传导性的凝块的外部碳 nanocable 层和 graphene 提供的有效缓冲。 | Li Li Kuok Hau Seng Dan Li Yongyao Xia Hua Kun Liu Zaiping Guo | 2014 | Nano Research2014，7，10： | 9 |
| 3 | Modeling of environmental influence in structural health assessment for reinforced concrete buildings显示文摘One branch of structural health monitoring (SHM) utilizes dynamic response measurements to assess the structural integrity of civil infrastructures. In particular,modal frequency is a widely adopted indicator for structural damage since its square is proportional to structural stiffness. However,it has been demonstrated in various SHM projects that this indicator is substantially affected by fluctuating environmental conditions. In order to provide reliable and consistent information on the health status of the monitored structures,it is necessary to develop a method to filter this interference. This study attempts to model and quantify the environmental influence on the modal frequencies of reinforced concrete buildings. Daily structural response measurements of a twenty-two story reinforced concrete building were collected and analyzed over a one-year period. The Bayesian spectral density approach was utilized to identify the modal frequencies of this building and it was clearly seen that the temperature and humidity fluctuation induced notable variations. A mathematical model was developed to quantify the environmental effects and model complexity was taken into consideration. Based on a Timoshenko beam model,the full model class was constructed and other reduced-order model class candidates were obtained. Then,the Bayesian modal class selection approach was employed to select the one with the most suitable complexity. The proposed model successfully characterizes the environmental influence on the modal frequencies. Furthermore,the estimated uncertainty of the model parameters allows for assessment of the reliability of the prediction. This study not only improves the understanding about the monitored structure,but also establishes a systematic approach for reliable health assessment of reinforced concrete buildings. | Ka-Veng Yuen Sin-Chi Kuok | 2010 | Earthquake Engineering and Engineering Vibration2010，9，2： | 3 |
| 4 | Mining fuzzy association rules in databases 显示文摘 | Kuok C Fu A Wong M | 1998 | SIGMOD Record1998，27，1： | 1 |
| 5 | Novel wavelet approach to current differential pilot relay protection显示文摘 | Wong Chi Kong Lam Chi Wai Lei Kuok Cheong | 2003 | IEEE Transactions on Power Delivery2003，18，1： | 1 |
| 6 | Mining fuzzy association rules in databases显示文摘 | Kuok C M Fu A Wong M | 1998 | SIGMOD Record1998，27，1： | 1 |
| 7 | Spin wave quantization in ferromagnetic nickel nanowires显示文摘 | Z K Wang M H Kuok S C Ng | 2002 | Pys Rev Lett2002，，89： | 1 |
| 8 | Palladium-catalyzed heterofunctional- ization of C - H, C = C and C=-C bonds显示文摘 | Adrio L Kuok M | 2011 | Current Or- ganic Chemistry2011，15，18： | 1 |
| 9 | Design of Simply Supported Deep Beams Using Strut-and-Tie Models显示文摘 | Adolfo B Matamoros Kuok Hong Wong | 2003 | ACI Structural Journal2003，100，6： | 1 |
| 10 | Mining Fuzzy Association Rules in Database 显示文摘 | Kuok C M Fu A | 1998 | SIGMOD Record1998，27，1： | 1 |
| 11 | Mining fuzzy association rules in databases显示文摘 | Kuok CM Fu AWC Wong MH | 1998 | SIGMOD Record1998，27，1： | 1 |
| 12 | Residential broadband internet services and applications requirements显示文摘 | KUOK T C | 1997 | IEEE Communications Magazine1997，35，6： | 1 |
| 13 | Mining fuzzy association rules in databases显示文摘 | FU A WONG M | 1998 | Geographic Information Systems1998，27，1： | 1 |
| 14 | Design ofSimply Supported Deep Beams Using Strut-and-TieModels显示文摘 | Matamoros Adolfo B Wong Hong Kuok | 2003 | ACI Structural Journal2003，100，6： | 1 |
| 15 | Spin wave quantization in ferromagnetic nickel nanowires 显示文摘 | Wang Z K Kuok M H Ng S C | 2002 | Phys Rev Lett2002，89，02： | 1 |
| 16 | Spin wave quantization in ferromagnetic nickel nanowires显示文摘 | Wang Z K Kuok M H Ng S C | 2002 | Phys Rev Lett2002，89，02： | 1 |
| 17 | A study of human resources recruitment, selection, and retention issues in the hospitality and tourism industry in macau 显示文摘 | Chan S H Kuok O M | 2011 | Journal of Human Resources in Hospitality & Tourism2011，10，4： | 1 |
| 18 | Particle swarm optimization feedforward neural network for modeling runoff显示文摘 | Kuok K K Harun S Shamsuddin S M | 2010 | hatemational Journal of Environmental Science and Technology2010，7，1： | 1 |
| 19 | Mining Fuzzy Association Rules in Databases 显示文摘 | Kuok C Fu A Wong M | 1998 | SIGMOD Record1998，17，1： | 1 |
| 20 | Mining fuzzy association rules in database显示文摘 | Kuok C M Fu A W C Wong M H | 1998 | SIGMOD Record1998，27，1： | 1 |
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